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Extract from the Register of European Patents

EP About this file: EP1737971

EP1737971 - MIXTURES OF BINDING PROTEINS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.06.2018
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  14.07.2017
FormerGrant of patent is intended
Status updated on  22.05.2017
FormerExamination is in progress
Status updated on  07.04.2017
Most recent event   Tooltip26.06.2020Lapse of the patent in a contracting state
New state(s): CY		published on 29.07.2020  [2020/31]
Applicant(s)For all designated states
Merus N.V.
Yalelaan 62
3584 CM Utrecht / NL
[2017/06]
Former [2016/27]For all designated states
Merus N.V.
Padualaan 8, postvak 133
3584 CH Utrecht / NL
Former [2013/14]For all designated states
Merus B.V.
Padualaan 8 (postvak 133)
3584 CH Utrecht / NL
Former [2007/01]For all designated states
Merus B.V.
Koningin Wilhelminalaan 22
3972 EX Driebergen / NL
Inventor(s)01 / LOGTENBERG, Ton
c/o Yalelaan 62
3584 CM Utrecht / NL
02 / HOOGENBOOM, Hendricus, Renerus, Jacobus, Mattheus
c/o Yalelaan 62
3584 CM Utrecht / NL
 [2017/30]
Former [2007/01]01 / LOGTENBERG, Ton
Koningin Wilhelminalaan 22
NL-3972 EX Driebergen / NL
02 / HOOGENBOOM, Hendricus, Renerus, Jacobus, Mattheus
Hertogsingel 46
NL-6214 AE Maastricht / NL
Representative(s)V.O.
P.O. Box 87930
2508 DH Den Haag / NL
[2017/33]
Former [2012/17]Jansen, Cornelis Marinus, et al
Vereenigde
Johan de Wittlaan 7
2517 JR Den Haag / NL
Former [2008/34]van Loon, C.J.J., et al
Vereenigde Johan de Wittlaan 7
2517 JR Den Haag / NL
Former [2007/01]van Loon, C.J.J., et al
c/o VEREENIGDE Johan de Wittlaan 7
2517 JR The Hague / NL
Application number, filing date05704566.819.01.2005
[2007/01]
WO2005NL00036
Priority number, dateEP2004007517020.01.2004         Original published format: EP 04075170
[2007/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005068622
Date:28.07.2005
Language:EN
[2005/30]
Type: A2 Application without search report 
No.:EP1737971
Date:03.01.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 28.07.2005 takes the place of the publication of the European patent application.
[2007/01]
Type: B1 Patent specification 
No.:EP1737971
Date:16.08.2017
Language:EN
[2017/33]
Search report(s)International search report - published on:EP02.03.2006
ClassificationIPC:C12P21/08
[2007/01]
CPC:
C12N15/1086 (EP,US); C07K16/10 (EP,US); C07K16/20 (EP,US);
C07K16/40 (EP,US); C12N15/1082 (EP,US); C07K2317/22 (EP,US);
C07K2317/569 (EP,US); C07K2318/20 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/33]
Former [2007/01]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:GEMISCHE BINDENDER PROTEINE[2007/01]
English:MIXTURES OF BINDING PROTEINS[2007/01]
French:MÉLANGES DE PROTEINES DE LIASON[2007/01]
Entry into regional phase03.11.2006National basic fee paid 
03.11.2006Designation fee(s) paid 
03.11.2006Examination fee paid 
Examination procedure06.10.2006Despatch of communication that the application is deemed to be withdrawn, reason: filing fee / search fee not paid in time
03.11.2006Examination requested  [2007/01]
21.11.2008Despatch of a communication from the examining division (Time limit: M06)
20.05.2009Reply to a communication from the examining division
01.09.2010Despatch of a communication from the examining division (Time limit: M06)
28.01.2011Reply to a communication from the examining division
06.06.2013Despatch of a communication from the examining division (Time limit: M06)
07.11.2013Reply to a communication from the examining division
05.02.2015Despatch of a communication from the examining division (Time limit: M06)
30.07.2015Reply to a communication from the examining division
03.02.2017Cancellation of oral proceeding that was planned for 07.02.2017
07.02.2017Date of oral proceedings (cancelled)
28.03.2017Despatch of a communication from the examining division (Time limit: M02)
11.04.2017Reply to a communication from the examining division
23.05.2017Communication of intention to grant the patent
04.07.2017Fee for grant paid
04.07.2017Fee for publishing/printing paid
04.07.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  21.11.2008
Opposition(s)17.05.2018No opposition filed within time limit [2018/30]
Fees paidRenewal fee
15.01.2007Renewal fee patent year 03
15.01.2008Renewal fee patent year 04
17.03.2008Renewal fee patent year 05
15.01.2010Renewal fee patent year 06
17.01.2011Renewal fee patent year 07
16.01.2012Renewal fee patent year 08
16.01.2013Renewal fee patent year 09
15.01.2014Renewal fee patent year 10
29.12.2014Renewal fee patent year 11
29.12.2015Renewal fee patent year 12
30.12.2016Renewal fee patent year 13
Penalty fee
Penalty fee Rule 85a EPC 1973
03.11.2006AT   M01   Fee paid on   03.11.2006
03.11.2006BE   M01   Fee paid on   03.11.2006
03.11.2006BG   M01   Fee paid on   03.11.2006
03.11.2006CH   M01   Fee paid on   03.11.2006
03.11.2006CY   M01   Fee paid on   03.11.2006
03.11.2006CZ   M01   Fee paid on   03.11.2006
03.11.2006DE   M01   Fee paid on   03.11.2006
03.11.2006DK   M01   Fee paid on   03.11.2006
03.11.2006EE   M01   Fee paid on   03.11.2006
03.11.2006ES   M01   Fee paid on   03.11.2006
03.11.2006FI   M01   Fee paid on   03.11.2006
03.11.2006FR   M01   Fee paid on   03.11.2006
03.11.2006GB   M01   Fee paid on   03.11.2006
03.11.2006GR   M01   Fee paid on   03.11.2006
03.11.2006HU   M01   Fee paid on   03.11.2006
03.11.2006IE   M01   Fee paid on   03.11.2006
03.11.2006IS   M01   Fee paid on   03.11.2006
03.11.2006IT   M01   Fee paid on   03.11.2006
03.11.2006LT   M01   Fee paid on   03.11.2006
03.11.2006LU   M01   Fee paid on   03.11.2006
03.11.2006MC   M01   Fee paid on   03.11.2006
03.11.2006NL   M01   Fee paid on   03.11.2006
03.11.2006PL   M01   Fee paid on   03.11.2006
03.11.2006PT   M01   Fee paid on   03.11.2006
03.11.2006RO   M01   Fee paid on   03.11.2006
03.11.2006SE   M01   Fee paid on   03.11.2006
03.11.2006SI   M01   Fee paid on   03.11.2006
03.11.2006SK   M01   Fee paid on   03.11.2006
03.11.2006TR   M01   Fee paid on   03.11.2006
Penalty fee Rule 85b EPC 1973
03.11.2006M01   Fee paid on   03.11.2006
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.01.2005
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
SI16.08.2017
SK16.08.2017
TR16.08.2017
BG16.11.2017
GR17.11.2017
[2020/31]
Former [2020/27]HU19.01.2005
AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
SI16.08.2017
SK16.08.2017
TR16.08.2017
BG16.11.2017
GR17.11.2017
Former [2020/16]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
PL16.08.2017
RO16.08.2017
SI16.08.2017
SK16.08.2017
TR16.08.2017
BG16.11.2017
GR17.11.2017
Former [2018/40]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
PL16.08.2017
RO16.08.2017
SI16.08.2017
SK16.08.2017
BG16.11.2017
GR17.11.2017
Former [2018/23]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
PL16.08.2017
RO16.08.2017
SK16.08.2017
BG16.11.2017
GR17.11.2017
Former [2018/21]AT16.08.2017
CZ16.08.2017
LT16.08.2017
PL16.08.2017
BG16.11.2017
GR17.11.2017
Former [2018/12]AT16.08.2017
LT16.08.2017
PL16.08.2017
BG16.11.2017
GR17.11.2017
Former [2018/10]AT16.08.2017
LT16.08.2017
Former [2018/07]LT16.08.2017
Cited inInternational search[X]WO9402610  (DANA FARBER CANCER INST INC [US], et al) [X] 1-40 * page 4, line 9 - page 5, line 9 * * page 23, line 15 - line 18 * * page 25, line 1 - line 2 * * page 44, line 22 - page 45, line 13 * * page 46, line 5 - line 11 * * page 52, line 7 - page 53, line 14 * * page 56, line 23 - line 26 *;
 [X]WO02096948  (IDEC PHARMA CORP [US], et al) [X] 1-40 * page 10, line 28 - line 31 * * page 12, line 16 - line 21 * * page 19, line 20 - line 22 * * page 27, line 23 - page 28, line 29 * * page 29, line 6 - line 11 *;
 [A]WO03048306  (IDEC PHARMA CORP [US], et al) [A] *pages 7 and 8 paragraphs [0021] to [0023], page 14, paragraph [0056], page 26 paragraph [0083], pages 26 and 27 paragraph [0084] * * pages 23 and 24 paragraphs [0075] to [0078] *;
 [X]US2003194403  (VAN DE WINKEL JAN G J [NL], et al) [X] 33,38 *page 1, paragraph [0007], page 4 paragrahs [0047], [0048] and [0052] and page 5 paragraph [0064] , page 8 paragraphs [0100] and [0103], page 11 and 12 paragraph [0139]*;
 [PX]WO2004106375  (MERUS BIOPHARMACEUTICALS B V I [NL], et al) [PX] 1-40 * example 2 * * page 2, line 8 - line 14 * * page 3, line 23 - line 28 * * page 10, line 10 - line 14 * * page 40, line 21 - line 28 * * page 45, line 1 - line 4 * * page 45, line 12 - line 18 * * page 44, line 21 - line 26 * * page 55, line 13 - page 68, line 11 *;
 [A]  - HOLLIGER P ET AL, "DIABODIES: SMALL BIVALENT AND BISPECIFIC ANTIBODY FRAGMENTS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, (19930701), vol. 90, ISSN 0027-8424, pages 6444 - 6448, XP002008022 [A] * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.90.14.6444
 [A]  - KORTT A A ET AL, "Dimeric and trimeric antibodies: high avidity scFvs for cancer targeting", BIOMOLECULAR ENGINEERING, ELSEVIER, NEW YORK, NY, US, (20011015), vol. 18, no. 3, ISSN 1389-0344, pages 95 - 108, XP004305907 [A] * section "8. Multispecific scFv multimers" pages 105 and 106 *

DOI:   http://dx.doi.org/10.1016/S1389-0344(01)00090-9
ExaminationWO03002609
 WO03046560
 WO03106684
    - MUYLDERMANS S, "SINGLE DOMAIN CAMEL ANTIBODIES: CURRENT STATUS", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20010101), vol. 74, no. 4, ISSN 0168-1656, pages 277 - 302, XP008019929
    - LOGTENBERG ET AL, "Antibody cocktails: next-generation biopharmaceuticals with improved potency", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, (20070823), vol. 25, no. 9, doi:10.1016/J.TIBTECH.2007.07.005, ISSN 0167-7799, pages 390 - 394, XP022210238

DOI:   http://dx.doi.org/10.1016/j.tibtech.2007.07.005
    - SKERRA A, "'Anticalins': a new class of engineered ligand-binding proteins with antibody-like properties", REVIEWS IN MOLECULAR BIOTECHNOLOGY, ELSEVIER, AMSTERDAM, NL, (20010601), vol. 74, no. 4, doi:10.1016/S1389-0352(01)00020-4, ISSN 1389-0352, pages 257 - 275, XP002269554

DOI:   http://dx.doi.org/10.1016/S1389-0352(01)00020-4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.