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EP1709045
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EP About this file: EP1709045
| EP1709045 - NAPHTHYRIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MUSCARINIC RECEPTORS [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 09.07.2010 Database last updated on 19.10.2024 | Most recent event Tooltip | 09.07.2010 | Application deemed to be withdrawn | published on 11.08.2010 [2010/32] | Applicant(s) | For all designated states VERTEX PHARMACEUTICALS INCORPORATED 130 Waverly Street Cambridge, MA 02139-4242 / US | [2006/41] | Inventor(s) | 01 /
GROOTENHUIS, Peter, D., J. 4801 Riding Ridge Road San Diego, CA 92130 / US | 02 /
GARCIA-GUZMAN BLANCO, Miguel 4076 Carmel Springs Way San Diego, CA 92130 / US | 03 /
MAKINGS, Lewis, R. 337 Cerro Street Encinitas, CA 92024 / US | 04 /
LONDO, Philip, Martin 9428 Terrywood Santee, CA 92071 / US | [2006/41] | Representative(s) | Cohausz & Florack Patent- & Rechtsanwälte Partnerschaftsgesellschaft mbB Bleichstrasse 14 40211 Düsseldorf / DE | [N/P] |
| Former [2008/31] | Cohausz & Florack Patent- und Rechtsanwälte Bleichstrasse 14 40211 Düsseldorf / DE | ||
| Former [2006/41] | Cohausz & Florack Patent- und Rechtsanwälte Bleichstrasse 14 40211 Düsseldorf / DE | Application number, filing date | 04817977.4 | 07.12.2004 | [2006/41] | WO2004US40839 | Priority number, date | US20030528049P | 09.12.2003 Original published format: US 528049 P | [2006/41] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2005056552 | Date: | 23.06.2005 | Language: | EN | [2005/25] | Type: | A1 Application with search report | No.: | EP1709045 | Date: | 11.10.2006 | Language: | EN | The application published by WIPO in one of the EPO official languages on 23.06.2005 takes the place of the publication of the European patent application. | [2006/41] | Search report(s) | International search report - published on: | EP | 23.06.2005 | Classification | IPC: | C07D471/04, A61K31/4745, A61P25/00 | [2006/41] | CPC: |
C07D471/04 (EP,KR,US);
A61P1/02 (EP);
A61P1/04 (EP);
A61P11/06 (EP);
A61P17/02 (EP);
A61P25/00 (EP);
A61P25/04 (EP);
A61P25/14 (EP);
A61P25/16 (EP);
A61P25/18 (EP);
A61P25/24 (EP);
A61P25/28 (EP);
A61P27/02 (EP);
A61P27/04 (EP);
A61P3/04 (EP);
A61P9/04 (EP)
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| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2006/41] | Extension states | AL | Not yet paid | BA | Not yet paid | HR | Not yet paid | LV | Not yet paid | MK | Not yet paid | YU | Not yet paid | Title | German: | NAPHTHYRIDINDERIVATE UND DEREN VERWENDUNG ALS MODULATOREN VON MUSCARINISCHEN REZEPTOREN | [2006/41] | English: | NAPHTHYRIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MUSCARINIC RECEPTORS | [2006/41] | French: | DERIVES DE NAPHTYRIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE RECEPTEURS MUSCARINIQUES | [2006/41] | Entry into regional phase | 08.06.2006 | National basic fee paid | 08.06.2006 | Designation fee(s) paid | 08.06.2006 | Examination fee paid | Examination procedure | 08.06.2006 | Examination requested [2006/41] | 11.09.2009 | Despatch of a communication from the examining division (Time limit: M04) | 22.01.2010 | Application deemed to be withdrawn, date of legal effect [2010/32] | 04.03.2010 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2010/32] | Fees paid | Renewal fee | 27.12.2006 | Renewal fee patent year 03 | 24.12.2007 | Renewal fee patent year 04 | 24.12.2008 | Renewal fee patent year 05 | 28.12.2009 | Renewal fee patent year 06 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [X]WO9943682 (NEUROGEN CORP [US], et al) [X] 1,33,36 * examples 9r,9s; claims 6,9 *; | [X]WO9943681 (NEUROGEN CORP [US], et al) [X] 1,33,36 * the whole document *; | [X]WO0222601 (VERTEX PHARMA [US], et al) [X] 1-8,16-20,33,36 * the whole document *; | [A]US2003162777 (LEONARDI AMEDEO [IT], et al) [A] 1,33-36 * the whole document *; | [X] - MACCHIA, MARCO ET AL, "new potential fluorescent probe 4-[6-(Dansylamino)hexylamino]-7-methyl-2- phenyl-1,8-naphthyridine for studying A1-adenosine receptor", FARMACO , 57(10), 783-786 CODEN: FRMCE8; ISSN: 0014-827X, (2002), XP002326001 [X] 1 * compounds 2 and 3 * DOI: http://dx.doi.org/10.1016/S0014-827X(02)01275-2 | [X] - ABBIATI, GIORGIO ET AL, "An efficient synthesis of 2,4-substituted [1,8]naphthyridines from 3-(2-Amino-5-methylpyridin-3-yl)-1-arylprop-2-yn-1-ones", SYNTHESIS , (13), 1912-1916 CODEN: SYNTBF; ISSN: 0039-7881, (2002), XP002326002 [X] 1 * Compounds 3i, 3j * DOI: http://dx.doi.org/10.1055/s-2002-33908 | [X] - FERRARINI, PIER LUIGI ET AL, "Synthesis of bis(2-chloroethyl)amino-1,8-naphthyridines for evaluation as anticancer agents", JOURNAL OF HETEROCYCLIC CHEMISTRY , 21(2), 417-19 CODEN: JHTCAD; ISSN: 0022-152X, (1984), XP002326003 [X] 1,33 * Table I: VIII d and VIII e * DOI: http://dx.doi.org/10.1002/jhet.5570210229 | [X] - CARBONI, S. ET AL, "Preparation and pharmacological study on some 1,2,3-triazolyl-1,8- naphthyridine derivatives", FARMACO, EDIZIONE SCIENTIFICA , 33(5), 315-23 CODEN: FRPSAX; ISSN: 0430-0920, (1978), XP002326004 [X] 1,33 * scheme 2; table I * | [X] - FERRARINI, PIER LUIGI ET AL, "A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives", JOURNAL OF MEDICINAL CHEMISTRY , 43(15), 2814-2823 CODEN: JMCMAR; ISSN: 0022-2623, (2000), XP002326005 [X] 1,33 * page 2815 * DOI: http://dx.doi.org/10.1021/jm990321p | [X] - FERRARINI ET AL, "Synthesis and antiplatelet activity of some 1,8-naphthyridine derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, (1994), vol. 29, ISSN 0223-5234, pages 735 - 741, XP002313074 [X] 1,33 * compound 1c * DOI: http://dx.doi.org/10.1016/0223-5234(94)90131-7 | [XP] - FERRARINI, PIER LUIGI ET AL, "Study on Affinity Profile toward Native Human and Bovine Adenosine Receptors of a Series of 1,8-Naphthyridine Derivatives", JOURNAL OF MEDICINAL CHEMISTRY , 47(12), 3019-3031 CODEN: JMCMAR; ISSN: 0022-2623, (2004), XP002326006 [XP] 1,33 * compounds 8-12 * DOI: http://dx.doi.org/10.1021/jm030977p |