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Extract from the Register of European Patents

EP About this file: EP1828192

EP1828192 - DIPEPTIDYL PEPTIDASE INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.10.2015
Database last updated on 24.04.2024
Most recent event   Tooltip30.08.2019Change - lapse in a contracting statepublished on 02.10.2019  [2019/40]
Applicant(s)For all designated states
Takeda Pharmaceutical Company Limited
1-1, Doshomachi 4-chome Chuo-ku Osaka-shi
Osaka 541-0045 / JP
[2007/36]
Inventor(s)01 / FENG, Jun
3536 Corte Yolanda
Carlsbad, CA 92009 / US
02 / GWALTNEY, Stephen, L., II
2620 Canyon Road
Escondido, CA 92025 / US
03 / STAFFORD, Jeffrey, A.
12752 Sandy Crest Court
San Diego, CA 92130 / US
04 / WALLACE, Michael B.
3766 Tomahawk Lane
San Diego, CA 92117 / US
05 / ZHANG, Zhiyuan
3775 Carmel View Road 2
San Diego, CA 92130 / US
 [2007/36]
Representative(s)D Young & Co LLP
3 Noble Street
London EC2V 7BQ / GB
[N/P]
Former [2014/49]Duncan, Garreth Andrew, et al
D Young & Co LLP
120 Holborn
London EC1N 2DY / GB
Former [2010/16]Duncan, Garreth Andrew, et al
D Young & Co 120 Holborn London
EC1N 2DY / GB
Former [2007/36]Nachshen, Neil Jacob, et al
D Young & Co 120 Holborn
London EC1N 2DY / GB
Application number, filing date05854475.016.12.2005
[2007/36]
WO2005US45769
Priority number, dateUS20040638248P21.12.2004         Original published format: US 638248 P
[2007/36]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006068978
Date:29.06.2006
Language:EN
[2006/26]
Type: A2 Application without search report 
No.:EP1828192
Date:05.09.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 29.06.2006 takes the place of the publication of the European patent application.
[2007/36]
Type: B1 Patent specification 
No.:EP1828192
Date:03.12.2014
Language:EN
[2014/49]
Search report(s)International search report - published on:EP22.02.2007
ClassificationIPC:C07D487/04
[2007/36]
CPC:
C07D471/04 (EP,US); A61P13/12 (EP); A61P17/06 (EP);
A61P19/02 (EP); A61P19/08 (EP); A61P25/28 (EP);
A61P29/00 (EP); A61P3/10 (EP); A61P31/18 (EP);
A61P35/00 (EP); A61P37/00 (EP); A61P37/06 (EP);
A61P43/00 (EP); A61P7/00 (EP); A61P7/06 (EP);
C07D487/04 (EP,US); C07D513/04 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/36]
Extension statesAL25.06.2007
BA25.06.2007
HR25.06.2007
MK25.06.2007
YU25.06.2007
TitleGerman:DIPEPTIDYLPEPTIDASEHEMMER[2007/36]
English:DIPEPTIDYL PEPTIDASE INHIBITORS[2007/36]
French:INHIBITEURS DE DIPEPTIDYLE PEPTIDASE[2007/36]
Entry into regional phase25.06.2007National basic fee paid 
25.06.2007Designation fee(s) paid 
25.06.2007Examination fee paid 
Examination procedure12.10.2006Request for preliminary examination filed
International Preliminary Examining Authority: US
25.06.2007Examination requested  [2007/36]
30.08.2007Amendment by applicant (claims and/or description)
07.04.2011Despatch of a communication from the examining division (Time limit: M06)
07.10.2011Reply to a communication from the examining division
30.07.2013Despatch of a communication from the examining division (Time limit: M06)
10.03.2014Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
09.05.2014Reply to a communication from the examining division
23.06.2014Communication of intention to grant the patent
13.10.2014Receipt of the translation of the claim(s)
23.10.2014Fee for grant paid
23.10.2014Fee for publishing/printing paid
Divisional application(s)EP14175458.0  / EP2805953
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.04.2011
Opposition(s)04.09.2015No opposition filed within time limit [2015/46]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
09.05.2014Request for further processing filed
09.05.2014Full payment received (date of receipt of payment)
Request granted
27.05.2014Decision despatched
Fees paidRenewal fee
24.12.2007Renewal fee patent year 03
24.12.2008Renewal fee patent year 04
28.12.2009Renewal fee patent year 05
27.12.2010Renewal fee patent year 06
27.12.2011Renewal fee patent year 07
26.12.2012Renewal fee patent year 08
27.12.2013Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.12.2005
AT03.12.2014
BE03.12.2014
BG03.12.2014
CY03.12.2014
CZ03.12.2014
DK03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
IT03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SI03.12.2014
SK03.12.2014
TR03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
[2018/17]
Former [2016/32]HU16.12.2005
AT03.12.2014
BE03.12.2014
BG03.12.2014
CY03.12.2014
CZ03.12.2014
DK03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
IT03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SI03.12.2014
SK03.12.2014
TR03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
Former [2016/24]AT03.12.2014
BE03.12.2014
BG03.12.2014
CY03.12.2014
CZ03.12.2014
DK03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
IT03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SI03.12.2014
SK03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
Former [2016/12]AT03.12.2014
CY03.12.2014
CZ03.12.2014
DK03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
IT03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SI03.12.2014
SK03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
Former [2016/03]AT03.12.2014
CY03.12.2014
CZ03.12.2014
DK03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
IT03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SK03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
Former [2015/50]AT03.12.2014
CY03.12.2014
CZ03.12.2014
DK03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SK03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
Former [2015/38]AT03.12.2014
CY03.12.2014
CZ03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SK03.12.2014
GR04.03.2015
IS03.04.2015
PT03.04.2015
Former [2015/37]AT03.12.2014
CY03.12.2014
CZ03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
PL03.12.2014
RO03.12.2014
SE03.12.2014
SK03.12.2014
GR04.03.2015
PT03.04.2015
Former [2015/36]AT03.12.2014
CY03.12.2014
CZ03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
RO03.12.2014
SE03.12.2014
GR04.03.2015
PT03.04.2015
Former [2015/35]AT03.12.2014
CY03.12.2014
EE03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
SE03.12.2014
GR04.03.2015
PT03.04.2015
Former [2015/26]AT03.12.2014
CY03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
SE03.12.2014
GR04.03.2015
Former [2015/25]AT03.12.2014
ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
SE03.12.2014
GR04.03.2015
Former [2015/24]ES03.12.2014
FI03.12.2014
LT03.12.2014
LV03.12.2014
NL03.12.2014
SE03.12.2014
GR04.03.2015
Former [2015/23]ES03.12.2014
FI03.12.2014
LT03.12.2014
NL03.12.2014
Former [2015/20]LT03.12.2014
Cited inInternational search[XY]WO03099286  (SQUIBB BRISTOL MYERS CO [US], et al) [X] 1-173 * page 18, line 15 - page 20, line 5; examples 26-29,33,40-42,47-52; claim - * * page 3 * [Y] 1-173;
 [X]DE2801289  (HOECHST AG [DE]) [X] 1-173 * page 7, paragraph 2 - paragraph 3; claims 1,12; table I *;
 [X]WO0209716  (PROCTER & GAMBLE [US]) [X] 1-173 * page 7, paragraph 2; claim 5 * * page 9, line 3 - line 8 *;
 [X]GB1464248  (ICI LTD) [X] 1,15 * table 1; compounds 1-38 *;
 [Y]WO2004087053  (SYRRX INC [US], et al) [Y] 1-173 * figures 1-4; example -; claim - *;
 [Y]DE10256264  (BOEHRINGER INGELHEIM PHARMA [DE]) [Y] 1-173 * example -; claim 1 *;
 [X]US3544570  (TIMMLER HELMUT, et al) [X] 1,15 * claim 1; table 10 *;
 [X]  - AKAHOSHI F ET AL, "Synthesis and pharmacological activity of triazolo[1,5-a]triazine derivatives inhibiting eosinophilia.", JOURNAL OF MEDICINAL CHEMISTRY, (19980730), vol. 41, no. 16, ISSN 0022-2623, pages 2985 - 2993, XP002390903 [X] 1-173 * page 2985, column L, paragraph 1; table 4; compounds 4A,5A, *

DOI:   http://dx.doi.org/10.1021/jm970759u
 [X]  - WANG F ET AL, "A novel Synthesis of Aryl[1,2-a]pyrazinone Derivatives", MOLECULES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, BASEL,, CH, (200405), vol. 9, ISSN 1420-3049, pages 574 - 582, XP002390904 [X] 1-173 * page 575, paragraph 1; table 1; compounds 2,2A * * page 578, paragraph 1 *
 [X]  - BAHAJI E-H ET AL, "STUDIES ON IMMUNOSTIMULATING DERIVATIVES SYNTHESIS OF SOME PYRROLO-1 2-C-PYRIMIDINES", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (1991), Database accession no. PREV199192140000, XP002392081 [X] 1-173 * abstract *
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 [X]  - KOTRA L P ET AL, "4-Azido-2-pyrimidone Nucleosides and Related Chemistry", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, (1997), vol. 62, ISSN 0022-3263, pages 7267 - 7271, XP002390905 [X] 1-173 * compounds 11,12 *

DOI:   http://dx.doi.org/10.1021/jo970761t
 [X]  - TAM S Y-K ET AL, "NUCLEOSIDES 112. SYNTHESIS OF SOME NEW PYRAZOLO-1 5-A-1 3 5-TRIAZINES AND THEIR C NUCLEOSIDES", JOURNAL OF ORGANIC CHEMISTRY, (1979), vol. 44, no. 25, ISSN 0022-3263, pages 4547 - 4553, XP002390906 [X] 1-173 * page 4547, column L, paragraph L; compound 10 * * page 4552, column L, paragraph 4 - paragraph 5 *

DOI:   http://dx.doi.org/10.1021/jo00393a019
 [X]  - ABDEL-RAHMAN R M, "SYNTHESIS OF SOME NEW FLUORINE BEARING TRISUBSTITUTED 3-THIOXO-1,2,4-TRIAZIN-5-ONES AS POTENTIAL ANTICANCER AGENTS", FARMACO, EDIZIONE SCIENTIFICA, SOCIETA CHIMICA ITALIANA, PAVIA, IT, (199203), vol. 47, no. 3, ISSN 0430-0920, pages 319 - 326, XP008000322 [X] 1,15 * page 319, paragraph 1; compounds 2,11,12 *
 [X]  - BORRELL J I ET AL, "SYNTHESIS, STRUCTURE AND CYTOTOXICITY EVALUATION OF PALLADIUM(II) COMPLEXES OF 4-AMINO-3-HYDRAZINO-1,2,4-TRIAZIN-5(4H)-ONES AND 4-AMINO-3-(N-METHYLHYDRAZINO)-1,2,4-TRIAZIN-5(4H)-ONES", ANALES DE QUIMICA, (1995), vol. 91, no. 3/4, ISSN 1130-2283, pages 243 - 252, XP008000323 [X] 1,15 * page 243, column L, paragraph 1; compounds 14,15, 4 *
 [X]  - BUYSENS K J ET AL, "Synthesis of New Pyrrolo[3,4-b]- and [3,4-c]pyridin(on)es and Related 1,7-Naphthyridinones and 2,7-Naphthyridines via Intramolecular Diels-Alder Reactions of 2(1H)-Pyrazinones", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (19960701), vol. 52, no. 27, ISSN 0040-4020, pages 9161 - 9178, XP004104003 [X] 1,15 * page 9161, line 7 - line 8; compound 7E *

DOI:   http://dx.doi.org/10.1016/0040-4020(96)00467-X
 [X]  - DONALD J DUMADS, "Total synthesis of peramine", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, (1988), vol. 5, ISSN 0022-3263, pages 4650 - 4653, XP002087391 [X] 1,15 * examples 1,19 *
 [X]  - BEILSTEIN, BEILSTEIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE, (1991), Database accession no. BRN 4810055,4810730,4812231, XP002392083 [X] 1,15 * column A *
 [X]  - LIU, GANG, "Fungal endophyte-Epichloe and its secondary metabolites", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 2004:340837, URL: STN, XP002392084 [X] 1,15 * abstract *
 [X]  - MOLINA P ET AL, "Iminophosphorane-mediated annulation of 1,3,5-triazine to benzimidazole: Synthesis of 1,3,5-triazino[1,2-a]benzimidazoles", SYNTHESIS 1992 GERMANY, (1992), no. 3, ISSN 0039-7881, pages 297 - 302, XP002390907 [X] 1,15 * page 297, column L, line 2, paragraph 1; table 1; compound 5 *

DOI:   http://dx.doi.org/10.1055/s-1992-26096
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 [X]  - BEILSTEIN, BEILSETIN CROSSFIRE INSTITUT ZUR FOERDERUNG DER CHEMISCHEN WISSENSCHAFTEN, DE, (1989), Database accession no. BRN 5951213, XP002392086 [X] 1,15 * column A *
 [X]  - KOBE J ET AL, "The synthesis of s-Triazolo[4.3-a]1,3,5-Triazines", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (197007), vol. 26, ISSN 0040-4020, pages 3357 - 3368, XP002390908 [X] 1 * page 3362, line 10; compound XIX *

DOI:   http://dx.doi.org/10.1016/S0040-4020(01)92914-X
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.