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EP About this file: EP1769795

EP1769795 - Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers [Right-click to bookmark this link]
Status	Patent revoked Status updated on 19.01.2022 Database last updated on 03.04.2025
Most recent event Tooltip	06.05.2022	Lapse of the patent in a contracting state New state(s): ES	published on 08.06.2022 [2022/23]
Applicant(s)	For all designated states Bayer HealthCare LLC 100 Bayer Boulevard Whippany, NJ 07981 / US
	[2015/14]
Former [2009/32]	For all designated states Bayer HealthCare LLC 555 White Plains Road Tarrytown, NY 10591 / US
Former [2007/14]	For all designated states Bayer Pharmaceuticals Corporation 400 Morgan Lane West Haven, CT 06516 / US
Inventor(s)	01 / Carter, Christopher A. 185 Ash Way Doylestown, PA 18901 / US
	02 / Gibson, Neil 5742 Brittany Forrest Lane San Diego, CA 92130-4827 / US
	03 / Hibner, Barbara 66 Thornberry Road Winchester, MA 01890 / US
	04 / Humphrey, Rachel W. 251 Bouvant Drive Princeton, NJ 08540 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 208 Beechtree Drive Encinitas, CA 92024 / US
	07 / Zhai, Yifan 13602 Gum Spring Drive Rockville MD 20850 / US
	08 / Dumas, Jacques 32 Suffolk Lane Carlisle, MA 01741 / US
	09 / Riedl, Bernd Von Der Goltz Strasse 7 42329 Wuppertal / DE
	10 / Khire, Uday 411 Ridge Rd. Orange, CT 06477 / US
	11 / Lowinger, Timothy, B. 352, School Street Carlisle, MA 01741 / US
	12 / Scott, William, J. 210 Saddle Hill Drive Guilford, CT 06437 / US
	13 / Smith, Roger, A. 206 Bayberry Drive Chester Springs, PA 19425 / US
	14 / Wood, Jill, E. 7988 Eagle Ranch Rd. Fort Collins, CO 80528 / US
	15 / Monahan, Mary-Katherine 1304 Winn Pl. Fort Worth, TX 76134 / US
	16 / Natero, Reina 2681 Flamingo Road 2004S Plantation, FL 33323 / US
	17 / Renick, Joel 6530 Zena Drive San Diego, CA 92115 / US
	18 / Sibley, Robert, N. 1187 Mt. Carmel Avenue North Haven, CT 06473 / US
	[2018/26]
Former [2018/01]	01 / Carter, Christopher A. 185 Ash Way Doylestown, PA 18901 / US
	02 / Gibson, Neil 5742 Brittany Forrest Lane San Diego, CA 92130-4827 / US
	03 / Hibner, Barbara 66 Thornberry Road Winchester, MA 01890 / US
	04 / Humphrey, Rachel W. 251 Bouvant Drive Princeton, NJ 08540 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 208 Beechtree Drive Encinitas, CA 92024 / US
	07 / Zhai, Yifan 13602 Gum Spring Drive Rockville MD 20850 / US
	08 / Dumas, Jacques 32 Suffolk Lane Carlisle, MA 01741 / US
	09 / Riedl, Bernd Von Der Goltz Strasse 7 42329 Wuppertal / DE
	10 / Khire, Uday 411 Ridge Rd. Orange, CT 06477 / US
	11 / Lowinger, Timothy, B. 352, School Street Carlisle, MA 01741 / US
	12 / Scott, William, J. 210 Saddle Hill Drive Guilford, CT 06437 / US
	13 / Smith, Roger, A. 206 Bayberry Drive Chester Springs, PA 19425 / US
	14 / Wood, Jill, E. 3007 Ridge Rd. North Haven, CT 06473 / US
	15 / Monahan, Mary-Katherine 1304 Winn Pl. Fort Worth, TX 76134 / US
	16 / Natero, Reina 2681 Flamingo Road 2004S Plantation, FL 33323 / US
	17 / Renick, Joel 6530 Zena Drive San Diego, CA 92115 / US
	18 / Sibley, Robert, N. 1187 Mt. Carmel Avenue North Haven, CT 06473 / US
Former [2016/32]	01 / Carter, Christopher A. 48 Blue Hills Drive Guilford CT 06437 / US
	02 / Gibson, Neil 41 Pinelawn Road Melville, New York 11747 / US
	03 / Hibner, Barbara 48 Nursey Lane Madison, Conneticut 06443 / US
	04 / Humphrey, Rachel W. 304 East 91st Street New York, NY 10128 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 208 Beechtree Drive Encinitas, CA 92024 / US
	07 / Zhai, Yifan 13602 Gum Spring Drive Rockville MD 20850 / US
	08 / Dumas, Jacques 821 Beechwood Orange CT 06477 / US
	09 / Riedl, Bernd Von Der Goltz Strasse 7 42329 Wuppertal / DE
	10 / Khire, Uday 101 Tanglewood Drive Hamden, CT 06518 / US
	11 / Lowinger, Timothy, B. 203, 5-7 Chitose-Cho Nishinomya City Hyogo 662-0046 / JP
	12 / Scott, William, J. 210 Saddle Hill Drive Guilford, CT 06437 / US
	13 / Smith, Roger, A. 65 Winterhill Road Madison, CT 06443 / US
	14 / Wood, Jill, E. 3007 Ridge Rd. North Haven, CT 06473 / US
	15 / Monahan, Mary-Katherine 134 Park Avenue Hamden, CT 06517 / US
	16 / Natero, Reina 113 Edgecomb Street Hamden, CT 06518 / US
	17 / Renick, Joel 11 Wall Street 4 Milford, CT 06460 / US
	18 / Sibley, Robert, N. 1187 Mt. Carmel Avenue North Haven, CT 06473 / US
Former [2011/47]	01 / Carter, Christopher A. 48 Blue Hills Drive Guilford CT 06437 / US
	02 / Gibson, Neil 41 Pinelawn Road Melville, New York 11747 / US
	03 / Hibner, Barbara 48 Nursey Lane Madison, Conneticut 06443 / US
	04 / Humphrey, Rachel W. 304 East 91st Street New York, NY 10128 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 208 Beechtree Drive Encinitas, CA 92024 / US
	07 / Zhai, Yifan 13602 Gum Spring Drive Rockville MD 20850 / US
Former [2008/15]	01 / Carter, Christopher A. 48 Blue Hills Drive Guilford CT 06437 / US
	02 / Gibson, Neil 41 Pinelawn Road Melville, New York 11747 / US
	03 / Hibner, Barbara 48 Nursey Lane Madison, Conneticut 06443 / US
	04 / Humphrey, Rachel W. 50 Penny Lane Woodbridge, CT 06525 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 208 Beechtree Drive Encinitas, CA 92024 / US
	07 / Zhai, Yifan 13602 Gum Spring Drive Rockville MD 20850 / US
Former [2007/41]	01 / Carter, Christopher A. 48 Blue Hills Drive Guilford CT 06437 / US
	02 / Gibson, Neil 41 Pinelawn Road Melville, New York 11747 / US
	03 / Hibner, Barbara 48 Nursey Lane Madison, Conneticut 06443 / US
	04 / Humphrey, Rachel W. 50 Penny Lane Woodbridge, CT 06525 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 82 Lansdowne Lane Cheshire, CT 06410 / US
	07 / Zhai, Yifan 511 Briarwood Drive Guilford, CT 06437 / US
Former [2007/14]	01 / Carter, Christopher A. 48 Blue Hills Drive Guilford CT 06437 / US
	02 / Gibson, Neil 73 Upland Drive East Northport, NY 11731 / US
	03 / Hibner, Barbara 315 Diabolo Creek Ct Clayton, CA 94517 / US
	04 / Humphrey, Rachel W. 50 Penny Lane Woodbridge, CT 06525 / US
	05 / Trail, Pamela 26 Silo Hill Road Madison, CT 06443 / US
	06 / Vincent, Patrick W. 82 Lansdowne Lane Cheshire, CT 06410 / US
	07 / Zhai, Yifan 511 Briarwood Drive Guilford, CT 06437 / US
Representative(s)	Weickmann & Weickmann PartmbB Postfach 860 820 81635 München / DE
	[N/P]
Former [2007/14]	Weiss, Wolfgang, et al Weickmann & Weickmann Patentanwälte Postfach 86 08 20 81635 München / DE
Application number, filing date	06023696.5	03.12.2002
	[2007/14]
Priority number, date	US20010334609P	03.12.2001 Original published format: US 334609 P
	[2007/14]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	EP1769795
	Date:	04.04.2007
	Language:	EN
	[2007/14]
	Type:	A3 Search report
	No.:	EP1769795
	Date:	12.03.2008
	[2008/11]
	Type:	B1 Patent specification
	No.:	EP1769795
	Date:	24.07.2013
	Language:	EN
	[2013/30]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	11.02.2008
Classification	IPC:	A61K31/44, A61K31/535, A61K31/65, A61K31/435, A61K31/505, A61K31/47	[2008/11]
	CPC:	C07D213/81 (EP,US); A61K31/337 (EP,US); A61K31/435 (EP,US); A61K31/44 (EP,US); A61K31/4412 (US); A61K31/47 (EP,US); (+) A61K31/4745 (EP,US); A61K31/505 (EP,US); A61K31/513 (US); A61K31/535 (EP,US); A61K31/65 (EP,US); A61K31/704 (EP,US); A61K31/7072 (EP,US); A61K45/06 (US); A61P35/00 (EP); A61P35/02 (EP); A61P43/00 (EP) (-)
	C-Set:	A61K31/337, A61K2300/00 (US,EP); A61K31/435, A61K2300/00 (US,EP); A61K31/44, A61K2300/00 (US,EP); A61K31/4745, A61K2300/00 (US,EP); (+) A61K31/505, A61K2300/00 (EP,US); A61K31/535, A61K2300/00 (EP,US); A61K31/65, A61K2300/00 (EP,US); A61K31/704, A61K2300/00 (EP,US); A61K31/7072, A61K2300/00 (EP,US) (-)
	Former IPC [2007/14]	A61K31/337, A61K31/435, A61K31/44, A61K31/47, A61K31/505, A61K31/535, A61K31/65, A61K31/704, A61K31/7072, A61P35/00
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IE, IT, LI, LU, MC, NL, PT, SE, SI, SK, TR [2007/14]
Extension states	AL	11.12.2006
	LT	11.12.2006
	LV	11.12.2006
	MK	11.12.2006
	RO	11.12.2006
Title	German:	Arylharnstoffverbindungen in Kombination mit anderen zytostatischen oder zytotoxischen Substanzen zur Behandlung von Krebs beim Menschen	[2007/14]
	English:	Aryl urea compounds in combination with other cytostatic or cytotoxic agents for treating human cancers	[2007/14]
	French:	Composés de type urée aryle combinés à d'autres agents cytostatiques ou cytotoxiques et servant a traiter des cancers humains	[2007/14]
Examination procedure	11.12.2006	Examination requested [2007/14]
	20.08.2008	Despatch of a communication from the examining division (Time limit: M06)
	26.02.2009	Reply to a communication from the examining division
	07.01.2011	Despatch of a communication from the examining division (Time limit: M04)
	16.05.2011	Reply to a communication from the examining division
	06.06.2011	Despatch of a communication from the examining division (Time limit: M04)
	22.07.2011	Reply to a communication from the examining division
	03.04.2013	Communication of intention to grant the patent
	13.06.2013	Fee for grant paid
	13.06.2013	Fee for publishing/printing paid
Parent application(s) Tooltip	EP02786842.1 / EP1450799
Divisional application(s)	EP10183659.1 / EP2305255
	EP10183680.7 / EP2295057
	EP10183700.3 / EP2305256
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20020786842) is 01.02.2005
Opposition(s)	Opponent(s)	01 24.04.2014 06.05.2014 ADMISSIBLE Altmann, Andreas Herzog Fiesser & Partner Patentanwälte Isartorplatz 1 80331 München / DE Opponent's representative Elkington and Fife LLP Prospect House 8 Pembroke Road Sevenoaks, Kent TN13 1XR / GB
		[2019/40]
	Former [2016/38]
	Opponent(s)	01 24.04.2014 06.05.2014 ADMISSIBLE Altmann, Andreas Herzog Fiesser & Partner Patentanwälte Isartorplatz 1 80331 München / DE Opponent's representative Herzog, Fiesser & Partner Patentanwälte PartG mbB Isartorplatz 1 80331 München / DE
	Former [2015/29]
	Opponent(s)	01 24.04.2014 06.05.2014 ADMISSIBLE Altmann, Andreas Herzog Fiesser & Partner Patentanwälte Isartorplatz 1 80331 München / DE Opponent's representative Altmann, Andreas Herzog Fiesser & Partner Patentanwälte PartG mbB Isartorplatz 1 80331 München / DE
	Former [2015/24]
	Opponent(s)	01 24.04.2014 06.05.2014 ADMISSIBLE Altmann, Andreas Herzog Fiesser & Partner Patentanwälte Isartorplatz 1 80331 München / DE Opponent's representative Herzog, Fiesser & Partner Patentanwälte PartG mbB Isartorplatz 1 80331 München / DE
	Former [2014/23]
	Opponent(s)	01 24.04.2014 Altmann, Andreas Herzog Fiesser & Partner Patentanwälte Isartorplatz 1 DE-80331 München / DE Opponent's representative Altmann, Andreas, et al, et al Herzog Fiesser & Partner Patentanwälte PartG mbB Isartorplatz 1 80331 München / DE
	deleted	Deletion: Legal effect of rejection of opposition [ N /P ]
	03.06.2014	Invitation to proprietor to file observations on the notice of opposition
	29.09.2014	Reply of patent proprietor to notice(s) of opposition
	27.04.2016	Date of oral proceedings
	07.06.2016	Despatch of minutes of oral proceedings
	07.06.2016	Date of despatch of rejection of opposition
	01.12.2021	Despatch of communication that the patent will be revoked
	11.12.2021	Legal effect of revocation of patent [2022/08]
Appeal following opposition	11.08.2016	Appeal received No. T1884/16
	17.10.2016	Statement of grounds filed
	23.11.2021	Result of appeal procedure: revocation of the patent
	01.12.2021	Despatch of the decision of the Board of Appeal
Fees paid	Renewal fee
	11.12.2006	Renewal fee patent year 03
	11.12.2006	Renewal fee patent year 04
	11.12.2006	Renewal fee patent year 05
	12.12.2007	Renewal fee patent year 06
	15.12.2008	Renewal fee patent year 07
	11.12.2009	Renewal fee patent year 08
	15.12.2010	Renewal fee patent year 09
	12.12.2011	Renewal fee patent year 10
	11.12.2012	Renewal fee patent year 11
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	AT	24.07.2013
	BE	24.07.2013
	BG	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	TR	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
	GB	03.12.2020
	IT	03.12.2020
	ES	04.12.2020
	FR	31.12.2020
	DE	01.07.2021
	[2022/23]
Former [2021/51]	AT	24.07.2013
	BE	24.07.2013
	BG	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	TR	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
	GB	03.12.2020
	IT	03.12.2020
	FR	31.12.2020
	DE	01.07.2021
Former [2021/49]	AT	24.07.2013
	BE	24.07.2013
	BG	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	TR	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
	GB	03.12.2020
	IT	03.12.2020
	FR	31.12.2020
Former [2021/48]	AT	24.07.2013
	BE	24.07.2013
	BG	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	TR	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
	IT	03.12.2020
	FR	31.12.2020
Former [2015/35]	AT	24.07.2013
	BE	24.07.2013
	BG	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	TR	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
Former [2015/32]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	TR	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
Former [2014/48]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	IE	03.12.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
Former [2014/46]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	LU	03.12.2013
	CH	31.12.2013
	LI	31.12.2013
Former [2014/38]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	MC	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
	LU	03.12.2013
Former [2014/23]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	CZ	24.07.2013
	DK	24.07.2013
	EE	24.07.2013
	FI	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	SK	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
Former [2014/21]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	DK	24.07.2013
	FI	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
Former [2014/18]	AT	24.07.2013
	BE	24.07.2013
	CY	24.07.2013
	FI	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
Former [2014/14]	CY	17.07.2013
	AT	24.07.2013
	BE	24.07.2013
	FI	24.07.2013
	NL	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
Former [2014/12]	CY	17.07.2013
	AT	24.07.2013
	BE	24.07.2013
	FI	24.07.2013
	SE	24.07.2013
	SI	24.07.2013
	GR	25.10.2013
	PT	25.11.2013
Former [2014/11]	CY	17.07.2013
	AT	24.07.2013
	BE	24.07.2013
	FI	24.07.2013
	SE	24.07.2013
	PT	25.11.2013
Former [2014/10]	CY	17.07.2013
	AT	24.07.2013
	BE	24.07.2013
	SE	24.07.2013
	PT	25.11.2013
Former [2014/09]	AT	24.07.2013
	BE	24.07.2013
	SE	24.07.2013
	PT	25.11.2013
Former [2014/08]	PT	25.11.2013
Documents cited:	Search	[Y]WO9852559 (BAYER AG [US], et al) [Y] 1-41 * claims 1-17 *;
		[Y]WO9932455 (BAYER AG [US]) [Y] 1-41 * page 2, line 6, paragraph 6 - page 10, line 8 *;
		[Y]WO9932106 (BAYER AG [US]) [Y] 1-41 * claims 1-77 *;
		[Y]WO0042012 (BAYER AG [US], et al) [Y] 1-41 * page 2, line 22 - page 6, line 31 * * page 10, line 13 - line 14 * * page 41, line 23 - page 42, line 11 *;
		[X]WO0056331 (VERTEX PHARMA [US], et al) [X] 1,5,16,20,29,30,38 * page 50, line 16 - line 32; claims 1,12,13,23-25 *;
		[X]WO0112188 (PHARMACIA & UPJOHN SPA [IT], et al) [X] 1-41 * page 3, paragraph 3 - page 4 * * page 26, paragraph 2 * * page 26, paragraph L - page 27, paragraph 3 ** page 28, paragraph 1 - paragraph 4 *;
		[X] - IWADATE Y ET AL, "[Intra-arterial ACNU, CDDP chemotherapy for brain metastases from lung cancer: comparison of cases with and without intra-arterial mannitol infusion]", MEDLINE, (199306), Database accession no. NLM8336809, XP002233466 [X] 1,5-7,14,16,20-22,29-31,38 * abstract *
		[Y] - GEIGER T ET AL, "Antitumor activity of a C-raf antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted subcutaneously into nude mice.", CLINICAL CANCER RESEARCH: AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. UNITED STATES JUL 1997, (199707), vol. 3, no. 7, ISSN 1078-0432, pages 1179 - 1185, XP001145779 [Y] 1-41 * page 1179, column R, paragraph L * * page 1180, column L, paragraph 2 * * page 1181, column R, paragraph 2 - page 1183, column L, line 2 * * page 1185, line 1 - line 3 *
		[Y] - CUNNINGHAM C CASEY ET AL, "A phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.", CANCER, (20010901), vol. 92, no. 5, ISSN 0008-543X, pages 1265 - 1271, XP002232130 [Y] 1-41 * page 1271, column L, paragraph L * DOI: http://dx.doi.org/10.1002/1097-0142(20010901)92:5<1265::AID-CNCR1447>3.0.CO;2-5
		[Y] - RIEDL B ET AL, "Potent Raf kinase inhibitors from the diphenylurea class: Structure activity relationships.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, (200103), vol. 42, ISSN 0197-016X, page 923, XP001145518 [Y] 1-41 * the whole document *
		[Y] - STRUMBERG DIRK ET AL, "Phase I and pharmacokinetic study of the Raf kinase inhibitor bay 43-9006 in patients with locally advanced or metastatic cancer.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, (200103), vol. 42, ISSN 0197-016X, page 543, XP001145481 [Y] 1-41 * the whole document *
		[ ] - NO SHINKEI GEKA. NEUROLOGICAL SURGERY. JAPAN JUN 1993, (199306), vol. 21, no. 6, ISSN 0301-2603, pages 513 - 518
	by applicant	WO9404157
		- BOLTON ET AL., ANN. RE. MED. CHEM., (1994), vol. 29, pages 165 - 174
		- BOS., CANCER RES., (1989), vol. 49, pages 4682 - 9
		- AVRUCH ET AL., TRENDS BIOCHEM. SCI., (1994), vol. 19, pages 279 - 83
		- MAGNUSON ET AL., SEMIN. CANCER BIOL., (1994), vol. 5, pages 247 - 53
		- DAUM ET AL., TRENDS BIOCHEM. SCI., (1994), vol. 19, pages 474 - 80
		- FRIEDMAN ET AL., J. BIOL. CHEM., (1994), vol. 269, pages 30105 - 8
		- KOCJ ET AL., NATURE, (1991), vol. 349, pages 426 - 28
		- MONIA ET AL., NAT. MED., (1996), vol. 2, pages 668 - 75
		- ORGANIC PROCESS RESEARCH AND DEVELOPMENT, (2002), vol. 6, no. #6, pages 777 - 781

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