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Extract from the Register of European Patents

EP About this file: EP1689443

EP1689443 - POLYMALIC ACID-BASED MULTIFUNCTIONAL DRUG DELIVERY SYSTEM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.01.2020
Database last updated on 30.10.2024
FormerThe patent has been granted
Status updated on  08.02.2019
FormerGrant of patent is intended
Status updated on  10.12.2018
FormerExamination is in progress
Status updated on  01.03.2017
Most recent event   Tooltip09.07.2021Lapse of the patent in a contracting state
New state(s): HU		published on 11.08.2021  [2021/32]
Applicant(s)For all designated states
ARROGENE, INC.
8631 West Third Street, Suite 800E
Los Angeles, CA 90048 / US
For all designated states
Cedars-Sinai Medical Center
8700 Beverly Boulevard
Los Angeles, CA 90048 / US
[2019/11]
Former [2006/44]For all designated states
ARROGENE, INC.
8631 West Third Street, Suite 800E
Los Angeles, CA 90048 / US
For all designated states
Cedars-Sinai Medical Center
8700 Beverley Boulevard
Los Angeles, CA 90048 / US
Former [2006/33]For all designated states
ARROGENE, INC.
8631 West Third Street, Suite 800E
Los Angeles, CA 90048 / US
Inventor(s)01 / LJUBIMOVA, Julia, Y.
11419 Dona Pegita Drive
Studio City, CA 91604 / US
02 / BLACK, Keith, L.
1233 Roberto Lane
Los Angeles, CA 90077 / US
03 / HOLLER, Eggehard
Universitat regensburg
93040 Regensburg / DE
 [2006/33]
Representative(s)HGF
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
[N/P]
Former [2019/11]HGF Limited
4th Floor
Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Former [2014/07]Russell, Karen A.J., et al
Harrison Goddard Foote LLP
4th Floor, Merchant Exchange
17-19 Whitworth Street West
Manchester M1 5WG / GB
Former [2010/29]Wells, Andrew, et al
Harrison Goddard Foote 4th Floor, Merchant Exchange 17-19 Whitworth Street West
Manchester M1 5WG / GB
Former [2010/20]Cawley, Aimee Elizabeth, et al
Marks & Clerk LLP Sussex House 83-85 Mosley Street Manchester
M2 3LG / GB
Former [2006/33]Banford, Paul Clifford, et al
Marks & Clerk, Sussex House, 83-85 Mosley Street
Manchester M2 3LG / GB
Application number, filing date04813049.603.12.2004
[2006/33]
WO2004US40660
Priority number, dateUS20030527330P05.12.2003         Original published format: US 527330 P
[2006/33]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005055980
Date:23.06.2005
Language:EN
[2005/25]
Type: A2 Application without search report 
No.:EP1689443
Date:16.08.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 23.06.2005 takes the place of the publication of the European patent application.
[2006/33]
Type: B1 Patent specification 
No.:EP1689443
Date:13.03.2019
Language:EN
[2019/11]
Search report(s)International search report - published on:EP05.01.2006
ClassificationIPC:A61K47/59, A61K47/60, A61K47/68, A61P35/00
[2019/01]
CPC:
A61K47/6883 (EP,US); A61K47/593 (EP,US); A61K47/60 (EP,US);
A61K47/6849 (EP,US); A61P35/00 (EP,US)
Former IPC [2006/33]A61K47/48
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2019/11]
Former [2006/33]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:MULTIFUNKTIONALE ARZNEIMITTELABGABESYSTEME AUF POLYMALINSÄURE-BASIS[2006/33]
English:POLYMALIC ACID-BASED MULTIFUNCTIONAL DRUG DELIVERY SYSTEM[2006/33]
French:SYSTÈME D'ADMINISTRATION DE MÉDICAMENTS MULTIFONCTIONNEL À BASE D'ACIDE POLYMALIQUE[2019/01]
Former [2006/33]SYSTEME D'ADMINISTRATION DE MEDICAMENTS MULTIFONCTIONNELS A BASE D'ACIDE POLYMALIQUE
Entry into regional phase05.06.2006National basic fee paid 
05.06.2006Designation fee(s) paid 
05.06.2006Examination fee paid 
Examination procedure06.06.2006Examination requested  [2006/33]
16.02.2007Despatch of a communication from the examining division (Time limit: M06)
03.08.2007Reply to a communication from the examining division
04.01.2008Despatch of a communication from the examining division (Time limit: M06)
25.06.2008Reply to a communication from the examining division
23.03.2010Despatch of a communication from the examining division (Time limit: M06)
16.09.2010Reply to a communication from the examining division
20.02.2017Despatch of a communication from the examining division (Time limit: M06)
29.08.2017Reply to a communication from the examining division
01.02.2018Despatch of a communication from the examining division (Time limit: M06)
07.08.2018Reply to a communication from the examining division
11.12.2018Communication of intention to grant the patent
23.01.2019Fee for grant paid
23.01.2019Fee for publishing/printing paid
23.01.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.02.2007
Opposition(s)16.12.2019No opposition filed within time limit [2020/08]
Fees paidRenewal fee
27.12.2006Renewal fee patent year 03
24.12.2007Renewal fee patent year 04
24.12.2008Renewal fee patent year 05
28.12.2009Renewal fee patent year 06
27.12.2010Renewal fee patent year 07
21.12.2011Renewal fee patent year 08
27.12.2012Renewal fee patent year 09
27.12.2013Renewal fee patent year 10
10.06.2015Renewal fee patent year 11
08.06.2016Renewal fee patent year 12
13.12.2016Renewal fee patent year 13
27.12.2017Renewal fee patent year 14
31.12.2018Renewal fee patent year 15
Penalty fee
Additional fee for renewal fee
31.12.201411   M06   Fee paid on   10.06.2015
31.12.201512   M06   Fee paid on   08.06.2016
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.12.2004
AT13.03.2019
CY13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
MC13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SI13.03.2019
SK13.03.2019
TR13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
LU03.12.2019
[2021/32]
Former [2021/26]AT13.03.2019
CY13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
MC13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SI13.03.2019
SK13.03.2019
TR13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
LU03.12.2019
Former [2020/46]AT13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
MC13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SI13.03.2019
SK13.03.2019
TR13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
LU03.12.2019
Former [2020/39]AT13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
MC13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SI13.03.2019
SK13.03.2019
TR13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
Former [2020/17]AT13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SI13.03.2019
SK13.03.2019
TR13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
Former [2020/13]AT13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SI13.03.2019
SK13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
Former [2020/09]AT13.03.2019
CZ13.03.2019
DK13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SK13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
Former [2020/04]AT13.03.2019
CZ13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SK13.03.2019
BG13.06.2019
GR14.06.2019
IS13.07.2019
PT13.07.2019
Former [2020/03]AT13.03.2019
CZ13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SK13.03.2019
BG13.06.2019
GR14.06.2019
PT13.07.2019
Former [2020/01]CZ13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
PL13.03.2019
RO13.03.2019
SE13.03.2019
SK13.03.2019
BG13.06.2019
GR14.06.2019
PT13.07.2019
Former [2019/49]CZ13.03.2019
EE13.03.2019
FI13.03.2019
LT13.03.2019
RO13.03.2019
SE13.03.2019
SK13.03.2019
BG13.06.2019
GR14.06.2019
PT13.07.2019
Former [2019/48]FI13.03.2019
LT13.03.2019
SE13.03.2019
BG13.06.2019
GR14.06.2019
PT13.07.2019
Former [2019/38]FI13.03.2019
LT13.03.2019
SE13.03.2019
BG13.06.2019
GR14.06.2019
Former [2019/37]FI13.03.2019
LT13.03.2019
SE13.03.2019
GR14.06.2019
Former [2019/34]FI13.03.2019
LT13.03.2019
SE13.03.2019
Former [2019/33]FI13.03.2019
LT13.03.2019
Cited inInternational search[A]EP0397307  (JAPAN RES DEV CORP [JP]) [A] 1-28 * claim 8 *;
 [A]WO0005270  (BARRITAULT DENIS [FR], et al) [A] 1-28 * page 76; examples 1,18 *
 [X]  - BULMUS V ET AL, "A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (200312), vol. 93, no. 2, ISSN 0168-3659, pages 105 - 120, XP004473631 [X] 1,2,6,14,18-20,24,25 * page 111, column 2, paragraph 4; figure 1 * * page 108, column 2, paragraph 3 - page 109, column 2 *

DOI:   http://dx.doi.org/10.1016/j.jconrel.2003.06.001
 [Y]  - ABDELLAOUI K ET AL, "METABOLITE-DERIVED ARTIFICIAL POLYMERS DESIGNED FOR DRUG TARGETING, CELL PENETRATION AND BIORESORPTION", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, (1998), vol. 6, no. 1, ISSN 0928-0987, pages 61 - 73, XP008047861 [Y] 1-28 * abstract * * see conclusions; page 63, column 2, paragraph 2; figures 1,2; table 3 *

DOI:   http://dx.doi.org/10.1016/S0928-0987(97)00069-9
 [Y]  - ZHANG Y. ET AL, "Antisense gene therapy of brain cancer with an artificial virus gene delivery system", MOLECULAR THERAPY, (200207), vol. 6, no. 1, pages 67 - 72, XP008054256 [Y] 1-28 * abstract *

DOI:   http://dx.doi.org/10.1006/mthe.2002.0633
 [Y]  - MARTINEZ BARBOSA M. E. ET AL, "Investigation of the degradation mechanisms of poly(malic acid) esters in vitro and their related cytotoxicities in J774 macrophages", BIOMACROMOLECULES, (200312), vol. 5, pages 137 - 143, XP008054218 [Y] 1-28 * page 137, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1021/bm0300608
 [Y]  - MING QIAN Z. ET AL, "Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway", PHARMACOLOGICAL REVIEWS, (2002), vol. 54, pages 561 - 587, XP008054257 [Y] 1-28 * page 580 - page 581; figure 7; table 4 *

DOI:   http://dx.doi.org/10.1124/pr.54.4.561
 [Y]  - KHAZENZON N M ET AL, "Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION OF CANCER RESEARCH, US, (200310), vol. 2, no. 10, ISSN 1535-7163, pages 985 - 994, XP002986547 [Y] 1-28 * abstract *
 [A]  - OSANAI S ET AL, "Effects of complexation between liposome and poly(malic acid) on aggregation and leakage behaviour", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, (200005), vol. 21, no. 9, ISSN 0142-9612, pages 867 - 876, XP004202452 [A] 1-28 * abstract *

DOI:   http://dx.doi.org/10.1016/S0142-9612(99)00210-0
 [PX]  - LJUBIMOVA J Y ET AL, "608 A new multifunctional drug delivery system based on polymalic acid to inhibit angiogenesis and invasion of human gliomas in vitro and in vivo", EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, (200409), vol. 2, no. 8, ISSN 1359-6349, page 184, XP004640052 [PX] 1-28 * abstract *

DOI:   http://dx.doi.org/10.1016/S1359-6349(04)80616-5
Examination   - LEE BONG-SEOP ET AL, "Delivery of antisense oligonucleotides and transferrin receptor antibody in vitro and in vivo using a new multifunctional drug delivery system based on polymalic acid.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, & 95TH ANNUAL MEETING OF THE AMERICAN-ASSOCIATION-FOR-CANCER-RESEARCH; ORLANDO, FL, USA; MARCH 27 -31, 2004, (200403), vol. 45, ISSN 0197-016X, pages 149 - 150, XP008120390
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.