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Extract from the Register of European Patents

EP About this file: EP1791841

EP1791841 - 2-SUBSTITUTED-1-DEAZA PURINE DERIVATIVES WITH ADENOSINE RECEPTOR MODULATING ACTIVITY [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  25.11.2011
Database last updated on 05.10.2024
Most recent event   Tooltip25.11.2011Refusal of applicationpublished on 28.12.2011  [2011/52]
Applicant(s)For all designated states
Abbott Healthcare Products B.V.
C.J. van Houtenlaan 36
1381 CP Weesp / NL
[2010/21]
Former [2007/23]For all designated states
Solvay Pharmaceuticals B.V.
C.J. van Houtenlaan 36
1381 CP Weesp / NL
Inventor(s)01 / KOCH, Melle c/o Solvay Pharmaceuticals B.V.
IPSI Department C.J. van Houtenlaan 36
NL-1381 CP WEESP / NL
02 / DEN HARTOG, J.A.J. c/o Solvay Pharmaceuticals B.V.
IPSI Department C.J. van Houtenlaan 36
NL-1381 CP Weesp / NL
03 / WANNER, M.J. c/o Solvay Pharmaceuticals B.V.
IPSI Department C.J. van Houtenlaan 36
NL-1381 CP Weesp / NL
04 / KOOMEN, Gerrit-Jan c/o Solvay Pharmaceuticals B.V.
IPSI Department C.J. van Houtenlaan 36
NL-1381 CP Weesp / NL
 [2007/23]
Representative(s)Verhage, Marinus, et al
Octrooibureau Zoan B.V. P.O. Box 140
1380 AC Weesp / NL
[2011/17]
Former [2007/23]Hogenbirk, Marijke, et al
Octrooibureau Zoan B.V. P.O. Box 140
NL-1380 AC Weesp / NL
Application number, filing date05789581.507.09.2005
[2007/23]
WO2005EP54405
Priority number, dateEP2004010434509.09.2004         Original published format: EP 04104345
US20040608145P09.09.2004         Original published format: US 608145 P
[2007/23]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006027366
Date:16.03.2006
Language:EN
[2006/11]
Type: A1 Application with search report 
No.:EP1791841
Date:06.06.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 16.03.2006 takes the place of the publication of the European patent application.
[2007/23]
Search report(s)International search report - published on:EP16.03.2006
ClassificationIPC:C07D471/04, A61K31/437, A61P9/00, A61P25/00
[2007/23]
CPC:
C07D471/04 (EP); A61P17/06 (EP); A61P19/02 (EP);
A61P19/10 (EP); A61P25/00 (EP); A61P25/08 (EP);
A61P25/16 (EP); A61P25/24 (EP); A61P25/28 (EP);
A61P3/10 (EP); A61P31/04 (EP); A61P31/12 (EP);
A61P35/00 (EP); A61P35/02 (EP); A61P37/00 (EP);
A61P9/00 (EP); A61P9/04 (EP); A61P9/06 (EP);
A61P9/10 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/23]
Extension statesALNot yet paid
BANot yet paid
HR10.04.2007
MKNot yet paid
YUNot yet paid
TitleGerman:2-SUBSTITUIERTE-1-DEAZA-PURINDERIVATE MIT ADENOSIN- REZEPTORMODULIERUNGSAKTIVITÄT[2007/23]
English:2-SUBSTITUTED-1-DEAZA PURINE DERIVATIVES WITH ADENOSINE RECEPTOR MODULATING ACTIVITY[2007/23]
French:DÉRIVÉS DE 1-DEAZA PURINE 2-SUBSTITUÉS À ACTIVITÉ MODULATRICE DU RECEPTEUR D'ADÉNOSINE[2007/23]
Entry into regional phase10.04.2007National basic fee paid 
10.04.2007Designation fee(s) paid 
10.04.2007Examination fee paid 
Examination procedure16.02.2006Request for preliminary examination filed
International Preliminary Examining Authority: EP
10.04.2007Examination requested  [2007/23]
20.07.2007Despatch of a communication from the examining division (Time limit: M06)
05.03.2008Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
08.04.2008Reply to a communication from the examining division
04.07.2011Cancellation of oral proceeding that was planned for 14.07.2011
14.07.2011Date of oral proceedings (cancelled)
09.08.2011Despatch of communication that the application is refused, reason: substantive examination [2011/52]
19.08.2011Application refused, date of legal effect [2011/52]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.07.2007
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
08.04.2008Request for further processing filed
08.04.2008Full payment received (date of receipt of payment)
Fees paidRenewal fee
01.10.2007Renewal fee patent year 03
30.09.2008Renewal fee patent year 04
30.09.2009Renewal fee patent year 05
30.09.2010Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
30.09.201107   M06   Not yet paid
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Cited inInternational search[Y]EP0354180  (CIBA GEIGY AG [CH]) [Y] 1-7 * abstract * * page 4, line 15 - page 5, line 9 * * examples 1-17,19,20 *;
 [Y]  - FRANCIS, JOHN E. ET AL, "A general synthesis of 5,7-diaminoimidazo[4,5-b]pyridine ribosides (2-amino-1-deazaadenosines) from 5-amino-4-imidazolecarboxamide riboside (AICA riboside)", CANADIAN JOURNAL OF CHEMISTRY , 70(5), 1288-95 CODEN: CJCHAG; ISSN: 0008-4042, (1992), XP009045697 [Y] 1-7 * page 1288, column 1, paragraph 2 - column 2, paragraph 3 * * page 1289; compounds 1,2 * * page 1290; compound 16 * * page 1291; compound 20 * * page 1291, column 1, paragraph 3 *

DOI:   http://dx.doi.org/10.1139/v92-166
 [Y]  - CAMAIONI, EMIDIO ET AL, "New substituted 9-alkylpurines as adenosine receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY , 6(5), 523-533 CODEN: BMECEP; ISSN: 0968-0896, (1998), XP002926121 [Y] 1-7 * abstract * * page 523, column 1, paragraph 1 - page 524, column 2, paragraph 2 * * page 526, column 2, paragraph 2 * * page 527; table 2 * * page 530, column 2, paragraph 2; example 10b *

DOI:   http://dx.doi.org/10.1016/S0968-0896(98)00007-8
 [Y]  - SULLIVAN GAIL W ET AL, "Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A2A receptor agonists", BRITISH JOURNAL OF PHARMACOLOGY, (200103), vol. 132, no. 5, ISSN 0007-1188, pages 1017 - 1026, XP002322595 [Y] 1-7 * abstract * * page 1018; compounds CGS21680, MRE0470 *

DOI:   http://dx.doi.org/10.1038/sj.bjp.0703893
 [Y]  - NIIYA K ET AL, "2-(N'-ALKYLIDENEHYDRAZINO)ADENOSINES: POTENT AND SELECTIVE CORONARYVASODILATORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (1992), vol. 35, no. 24, ISSN 0022-2623, pages 4557 - 4561, XP000918397 [Y] 1-7 * abstract * * page 4557, column 2, line 7 - page 4558, column 1, paragraph 2 * * page 4558, column 2, paragraph LAST - page 4560, column 2, paragraph LAST *

DOI:   http://dx.doi.org/10.1021/jm00102a007
 [Y]  - NIIYA K ET AL, "2-(N'-ARALKYLIDENEHYDRAZINO)ADENOSINES: POTENT AND SELECTIVE CORONARY VASODILATORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (1992), vol. 35, no. 24, ISSN 0022-2623, pages 4562 - 4566, XP000918386 [Y] 1-7 * abstract * * page 4562, column 1, paragraph 1 - column 2, paragraph 2 * * page 4563, column 1, paragraph LAST - page 4565, column 2, paragraph 1 * * page 4566; examples 29,31,32,35 * * table III *

DOI:   http://dx.doi.org/10.1021/jm00102a008
 [YD]  - WANNER M J ET AL, "2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, (200009), vol. 10, no. 18, ISSN 0960-894X, pages 2141 - 2144, XP004208330 [YD] 5 * abstract * * page 2141, column 1, paragraph 1 * * page 2143, column 1, paragraph 2 - column 2, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0960-894X(00)00415-7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.