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EP About this file: EP1782809

EP1782809 - Use of ligands of PPARGamma for inducing foetal lung maturity and the prevention of the respiratory-distress syndrome in premature infants [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 13.02.2009 Database last updated on 13.07.2024
Most recent event Tooltip	13.02.2009	Application deemed to be withdrawn	published on 18.03.2009 [2009/12]
Applicant(s)	For all designated states Charité - Universitätsmedizin Berlin Schumannstrasse 20/21 10117 Berlin / DE
	[N/P]
Former [2007/19]	For all designated states Charité-Universitätsmedizin Berlin Schumannstrasse 20/21 10117 Berlin / DE
Inventor(s)	01 / Guthmann, Florian Westfalenring 8A 12207 Berlin / DE
	02 / Rüstow, Bernd Bieselheider Weg 6A 13465 Berlin / DE
	[2007/19]
Representative(s)	Krauss, Jan Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22 80336 München / DE
	[N/P]
Former [2007/19]	Krauss, Jan Forrester & Boehmert, Pettenkoferstrasse 20-22 80336 München / DE
Application number, filing date	05020264.7	16.09.2005
	[2007/19]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP1782809
	Date:	09.05.2007
	Language:	EN
	[2007/19]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	28.02.2006
Classification	IPC:	A61K31/4439, A61K31/426, A61P11/00	[2008/08]
	CPC:	A61K31/4439 (EP); A61P11/00 (EP)
	Former IPC [2007/19]	A61K31/4439, A61P11/00
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2007/19]
Title	German:	Verwendung von PPAR-gamma-Liganden zur Induktion von fötaler Lungenreife und zur Prävention von Atemnotsyndrom in Frühgeborenen	[2007/19]
	English:	Use of ligands of PPARGamma for inducing foetal lung maturity and the prevention of the respiratory-distress syndrome in premature infants	[2007/19]
	French:	Utilisation de ligands de PPAR-gamma pour l'induction de la maturité du poumon foetal et pour la prévention du syndrome de détresse respiratoire	[2007/19]
Examination procedure	04.05.2006	Examination requested [2007/19]
	20.06.2006	Despatch of a communication from the examining division (Time limit: M04)
	17.08.2006	Reply to a communication from the examining division
	27.03.2007	Despatch of a communication from the examining division (Time limit: M06)
	28.09.2007	Reply to a communication from the examining division
	09.05.2008	Communication of intention to grant the patent
	20.09.2008	Application deemed to be withdrawn, date of legal effect [2009/12]
	28.10.2008	Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time [2009/12]
Fees paid	Renewal fee
	12.09.2007	Renewal fee patent year 03
	Penalty fee
	Additional fee for renewal fee
	30.09.2008	04 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]WO2005000196 (UNIV COLUMBIA [US]) [X] 1,3,4,6,7 * claim 55 *;
		[X] - VAYRYNEN OUTI ET AL, "Regulation of surfactant proteins by LPS and proinflammatory cytokines in fetal and newborn lung", AMERICAN JOURNAL OF PHYSIOLOGY, (200204), vol. 282, no. 4 Part 1, ISSN 0002-9513, pages L803 - L810, XP009061724 [X] 1-9 * page L807, column 1, paragraph 2 *
		[X] - MICHAEL LAURA F ET AL, "Peroxisome proliferator-activated receptor gamma 1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumocytes", ENDOCRINOLOGY, (1997), vol. 138, no. 9, ISSN 0013-7227, pages 3695 - 3703, XP002367803 [X] 1-9 * page 3702, column 2, paragraph L * DOI: http://dx.doi.org/10.1210/en.138.9.3695
		[A] - BOYD STEVIE, "Causes and treatment of neonatal respiratory distress syndrome.", NURSING TIMES. 2004 JUL 27-AUG 2, (20040727), vol. 100, no. 30, ISSN 0954-7762, pages 40 - 44, XP009061711 [A] 1-9 * page 40, column 2, paragraph L - page 41, column 1, paragraph 1 *
	by applicant	US6821737
		- "Phenotype of palmitic acid transport and of sig- nalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveo- lin-1 and PPARy", BIOCHIMICA ET BIOPHYSICA ACTA, (2004), vol. 1636, pages 196 - 204
		- HORBAR JD ET AL., "Trends in mortality and morbidity for very low birth weight infants, 1991-1999", PEDIATRICS, (2002), vol. 110, pages 143 - 151
		- CRAPO JD ET AL., "Pathologic changes in the lungs of oxygen-adapted rats: a morphometric analysis", LAB INVEST, (1978), vol. 39, no. 6, pages 640 - 653
		- HAIES DM; GIL J; WEIBEL ER, "Morphometric study of rat lung cells. 1. Numerical and di- mensional characteristics of parenchymal cell population", AM REV RESPIR DIS, (1981), vol. 123, no. 5, pages 533 - 541
		- LIGGINS GC, "Premature delivery of foetal lambs infused with glucocorticoids", J ENDOCRINOL, (1969), vol. 45, no. 4, pages 515 - 523
		- SHULENIN S ET AL., "ABCA3 gene mutations in newborns with fatal surfactant deficiency", N ENGI J MED, (2004), vol. 350, no. 13, pages 1296 - 1303
		- GORTNER L; HILGENDORFF A, "Surfactant-associated proteins B and C: molecular biology and physiologic properties", Z GEBURTSHILFE NEONATOL, (2004), vol. 208, no. 3, pages 91 - 97
		- WHITTSETT JA; WERT, SE; XU, Y, "Genetic disorders of surfactant homeostasis", BIOL NEONATE, (2005), vol. 87, pages 283 - 287
		- "Effect of corticosteroids for foetal maturation on perinatal outcomes. NIH Consensus Development Panel on the Effect of Corticosteroids for Foetal Maturation on Peri- natal Outcomes", JAMA, (1995), vol. 273, no. 5, pages 413 - 418
		- CROWLEY PA, "Antenatal corticosteroid therapy: a meta-analysis of the randomized trials, 1972 to 1994", AM J OBSTET GYNECOL, (1995), vol. 173, no. 1, pages 322 - 335
		- GORTNER L ET AL., "Neonatal outcome in small for gestational age infants: do they really better?", J PERINAT MED JID - 0361031, (1999), vol. 27, no. 6, pages 484 - 489
		- CLARK PM, "Programming of the hypothalamo-pituitary-adrenal axis and the foetal origins of adult disease hypothesis", EURJ PEDIATR, (1998), vol. 157, pages 7 - 10
		- DODIC M ET AL., "Effect of steroid hormones on blood pressure", CLIN EXP PHARMACOL PHYSIOL, (1999), vol. 26, no. 7, pages 550 - 552
		- EDWARDS LJ ET AL., "Prenatal undernutrition, glucocorti- coids and the programming of adult hypertension", CLIN EXP PHARMACOL PHYSIOL, (2001), vol. 28, no. 11, pages 938 - 941
		- JOBE AH ET AL., "Single and repetitive maternal glu- cocorticoid exposures reduce foetal growth in sheep", AM J OBSTET GYNECOL, (1998), vol. 178, no. 5, pages 880 - 885
		- HUANG WL ET AL., "Effect of corticosteroids on brain growth in foetal sheep", OBSTET GYNECOL, (1999), vol. 94, no. 2, pages 213 - 218
		- MATTHEWS, SG ET AL., "Foetal glucocorticoid exposure and hypothalamo-pituitary-adrenal (HPA) function after birth", ENDOCR-RES., (200411), vol. 30, no. 4, pages 827 - 36
		- ENGLE, MJ ET AL., "Effects of maternal dexa- methasone therapy on foetal lung development in the rhesus monkey", AM J PERINATOL, (1996), vol. 13, pages 399 - 407
		- ANTONOW-SCHLORKE, I ET AL., "Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the foetal baboon brain", J PHYSIOL, (2003), vol. 547, pages 117 - 123
		- COE, CL; LUBACH, GR, "Developmental consequences of antenatal dexamethasone treat- ment in nonhuman primates", NEUROSCI BIOBEHAV REV, (2005), vol. 29, pages 227 - 235
		- YOSHIDA I; BAN N; INAGAKI N, "Expression of ABCA3, a causative gene for fatal surfactant deficiency, is up-regulated by glucocorticoids in lung alveolar type II cells", BIOCHEM BIOPHYS RES COMMUN, (2004), vol. 323, no. 2, pages 547 - 555
		- SERENIUS F ET AL., "Short-term out- come after active perinatal management at 23-25 weeks of gestation. A study from two Swed- ish tertiary care centres. Part 1: maternal and obstetric factors", ACTA PAEDIATR, (2004), vol. 93, no. 7, pages 945 - 953
		- HE K ET AL., "Metabolie activation of troglitazone: identification of a reactive metabolite and mechanisms involved", DRUG METAB DISPOS, (2004), vol. 32, no. 6, pages 639 - 646
		- NOZAWA T ET AL., "Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10- hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms", DRUG METAB DISPOS, (2005), vol. 33, no. 3, pages 434 - 439
		- SCHEEN AJ, "Hepatotoxicity with thiazolidinediones: is it a class effect?", DRUG SAF, (2001), vol. 24, no. 12, pages 873 - 888
		- FARLEY-HILLS E; SIVASANKAR R; MARTIN M, "Fatal liver failure associated with pioglitazone", BMJ, (2004), vol. 329, no. 7463, page 429
		- AMIN P, "Liver toxicity and pioglitazone: data are missing", BMJ, (2004), vol. 329, no. 7471, page 918
		- MAY LD ET AL., "Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy", ANN INTERN MED, (2002), vol. 136, no. 6, pages 449 - 452
		- AZZIZ R ET AL., "Trogii- tazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter, double blind, placebo-controlled trial", J CLIN ENDOCRINOL METAB, (2001), vol. 86, no. 4, pages 1626 - 1632
		- KALYONCU NI ET AL., "A case of rosiglita- zone exposure in the second trimester of pregnancy", REPROD TOXICOL, (2005), vol. 19, no. 4, pages 563 - 564
		- YARIS F ET AL., "Normal pregnancy out- come following inadvertent exposure to rosiglitazone, glidazide, and atorvastatin in a diabetic and hypertensive woman", REPROD TOXICOL, (2004), vol. 18, no. 4, pages 619 - 621
		- CHAN LY; YEUNG JH; LAU TK, "Placental transfer of rosiglitazone in the first trimester of human pregnancy", FERTIL STERIL, (2005), vol. 83, no. 4, pages 955 - 958
		- AVERY ME; MEAD J, "Surface properties in relation to atelectasis and hyaline membrane disease", AMA J DIS CHILD., (195905), vol. 97, no. 5, pages 517 - 23

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