EP1753452 - A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 02.09.2016 Database last updated on 24.08.2024 | Most recent event Tooltip | 17.08.2018 | Lapse of the patent in a contracting state New state(s): BG | published on 19.09.2018 [2018/38] | Applicant(s) | For all designated states Cel-Sci Corporation Suite 802 8229 Boone Boulevard Vienna, VA 22182 / US | [N/P] |
Former [2015/44] | For all designated states Cel-Sci Corporation Suite 802, 8229 Boone Boulevard Vienna, VA 22182 / US | ||
Former [2007/08] | For all designated states Cel-Sci Corporation Suite 802, 8229 Boone Boulevard Vienna, VA 22182 / US | Inventor(s) | 01 /
TALOR, Eyal 6603 Deancroft Road Baltimore, MD 21209 / US | [2007/08] | Representative(s) | Potter Clarkson Chapel Quarter Mount Street Nottingham NG1 6HQ / GB | [N/P] |
Former [2015/44] | Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham, NG1 5GG / GB | ||
Former [2013/12] | Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB | ||
Former [2007/08] | Zwicker, Jörk Dr. Volker Vossius Patentanwälte-Rechtsanwälte Geibelstrasse 6 81679 München / DE | Application number, filing date | 05756247.2 | 03.06.2005 | [2007/08] | WO2005US19263 | Priority number, date | US20040576601P | 04.06.2004 Original published format: US 576601 P | [2007/08] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2005120550 | Date: | 22.12.2005 | Language: | EN | [2005/51] | Type: | A2 Application without search report | No.: | EP1753452 | Date: | 21.02.2007 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.12.2005 takes the place of the publication of the European patent application. | [2007/08] | Type: | B1 Patent specification | No.: | EP1753452 | Date: | 28.10.2015 | Language: | EN | [2015/44] | Search report(s) | International search report - published on: | US | 22.03.2007 | (Supplementary) European search report - dispatched on: | EP | 24.06.2009 | Classification | IPC: | A01N37/18, A61K39/00 | [2007/24] | CPC: |
A61K38/193 (EP);
A61K31/5575 (EP);
A61K31/558 (EP);
A61K38/1808 (EP);
A61K38/191 (EP);
A61K38/195 (EP);
A61K38/20 (EP);
A61K38/2006 (EP);
A61K38/2013 (EP);
| C-Set: |
A61K31/5575, A61K2300/00 (EP);
A61K31/558, A61K2300/00 (EP);
A61K38/1808, A61K2300/00 (EP);
A61K38/191, A61K2300/00 (EP);
A61K38/193, A61K2300/00 (EP);
A61K38/195, A61K2300/00 (EP);
A61K38/2006, A61K2300/00 (EP);
A61K38/2013, A61K2300/00 (EP); |
Former IPC [2007/08] | A61K38/20 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2015/44] |
Former [2007/08] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR | Title | German: | VERFAHREN ZUR VERÄNDERUNG DES CD4/CD8-VERHÄLTNISSES UND DES MONONUKLEÄREN ZELLULÄREN INFILTRATS IN EINEN TUMOR | [2007/08] | English: | A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR | [2007/08] | French: | PROCEDE PERMETTANT DE MODIFIER LE RAPPORT CD4/CD8 ET L'INFILTRAT CELLULAIRE MONONUCLEAIRE D'UNE TUMEUR | [2007/08] | Entry into regional phase | 24.11.2006 | National basic fee paid | 24.11.2006 | Search fee paid | 09.02.2007 | Designation fee(s) paid | 23.08.2007 | Examination fee paid | Examination procedure | 04.01.2005 | Request for preliminary examination filed International Preliminary Examining Authority: US | 14.06.2007 | Amendment by applicant (claims and/or description) | 23.08.2007 | Examination requested [2007/41] | 05.08.2010 | Despatch of a communication from the examining division (Time limit: M04) | 15.12.2010 | Reply to a communication from the examining division | 31.10.2011 | Despatch of a communication from the examining division (Time limit: M04) | 12.03.2012 | Reply to a communication from the examining division | 08.08.2012 | Despatch of a communication from the examining division (Time limit: M02) | 16.10.2012 | Reply to a communication from the examining division | 14.05.2013 | Despatch of a communication from the examining division (Time limit: M06) | 25.11.2013 | Reply to a communication from the examining division | 19.02.2014 | Despatch of a communication from the examining division (Time limit: M04) | 18.06.2014 | Reply to a communication from the examining division | 06.05.2015 | Communication of intention to grant the patent | 15.09.2015 | Fee for grant paid | 15.09.2015 | Fee for publishing/printing paid | 15.09.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 05.08.2010 | Opposition(s) | 29.07.2016 | No opposition filed within time limit [2016/40] | Fees paid | Renewal fee | 27.06.2007 | Renewal fee patent year 03 | 25.06.2008 | Renewal fee patent year 04 | 25.09.2009 | Renewal fee patent year 05 | 25.06.2010 | Renewal fee patent year 06 | 27.06.2011 | Renewal fee patent year 07 | 26.06.2012 | Renewal fee patent year 08 | 27.06.2013 | Renewal fee patent year 09 | 30.06.2014 | Renewal fee patent year 10 | 29.06.2015 | Renewal fee patent year 11 | Penalty fee | Additional fee for renewal fee | 30.06.2009 | 05   M06   Fee paid on   25.09.2009 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 03.06.2005 | AT | 28.10.2015 | BE | 28.10.2015 | BG | 28.10.2015 | CY | 28.10.2015 | CZ | 28.10.2015 | DK | 28.10.2015 | EE | 28.10.2015 | FI | 28.10.2015 | LT | 28.10.2015 | MC | 28.10.2015 | NL | 28.10.2015 | PL | 28.10.2015 | RO | 28.10.2015 | SE | 28.10.2015 | SI | 28.10.2015 | SK | 28.10.2015 | TR | 28.10.2015 | GR | 29.01.2016 | IS | 28.02.2016 | PT | 29.02.2016 | IE | 03.06.2016 | LU | 03.06.2016 | [2018/38] |
Former [2018/29] | HU | 03.06.2005 | |
AT | 28.10.2015 | ||
BE | 28.10.2015 | ||
CY | 28.10.2015 | ||
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
MC | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SI | 28.10.2015 | ||
SK | 28.10.2015 | ||
TR | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
IE | 03.06.2016 | ||
LU | 03.06.2016 | ||
Former [2018/28] | HU | 03.06.2005 | |
AT | 28.10.2015 | ||
BE | 28.10.2015 | ||
CY | 28.10.2015 | ||
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
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MC | 28.10.2015 | ||
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RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SI | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
IE | 03.06.2016 | ||
Former [2017/38] | AT | 28.10.2015 | |
BE | 28.10.2015 | ||
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
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LT | 28.10.2015 | ||
MC | 28.10.2015 | ||
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PL | 28.10.2015 | ||
RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SI | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
IE | 03.06.2016 | ||
Former [2017/07] | AT | 28.10.2015 | |
BE | 28.10.2015 | ||
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
MC | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SI | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
Former [2017/03] | AT | 28.10.2015 | |
BE | 28.10.2015 | ||
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SI | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
Former [2016/49] | AT | 28.10.2015 | |
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SI | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
Former [2016/39] | AT | 28.10.2015 | |
CZ | 28.10.2015 | ||
DK | 28.10.2015 | ||
EE | 28.10.2015 | ||
FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
RO | 28.10.2015 | ||
SE | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
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CZ | 28.10.2015 | ||
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FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
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SE | 28.10.2015 | ||
SK | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
Former [2016/34] | AT | 28.10.2015 | |
CZ | 28.10.2015 | ||
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LT | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
SE | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
Former [2016/24] | AT | 28.10.2015 | |
FI | 28.10.2015 | ||
LT | 28.10.2015 | ||
NL | 28.10.2015 | ||
PL | 28.10.2015 | ||
SE | 28.10.2015 | ||
GR | 29.01.2016 | ||
IS | 28.02.2016 | ||
PT | 29.02.2016 | ||
Former [2016/23] | LT | 28.10.2015 | |
NL | 28.10.2015 | ||
SE | 28.10.2015 | ||
IS | 28.02.2016 | ||
Former [2016/22] | LT | 28.10.2015 | |
NL | 28.10.2015 | ||
IS | 28.02.2016 | ||
Former [2016/20] | LT | 28.10.2015 | Documents cited: | Search | [X]US5698194 (HADDEN JOHN WINTHROP [US]) [X] 1-30 * example -; claim - *; | [X] - FEINMESSER R ET AL, "REPORT OF A CLINICAL TRIAL IN 12 PATIENTS WITH HEAD AND NECK CANCER TREATED INTRATUMORALLY AND PERITUMORALLY WITH MULTIKINE", ARCHIVES OF OTOLARYNGOLOGY HEAD AND NECK SURGERY, AMERICAN MEDICAL ASSOCIATION, US, (20030801), vol. 129, ISSN 0886-4470, pages 874 - 881, XP008059890 [X] 1-30 * the whole document * DOI: http://dx.doi.org/10.1001/archotol.129.8.874 | [DA] - TIMAR J ET AL, "THE EFFECT OF LEUKOCYTE INTERLEUKIN INJECTION (MULTIKINE) TREATMENT ON THE PERITUMORAL AND INTRATUMORAL SUBPOPULATION OF MONONUCLEAR CELLS AND ON TUMOR EPITHELIA: A POSSIBLE NEW APPROACH TO AUGMENTING SENSITIVITY TO RADIATION THERAPY AND CHEMOTHERAPY IN", LARYNGOSCOPE, TRIOLOGICAL FOUNDATION, ST LOUIS, US, (20031201), vol. 113, ISSN 0023-852X, pages 2206 - 2217, XP008048121 [DA] 1-30 * the whole document * DOI: http://dx.doi.org/10.1097/00005537-200312000-00031 | [A] - CHIRIGOS M A ET AL, "LEUKOCYTE INTERLEUKIN, INJ. (LI) AUGMENTATION OF NATURAL KILLER CELLS AND CYTOLYTIC T-LYMPHOCYTES", IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, MARCEL DEKKER, NEW YORK, NY, US, (19950101), vol. 17, no. 2, ISSN 0892-3973, pages 247 - 264, XP008048122 [A] 1-30 * the whole document * | [L] - TÍMÁR JÓZSEF ET AL, "Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CD4/CD8 ratio and tumor microenvironment: a multicenter phase II clinical trial.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 20 MAY 2005, (20050520), vol. 23, no. 15, ISSN 0732-183X, pages 3421 - 3432, XP002531443 [L] 1-30 * the whole document * DOI: http://dx.doi.org/10.1200/JCO.2005.06.005 | International search | [Y]US2001006681 (VICO ANTHONY DE [US], et al); | US6017544 [ ] (SRIVASTAVA PRAMOD K [US]) | [Y] - GEZ E. ET AL ., CANCER INVEST, (1999), vol. 17, no. 4, pages 259 - 263, XP008078987 | [ ] - HERNBERG ET AL., ANN. ONCOL, (1997), vol. 8, pages 71 - 77, XP003010747 DOI: http://dx.doi.org/10.1023/A:1008293117223 | [ ] - CHAN B. ET AL, CYTOTHERAPY, (2003), vol. 5, pages 46 - 54, XP008078988 DOI: http://dx.doi.org/10.1080/14653240310000074 | [ ] - WEI Y.-F. ET AL, ZHONGUO ZHONG ZI YI JIE HE ZA ZHI, (2003), vol. 23, pages 258 - 260, XP008079058 | Examination | WO2005007086 | by applicant | US2005002896 | WO2005007086 | - TíMáR ET AL., "Molecular pathology of tumor metastasis 111. Target array and combinatorial therapies", PATHOL ONCOL RES, (2003), vol. 9, page 49 | - WHITESIDE, "Immunobiology and immunotherapy of head and neck cancer", CURRENT ONCOL REP, (2001), vol. 3, page 46 | - FEINMESSER, R. ET AL., ARCH. OTOLARYNGOL. HEAD NECK SURG., (2003), vol. 129, pages 74 - 881 | - TIMAR, J. ET AL., LARYNGOSCOPE, (2003), vol. 113, pages 2206 - 2217 | - TíMáR, J. ET AL., J. CLIN. ONCOL., (2005), vol. 23, pages 3421 - 3432 |