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Extract from the Register of European Patents

EP About this file: EP1766091

EP1766091 - BIOMARKERS FOR MONITORING INHIBITION OF IMPDH PATHWAY [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  21.05.2010
Database last updated on 26.06.2024
Most recent event   Tooltip21.05.2010Application deemed to be withdrawnpublished on 23.06.2010  [2010/25]
Applicant(s)For all designated states
VERTEX PHARMACEUTICALS INCORPORATED
130 Waverly Street
Cambridge, MA 02139-4242 / US
[2007/13]
Inventor(s)01 / JAIN-PANDEY, Jugnu
21 Eisenhower Avuen
Natick, MA 01760 / US
02 / HARDING, Matthew, W.
4 Chestnut Street
Acton, MA 01720 / US
03 / RAMACHANDRAN, Ravi
425 Great Elm Way
Acton, MA 01718 / US
04 / BOTFIELD, Martyn
363 Marlborough Street
Boston, MA 02115 / US
 [2007/13]
Representative(s)Plasseraud IP
66, rue de la Chaussée d'Antin
75440 Paris Cedex 09 / FR
[N/P]
Former [2008/35]Cabinet Plasseraud
52 rue de la Victoire
75440 Paris Cedex 09 / FR
Former [2007/13]Cabinet Plasseraud
52, rue de la Victoire
75440 Paris Cedex 09 / FR
Application number, filing date05804844.827.05.2005
[2007/13]
WO2005US18551
Priority number, dateUS20040575076P27.05.2004         Original published format: US 575076 P
[2007/13]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2005117943
Date:15.12.2005
Language:EN
[2005/50]
Type: A2 Application without search report 
No.:EP1766091
Date:28.03.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 15.12.2005 takes the place of the publication of the European patent application.
[2007/13]
Search report(s)International search report - published on:US19.10.2006
(Supplementary) European search report - dispatched on:EP17.02.2009
ClassificationIPC:C12Q1/68, G01N33/53, C07H21/02
[2007/21]
CPC:
C12Q1/6883 (EP,US); C12Q1/6886 (EP,US); C12Q1/6837 (EP,US);
C12Q2600/106 (EP,US); C12Q2600/158 (EP,US)
Former IPC [2007/13]C12Q1/68, C07H21/02, G01N33/53
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/13]
Extension statesAL18.12.2006
BA18.12.2006
HR18.12.2006
LV18.12.2006
MK18.12.2006
YU18.12.2006
TitleGerman:BIOMARKER ZUR ÜBERWACHUNG DER HEMMUNG DES IMPDH-WEGES[2007/13]
English:BIOMARKERS FOR MONITORING INHIBITION OF IMPDH PATHWAY[2007/13]
French:BIOMARQUEURS POUR LE SUIVI D'INHIBITION DE LA VOIE DE L'INOSINE MONOPHOSPHATE DESHYDROGENASE (IMPDH)[2007/13]
Entry into regional phase18.12.2006National basic fee paid 
18.12.2006Search fee paid 
18.12.2006Designation fee(s) paid 
18.12.2006Examination fee paid 
Examination procedure18.12.2006Examination requested  [2007/13]
19.06.2009Despatch of a communication from the examining division (Time limit: M06)
30.12.2009Application deemed to be withdrawn, date of legal effect  [2010/25]
04.02.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2010/25]
Fees paidRenewal fee
30.05.2007Renewal fee patent year 03
28.05.2008Renewal fee patent year 04
27.05.2009Renewal fee patent year 05
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]US2004009495  (O'MALLEY SHAWN [US], et al) [Y] 27-53 * paragraphs [0022] , [0034] - [0044] - [0058] - [0063] - [0090] * * claims 30-43 *;
 [A]WO03089903  (SCRIPPS RESEARCH INST [US], et al) [A] * claims 1-6,13-15 * * page 5, line 14 - page 7 *
 [X]  - ZHANG YUHONG ET AL, "Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells.", JOURNAL OF VIROLOGY, (200305), vol. 77, no. 10, ISSN 0022-538X, pages 5933 - 5947, XP002513718 [X] 1-55 * the whole document *

DOI:   http://dx.doi.org/10.1128/JVI.77.10.5933-5947.2003
 [Y]  - PING CHEN ET AL, "Identification of Novel and Potent Isoquinoline Aminooxazole-Based IMPDH Inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, (20030101), vol. 13, ISSN 0960-894X, pages 1345 - 1348, XP002488849 [Y] 27-53 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0960-894X(03)00107-0
 [Y]  - JAIN J ET AL, "VX-944: A SPECIFIC, REVERSIBLE IMPDH INHIBITOR WITH POTENT ANTI-PROLIFERATIVE EFFECTS IN HUMAN TUMOR CELL LINES DERIVED FROM HEMATOLOGICAL MALIGNANCIES", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20021116), vol. 100, no. 11, ISSN 0006-4971, page ABSTR.NO.2248, XP001190825 [Y] 27-53 * the whole document *
 [Y]  - OHNO R ET AL, "PREDICTION OF RESPONSE TO IMATINIB BY CDNA MICROARRAY ANALYSIS", SEMINARS IN HEMATOLOGY, PHILADELPHIA, PA, US, (20030401), vol. 40, no. 2, SUPPL. 02, ISSN 0037-1963, pages 42 - 49, XP009059427 [Y] 27-53 * the whole document *
 [Y]  - CERTA U ET AL, "HIGH DENSITY OLIGONUCLEOTIDE ARRAY ANALYSIS OF INTERFERON-ALPHA2A SENSITIVITY AND TRANSCRIPTIONAL RESPONSE IN MELANOMA CELLS", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, LONDON, GB, (20010706), vol. 85, no. 1, ISSN 0007-0920, pages 107 - 114, XP008016089 [Y] 27-53 * the whole document *

DOI:   http://dx.doi.org/10.1054/bjoc.2001.1865
 [Y]  - LOS G ET AL, "Using mRNA expression profiling to determine anticancer drug efficacy", CYTOMETRY, ALAN LISS, NEW YORK, US, (20020101), vol. 47, no. 1, ISSN 0196-4763, pages 66 - 71, XP002321902 [Y] 27-53 * the whole document *

DOI:   http://dx.doi.org/10.1002/cyto.10037
 [Y]  - SOTIRIOU CHRISTOS ET AL, "Gene expression profiles derived from fine needle aspiration correlate with response to systemic chemotherapy in breast cancer", BREAST CANCER RESEARCH, CURRENT SCIENCE, LONDON, GB, (20020320), vol. 4, no. 3, ISSN 1465-5411, page R3, XP021020763 [Y] 27-53 * the whole document *

DOI:   http://dx.doi.org/10.1186/bcr433
International search[X]US6331396  (SILVERMAN ROBERT H [US], et al);
 [X]US6040138  (LOCKHART DAVID J [US], et al);
 [X]US6344316  (LOCKHART DAVID J [US], et al)
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.