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Extract from the Register of European Patents

EP About this file: EP1685836

EP1685836 - Antifungal activity of dicationic molecules [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  01.10.2010
Database last updated on 08.10.2024
Most recent event   Tooltip01.10.2010Application deemed to be withdrawnpublished on 03.11.2010  [2010/44]
Applicant(s)For all designated states
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
308 Bynum Hall Campus Box 145 Chapel Hill
North Carolina 27599-4105 / US
For all designated states
The Georgia State University
Research Foundation, Inc. University Plaza
Atlanta, GA 30303 / US
For all designated states
Duke University
230 North Building, Research Drive, P.O. Box 90083
Durham, NC 27712 / US
[2006/31]
Inventor(s)01 / Tidwell, Richard R.
390 W.R. Clark Road
Pittsboro, NC 27312 / US
02 / Boykin, David W.
1369 Springdale Road NE
Atlanta, GA 30303 / US
03 / Perfect, John R.
3533 Mossdale Avenue
Durham, NC 27707-3813 / US
 [2006/31]
Representative(s)Sanderson, Nigel Paul, et al
HGF Limited
Saviour House
9 St Saviourgate
York YO1 8NQ / GB
[N/P]
Former [2008/16]Sanderson, Nigel Paul, et al
Harrison Goddard Foote 106 Micklegate
York Y01 6JX / GB
Former [2006/31]Harrison Goddard Foote
Belgrave Hall Belgrave Street
Leeds LS2 8DD / GB
Application number, filing date06075828.115.09.1999
[2006/31]
Priority number, dateUS19980100928P17.09.1998         Original published format: US 100928 P
[2006/31]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1685836
Date:02.08.2006
Language:EN
[2006/31]
Type: A3 Search report 
No.:EP1685836
Date:09.05.2007
[2007/19]
Search report(s)(Supplementary) European search report - dispatched on:EP11.04.2007
ClassificationIPC:A61K31/341, A61K31/4184, A61P31/10
[2006/34]
CPC:
A61K31/341 (EP); A61K31/4184 (EP); A61P31/10 (EP)
Former IPC [2006/31]A61K31/341, A61P31/10, A61K31/4184, A61K31/5377, A61K31/4439
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2006/31]
TitleGerman:Antimykotische Wirkung von dikationischen Molekülen[2006/31]
English:Antifungal activity of dicationic molecules[2006/31]
French:activite antifongique de molécules dicationiques[2006/31]
Examination procedure30.03.2006Examination requested  [2006/31]
08.08.2007Despatch of a communication from the examining division (Time limit: M06)
06.06.2008Reply to a communication from the examining division
01.04.2010Application deemed to be withdrawn, date of legal effect  [2010/44]
31.05.2010Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2010/44]
Parent application(s)   TooltipEP99969025.8  / EP1143959
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
06.06.2008Request for further processing filed
Fees paidRenewal fee
30.03.2006Renewal fee patent year 03
30.03.2006Renewal fee patent year 04
30.03.2006Renewal fee patent year 05
30.03.2006Renewal fee patent year 06
30.03.2006Renewal fee patent year 07
11.09.2006Renewal fee patent year 08
12.09.2007Renewal fee patent year 09
31.03.2008Renewal fee patent year 10
Penalty fee
Additional fee for renewal fee
30.09.200911   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[DX]US5602172  (BOYKIN DAVID W [US], et al) [DX] 1,4 * column W * * column 2, line 1 - column 3, line 14 *;
 [X]DE2122208  (HOECHST AG) [X] 1-3,5 * the whole document * * page 1 * * page 4, paragraph 1 * * claim 1 *;
 [X]WO9640145  (UNIV NORTH CAROLINA [US], et al) [X] 1-3 * the whole document * * page 25; table 1 *;
 [A]DE2833135  (HENKEL KGAA) [A] * the whole document * * especially page 6, line 8-9 *;
 [A]US4034010  (HAMANO SACHIYUKI, et al) [A] * column W * * especially column 3, line 43-column 5, line 56 *;
 [A]US5643935  (DYKSTRA CHRISTINE C [US], et al) [A] * column 1, line 45 - column 3, line 45 *;
 [X]  - GOLDMAN G H ET AL, "DIFFERENTIAL POISONING OF HUMAN AND ASPERGILLUS NIDULANS DNA TOPOISOMERASE I BY- AND TERBENZIMIDAZOLES", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, (19970527), vol. 36, no. 21, ISSN 0006-2960, pages 6488 - 6494, XP002066842 [X] 1,5 * page 6490, column 2 * * page 6492, column 2 * * figure 8 *

DOI:   http://dx.doi.org/10.1021/bi963033t
 [A]  - ANNÉ, J. ET AL, "Antifungal and antibacterial activities of diarylamidine derivatives", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1980), vol. 18, no. 2, pages 231 - 239, XP000886495 [A] * the whole document * * especially page 233, Table 2, compounds 25,27,30 *
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 [A]  - HOPKINS, K.T. ET AL, "Extended aromatic furan amidino derivaives as anti-Pneumocystis carinii agents", JOURNAL OF MEDICINAL CHEMISTRY, (19980910), vol. 41, no. 20, pages 3872 - 3878, XP000914716 [A] * table 1 *

DOI:   http://dx.doi.org/10.1021/jm980230c
 [DA]  - BERGER, B.J. ET AL, "Hydroxylation of pentamidine by rat liver microsomes", THE JOURNAL OF PHARMACOLOGICAL AND EXPERIMENTAL THERAPEUTICS, (1991), vol. 256, pages 883 - 889, XP000921003 [DA] * the whole document * * especially abstract, first line and page 887, figure 4 *
 [A]  - LI, KE ET AL, "Design and analysis of organic cations that inhibit interactions of the HIV-1 Rev protein with RRE RNA", STRUCT., MOTION, INTERACT. EXPRESSION BIOL. MACROMOL., PROC. CONVERSATION DISCIP. BIOMOL. STEREODYN., 10TH, 1998, 2,, 137-145, (1998), XP000921396 [A] * page 140, compounds 9 and 1-3 *
 [A]  - WPI WORLD PATENT INFORMATION DERWENT, DERWENT, GB, (1976), vol. 76, no. 46 PA - EISAI CO. LTD PN - JP51110531 A, XP002154138 [A] * abstract *
 [A]  - DONKOR, I.O. ET AL, "Antimicrobial activity of geometric isomers of butamidine and related compounds", PHARMACEUTICAL RESEARCH, (1996), vol. 13, no. 9, page S141, XP000972148 [A] * abstract *
 [A]  - ST-GERMAIN, G., "Effects of pentamidine alone and in combination with ketoconazole or itraconazole on the growth of Candida albicans", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1990), vol. 34, no. 12, pages 2304 - 2306, XP000961099 [A] * abstract * * table 1 *
 [A]  - BARCHIESI, F. ET AL, "Effect of pentamidine on the growth of Cryptococcus neoformans", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, (1994), vol. 33, no. 6, pages 1229 - 1232, XP000961082 [A] * abstract * * figure 1 *

DOI:   http://dx.doi.org/10.1093/jac/33.6.1229
 [DA]  - DAS, B.P. ET AL, "Synthesis and antiprotozoal activity of 2,5-Bis(4-guanylphenyl)furans", JOURNAL OF MEDICINAL CHEMISTRY, (1977), vol. 20, no. 4, pages 531 - 536, XP000605199 [DA] * abstract * * table 1 *

DOI:   http://dx.doi.org/10.1021/jm00214a014
 [DA]  - BOYKIN, D.W. ET AL, "Anti-Pneumocystis activity of bis-amidoximes and bis-O-alkylamidoxies prodrugs", BIORGANIC AND MEDICINAL CHEMISTRY LETTERS, (1996), vol. 6, no. 24, pages 3017 - 3020, XP002142274 [DA] * abstract * * page 3018, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0960-894X(96)00557-4
 [DA]  - TRENT, J.O. ET AL, "Targeting the minor groove of DNA: Crystal structures of two complexes between furan derivatives of Berenil and the DNA dodecamer", JOURNAL OF MEDICINAL CHEMISTRY, (1996), vol. 39, pages 4554 - 4562, XP000914678 [DA] * abstract * * figure 1 *

DOI:   http://dx.doi.org/10.1021/jm9604484
 [DA]  - BOYKIN, D.W. ET AL, "2,5-Bis(4-(N-alkylamidino)phenyl)furans as anti-Pneumocystis carinii agents", JOURNAL OF MEDICINAL CHEMISTRY, (19980101), vol. 41, pages 124 - 129, XP000914677 [DA] * abstract * * table 1 *

DOI:   http://dx.doi.org/10.1021/jm970570i
 [DA]  - TIDWELL, R.R. ET AL, "Analogues of 1,5-Bis(4-amidinophenoxy)pentane (Pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia", THE JOURNAL OF MEDICINAL CHEMISTRY, (1990), vol. 33, no. 4, pages 1252 - 1257, XP000644781 [DA] * abstract * * table 1 *

DOI:   http://dx.doi.org/10.1021/jm00166a026
 [DA]  - JONES, S.K. ET AL, "Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1990), vol. 34, no. 6, pages 1026 - 1030, XP000921002 [DA] * abstract * * figure 1 *
 [DA]  - TIDWELL, R.R. ET AL, "Diarylamidine derivatives with one or both of the aryl moieties consisting of an indole or indole-like ring. Inhibitors of arginine-specific esteroproteases", JOURNAL OF MEDICINAL CHEMISTRY, (1978), vol. 21, no. 7, pages 613 - 623, XP000573913 [DA] * abstract *

DOI:   http://dx.doi.org/10.1021/jm00205a005
 [DA]  - FAIRLEY, T.A. ET AL, "Structure, DNA minor groove binding and base pair specificity of alkyl- and aryl- linked bis(amidinobenzimidazoles) and bis(amidinoindoles)", JOURNAL OF MEDICINAL CHEMISTRY, (1993), vol. 36, no. 12, pages 1746 - 1753, XP002067234 [DA] * abstract * * tables I,II,III * * page 1746, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1021/jm00064a008
 [A]  - BELL, C.A. ET AL, "Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: Correlation of antigiardial activity with DNA binding affinity and Giardial topoisomerase II inhibition", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1993), vol. 37, no. 12, pages 2668 - 2673, XP000972059 [A] * abstract * * table 2 *
 [PX]  - DEL POETA, M. ET AL, "In vitro antifungal activities of a series of dication-substituted carbazoles, furans and benzimidazoles", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (199810), vol. 42, no. 10, pages 2503 - 2510, XP000920943 [PX] 1-4 * tables 3,5 *
 [PX]  - POETA DEL M ET AL, "IN-VITRO ACTIVITY OF DICATIONIC AROMATIC COMPOUNDS AND FLUCONAZOLE AGAINST CRYPTOCOCCUS NEOFORMANS AND CANDIDA SPP", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, SAUNDERS CO. LTD., LONDON, GB, (199908), vol. 44, no. 2, ISSN 0305-7453, pages 223 - 228, XP000920923 [PX] 1-3 * table 1; compound 57 *

DOI:   http://dx.doi.org/10.1093/jac/44.2.223
 [PX]  - DEL POETA, M. ET AL, "Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (199810), vol. 42, no. 10, pages 2495 - 2502, XP000920922 [PX] 1-3 * table 3 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.