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Extract from the Register of European Patents

EP About this file: EP1679080

EP1679080 - Prevention and treatment of amyloidogenic disease [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  09.08.2017
Database last updated on 20.03.2026
Most recent event   Tooltip17.11.2017Lapse of the patent in a contracting state
???moredetails.lapse.edited??? CH, LI		published on 20.12.2017  [2017/51]
Applicant(s)For all designated states
Janssen Alzheimer Immunotherapy
Little Island Industrial Estate
Little Island, County Cork / IE
[2010/15]
Former [2009/26]For all designated states
Elan Pharma International Limited
Monksland Athlone
Westmeath / IE
Former [2006/28]For all designated states
Neuralab Limited
102 St. James Court Flatts
Smiths FL04 / BM
Inventor(s)01 / Schenk, Dale B.
1542 Los Altos Drive
Burlingame, CA 94010-5941 / US
 [2006/28]
Representative(s)Kirsch, Susan Edith, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2009/51]Kirsch, Susan Edith, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2006/28]Kirsch, Susan Edith, et al
Carpmaels & Ransford 43 Bloomsbury Square
LONDON WC1A 2RA / GB
Application number, filing date06075479.330.11.1998
[2006/28]
Priority number, dateUS19970067740P02.12.1997         Original published format: US 67740 P
US19980080970P07.04.1998         Original published format: US 80970 P
[2006/28]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1679080
Date:12.07.2006
Language:EN
[2006/28]
Type: A3 Search report 
No.:EP1679080
Date:19.07.2006
[2006/29]
Type: B1 Patent specification 
No.:EP1679080
Date:17.06.2009
Language:EN
[2009/25]
Search report(s)(Supplementary) European search report - dispatched on:EP19.06.2006
ClassificationIPC:A61K39/00, A61K39/39, A61P25/28, // C07K14/47
[2008/51]
CPC:
C07K16/18 (EP,US); A61K31/00 (EP,US); A61K31/739 (EP,US);
A61K38/1709 (EP,US); A61K38/193 (EP,US); A61K39/0007 (EP,US);
A61K47/646 (EP,US); A61K9/2031 (EP,US); A61K9/2054 (EP,US);
A61K9/4866 (EP,US); A61P25/00 (EP); A61P25/28 (EP);
A61P37/00 (EP); A61P43/00 (EP); C07K14/4711 (EP,US);
A61K2039/505 (EP,US); A61K2039/53 (EP,US); A61K2039/55505 (EP,US);
A61K2039/55555 (EP,US); A61K2039/55566 (EP,US); A61K2039/55572 (EP,US);
A61K2039/55577 (EP,US); A61K2039/6037 (EP,US); A61K2039/605 (EP,US);
A61K39/00 (EP,KR,US); A61K9/0019 (EP,US); A61K9/2009 (EP,US);
A61K9/7023 (EP,US); C07K2317/24 (EP,US); C07K2317/567 (EP,US);
C07K2319/00 (EP,US) (-)
C-Set:
A61K38/193, A61K2300/00 (EP,US)
Former IPC [2006/28]A61K38/00, A61K38/28, A61K9/26, A61K33/06
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2006/28]
Extension statesAL18.01.2007
LT18.01.2007
LV18.01.2007
MK18.01.2007
RO18.01.2007
SI18.01.2007
TitleGerman:Vorbeugung und Behandlung von amyloidogener Krankheit[2006/28]
English:Prevention and treatment of amyloidogenic disease[2006/28]
French:Prévention et traitement de maladie amyloidogène[2006/28]
Examination procedure02.03.2006Examination requested  [2006/28]
15.11.2007Despatch of a communication from the examining division (Time limit: M06)
26.05.2008Reply to a communication from the examining division
10.07.2008Despatch of a communication from the examining division (Time limit: M02)
19.09.2008Reply to a communication from the examining division
30.12.2008Communication of intention to grant the patent
28.04.2009Fee for grant paid
28.04.2009Fee for publishing/printing paid
Parent application(s)   TooltipEP98961833.5  / EP1033996
Opposition(s)Opponent(s)01  15.03.2010  18.05.2010  ADMISSIBLE
H. Lundbeck A/S
Ottilavej 9
2500Valby / DK
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 02  16.03.2010  08.12.2014  WITHDRAWN
Esslinger, Dr., Alexander
Theatinerstr. 8
80333 München / DE
Opponent's representative
Sheard, Andrew Gregory
Patent Attorney
P.O. Box 521
Berkhamsted, Herts. HP4 1YP / GB
 03  17.03.2010  21.05.2010  ADMISSIBLE
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
Opponent's representative
Buchan, Gavin MacNicol
Merck & Co., Inc.
European Patent Department
Hertford Road
Hoddesdon, Hertfordshire EN11 9BU / GB
 04  16.03.2010  14.06.2016  WITHDRAWN
Chiesi Farmaceutici S.p.A.
Via Palermo 26/A
IT-43100 Parma / IT
Opponent's representative
Hiebl, Inge Elisabeth
Kraus & Weisert
Patentanwälte PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
 05  17.03.2010  21.05.2010  ADMISSIBLE
Meier, Jürgen
Vossius & Partner Siebertstr. 3
81675 München / DE
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
 [2016/29]
Former [2015/03]
Opponent(s)01  15.03.2010  18.05.2010  ADMISSIBLE
H. Lundbeck A/S
Ottilavej 9
2500Valby / DK
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 02  16.03.2010  08.12.2014  WITHDRAWN
Esslinger, Dr., Alexander
Theatinerstr. 8
80333 München / DE
Opponent's representative
Sheard, Andrew Gregory
Patent Attorney
P.O. Box 521
Berkhamsted, Herts. HP4 1YP / GB
 03  17.03.2010  21.05.2010  ADMISSIBLE
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
Opponent's representative
Buchan, Gavin MacNicol
Merck & Co., Inc.
European Patent Department
Hertford Road
Hoddesdon, Hertfordshire EN11 9BU / GB
 04  16.03.2010  21.05.2010  ADMISSIBLE
Chiesi Farmaceutici S.p.A.
Via Palermo 26/A
IT-43100 Parma / IT
Opponent's representative
Hiebl, Inge Elisabeth
Kraus & Weisert
Patentanwälte PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
 05  17.03.2010  21.05.2010  ADMISSIBLE
Meier, Jürgen
Vossius & Partner Siebertstr. 3
81675 München / DE
Opponent's representative
Vossius & Partner
Siebertstrasse 4
81675 München / DE
Former [2011/24]
Opponent(s)01  15.03.2010  18.05.2010  ADMISSIBLE
H. Lundbeck A/S
Ottilavej 9
2500Valby / DK
Opponent's representative
HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastraße 4
81925 München / DE
 02  16.03.2010  21.05.2010  ADMISSIBLE
Esslinger, Dr., Alexander
Theatinerstr. 8
80333 München / DE
Opponent's representative
Sheard, Andrew Gregory
Patent Attorney P.O. Box 521
Berkhamsted, Herts. HP4 1YP / GB
 03  17.03.2010  21.05.2010  ADMISSIBLE
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
Opponent's representative
Buchan, Gavin MacNicol
Merck & Co., Inc. European Patent Department Hertford Road
Hoddesdon, Hertfordshire EN11 9BU / GB
 04  16.03.2010  21.05.2010  ADMISSIBLE
Chiesi Farmaceutici S.p.A.
Via Palermo 26/A
IT-43100 Parma / IT
Opponent's representative
Hiebl, Inge Elisabeth
Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15
80539 München / DE
 05  17.03.2010  21.05.2010  ADMISSIBLE
Meier, Jürgen
Vossius & Partner Siebertstr. 3
81675 München / DE
Opponent's representative
Vossius & Partner
Siebertstrasse 4
81675 München / DE
Former [2010/20]
Opponent(s)01  15.03.2010   
H. Lundbeck A/S
Ottilavej 9
2500Valby / DK
Opponent's representative
HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
 02  16.03.2010   
Esslinger, Dr., Alexander
Theatinerstr. 8
80333 München / DE
Opponent's representative
Betten & Resch
Patentanwälte Theatinerstrasse 8
80333 München / DE
 03  17.03.2010    ADMISSIBLE
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
Opponent's representative
Buchan, Gavin MacNicol
Merck & Co., Inc. Patent Department Hertford Road
Hoddesdon, Hertfordshire EN11 9BU / GB
 04  16.03.2010    WITHDRAWN
Chiesi Farmaceutici S.p.A.
Via Palermo 26/A
IT-43100 Parma / IT
Opponent's representative
Hiebl, Inge Elisabeth
Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15
80539 München / DE
 05  17.03.2010    ADMISSIBLE
Meier, Jürgen
Vossius & Partner Siebertstr. 3
81675 München / DE
Opponent's representative
Vossius & Partner
Siebertstraße 4
81675 München / DE
Former [2010/16]
Opponent(s)01  15.03.2010    ADMISSIBLE
H. Lundbeck A/S
Ottilavej 9
2500Valby / DK
Opponent's representative
HOFFMANN EITLE
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
 02  16.03.2010   
Esslinger, Dr., Alexander
Theatinerstr. 8
80333 München / DE
Opponent's representative
Betten & Resch
Patentanwälte Theatinerstrasse 8
80333 München / DE
01.06.2010Invitation to proprietor to file observations on the notice of opposition
11.02.2011Reply of patent proprietor to notice(s) of opposition
23.01.2012Date of oral proceedings
04.06.2012Despatch of minutes of oral proceedings
05.06.2012Despatch of interlocutory decision in opposition
01.12.2016Legal effect of revocation of patent [2017/37]
17.07.2017Despatch of communication that the patent will be revoked
Appeal following opposition15.08.2012Appeal received No.  T1825/12
15.10.2012Statement of grounds filed
24.11.2016Result of appeal procedure: revocation of the patent
03.08.2012Appeal received No.  T1825/12
12.10.2012Statement of grounds filed
24.11.2016Result of appeal procedure: revocation of the patent
31.07.2012Appeal received No.  T1825/12
12.10.2012Statement of grounds filed
24.11.2016Result of appeal procedure: revocation of the patent
24.11.2016Date of oral proceedings
07.12.2016Minutes of the oral proceedings despatched
Fees paidRenewal fee
02.03.2006Renewal fee patent year 03
02.03.2006Renewal fee patent year 04
02.03.2006Renewal fee patent year 05
02.03.2006Renewal fee patent year 06
02.03.2006Renewal fee patent year 07
02.03.2006Renewal fee patent year 08
27.11.2006Renewal fee patent year 09
27.11.2007Renewal fee patent year 10
07.11.2008Renewal fee patent year 11
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competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCH17.06.2009
LI17.06.2009
[2017/51]
Former [2017/37]deleted
Former [2016/36]IT30.11.2015
Documents cited:Search[X] WO9116819  (MOLECULAR RX INC et al.) [X] 1,12-16,18-24,29-31 * the whole document *
 [Y] WO9703192  (DARWIN MOLECULAR CORP et al.) [Y] 2-5,7,9-11,25-31 * pages 19,23,32 *
 [Y] WO9400153  (SMITHKLINE BEECHAM BIOLOG et al.) [Y] 2-5,7,9-11,25-31 * the whole document *
 [A] EP0683234  (TAKEDA CHEMICAL INDUSTRIES LTD et al.) [A] * the whole document *
 [XY]   SAITO Y ET AL: "Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 92, no. 22, October 1995 (1995-10-01), pages 10227 - 10231, XP002090767, ISSN: 0027-8424 [X] 1,6,8,12-16,18-24 * the whole document * [Y] 2-5,7,9-11,25-31

DOI:   http://dx.doi.org/10.1073/pnas.92.22.10227
 [XY]   WU ET AL: "Drug targeting of a peptide radiopharmaceutical through the primate blood - brain barrier in vivo with a monoclonal antibody to the human insulin receptor", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 100, no. 7, October 1997 (1997-10-01), pages 1804 - 1812, XP002090766, ISSN: 0021-9738 [X] 1,6,8,12-16,18,22-24,29 * the whole document *[Y] 2-5,7,9-11,25-31

DOI:   http://dx.doi.org/10.1172/JCI119708
 [X]   URMONEIT B ET AL: "CEREBROVASCULAR SMOOTH MUSCLE CELLS INTERNALIZE ALZHEIMER AMYLOID BETA PROTEIN VIA A LIPOPROTEIN PATHWAY: IMPLICATIONS FOR CEREBRAL AMYLOID ANGIOPATHY", LABORATORY INVESTIGATION, UNITED STATES AND CANADIAN ACADEMY OF PATHOLOGY, BALTIMORE,, US, vol. 77, no. 2, August 1997 (1997-08-01), pages 157 - 166, XP002940016, ISSN: 0023-6837 [X] 1,6,8,12-16,18-21 * the whole document *
 [X]   LADU M J ET AL: "Isoform-specific binding of apolipoprotein E to beta-amyloid.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 23 SEP 1994, vol. 269, no. 38, 23 September 1994 (1994-09-23), pages 23403 - 23406, XP002381631, ISSN: 0021-9258 [X] 1,6,8,12-16,18-21 * the whole document *
 [X]   DU Y ET AL: "alpha2-Macroglobulin as a beta-amyloid peptide-binding plasma protein.", JOURNAL OF NEUROCHEMISTRY. JUL 1997, vol. 69, no. 1, July 1997 (1997-07-01), pages 299 - 305, XP002381632, ISSN: 0022-3042 [X] 1,6,8,12-16,18-21 * the whole document *
 [X]   JOHNSON-WOOD K ET AL: "Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, no. 4, 18 February 1997 (1997-02-18), pages 1550 - 1555, XP002275435, ISSN: 0027-8424 [X] 1,2,12-16,18-27 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.94.4.1550
 [A]   SHINKAI Y ET AL: "Amyloid beta-proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels.", ANNALS OF NEUROLOGY. SEP 1995, vol. 38, no. 3, September 1995 (1995-09-01), pages 421 - 428, XP002381836, ISSN: 0364-5134 [A] * the whole document *

DOI:   http://dx.doi.org/10.1002/ana.410380312
Examination  TRAVIS: "A vaccine for Alzheimer's Disease?", SCIENCE, vol. 309, 2005, pages 731 - 734 [X] 1,6,8,12-16,18-24 * the whole document * [Y] 2-5,7,9-11,25-31
   SCIENCE, NEWS ONLINE, vol. 156, 10 July 1999 (1999-07-10), pages 2 [X] 1,6,8,12-16,18,22-24,29 * the whole document *[Y] 2-5,7,9-11,25-31
   8 May 2001, WASHINGTON POST [X] 1,6,8,12-16,18-21 * the whole document *
   ZUBRIGGEN ET AL, J. MOL. NEUROSCIENCE, vol. 27, 2005, pages 157 - 166 [X] 1,6,8,12-16,18-21 * the whole document *
   BUTTINI ET AL, J. NEUROSCIENCE, vol. 25, 2005, pages 9096 - 9101 [X] 1,6,8,12-16,18-21 * the whole document *
   MAIER ET AL, J. NEROSCIENCE, vol. 26, 2006, pages 4717 - 4728 [X] 1,2,12-16,18-27 * the whole document *
   WANG ET AL, VACCINE, vol. 25, pages 3041 - 3052
   SOOD ET AL, IND. J. EXP. BIOL., vol. 35, 1998, pages 849 - 861
   DATABASE WWW.FREEP.COM [online] 23 July 2001 (2001-07-23), SETH BORENSTEIN: "New Alzheimer's vaccine to be tested on people soon"
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.