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Extract from the Register of European Patents

EP About this file: EP1709962

EP1709962 - THE USE OF L-BUTYLPHTHALIDE IN THE MANUFACTURING OF MEDICINES FOR THE PREVENTION AND TREATMENT OF CEREBRAL ISCHEMIA DISEASE [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  22.11.2013
Database last updated on 05.10.2024
Most recent event   Tooltip22.11.2013New entry: Date of cancellation oral proceedings 
22.11.2013Withdrawal of applicationpublished on 25.12.2013  [2013/52]
Applicant(s)For all designated states
Shijiazhuang Pharma. Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.
Zhong-Shan West Road 276, Shijiazhuang
Hebei 050051 / CN
[2006/41]
Inventor(s)01 / LIU, Zhentao
No. 276 Zhongshan West Road
Shijiazhuang, Hebei 050051 / CN
02 / ZHANG, Hongwu
No. 276 Zhongshan West Road
Shijiazhuang, Hebei 050051 / CN
03 / NIU, Zhanqi
No. 276 Zhongshan West Road
Shijiazhuang, Hebei 050051 / CN
04 / SHEN, Dongmin
No. 276 Zhongshan West Road
Shijiazhuang, Hebei 050051 / CN
05 / WANG, Rongduan
No. 276 Zhongshan West Road
Shijiazhuang, Hebei 050051 / CN
06 / FENG, Xiaolong
No. 276 Zhongshan West Road
Shijiazhuang, Hebei 050051 / CN
 [2006/41]
Representative(s)Wibbelmann, Jobst, et al
Wuesthoff & Wuesthoff
Patentanwälte und Rechtsanwalt PartG mbB
Schweigerstrasse 2
81541 München / DE
[N/P]
Former [2006/41]Wibbelmann, Jobst, et al
Wuesthoff & Wuesthoff, Patent- und Rechtsanwälte, Schweigerstrasse 2
81541 München / DE
Application number, filing date05700438.417.01.2005
[2006/41]
WO2005CN00064
Priority number, dateCN2004100174820.01.2004         Original published format: CN200410001748
[2006/41]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2005072725
Date:11.08.2005
Language:EN
[2005/32]
Type: A1 Application with search report 
No.:EP1709962
Date:11.10.2006
Language:EN
The application published by WIPO in one of the EPO official languages on 11.08.2005 takes the place of the publication of the European patent application.
[2006/41]
Search report(s)International search report - published on:CN11.08.2005
(Supplementary) European search report - dispatched on:EP12.01.2010
ClassificationIPC:A61K31/343, A61P9/10
[2006/41]
CPC:
A61K31/343 (EP,US); A61P25/00 (EP); A61P25/28 (EP);
A61P7/10 (EP); A61P9/10 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2006/41]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
LVNot yet paid
MKNot yet paid
YUNot yet paid
TitleGerman:VERWENDUNG VON L-BUTYLPHTHALID BEI DER HERSTELLUNG VON MEDIKAMENTEN ZUR PRÄVENTION UND BEHANDLUNG ZEREBRALER ISCHÄMIE[2006/41]
English:THE USE OF L-BUTYLPHTHALIDE IN THE MANUFACTURING OF MEDICINES FOR THE PREVENTION AND TREATMENT OF CEREBRAL ISCHEMIA DISEASE[2006/41]
French:UTILISATION DE L-BUTYLPHTALIDE DANS LA FABRICATION DE MEDICAMENTS DESTINES A PREVENIR ET A TRAITER UNE MALADIE INDUITE PAR L'ISCHEMIE CEREBRALE[2006/41]
Entry into regional phase09.08.2006Translation filed 
09.08.2006National basic fee paid 
09.08.2006Search fee paid 
09.08.2006Designation fee(s) paid 
09.08.2006Examination fee paid 
Examination procedure27.06.2005Request for preliminary examination filed
International Preliminary Examining Authority: CN
09.08.2006Examination requested  [2006/41]
07.10.2011Despatch of a communication from the examining division (Time limit: M04)
07.02.2012Reply to a communication from the examining division
21.11.2013Application withdrawn by applicant  [2013/52]
21.11.2013Cancellation of oral proceeding that was planned for 22.11.2013
22.11.2013Date of oral proceedings (cancelled)
Divisional application(s)EP13004735.0  / EP2682117
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.10.2011
Fees paidRenewal fee
17.01.2007Renewal fee patent year 03
17.01.2008Renewal fee patent year 04
19.01.2009Renewal fee patent year 05
19.01.2010Renewal fee patent year 06
19.01.2011Renewal fee patent year 07
19.01.2012Renewal fee patent year 08
17.01.2013Renewal fee patent year 09
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:SearchCN1257706  [ ] (INST OF MEDICINAL MATERIALS CH [CN]);
 [E]EP1679070  (SHIJIAZHUANG PHARMA GROUP [CN], et al) [E] 1,2 * the whole document *;
 [E]EP1757286  (SHIJIAZHUANG PHARMA GROUP [CN], et al) [E] 1,2 * the whole document *;
 [X]  - CHANG QING ET AL, "Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats", ACTA PHARMACOLOGICA SINICA AUG 2003,, (20030801), vol. 24, no. 8, pages 796 - 804, XP002558734 [X] 1,2 * the whole document *
 [X]  - XU HAOLIANG ET AL, "EFFECTS OF 3-N-BUTYLPHTHALDE ON PIAL ARTEROLES INFOCAL CEREBRAL ISCHEIA RATS", YAO HSUEH HSUEH PAO - ACTA PHARMACEUTICA SINICA, BEIJING, CN, (19990301), vol. 34, no. 3, ISSN 0513-4870, pages 172 - 175, XP008071717 [X] 1,2 * abstract *
 [X]  - XU HAO-LIANG ET AL, "Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (200005), Database accession no. PREV200000331032, XP002558736 [X] 1,2 * abstract *
 [X]  - EPODOC, EUROPEAN PATENT OFFICE, THE HAGUE, NL, XP002558735 [X] 1,2 * column A *
 [X]  - CHONG Z Z ET AL, "Effect of dl-n-butylphthalide on the activity of the choline acetyltransferase in ischemic brain and cultured neurons subjected to hypoglycemia/hypoxia", ZHONGGUO YAOXUE ZAZHI - CHINESE PHARMACEUTICAL JOURNAL, GAI KAN BIAN-WEI-HUI, BEIJING, CN, (19990801), vol. 34, no. 8, ISSN 1001-2494, pages 519 - 522, XP008102416 [X] 1,2 * abstract *
 [X]  - XIONG JIE ET AL, "The protective effect of butylphthalide against mitochondrial injury during cerebral ischemia", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (200006), Database accession no. PREV200000498562, XP002559421 [X] 1,2 * abstract *
 [Y]  - LIN J F ET AL, "Effect of DL-3-N-butylphthalide on delayed neuronal damage after focal cerebral ischemia and intrasynaptosomes calcium in rats", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1996), Database accession no. PREV199699158021, XP002558737 [Y] 1,2 * abstract *
 [Y]  - LIU X G ET AL, "[Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia]", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (199512), Database accession no. NLM8712015, XP002558738 [Y] 1,2 * abstract *
 [Y]  - ZHANG L Y ET AL, "[Effect of dl-3-n-butylphthalide (NBP) on life span and neurological deficit in SHRsp rats]", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (1996), Database accession no. NLM8762459, XP002558739 [Y] 1,2 * abstract *
 [Y]  - FENG Y P ET AL, "[Effect of DL-butylphthalide (NBP) on mouse brain energy metabolism in complete brain ischemia induced by decapitation]", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (1995), Database accession no. NLM8701729, XP002559422 [Y] 1,2 * abstract *
 [Y]  - YAN C H ET AL, "Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats", ZHONGGUO YAO LI XUE BAO = ACTA PHARMACOLOGICA SINICA MAR 1998,, (19980301), vol. 19, no. 2, pages 117 - 120, XP002558745 [Y] 1,2 * abstract *
 [Y]  - CHONG Z ET AL, "dl-3-n-butylphthalide reduces brain damage in mice with closed head injury.", CHINESE MEDICAL JOURNAL JUL 2000, (200007), vol. 113, no. 7, ISSN 0366-6999, pages 613 - 616, XP002559419 [Y] 1,2 * the whole document *
 [Y]  - YU S R ET AL, "[Facilitated performance of learning and memory in rats by 3-n-butyl phthalide]", ZHONGGUO YAO LI XUE BAO = ACTA PHARMACOLOGICA SINICA SEP 1988, (198809), vol. 9, no. 5, ISSN 0253-9756, pages 385 - 388, XP002559420 [Y] 1,2 * abstract *
 [PX]  - PENG YING ET AL, "Effects of chiral NBP on cerebral infarct volume due to transient focal cerebral ischemia", ZHONGGUO XIN YAO ZAZHI - CHINESE NEW DRUGS JOURNAL, GAI-KAN BIANJIBU, BEIJING, CN, (20050101), vol. 14, no. 4, ISSN 1003-3734, pages 420 - 423, XP001539275 [PX] 1,2 * abstract *
    [ ] - ACTA PHARMACOLOGICA SINICA, (200005), vol. 21, no. 5, ISSN 0253-9756, pages 433 - 438
    [ ] - YAOXUE XUEBAO, (200006), vol. 35, no. 6, ISSN 0513-4870, pages 408 - 412
    [ ] - YAOXUE XUEBAO, (1996), vol. 31, no. 3, ISSN 0513-4870, pages 166 - 170
    [ ] - YAO XUE XUE BAO = ACTA PHARMACEUTICA SINICA DEC 1995, (199512), vol. 30, no. 12, ISSN 0513-4870, pages 896 - 903
    [ ] - YAO XUE XUE BAO = ACTA PHARMACEUTICA SINICA 1996, (1996), vol. 31, no. 1, ISSN 0513-4870, pages 18 - 23
    [ ] - YAO XUE XUE BAO = ACTA PHARMACEUTICA SINICA 1995, (1995), vol. 30, no. 10, ISSN 0513-4870, pages 741 - 744
International search[X]CN1100097  (PHARMACOLOGY INST CHINESE ACAD [CN]);
 [X]  - HU D. ET AL, "Effect of dl-n-butylphthalide on mermory disturbance induced by focal cerebral ischemia in rats", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, (199702), vol. 11, no. 1, XP008111297
 [X]  - YAN C-H. ET AL, "Effect of dl-n-butylphthalide on striatum cerebral blood flow in normal and middle cerebral artery occlusion rats", CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY, (199802), vol. 12, no. 1, XP008111296
Examination   - DENG W ET AL, "Effect of dl-3-n-butylphthalide on brain edema in rats subjected to focal cerebral ischemia.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (199706), Database accession no. NLM11324493, XP002716864
    - WANG XING-WANG, "3-n-Butylphthalide: Cerebral antiischemic", DRUGS OF THE FUTURE, (200001), vol. 25, no. 1, ISSN 0377-8282, pages 16 - 23, XP002716865

DOI:   http://dx.doi.org/10.1358/dof.2000.025.01.562281
    - CHINESE MEDICAL SCIENCES JOURNAL = CHUNG-KUO I HSÜEH K'O HSÜEH TSA CHIH / CHINESE ACADEMY OF MEDICAL SCIENCES JUN 1997, (199706), vol. 12, no. 2, ISSN 1001-9294, pages 102 - 106
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.