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Extract from the Register of European Patents

EP About this file: EP1793824

EP1793824 - NEW PHARMACEUTICAL COMPOSITIONS COMPRISING 4-(4-(3-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-UREIDO)-3-FLUORO-PHENOXY)-PYRIDINE-2-CARBOXYLIC ACID FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  19.01.2022
Database last updated on 20.12.2024
FormerThe patent has been granted
Status updated on  27.11.2017
Most recent event   Tooltip21.01.2022Revocation of patentpublished on 23.02.2022  [2022/08]
Applicant(s)For all designated states
Bayer HealthCare LLC
100 Bayer Boulevard
Whippany, NJ 07981-0915 / US
[2014/47]
Former [2010/27]For all designated states
Bayer HealthCare LLC
555 White Plains Road
Tarrytown, NY 10591 / US
Former [2007/24]For all designated states
Bayer Pharmaceuticals Corporation
400 Morgan Lane
West Haven, CT 06516 / US
Inventor(s)01 / DUMAS, Jacques
98 Farmview Road
Bethany, CT 06524 / US
02 / EHRLICH, Paul
Bockumer Straase 48
40489 Duesseldorf-Wittlaer / DE
03 / ZULEGER, Susanne
Klosterstrasse 92
50931 Koeln / DE
 [2007/24]
Representative(s)Weickmann & Weickmann PartmbB
Postfach 860 820
81635 München / DE
[N/P]
Former [2015/47]BIP Patents, et al
c/o Bayer Intellectual Property GmbH
Alfred-Nobel-Straße 10
40789 Monheim am Rhein / DE
Former [2013/29]BIP Patents, et al
Bayer Intellectual Property GmbH
IPO-P-MON
Creative Campus Monheim
Alfred-Nobel-Straße 10
40789 Monheim / DE
Former [2010/27]Köhler, Ferdinand, et al
Bayer Healthcare AG Law & Patents Patents and Licensing Building Q 18
51368 Leverkusen / DE
Former [2007/24]Albers, Markus
Bayer HealthCare AG LP-PL, Q 18
51368 Leverkusen / DE
Application number, filing date05792486.229.08.2005
[2007/24]
WO2005US30541
Priority number, dateUS20040604752P27.08.2004         Original published format: US 604752 P
[2007/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2006026500
Date:09.03.2006
Language:EN
[2006/10]
Type: A1 Application with search report 
No.:EP1793824
Date:13.06.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 09.03.2006 takes the place of the publication of the European patent application.
[2007/24]
Type: B1 Patent specification 
No.:EP1793824
Date:18.11.2015
Language:EN
[2015/47]
Search report(s)International search report - published on:EP09.03.2006
ClassificationIPC:A61K31/44, A61K31/4415, A61K9/14, A61K9/16, A61K9/20, A61P35/00
[2015/22]
CPC:
A61K31/44 (EP,KR,NO,US); A61K31/4415 (EP,US); A61K9/0053 (US);
A61K9/14 (NO); A61K9/146 (EP,US); A61K9/16 (KR);
A61K9/1623 (US); A61K9/1635 (EP,US); A61K9/1652 (EP,US);
A61K9/2027 (EP,US); A61K9/2054 (EP,US); A61K9/48 (US);
A61P35/00 (EP,NO); A61P35/02 (EP) (-)
Former IPC [2007/24]A61K31/44, A61K9/16, A61P35/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/47]
Former [2007/24]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesBA27.03.2007
HR27.03.2007
MK27.03.2007
YU27.03.2007
TitleGerman:NEUE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN MIT 4-(3-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-UREIDO)-3-FLUOR-PHENOXY)-PYRIDIN-2-CARBONSÄURE ZUR BEHANDLUNG VON HYPERPROLIFERATIVEN ERKRANKUNGEN[2007/24]
English:NEW PHARMACEUTICAL COMPOSITIONS COMPRISING 4-(4-(3-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-UREIDO)-3-FLUORO-PHENOXY)-PYRIDINE-2-CARBOXYLIC ACID FOR THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS[2007/24]
French:COMPOSITIONS PHARMACEUTIQUES COMPORTANT DE L'ACIDE 4-(4-(3-(4-CHLORO-3-TRIFLUOROMETHYL-PHENYL)-UREIDO)-3-FLUORO-PHENOXY)-PYRIDINE-2-CARBOXYLIQUE POUR LE TRAITEMENT DE TROUBLES HYPERPROLIFERATIFS[2007/24]
Entry into regional phase27.03.2007National basic fee paid 
27.03.2007Designation fee(s) paid 
27.03.2007Examination fee paid 
Examination procedure27.06.2006Request for preliminary examination filed
International Preliminary Examining Authority: US
27.03.2007Examination requested  [2007/24]
14.01.2011Despatch of a communication from the examining division (Time limit: M06)
20.07.2011Reply to a communication from the examining division
14.12.2011Despatch of a communication from the examining division (Time limit: M06)
19.06.2012Reply to a communication from the examining division
02.11.2012Despatch of a communication from the examining division (Time limit: M04)
11.01.2013Reply to a communication from the examining division
25.03.2013Despatch of a communication from the examining division (Time limit: M02)
23.04.2013Reply to a communication from the examining division
20.02.2014Despatch of a communication from the examining division (Time limit: M06)
20.08.2014Reply to a communication from the examining division
26.05.2015Communication of intention to grant the patent
08.06.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
14.07.2015Communication of intention to grant the patent
08.10.2015Fee for grant paid
08.10.2015Fee for publishing/printing paid
08.10.2015Receipt of the translation of the claim(s)
Divisional application(s)EP13151040.6  / EP2589384
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.01.2011
Opposition(s)Opponent(s)01  17.08.2016  23.08.2016  ADMISSIBLE
Ter Meer Steinmeister & Partner Patentanwälte mbB
Nymphenburger Strasse 4
80335 München / DE
Opponent's representative
Ter Meer Steinmeister & Partner
Patentanwälte mbB
Nymphenburger Straße 4
80335 München / DE
 [2016/39]
deletedDeletion: Legal effect of rejection of opposition [ N /P ]
26.09.2016Invitation to proprietor to file observations on the notice of opposition
16.01.2017Reply of patent proprietor to notice(s) of opposition
20.10.2017Date of oral proceedings
28.11.2017Despatch of minutes of oral proceedings
28.11.2017Date of despatch of rejection of opposition
07.09.2021Legal effect of revocation of patent [2022/08]
17.12.2021Despatch of communication that the patent will be revoked
Appeal following opposition08.02.2018Appeal received No.  T0377/18
06.04.2018Statement of grounds filed
07.09.2021Result of appeal procedure: revocation of the patent
17.12.2021Despatch of the decision of the Board of Appeal
07.09.2021Date of oral proceedings
Fees paidRenewal fee
31.08.2007Renewal fee patent year 03
22.03.2008Renewal fee patent year 04
31.08.2009Renewal fee patent year 05
31.08.2010Renewal fee patent year 06
31.08.2011Renewal fee patent year 07
27.08.2012Renewal fee patent year 08
27.08.2013Renewal fee patent year 09
13.08.2014Renewal fee patent year 10
10.08.2015Renewal fee patent year 11
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  Tooltipdeleted
[2016/27]
Former [2016/25]LV18.11.2015
Cited inInternational search[DY]WO0042012  (BAYER AG [US], et al) [DY] 1-35 * page 4, line 12-14; compound 49 in table 4 *;
 [Y]WO0041698  (BAYER AG [US], et al) [Y] 1-35 * page 8, line 10 - page 11, line 6; compound 49 in table 4 *;
 [Y]WO03068228  (BAYER AG [US], et al) [Y] 1-35 * page 4, line 1- page, line 21; compound 49 on page 57 *;
 [PX]WO2005009961  (BAYER PHARMACEUTICALS CORP [US], et al) [PX] 1-35* examples 1-11 on pages 47-56 *;
 [Y]  - AHMAD TANYA ET AL, "Kinase inhibition with BAY 43-9006 in renal cell carcinoma.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 15 SEP 2004, Presentation at First International Conference on Innovations and Challenges in Renal Cancer, Cambridge, Massachusetts, (20040319), vol. 10, no. 18 Pt 2, ISSN 1078-0432, pages 6388S - 92S, XP002362669 [Y] 1-35 * formula and table on page 6389S *

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-040028
 [A]  - LEUNER C ET AL, "Improving drug solubility for oral delivery using solid dispersions", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, (20000703), vol. 50, no. 1, ISSN 0939-6411, pages 47 - 60, XP004257179 [A] 1-35 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0939-6411(00)00076-X
Examination   - WILHELM SCOTT M ET AL, "Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity", INTERNATIONAL JOURNAL OF CANCER, (201107), vol. 129, no. 1, ISSN 0020-7136(print), pages 245 - 255
    - WILHELM SCOTT ET AL, "Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.", NATURE REVIEWS. DRUG DISCOVERY OCT 2006 LNKD- PUBMED:17016424, (200610), vol. 5, no. 10, ISSN 1474-1776, pages 835 - 844
    - Bruno C Hancock ET AL, Pharmaceutical Research, (20000101), vol. 17, XP055102285
other   - European Medicines Agency Science Medicines Health,, "Assessment report Stivarga International non-proprietary name: REGORAFENIB", Assessment report EMA/467788/2017, (20170704), pages 1 - 91, XP055714681
OppositionWO0042012
 EP1350792
 WO2005009961
    - Excerpt from the DrugBank, page 1 and 4, URL: http://www.drugbank.ca/drugs/DB08896
    - C. LEUNER et al., "Improving drug solubility for oral delivery using solid dispersions", Eur. J. Pharm. Biopharm., (20000000), vol. 50, pages 47 - 60, XP004257179

DOI:   http://dx.doi.org/10.1016/S0939-6411(00)00076-X
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.