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Extract from the Register of European Patents

EP About this file: EP1753452

EP1753452 - A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  02.09.2016
Database last updated on 24.08.2024
Most recent event   Tooltip17.08.2018Lapse of the patent in a contracting state
New state(s): BG		published on 19.09.2018  [2018/38]
Applicant(s)For all designated states
Cel-Sci Corporation
Suite 802
8229 Boone Boulevard
Vienna, VA 22182 / US
[N/P]
Former [2015/44]For all designated states
Cel-Sci Corporation
Suite 802, 8229 Boone Boulevard
Vienna, VA 22182 / US
Former [2007/08]For all designated states
Cel-Sci Corporation
Suite 802, 8229 Boone Boulevard
Vienna, VA 22182 / US
Inventor(s)01 / TALOR, Eyal
6603 Deancroft Road
Baltimore, MD 21209 / US
 [2007/08]
Representative(s)Potter Clarkson
Chapel Quarter
Mount Street
Nottingham NG1 6HQ / GB
[N/P]
Former [2015/44]Potter Clarkson LLP
The Belgrave Centre
Talbot Street
Nottingham, NG1 5GG / GB
Former [2013/12]Potter Clarkson LLP
The Belgrave Centre
Talbot Street
Nottingham
NG1 5GG / GB
Former [2007/08]Zwicker, Jörk
Dr. Volker Vossius Patentanwälte-Rechtsanwälte Geibelstrasse 6
81679 München / DE
Application number, filing date05756247.203.06.2005
[2007/08]
WO2005US19263
Priority number, dateUS20040576601P04.06.2004         Original published format: US 576601 P
[2007/08]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005120550
Date:22.12.2005
Language:EN
[2005/51]
Type: A2 Application without search report 
No.:EP1753452
Date:21.02.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 22.12.2005 takes the place of the publication of the European patent application.
[2007/08]
Type: B1 Patent specification 
No.:EP1753452
Date:28.10.2015
Language:EN
[2015/44]
Search report(s)International search report - published on:US22.03.2007
(Supplementary) European search report - dispatched on:EP24.06.2009
ClassificationIPC:A01N37/18, A61K39/00
[2007/24]
CPC:
A61K38/193 (EP); A61K31/5575 (EP); A61K31/558 (EP);
A61K38/1808 (EP); A61K38/191 (EP); A61K38/195 (EP);
A61K38/20 (EP); A61K38/2006 (EP); A61K38/2013 (EP);
A61K38/217 (EP); A61K45/06 (EP); A61P35/00 (EP) (-)
C-Set:
A61K31/5575, A61K2300/00 (EP);
A61K31/558, A61K2300/00 (EP);
A61K38/1808, A61K2300/00 (EP);
A61K38/191, A61K2300/00 (EP);
A61K38/193, A61K2300/00 (EP);
A61K38/195, A61K2300/00 (EP);
A61K38/2006, A61K2300/00 (EP);
A61K38/2013, A61K2300/00 (EP);
A61K38/20, A61K2300/00 (EP);
A61K38/217, A61K2300/00 (EP)
(-)
Former IPC [2007/08]A61K38/20
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/44]
Former [2007/08]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERFAHREN ZUR VERÄNDERUNG DES CD4/CD8-VERHÄLTNISSES UND DES MONONUKLEÄREN ZELLULÄREN  INFILTRATS IN EINEN TUMOR[2007/08]
English:A METHOD FOR ALTERING THE CD4/CD8 RATIO AND THE MONONUCLEAR CELLULAR INFILTRATE INTO A TUMOR[2007/08]
French:PROCEDE PERMETTANT DE MODIFIER LE RAPPORT CD4/CD8 ET L'INFILTRAT CELLULAIRE MONONUCLEAIRE D'UNE TUMEUR[2007/08]
Entry into regional phase24.11.2006National basic fee paid 
24.11.2006Search fee paid 
09.02.2007Designation fee(s) paid 
23.08.2007Examination fee paid 
Examination procedure04.01.2005Request for preliminary examination filed
International Preliminary Examining Authority: US
14.06.2007Amendment by applicant (claims and/or description)
23.08.2007Examination requested  [2007/41]
05.08.2010Despatch of a communication from the examining division (Time limit: M04)
15.12.2010Reply to a communication from the examining division
31.10.2011Despatch of a communication from the examining division (Time limit: M04)
12.03.2012Reply to a communication from the examining division
08.08.2012Despatch of a communication from the examining division (Time limit: M02)
16.10.2012Reply to a communication from the examining division
14.05.2013Despatch of a communication from the examining division (Time limit: M06)
25.11.2013Reply to a communication from the examining division
19.02.2014Despatch of a communication from the examining division (Time limit: M04)
18.06.2014Reply to a communication from the examining division
06.05.2015Communication of intention to grant the patent
15.09.2015Fee for grant paid
15.09.2015Fee for publishing/printing paid
15.09.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.08.2010
Opposition(s)29.07.2016No opposition filed within time limit [2016/40]
Fees paidRenewal fee
27.06.2007Renewal fee patent year 03
25.06.2008Renewal fee patent year 04
25.09.2009Renewal fee patent year 05
25.06.2010Renewal fee patent year 06
27.06.2011Renewal fee patent year 07
26.06.2012Renewal fee patent year 08
27.06.2013Renewal fee patent year 09
30.06.2014Renewal fee patent year 10
29.06.2015Renewal fee patent year 11
Penalty fee
Additional fee for renewal fee
30.06.200905   M06   Fee paid on   25.09.2009
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.06.2005
AT28.10.2015
BE28.10.2015
BG28.10.2015
CY28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
MC28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
TR28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
IE03.06.2016
LU03.06.2016
[2018/38]
Former [2018/29]HU03.06.2005
AT28.10.2015
BE28.10.2015
CY28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
MC28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
TR28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
IE03.06.2016
LU03.06.2016
Former [2018/28]HU03.06.2005
AT28.10.2015
BE28.10.2015
CY28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
MC28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
IE03.06.2016
Former [2017/38]AT28.10.2015
BE28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
MC28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
IE03.06.2016
Former [2017/07]AT28.10.2015
BE28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
MC28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2017/03]AT28.10.2015
BE28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2016/49]AT28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SI28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2016/39]AT28.10.2015
CZ28.10.2015
DK28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2016/36]AT28.10.2015
CZ28.10.2015
EE28.10.2015
FI28.10.2015
LT28.10.2015
NL28.10.2015
PL28.10.2015
RO28.10.2015
SE28.10.2015
SK28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2016/34]AT28.10.2015
CZ28.10.2015
FI28.10.2015
LT28.10.2015
NL28.10.2015
PL28.10.2015
SE28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2016/24]AT28.10.2015
FI28.10.2015
LT28.10.2015
NL28.10.2015
PL28.10.2015
SE28.10.2015
GR29.01.2016
IS28.02.2016
PT29.02.2016
Former [2016/23]LT28.10.2015
NL28.10.2015
SE28.10.2015
IS28.02.2016
Former [2016/22]LT28.10.2015
NL28.10.2015
IS28.02.2016
Former [2016/20]LT28.10.2015
Documents cited:Search[X]US5698194  (HADDEN JOHN WINTHROP [US]) [X] 1-30 * example -; claim - *;
 [X]  - FEINMESSER R ET AL, "REPORT OF A CLINICAL TRIAL IN 12 PATIENTS WITH HEAD AND NECK CANCER TREATED INTRATUMORALLY AND PERITUMORALLY WITH MULTIKINE", ARCHIVES OF OTOLARYNGOLOGY HEAD AND NECK SURGERY, AMERICAN MEDICAL ASSOCIATION, US, (20030801), vol. 129, ISSN 0886-4470, pages 874 - 881, XP008059890 [X] 1-30 * the whole document *

DOI:   http://dx.doi.org/10.1001/archotol.129.8.874
 [DA]  - TIMAR J ET AL, "THE EFFECT OF LEUKOCYTE INTERLEUKIN INJECTION (MULTIKINE) TREATMENT ON THE PERITUMORAL AND INTRATUMORAL SUBPOPULATION OF MONONUCLEAR CELLS AND ON TUMOR EPITHELIA: A POSSIBLE NEW APPROACH TO AUGMENTING SENSITIVITY TO RADIATION THERAPY AND CHEMOTHERAPY IN", LARYNGOSCOPE, TRIOLOGICAL FOUNDATION, ST LOUIS, US, (20031201), vol. 113, ISSN 0023-852X, pages 2206 - 2217, XP008048121 [DA] 1-30 * the whole document *

DOI:   http://dx.doi.org/10.1097/00005537-200312000-00031
 [A]  - CHIRIGOS M A ET AL, "LEUKOCYTE INTERLEUKIN, INJ. (LI) AUGMENTATION OF NATURAL KILLER CELLS AND CYTOLYTIC T-LYMPHOCYTES", IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, MARCEL DEKKER, NEW YORK, NY, US, (19950101), vol. 17, no. 2, ISSN 0892-3973, pages 247 - 264, XP008048122 [A] 1-30 * the whole document *
 [L]  - TÍMÁR JÓZSEF ET AL, "Neoadjuvant immunotherapy of oral squamous cell carcinoma modulates intratumoral CD4/CD8 ratio and tumor microenvironment: a multicenter phase II clinical trial.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY 20 MAY 2005, (20050520), vol. 23, no. 15, ISSN 0732-183X, pages 3421 - 3432, XP002531443 [L] 1-30 * the whole document *

DOI:   http://dx.doi.org/10.1200/JCO.2005.06.005
International search[Y]US2001006681  (VICO ANTHONY DE [US], et al);
 US6017544  [ ] (SRIVASTAVA PRAMOD K [US])
 [Y]  - GEZ E. ET AL ., CANCER INVEST, (1999), vol. 17, no. 4, pages 259 - 263, XP008078987
    [ ] - HERNBERG ET AL., ANN. ONCOL, (1997), vol. 8, pages 71 - 77, XP003010747

DOI:   http://dx.doi.org/10.1023/A:1008293117223
    [ ] - CHAN B. ET AL, CYTOTHERAPY, (2003), vol. 5, pages 46 - 54, XP008078988

DOI:   http://dx.doi.org/10.1080/14653240310000074
    [ ] - WEI Y.-F. ET AL, ZHONGUO ZHONG ZI YI JIE HE ZA ZHI, (2003), vol. 23, pages 258 - 260, XP008079058
ExaminationWO2005007086
by applicantUS2005002896
 WO2005007086
    - TíMáR ET AL., "Molecular pathology of tumor metastasis 111. Target array and combinatorial therapies", PATHOL ONCOL RES, (2003), vol. 9, page 49
    - WHITESIDE, "Immunobiology and immunotherapy of head and neck cancer", CURRENT ONCOL REP, (2001), vol. 3, page 46
    - FEINMESSER, R. ET AL., ARCH. OTOLARYNGOL. HEAD NECK SURG., (2003), vol. 129, pages 74 - 881
    - TIMAR, J. ET AL., LARYNGOSCOPE, (2003), vol. 113, pages 2206 - 2217
    - TíMáR, J. ET AL., J. CLIN. ONCOL., (2005), vol. 23, pages 3421 - 3432
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.