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Extract from the Register of European Patents

EP About this file: EP1709421

EP1709421 - METHODS FOR DIAGNOSIS AND PRONOSIS OF CANCERS OF EPITHELIAL ORIGIN [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 08.06.2018 Database last updated on 15.06.2024
Former	The patent has been granted Status updated on 30.06.2017
Former	Grant of patent is intended Status updated on 14.02.2017
Most recent event Tooltip	26.06.2020	Lapse of the patent in a contracting state New state(s): CY	published on 29.07.2020 [2020/31]
Applicant(s)	For all designated states CHILDREN'S MEDICAL CENTER CORPORATION 55 Shattuck Street Boston, Massachusetts 02115 / US
	[2006/41]
Inventor(s)	01 / MOSES, Marsha, A. 64 Dean Road Brookline, MA 02445 / US
	02 / ROY, Roopali 412 Langley Road, Apt. No. 7 Newton, MA 02459 / US
	[2007/02]
Former [2006/41]	01 / MOSES, Marsha, A. 64 Dean Road Brookline, MA 02445 / US
	02 / ROY, Roopali 340 O'Neil Boulevard, Apt. 7A Attleboro, MA 02703 / US
Representative(s)	Brown, David Leslie Haseltine Lake Kempner LLP Redcliff Quay 120 Redcliff Street Bristol BS1 6HU / GB
	[N/P]
Former [2017/31]	Brown, David Leslie Haseltine Lake LLP Redcliff Quay 120 Redcliff Street Bristol BS1 6HU / GB
Former [2006/41]	Brown, David Leslie HASELTINE LAKE, Redcliff Quay 120 Redcliff Street Bristol BS1 6HU / GB
Application number, filing date	05705399.3	10.01.2005
	[2006/41]
	WO2005US00714
Priority number, date	US20040535306P	09.01.2004 Original published format: US 535306 P
	[2006/41]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2005071387
	Date:	04.08.2005
	Language:	EN
	[2005/31]
	Type:	A1 Application with search report
	No.:	EP1709421
	Date:	11.10.2006
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 04.08.2005 takes the place of the publication of the European patent application.
	[2006/41]
	Type:	B1 Patent specification
	No.:	EP1709421
	Date:	02.08.2017
	Language:	EN
	[2017/31]
Search report(s)	International search report - published on:	US	04.08.2005
	(Supplementary) European search report - dispatched on:	EP	15.07.2008
Classification	IPC:	G01N33/574	[2017/07]
	CPC:	G01N33/57415 (EP,US); G01N33/57492 (US); G01N33/57484 (EP,US); G01N33/57488 (EP,US); G01N2333/96486 (EP,US); G01N2800/52 (EP,US)
	Former IPC [2008/32]	G01N1/00, G01N33/48, C07K1/00, C07K14/00, C07K17/00, C07K16/00, G01N33/574
	Former IPC [2006/41]	G01N1/00, G01N33/48, C07K1/00, C07K14/00, C07K17/00, C07K16/00
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2017/31]
Former [2006/41]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR
Title	German:	VERFAHREN ZUR DIAGNOSE UND PROGNOSE VON KREBSERKRANKUNGEN EPITHELIALER GENESE	[2006/41]
	English:	METHODS FOR DIAGNOSIS AND PRONOSIS OF CANCERS OF EPITHELIAL ORIGIN	[2006/41]
	French:	METHODES DE DIAGNOSTIC ET DE PRONOSTIC DE CANCERS D'ORIGINE EPITHELIALE	[2006/41]
Entry into regional phase	02.08.2006	National basic fee paid
	02.08.2006	Search fee paid
	02.08.2006	Designation fee(s) paid
	02.08.2006	Examination fee paid
Examination procedure	07.08.2006	Examination requested [2006/41]
	01.12.2008	Despatch of a communication from the examining division (Time limit: M06)
	25.09.2009	Reply to a communication from the examining division
	01.02.2012	Despatch of a communication from the examining division (Time limit: M06)
	31.10.2012	Reply to a communication from the examining division
	18.06.2014	Despatch of a communication from the examining division (Time limit: M06)
	26.01.2015	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	07.04.2015	Reply to a communication from the examining division
	21.12.2016	Cancellation of oral proceeding that was planned for 17.01.2017
	17.01.2017	Date of oral proceedings (cancelled)
	15.02.2017	Communication of intention to grant the patent
	21.06.2017	Fee for grant paid
	21.06.2017	Fee for publishing/printing paid
	21.06.2017	Receipt of the translation of the claim(s)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.12.2008
Opposition(s)	03.05.2018	No opposition filed within time limit [2018/28]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	07.04.2015	Request for further processing filed
	07.04.2015	Full payment received (date of receipt of payment) Request granted
	16.04.2015	Decision despatched
	The application is deemed to be withdrawn due to failure to reply to the examination report
	31.10.2012	Request for further processing filed
	31.10.2012	Full payment received (date of receipt of payment) Request granted
	09.11.2012	Decision despatched
	The application is deemed to be withdrawn due to failure to reply to the examination report
	25.09.2009	Request for further processing filed
	25.09.2009	Full payment received (date of receipt of payment) Request granted
	04.11.2009	Decision despatched
Fees paid	Renewal fee
	27.04.2007	Renewal fee patent year 03
	25.01.2008	Renewal fee patent year 04
	30.01.2009	Renewal fee patent year 05
	25.01.2010	Renewal fee patent year 06
	25.01.2011	Renewal fee patent year 07
	25.01.2012	Renewal fee patent year 08
	25.01.2013	Renewal fee patent year 09
	27.01.2014	Renewal fee patent year 10
	27.01.2015	Renewal fee patent year 11
	27.01.2016	Renewal fee patent year 12
	27.01.2017	Renewal fee patent year 13
	Penalty fee
	Additional fee for renewal fee
	31.01.2007	03 M06 Fee paid on 27.04.2007
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	10.01.2005
	AT	02.08.2017
	CY	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	MC	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	PT	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	TR	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	IE	10.01.2018
	LU	10.01.2018
	BE	31.01.2018
	CH	31.01.2018
	LI	31.01.2018
	[2020/31]
Former [2020/27]	HU	10.01.2005
	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	MC	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	PT	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	TR	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	IE	10.01.2018
	LU	10.01.2018
	BE	31.01.2018
	CH	31.01.2018
	LI	31.01.2018
Former [2020/15]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	MC	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	TR	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	IE	10.01.2018
	LU	10.01.2018
	BE	31.01.2018
	CH	31.01.2018
	LI	31.01.2018
Former [2019/30]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	MC	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	IE	10.01.2018
	LU	10.01.2018
	BE	31.01.2018
	CH	31.01.2018
	LI	31.01.2018
Former [2019/09]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	IE	10.01.2018
	LU	10.01.2018
	BE	31.01.2018
	CH	31.01.2018
	LI	31.01.2018
Former [2018/51]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	LU	10.01.2018
	BE	31.01.2018
	CH	31.01.2018
	LI	31.01.2018
Former [2018/50]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	LU	10.01.2018
	BE	31.01.2018
Former [2018/47]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
	LU	10.01.2018
Former [2018/40]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SI	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
Former [2018/24]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	IT	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
Former [2018/23]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	EE	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	RO	02.08.2017
	SE	02.08.2017
	SK	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
Former [2018/21]	AT	02.08.2017
	CZ	02.08.2017
	DK	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	SE	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
Former [2018/12]	AT	02.08.2017
	ES	02.08.2017
	FI	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	PL	02.08.2017
	SE	02.08.2017
	BG	02.11.2017
	GR	03.11.2017
	IS	02.12.2017
Former [2018/10]	AT	02.08.2017
	FI	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	SE	02.08.2017
Former [2018/09]	FI	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
	SE	02.08.2017
Former [2018/08]	FI	02.08.2017
	LT	02.08.2017
	NL	02.08.2017
Former [2018/07]	LT	02.08.2017
Documents cited:	Search	[XY]WO9740072 (UNIV SHEFFIELD [GB], et al) [X] 1,2,4,5,9-19 * abstract * * page 41, line 23 - page 44, line 10 * * page 52, line 16 - line 26 * * claims 1,37-41,45,56 * [Y] 3,6-8;
		[Y]US2002081641 (MOSES MARSHA A [US], et al) [Y] 1-16 * abstract * * paragraphs [0025] , [0029] , [0032] , [0044] , [0045] , [0051] * * claims 1,2,6,7,13,14,49,50,54,55,61,62,75 *;
		[XY]WO02059377 (EOS BIOTECHNOLOGY INC [US]) [X] 1,2,4,5,9-19 * abstract * * page 52, line 28 - page 58, line 12 * * page 61, line 22 - line 23 * * page 84, line 3 - line 12 * * page 92, line 16 - page 93, line 12 * * claims 13-22 * [Y] 3,6-8;
		[Y] - LE PABIC H. ET AL., "ADAM12 in human liver cancers: TGF-b-regulated expression in stellate cells is associated with matrix remodeling", HEPATOLOGY, (200305), vol. 37, no. 5, pages 1056 - 1066, XP002486182 [Y] 1-16 * abstract * * page 1057, column 1, paragraph 2 * DOI: http://dx.doi.org/10.1053/jhep.2003.50205
	International search	[XP] - ROY R. ET AL., "ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (20041203), vol. 279, no. 49, pages 51323 - 51330, XP002321631 DOI: http://dx.doi.org/10.1074/jbc.M409565200
	Examination	- FRÖHLICH C. ET AL., "Molecular profiling of ADAM12 in human bladder cancer", CLIN. CANCER RES., (20061215), vol. 12, no. 24, pages 7359 - 7368
		- DADUANG J. ET AL., "Biomarker to distinguish hepatocellular carcinoma from cholangiocarcinoma by serum a disintegrin and metalloprotease 12", ARCH. MED. SCI., (20111231), vol. 7, no. 6, pages 1013 - 1016
		- ROY R. ET AL., "Potential of fluorescent metalloproteinase substrates for cancer detection", CLIN. BIOCHEM., (201112), vol. 44, no. 17-18, ISSN 1873-2933, pages 1434 - 1439
		- CIREAP N. ET AL., "Molecular profiling of ADAM12 and ADAM17 genes in human malignant melanoma", PATHOL. ONCOL. RES., (201310), vol. 19, no. 4, pages 755 - 762
		- MINO N. ET AL., "A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma", J. SURG. ONCOL., (200909), vol. 100, no. 3, pages 267 - 272
		- SHAO S. ET AL., "ADAM-12 as a diagnostic marker for the proliferation, migration and invasion in patients with small cell lung cancer", PLOS ONE, (20140121), vol. 9, no. 1, pages 1 - 10
	by applicant	WO9740072
		WO9802539
		US6358683
		US2002081641
		WO02059377
		US2003124543
		- PABIC ET AL., HEPATOLOGY, (2003), vol. 37, no. 5, pages 1056 - 1066
		- HEPATOLOGY, (200305), vol. 37, no. 5, pages 1056 - 1066
		- CANCER RESEARCH, (19980401), vol. 58, no. 7, pages 1395 - 1399

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