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Extract from the Register of European Patents

EP About this file: EP1670954

EP1670954 - METHODS FOR RISK ASSESSMENT, SURVIVAL PREDICTION AND TREATMENT OF HEART FAILURE AND OTHER CONDITIONS BASED ON ADRENERGIC RECEPTOR POLYMORPHISMS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.09.2011
Database last updated on 03.08.2024
Most recent event   Tooltip04.10.2013Lapse of the patent in a contracting state
New state(s): HU		published on 06.11.2013  [2013/45]
Applicant(s)For all designated states
UNIVERSITY OF CINCINNATI
3223 Eden Avenue, Mail Location 0829, G-7 Wherry Hall
Cincinnati, Ohio 45267-0829 / US
[2006/25]
Inventor(s)01 / LIGGETT, Stephen, Bryant
9180 Village Green Drive
Cincinnati, OH 45242 / US
02 / WAGONER, Lynne, Elizabeth
3003 Observatory Avenue
Cincinnati, OH 45208 / US
 [2006/25]
Representative(s)Kiddle, Simon John, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2006/25]Kiddle, Simon John, et al
Mewburn Ellis LLP York House, 23 Kingsway
London WC2B 6HP / GB
Application number, filing date04816181.413.09.2004
[2006/25]
WO2004US29838
Priority number, dateUS20030502837P12.09.2003         Original published format: US 502837 P
[2006/25]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005025409
Date:24.03.2005
Language:EN
[2005/12]
Type: A2 Application without search report 
No.:EP1670954
Date:21.06.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 24.03.2005 takes the place of the publication of the European patent application.
[2006/25]
Type: B1 Patent specification 
No.:EP1670954
Date:24.11.2010
Language:EN
[2010/47]
Search report(s)International search report - published on:US08.12.2005
(Supplementary) European search report - dispatched on:EP11.10.2006
ClassificationIPC:C12Q1/68
[2006/45]
CPC:
C12Q1/6883 (EP,US); C12Q2600/106 (EP,US); C12Q2600/136 (EP,US);
C12Q2600/156 (EP,US); C12Q2600/158 (EP,US)
Former IPC [2006/25]C12Q1/68, C12P19/34, C07H21/02, C07H21/04
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/25]
Extension statesALNot yet paid
HRNot yet paid
LTNot yet paid
LVNot yet paid
MKNot yet paid
TitleGerman:VERFAHREN ZUR RISIKOBEURTEILUNG, ÜBERLEBENSVORHERSAGE UND BEHANDLUNG VON HERZVERSAGEN UND ANDEREN LEIDEN AUF DER GRUNDLAGE VON POLYMORPHISMEN ADRENERGER REZEPTOREN[2006/25]
English:METHODS FOR RISK ASSESSMENT, SURVIVAL PREDICTION AND TREATMENT OF HEART FAILURE AND OTHER CONDITIONS BASED ON ADRENERGIC RECEPTOR POLYMORPHISMS[2006/25]
French:METHODES D'EVALUATION DE RISQUES, DE PREVISION DE SURVIE ET DE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE ET D'AUTRES ETATS PATHOLOGIQUES A PARTIR DE POLYMORPHISMES DES RECEPTEURS ADRENERGIQUES[2006/25]
Entry into regional phase28.03.2006National basic fee paid 
28.03.2006Search fee paid 
28.03.2006Designation fee(s) paid 
28.03.2006Examination fee paid 
Examination procedure28.03.2006Examination requested  [2006/25]
07.06.2006Amendment by applicant (claims and/or description)
06.02.2007Despatch of a communication from the examining division (Time limit: M06)
15.08.2007Reply to a communication from the examining division
20.11.2007Despatch of a communication from the examining division (Time limit: M06)
28.05.2008Reply to a communication from the examining division
25.05.2009Despatch of a communication from the examining division (Time limit: M06)
13.01.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
18.03.2010Reply to a communication from the examining division
30.06.2010Communication of intention to grant the patent
06.10.2010Fee for grant paid
06.10.2010Fee for publishing/printing paid
Opposition(s)25.08.2011No opposition filed within time limit [2011/44]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
18.03.2010Request for further processing filed
18.03.2010Full payment received (date of receipt of payment)
Fees paidRenewal fee
28.03.2006Renewal fee patent year 03
26.09.2007Renewal fee patent year 04
25.09.2008Renewal fee patent year 05
25.09.2009Renewal fee patent year 06
27.09.2010Renewal fee patent year 07
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT24.11.2010
BE24.11.2010
CY24.11.2010
CZ24.11.2010
DK24.11.2010
EE24.11.2010
FI24.11.2010
HU24.11.2010
IT24.11.2010
NL24.11.2010
PL24.11.2010
RO24.11.2010
SE24.11.2010
SI24.11.2010
SK24.11.2010
TR24.11.2010
BG24.02.2011
GR25.02.2011
ES07.03.2011
PT24.03.2011
[2013/45]
Former [2013/44]AT24.11.2010
BE24.11.2010
CY24.11.2010
CZ24.11.2010
DK24.11.2010
EE24.11.2010
FI24.11.2010
IT24.11.2010
NL24.11.2010
PL24.11.2010
RO24.11.2010
SE24.11.2010
SI24.11.2010
SK24.11.2010
TR24.11.2010
BG24.02.2011
GR25.02.2011
ES07.03.2011
PT24.03.2011
Former [2012/03]AT24.11.2010
BE24.11.2010
CY24.11.2010
CZ24.11.2010
DK24.11.2010
EE24.11.2010
FI24.11.2010
IT24.11.2010
NL24.11.2010
PL24.11.2010
RO24.11.2010
SE24.11.2010
SI24.11.2010
SK24.11.2010
BG24.02.2011
GR25.02.2011
ES07.03.2011
PT24.03.2011
Former [2011/38]AT24.11.2010
BE24.11.2010
CY24.11.2010
CZ24.11.2010
DK24.11.2010
EE24.11.2010
FI24.11.2010
NL24.11.2010
PL24.11.2010
RO24.11.2010
SE24.11.2010
SI24.11.2010
SK24.11.2010
BG24.02.2011
GR25.02.2011
ES07.03.2011
PT24.03.2011
Former [2011/35]AT24.11.2010
BE24.11.2010
CY24.11.2010
CZ24.11.2010
EE24.11.2010
FI24.11.2010
NL24.11.2010
SE24.11.2010
SI24.11.2010
BG24.02.2011
GR25.02.2011
ES07.03.2011
PT24.03.2011
Former [2011/32]AT24.11.2010
BE24.11.2010
CY24.11.2010
FI24.11.2010
NL24.11.2010
SE24.11.2010
SI24.11.2010
BG24.02.2011
GR25.02.2011
ES07.03.2011
PT24.03.2011
Former [2011/29]AT24.11.2010
CY24.11.2010
FI24.11.2010
NL24.11.2010
SE24.11.2010
SI24.11.2010
BG24.02.2011
GR25.02.2011
PT24.03.2011
Documents cited:Search[X]WO0111039  (MAX DELBRUECK CENTRUM [DE], et al) [X] 1-3,5,6,8-10 * page 3, paragraph 3 - paragraph 4; sequence 4 * * page 4, paragraph 4 - paragraph 5 * * page 6; table 3 * * page 9; claim 19 *;
 [X]US2002187491  (JOHNSON JULIE A [US]) [X] 1,2,4-6,8,9 * paragraph [0011] * * paragraph [0033] * * paragraph [0053] * * page 7; claims 4,6 *;
 [X]  - MASON ET AL, "A gain-of-function polymorphism in a G-protein coupling domain of the human B1-adrenergic receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, (199904), vol. 274, ISSN 0021-9258, pages 12670 - 12674, XP002163861 [X] 1,2 * page 12674, column 1 *

DOI:   http://dx.doi.org/10.1074/jbc.274.18.12670
 [X]  - SOFOWORA G G ET AL, "A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade", CLINICAL PHARMACOLOGY & THERAPEUTICS, MOSBY-YEAR BOOK, ST LOUIS, MO, US, (200304), vol. 73, no. 4, ISSN 0009-9236, pages 366 - 371, XP002380711 [X] 1,2 * page 370, column 2, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/S0009-9236(02)17734-4
 [X]  - SMALL K M ET AL, "SYNERGISTIC POLYMORPHISMS OF BETA1- AND ALPHA2C-ADRENERGIC RECEPTORS AND THE RISK OF CONGESTIVE HEART FAILURE", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, (20021010), vol. 347, no. 15, ISSN 0028-4793, pages 1135 - 1142, XP008055150 [X] 1-3,5-9 * the whole document *

DOI:   http://dx.doi.org/10.1056/NEJMoa020803
 [A]  - MAQBOOL A ET AL, "Common polymorphisms of beta1-adrenoceptor: identification and rapid screening assay", LANCET THE, LANCET LIMITED. LONDON, GB, (19990313), vol. 353, no. 9156, ISSN 0140-6736, page 897, XP004824432 [A] 1-5 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0140-6736(99)00549-8
 [A]  - TESSON F ET AL, "Characterization of a unique genetic variant in the B1-adrenoceptor gene and evaluation of its role in idiopathic dilated cardiomyopathy", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (199905), vol. 31, ISSN 0022-2828, pages 1025 - 1032, XP002163859 [A] 1-5 * page 1030 *

DOI:   http://dx.doi.org/10.1006/jmcc.1999.0947
 [A]  - WAGONER LYNNE E ET AL, "Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure.", AMERICAN HEART JOURNAL. NOV 2002, (200211), vol. 144, no. 5, ISSN 1097-6744, pages 840 - 846, XP002398686 [A] 1-5 * the whole document *

DOI:   http://dx.doi.org/10.1067/mhj.2002.125325
 [PA]  - KASS DAVID A, "Beta-receptor polymorphisms: heart failure's crystal ball.", NATURE MEDICINE. OCT 2003, (200310), vol. 9, no. 10, ISSN 1078-8956, pages 1260 - 1262, XP002396606 [PA] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1038/nm1003-1260
 [A]  - DE BOER R A ET AL, "Polypharmacy in chronic heart failure: practical issues regarding the use of angiotensin-converting enzyme inhibitors, beta-blockers and other drugs", EUROPEAN HEART JOURNAL SUPPLEMENTS, SAUNDERS, US, (200204), vol. 4, ISSN 1520-765X, pages D111 - D116, XP004705419 [A] 1-10 * page D114 - page D115; figure 3 *

DOI:   http://dx.doi.org/10.1016/S1520-765X(02)90168-9
    [ ] - "POLYMORPHISMS OF ADRENERGIC RECEPTORS AND THE RISK OF HEART FAILURE", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US, (20030130), vol. 348, no. 5, ISSN 0028-4793, pages 468 - 470, XP008058380 [ ] * the whole document *

DOI:   http://dx.doi.org/10.1056/NEJM200301303480518
 [PA]  - PEREZ JEANNE MIALET ET AL, "beta1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.", NATURE MEDICINE, (200310), vol. 9, no. 10, ISSN 1078-8956, pages 1300 - 1305, XP002396607 [PA] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1038/nm930
International search[A]US6498009  (LIGGETT STEPHEN BRYANT [US]);
 [X]  - SMALL K.M. ET AL, "Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.", N ENGL J MED., (20021010), vol. 347, no. 15, pages 1135 - 1142, XP008055150

DOI:   http://dx.doi.org/10.1056/NEJMoa020803
Examination   - MIALET PEREZ J ET AL., "Beta1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure", NATURE MEDICINE, (20030914), vol. 9, no. 10, pages 1300 - 1305
    - WHITE H ET AL., "An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study.", EUROPEAN JOURNAL OF HEART FAILURE, THE NETHERLANDS, (200308), vol. 5, no. 4, pages 463 - 468
    - O'SHAUGHNESSY K. M. ET AL., "The gain-of-function G389R variant of the beta1-adrenoceptor does not influence blood pressure or heart rate response to beta-blockade in hypertensive subjects.", CLINICAL SCIENCE, LONDON, UK, (200009), vol. 99, no. 3, pages 233 - 238
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.