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Extract from the Register of European Patents

EP About this file: EP1668162

EP1668162 - DETECTION OF IMMOBILIZED NUCLEIC ACID [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.02.2010
Database last updated on 10.07.2024
Most recent event   Tooltip07.09.2012Lapse of the patent in a contracting state
New state(s): PT		published on 10.10.2012  [2012/41]
Applicant(s)For all designated states
Molecular Probes Inc.
29851 Willow Creek Road
Eugene, OR 97402 / US
[2006/24]
Inventor(s)01 / BEAUDET, Matthew, P.
996 Sherwood Place
Eugene, OR 97401 / US
02 / COX, Gregory, W.
5155 Nectar Way
Eugene, OR 97402 / US
03 / YUE, Stephen
2940 West 19th Avenue
Eugene, OR 97405 / US
 [2006/24]
Representative(s)HGF
1 City Walk
Leeds LS11 9DX / GB
[N/P]
Former [2006/24]Harrison Goddard Foote
Belgrave Hall Belgrave Street
Leeds LS2 8DD / GB
Application number, filing date04789513.130.09.2004
[2006/24]
WO2004US32693
Priority number, dateUS20030507630P30.09.2003         Original published format: US 507630 P
[2006/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005033342
Date:14.04.2005
Language:EN
[2005/15]
Type: A1 Application with search report 
No.:EP1668162
Date:14.06.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 14.04.2005 takes the place of the publication of the European patent application.
[2006/24]
Type: B1 Patent specification 
No.:EP1668162
Date:08.04.2009
Language:EN
[2009/15]
Search report(s)International search report - published on:EP14.04.2005
ClassificationIPC:C12Q1/68
[2006/24]
CPC:
C07D417/06 (EP,US); G01N21/64 (US); C09B23/02 (EP,US);
C09B23/04 (US); C12Q1/6816 (EP,US); C12Q1/6825 (US);
G01N1/30 (US); G01N2001/302 (US); Y10T436/143333 (EP,US) (-)
C-Set:
C12Q1/6816, C12Q2563/173, C12Q2565/125 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/24]
Extension statesALNot yet paid
HRNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:NACHWEIS VON IMMOBILISIERTER NUKLEINSÄURE[2006/24]
English:DETECTION OF IMMOBILIZED NUCLEIC ACID[2006/24]
French:DETECTION D'ACIDE NUCLEIQUE IMMOBILISE[2006/24]
Entry into regional phase31.03.2006National basic fee paid 
31.03.2006Designation fee(s) paid 
31.03.2006Examination fee paid 
Examination procedure31.03.2006Amendment by applicant (claims and/or description)
31.03.2006Examination requested  [2006/24]
26.02.2007Despatch of a communication from the examining division (Time limit: M06)
10.09.2007Reply to a communication from the examining division
14.02.2008Despatch of a communication from the examining division (Time limit: M04)
13.06.2008Reply to a communication from the examining division
28.10.2008Communication of intention to grant the patent
10.02.2009Fee for grant paid
10.02.2009Fee for publishing/printing paid
Divisional application(s)EP08158255.3  / EP1988177
Opposition(s)11.01.2010No opposition filed within time limit [2010/11]
Fees paidRenewal fee
31.03.2006Renewal fee patent year 03
26.09.2007Renewal fee patent year 04
25.09.2008Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT08.04.2009
BE08.04.2009
CY08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
IT08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
TR08.04.2009
BG08.07.2009
SE08.07.2009
GR09.07.2009
ES19.07.2009
PT08.09.2009
CH30.09.2009
IE30.09.2009
LI30.09.2009
LU30.09.2009
MC30.09.2009
HU09.10.2009
[2012/41]
Former [2011/44]AT08.04.2009
BE08.04.2009
CY08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
IT08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
TR08.04.2009
BG08.07.2009
SE08.07.2009
GR09.07.2009
ES19.07.2009
CH30.09.2009
IE30.09.2009
LI30.09.2009
LU30.09.2009
MC30.09.2009
HU09.10.2009
Former [2011/32]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
IT08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
GR09.07.2009
ES19.07.2009
CH30.09.2009
IE30.09.2009
LI30.09.2009
LU30.09.2009
MC30.09.2009
HU09.10.2009
Former [2011/21]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
IT08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
GR09.07.2009
ES19.07.2009
CH30.09.2009
IE30.09.2009
LI30.09.2009
LU30.09.2009
MC30.09.2009
Former [2011/15]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
IT08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
GR09.07.2009
ES19.07.2009
CH30.09.2009
IE30.09.2009
LI30.09.2009
MC30.09.2009
Former [2010/46]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
GR09.07.2009
ES19.07.2009
CH30.09.2009
IE30.09.2009
LI30.09.2009
MC30.09.2009
Former [2010/36]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
ES19.07.2009
IE30.09.2009
MC30.09.2009
Former [2010/20]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
ES19.07.2009
MC30.09.2009
Former [2010/18]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
BG08.07.2009
SE08.07.2009
ES19.07.2009
Former [2010/10]AT08.04.2009
BE08.04.2009
CZ08.04.2009
DK08.04.2009
EE08.04.2009
FI08.04.2009
NL08.04.2009
PL08.04.2009
RO08.04.2009
SI08.04.2009
SK08.04.2009
SE08.07.2009
ES19.07.2009
Former [2010/01]AT08.04.2009
FI08.04.2009
NL08.04.2009
PL08.04.2009
SI08.04.2009
SE08.07.2009
ES19.07.2009
Former [2009/51]AT08.04.2009
FI08.04.2009
NL08.04.2009
SI08.04.2009
SE08.07.2009
ES19.07.2009
Former [2009/46]SI08.04.2009
ES19.07.2009
Former [2009/36]SI08.04.2009
Cited inInternational search[Y]US4883867  (LEE LINDA G [US], et al) [Y] 1-49 * claim 1; examples *;
 [X]US5321130  (YUE STEPHEN T [US], et al) [X] 37,38,43-45 * table 1, compounds 3, 4, 7-14; examples 2, 6 *;
 [X]WO9424213  (MOLECULAR PROBES INC [US]) [X] 37,38,43-45 * examples 13, 14, 17 *;
 [Y]US5656449  (YUE STEPHEN T [US]) [Y] 6,9,16 * examples 2, 9, 22 *;
 [X]US5929227  (GLAZER ALEXANDER N [US], et al) [X] 20,23-26,29,34-38,43,44 * figure 5, compounds 10, 12-14; column 10, table 3 *;
 [XY]  - MCINTOSH S L ET AL, "Fluorescence lifetime for on-the-fly multiplex detection of DNA restriction fragments in capillary electrophoresis.", ANALYTICAL CHEMISTRY. 1 NOV 2000, (20001101), vol. 72, no. 21, ISSN 0003-2700, pages 5444 - 5449, XP002314094 [X] 1-5,7,8,11,12,14,15,17-23,25,26,28-32,35-39,41,43-46,48 * page 5445, figure 1, dyes 1, 4, and YO; page 5445, left-hand column, last full paragraph; page 5446, table 1; page 5447, right-hand column, fore last paragraph - page 5449, last paragraph and figures. * [Y] 6,9,16

DOI:   http://dx.doi.org/10.1021/ac000235t
 [X]  - RYE H S ET AL, "STABLE FLUORESCENT COMPLEXES OF DOUBLE-STRANDED DNA WITH BIS-INTERCALATING ASYMMETRIC CYANINE DYES: PROPERTIES AND APPLICATIONS", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, (1992), vol. 20, no. 11, ISSN 0305-1048, pages 2803 - 2812, XP002911844 [X] 1-4,7,8,11,12,14,17-20,22-26,28,29,31,32,34-41,43-48 * page 2804, right-hand column; page 2805, figure 1; page 2806, figure 3 and "Complex formation..."; page 2808, middle right column; page 2809, "Interaction of YO with dsDNA" *
 [PX]  - ERIKSSON MAJA ET AL, "Groove-binding unsymmetrical cyanine dyes for staining of DNA: dissociation rates in free solution and electrophoresis gels.", NUCLEIC ACIDS RESEARCH. 1 NOV 2003, (20031101), vol. 31, no. 21, ISSN 1362-4962, pages 6235 - 6242, XP002314095 [PX] 20,29,37,43 * page 6236, figure 1 and "Materials and Methods" *

DOI:   http://dx.doi.org/10.1093/nar/gkg822
 [Y]  - RYE H S ET AL, "HIGH-SENSITIVITY TWO-COLOR DETECTION OF DOUBLE-STRANDED DNA WITH A CONFOCAL FLUORESCENCE GEL SCANNER USING ETHIDIUM HOMODIMER AND THIAZOLE ORANGE", NUCLEIC ACIDS RESEARCH, (1991), vol. 19, no. 2, ISSN 0305-1048, pages 327 - 333, XP002314096 [Y] 1-49 * page 328, "Results" *
 [Y]  - TIMTCHEVA, I. ET AL, "New asymmetric monomethine cyanine dyes for nucleic - acid labelling : absorption and fluorescence spectral characteristics", JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY, A: CHEMISTRY , 130(1), 7-11 CODEN: JPPCEJ; ISSN: 1010-6030, (2000), XP002314097 [Y] 1-49 * page 8, figure 1 *

DOI:   http://dx.doi.org/10.1016/S1010-6030(99)00207-5
by applicantUS4883867
 US4957870
 US5321130
 WO9424213
 US5436134
 US5534416
 WO9634276
 US5582702
 US5658751
 WO9741070
 US5863753
 US5865974
 US5929227
 WO9942620
 EP1057001
 US6198107
 US6379516
 US2002112960
 US2002134680
 US6512236
 US6562213
    - M.J. WARING, J. MOL. BIOL., (1965), vol. 13, pages 269 - 282
    - MCCANN ET AL., PNAS, (1975), vol. 72, pages 5135 - 5139
    - SINGER ET AL., MUTATION RESEARCH, (1999), vol. 439, pages 37 - 47
    - FUKUNAGA ET AL., MUTATION RESEARCH, (1984), vol. 127, pages 31 - 37
    - MCINTOSH ET AL., ANAL. CHEM, (2000), vol. 72, pages 5444 - 5449
    - RYE ET AL., NUCLEIC ACIDS RES., (1992), vol. 20, pages 2807 - 2812
    - J. B. LEPECQ, ANAL. BIOCHEM., (1966), vol. 17, pages 100 - 107
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.