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Extract from the Register of European Patents

EP About this file: EP1771192

EP1771192 - USE OF ASPARTATE FOR REGULATING GLUCOSE LEVELS IN BLOOD [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  24.11.2023
Database last updated on 19.07.2024
FormerThe patent has been granted
Status updated on  10.08.2018
FormerGrant of patent is intended
Status updated on  08.05.2018
FormerExamination is in progress
Status updated on  20.02.2017
Most recent event   Tooltip24.11.2023Revocation of patentpublished on 27.12.2023  [2023/52]
Applicant(s)For all designated states
N.V. Nutricia
Eerste Stationsstraat 186
2712 HM Zoetermeer / NL
[N/P]
Former [2007/15]For all designated states
N.V. Nutricia
Eerste Stationsstraat 186
2712 HM Zoetermeer / NL
Inventor(s)01 / HAGEMAN, Robert, Johan, Joseph
Hamsterlaan 12
NL-6705 CT Wageningen / NL
 [2007/15]
Representative(s)Nederlandsch Octrooibureau
P.O. Box 29720
2502 LS The Hague / NL
[2013/28]
Former [2007/15]Swinkels, Bart Willem
Nederlandsch Octrooibureau, P.O. Box 29720
2502 LS The Hague / NL
Application number, filing date05762926.318.07.2005
[2007/15]
WO2005NL00519
Priority number, dateEP2004007710019.07.2004         Original published format: EP 04077100
US20040588793P19.07.2004         Original published format: US 588793 P
EP2004007735920.08.2004         Original published format: EP 04077359
[2007/15]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006009437
Date:26.01.2006
Language:EN
[2006/04]
Type: A2 Application without search report 
No.:EP1771192
Date:11.04.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 26.01.2006 takes the place of the publication of the European patent application.
[2007/15]
Type: B1 Patent specification 
No.:EP1771192
Date:12.09.2018
Language:EN
[2018/37]
Search report(s)International search report - published on:EP06.04.2006
ClassificationIPC:A61K31/4188, A61K31/714, A61K36/81, A61K36/899, A61K38/01, A61K31/198, A61K36/48, A23L33/00, A23L33/17, A23L33/175, A23L33/18, A23L33/185, A23L33/19, A23L13/40, A23L13/60, A23L23/10, A61K38/02
[2018/21]
CPC:
A61K31/714 (EP,CN,US); A61K31/198 (RU,US); A23L33/18 (EP,CN,US);
A23L13/424 (EP,CN,US); A23L13/65 (EP,CN,US); A23L23/10 (EP,CN,US);
A23L33/17 (EP,US); A23L33/175 (EP,CN,US); A23L33/185 (EP,CN,US);
A23L33/19 (EP,US); A23L33/40 (EP,CN,US); A61K31/4188 (EP,CN,US);
A61K36/48 (EP,CN,US); A61K36/81 (EP,CN,US); A61K36/899 (EP,CN,US);
A61K38/01 (EP,CN,US); A61K38/02 (EP,CN,US); A61P1/16 (EP);
A61P11/00 (EP); A61P13/12 (EP); A61P15/08 (EP);
A61P19/06 (EP); A61P27/10 (EP); A61P29/00 (EP);
A61P3/00 (EP); A61P3/04 (EP); A61P3/08 (EP);
A61P3/10 (EP); A61P31/00 (EP); A61P37/04 (EP);
A61P5/50 (EP); A61P7/00 (EP); A61P9/00 (EP);
A61P9/10 (EP); A61P9/12 (EP); A23V2002/00 (EP,CN,US);
A61K2300/00 (RU); A61K9/08 (RU); A61K9/10 (RU) (-)
C-Set:
A61K36/48, A61K2300/00 (US,CN,EP);
A61K36/81, A61K2300/00 (US,CN,EP);
A61K36/899, A61K2300/00 (US,CN,EP);
A23V2002/00, A23V2200/328, A23V2250/0636, A23V2250/061, A23V2250/0628, A23V2250/062, A23V2250/5114, A23V2250/608, A23V2250/61, A23V2250/1882, A23V2250/5106, A23V2250/156, A23V2250/15 (US,CN,EP);
A23V2002/00, A23V2200/332, A23V2250/5488, A23V2250/15, A23V2250/61, A23V2250/612, A23V2250/5114, A23V2250/1842, A23V2250/1882, A23V2250/1614, A23V2250/1618, A23V2250/1582, A23V2250/1592, A23V2250/1588, A23V2250/702, A23V2250/712, A23V2250/7046, A23V2250/7052, A23V2250/0644 (CN);
A23V2002/00, A23V2200/332, A23V2250/5488, A23V2250/15, A23V2250/61, A23V2250/612, A23V2250/5114, A23V2250/1842, A23V2250/1882, A23V2250/1614, A23V2250/1618, A23V2250/1582, A23V2250/1592, A23V2250/1588, A23V2250/702, A23V2250/712, A23V2250/7046, A23V2250/7052, A23V2250/7046, A23V2250/0644 (EP,US);
A23V2002/00, A23V2200/332, A23V2250/61, A23V2250/0618, A23V2250/54252, A23V2250/5488, A23V2250/612, A23V2250/5114, A23V2250/1842, A23V2250/156, A23V2250/702, A23V2250/712, A23V2250/7042, A23V2250/7052, A23V2250/72, A23V2250/7046, A23V2250/0644 (CN,EP,US)
(-)
Former IPC [2007/15]A61K38/02, A61K38/16
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/37]
Former [2007/15]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERWENDUNG VON ASPARTAT ZUR REGULATION DES GLUKOSESPIEGELS IM BLUT[2018/21]
English:USE OF ASPARTATE FOR REGULATING GLUCOSE LEVELS IN BLOOD[2007/15]
French:UTILISATION DE L'ASPARTATE POUR LA RÉGULATION DU TAUX SANGUIN DE GLUCOSE[2007/15]
Former [2007/15]VERWENDUNG VON ASPARTAT ZUR REGULIERUNG DER BLUTZUCKERSPIEGEL
Entry into regional phase19.02.2007National basic fee paid 
19.02.2007Designation fee(s) paid 
19.02.2007Examination fee paid 
Examination procedure17.05.2006Request for preliminary examination filed
International Preliminary Examining Authority: EP
22.01.2007Amendment by applicant (claims and/or description)
19.02.2007Examination requested  [2007/15]
27.01.2011Despatch of a communication from the examining division (Time limit: M06)
07.07.2011Reply to a communication from the examining division
22.08.2012Despatch of a communication from the examining division (Time limit: M06)
01.03.2013Reply to a communication from the examining division
18.10.2013Despatch of a communication from the examining division (Time limit: M06)
28.04.2014Reply to a communication from the examining division
19.03.2015Despatch of a communication from the examining division (Time limit: M06)
27.10.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
06.01.2016Reply to a communication from the examining division
09.02.2017Despatch of a communication from the examining division (Time limit: M04)
15.05.2017Reply to a communication from the examining division
09.05.2018Communication of intention to grant the patent
01.08.2018Fee for grant paid
01.08.2018Fee for publishing/printing paid
01.08.2018Receipt of the translation of the claim(s)
Divisional application(s)EP13152810.1  / EP2705849
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  27.01.2011
Opposition(s)Opponent(s)01  11.06.2019    ADMISSIBLE
Fresenius Kabi Deutschland GmbH
Else-Kröner-Str. 1
61352 Bad Homburg / DE
Opponent's representative
Fresenius Kabi Deutschland GmbH
Patent Department
Pharmaceuticals Division
Borkenberg 14
61440 Oberursel / DE
 [2019/29]
01.07.2019Invitation to proprietor to file observations on the notice of opposition
07.11.2019Reply of patent proprietor to notice(s) of opposition
25.08.2020Cancellation of oral proceeding that was planned for 13.10.2020
13.10.2020Date of oral proceedings
11.03.2021Date of oral proceedings
07.04.2021Despatch of minutes of oral proceedings
07.04.2021Despatch of communication that the patent will be revoked
08.11.2023Legal effect of revocation of patent [2023/52]
Appeal following opposition03.06.2021Appeal received No.  T1051/21
03.06.2021Payment of appeal fee
17.08.2021Statement of grounds filed
08.11.2023Result of appeal procedure: appeal of the proprietor withdrawn
08.11.2023Date of oral proceedings
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
06.01.2016Request for further processing filed
06.01.2016Full payment received (date of receipt of payment)
Request granted
22.01.2016Decision despatched
Fees paidRenewal fee
31.05.2007Renewal fee patent year 03
30.06.2008Renewal fee patent year 04
17.06.2009Renewal fee patent year 05
30.06.2010Renewal fee patent year 06
30.06.2011Renewal fee patent year 07
29.06.2012Renewal fee patent year 08
28.06.2013Renewal fee patent year 09
30.06.2014Renewal fee patent year 10
30.06.2015Renewal fee patent year 11
30.06.2016Renewal fee patent year 12
29.06.2017Renewal fee patent year 13
04.07.2018Renewal fee patent year 14
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.07.2005
AT12.09.2018
CY12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
MC12.09.2018
RO12.09.2018
SI12.09.2018
SK12.09.2018
TR12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
LU18.07.2019
BE31.07.2019
[2021/32]
Former [2021/26]AT12.09.2018
CY12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
MC12.09.2018
RO12.09.2018
SI12.09.2018
SK12.09.2018
TR12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
LU18.07.2019
BE31.07.2019
Former [2020/26]AT12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
MC12.09.2018
RO12.09.2018
SI12.09.2018
SK12.09.2018
TR12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
LU18.07.2019
BE31.07.2019
Former [2020/17]AT12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
MC12.09.2018
RO12.09.2018
SI12.09.2018
SK12.09.2018
TR12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
Former [2020/14]AT12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
MC12.09.2018
RO12.09.2018
SI12.09.2018
SK12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
Former [2019/37]AT12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
RO12.09.2018
SI12.09.2018
SK12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
Former [2019/34]AT12.09.2018
CZ12.09.2018
DK12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
RO12.09.2018
SK12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
Former [2019/26]AT12.09.2018
CZ12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
RO12.09.2018
SK12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
PT12.01.2019
Former [2019/23]AT12.09.2018
CZ12.09.2018
EE12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
RO12.09.2018
SK12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
Former [2019/22]CZ12.09.2018
FI12.09.2018
LT12.09.2018
LV12.09.2018
RO12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
Former [2019/21]FI12.09.2018
LT12.09.2018
LV12.09.2018
BG12.12.2018
GR13.12.2018
IS12.01.2019
Former [2019/13]FI12.09.2018
LT12.09.2018
LV12.09.2018
BG12.12.2018
GR13.12.2018
Former [2019/11]FI12.09.2018
LT12.09.2018
BG12.12.2018
GR13.12.2018
Former [2019/08]FI12.09.2018
LT12.09.2018
Former [2019/07]LT12.09.2018
Cited inInternational search[X]EP0629350  (SANDOZ NUTRITION LTD [CH]) [X] 1,3,5-7,11,12,16,17,21 * page 9, lines 14-30; claim 15 *;
 [X]US6042834  (BARAKA MOHAMED WASIF [KW]) [X] 1,3,5-7,11,12,16,17,21 * claim 1 *;
 [X]WO0137850  (NESTLE SA [CH], et al) [X] 1,3,5-7,10-12,16,17,21 * page 9, lines 29,30; claims 1,5,6 ** page 10, lines 4-12 *;
 [X]US2003118663  (CHANG CHING-MING [TW]) [X] 1,3,5-7,11,12,16,17,21 * claims 1-3 *;
 [DX]WO03105882  (NOVARTIS NUTRITION AG [CH], et al) [DX] 1,3,5-7,11,12,16,17,21 * claims 1-3 *;
 [DX]US6706697  (MACDONALD BRADLEY T [US]) [DX] 1,3,5-7,11,12,16,17,21 * abstract *
ExaminationWO2004056207
    - LAVIGNE C ET AL, "COD AND SOY PROTEINS COMPARED WITH CASEIN IMPROVE GLUCOSE TOLERANCEAND INSULIN SENSITIVITY IN RATS", AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, (20000101), vol. 278, no. 3 part 1, ISSN 0193-1849, pages E491 - E500, XP000978740
    - Mikael Nilsson ET AL, "Glycemia and insulinemia in healthy subjects after lactose-equivalent meals of milk and other food proteins: the role of plasma amino acids and incretins.", American Journal of Clinical Nutrition, (20041101), vol. 80, no. 5, ISSN 0002-9165, pages 1246 - 1253, XP055077987
    - HAGEMAN ROBERT ET AL, "A specific blend of intact protein rich in aspartate has strong postprandial glucose attenuating properties in rats", THE JOURNAL OF NUTRITION, AMERICAN SOCIETY FOR NUTRITION, US, (20080901), vol. 138, no. 9, ISSN 0022-3166, pages 1634 - 1640, XP002555472
OppositionWO9110441
 WO9742834
 WO0077034
 WO2004056207
    - RALET et al., "Potato proteins: Composition, recovery and functional properties", Sciences des Aliments, (19990000), vol. 19, pages 147 - 165, XP055613445
    - SONG et al., "Evidence of Enhancement of Malate-Aspartate Shuttle Activity in beta Cells of Streptozotocin-Induced Non-Insulin-Dependent Diabetic Rats", Metabolism, (20000100), vol. 49, no. 1, doi:10.1016/S0026-0495(00)90838-2, pages 92 - 96, XP001098549

DOI:   http://dx.doi.org/10.1016/S0026-0495(00)90838-2
    - FRESENIUS KABI, "Trink- und Sondennahrungen", Produktkatalog, (20001000), pages 1 - 63, XP055613448
    - SATHE et al., "High-Resolution Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis of Soybean (Glycine max L.) Seed Proteins", Cereal Chem., (19870000), vol. 64, no. 6, pages 380 - 384, XP055613452
    - CRESPILLO et al., "Metabolic effects of an enteral nutrition formula for diabetes: comparison with standard formulas in patients with type 1 diabetes", Clinical Nutrition, (20030000), vol. 22, no. 5, doi:10.1016/S0261-5614(03)00047-5, pages 483 - 487, XP055545839

DOI:   http://dx.doi.org/10.1016/S0261-5614(03)00047-5
    - SOUCI et al., "Potato, Soya Flour", SOUCI et al., S.W. Souci, W. Fachmann, H. Kraut, Food Composition and Nutrition Tables, (20080000), pages 749 - 751, 980-981, XP055613454
    - GRIZARD, "Non-digestible oligosaccharides used as prebiotic agents: mode of production and beneficial effects on animal and human health. Reproduction Nutrition Development", REPRODUCTION, NUTRITION, DEVELOPMENT, (19990000), vol. 39, no. 5-6, pages 563 - 588, XP008056157
    - STEINBERGER et al., "Obesity, Insulin Resistance, Diabetes, and Cardiovascular Risk in Children", Circulation, (20030000), vol. 107, pages 1448 - 1453, XP055613455

DOI:   http://dx.doi.org/10.1161/01.CIR.0000060923.07573.F2
    - MARIOTTI et al., "Nutritional Value of [15N]-Soy Protein Isolate Assessed from Ileal Digestibility and Postprandial Protein Utilization in Humans", J. Nutr., (19990000), vol. 129, pages 1992 - 1997, XP055613457
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.