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Extract from the Register of European Patents

EP About this file: EP1863816

EP1863816 - SYNTHESIS AND PURIFICATION OF PTEROIC ACID AND CONJUGATES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.05.2015
Database last updated on 22.08.2024
Most recent event   Tooltip13.10.2017Lapse of the patent in a contracting state
New state(s): BG, HU, TR		published on 15.11.2017  [2017/46]
Applicant(s)For all designated states
Endocyte, Inc.
3000 Kent Avenue
West Lafayette, IN 47906 / US
[2007/50]
Inventor(s)01 / XU, Le-Cun
2845 Ashland Street
West Lafayette, IN 47906 / US
02 / VLAHOV, Iontcho, Radoslavov
1041 Shooting Strar Court
West Lafayette, IN 47906 / US
03 / LEAMON, Christopher, Paul
5830 Farm Ridge Road
West Lafayette, IN 47906 / US
04 / SANTHAPURAM, Hari, Krishna
1704 Sandpiper Drive South
West Lafayette, IN 47906 / US
05 / LI, Chunhong
15 Crimson King Drive
Bear, DE 19701 / US
 [2007/50]
Representative(s)Elsy, David, et al
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
[N/P]
Former [2014/26]Elsy, David, et al
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Former [2007/50]Elsy, David, et al
Withers & Rogers LLP Goldings House, 2 Hays Lane
London SE1 2HW / GB
Application number, filing date06738235.814.03.2006
[2007/50]
WO2006US09153
Priority number, dateUS20050662277P16.03.2005         Original published format: US 662277 P
[2007/50]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2006101845
Date:28.09.2006
Language:EN
[2006/39]
Type: A2 Application without search report 
No.:EP1863816
Date:12.12.2007
Language:EN
The application published by WIPO in one of the EPO official languages on 28.09.2006 takes the place of the publication of the European patent application.
[2007/50]
Type: B1 Patent specification 
No.:EP1863816
Date:25.06.2014
Language:EN
[2014/26]
Search report(s)International search report - published on:EP29.03.2007
ClassificationIPC:C07D475/08, A61K31/519, A61K31/00
[2007/50]
CPC:
C07D475/08 (EP,US); A61P31/00 (EP); A61P31/04 (EP);
A61P31/10 (EP); A61P31/12 (EP); A61P31/14 (EP);
A61P31/16 (EP); A61P31/20 (EP); A61P31/22 (EP);
A61P33/02 (EP); A61P33/10 (EP); A61P33/12 (EP);
A61P33/14 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P43/00 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2007/50]
TitleGerman:SYNTHESE UND AUFREINIGUNG VON PTEROINSÄURE UND KONJUGATEN DAVON[2007/50]
English:SYNTHESIS AND PURIFICATION OF PTEROIC ACID AND CONJUGATES THEREOF[2007/50]
French:SYNTHESE ET PURIFICATION D'ACIDE PTEROIQUE ET DES CONJUGUES DE CELUI-CI[2007/50]
Entry into regional phase05.10.2007National basic fee paid 
05.10.2007Designation fee(s) paid 
05.10.2007Examination fee paid 
Examination procedure05.10.2007Examination requested  [2007/50]
23.11.2007Amendment by applicant (claims and/or description)
16.10.2008Despatch of a communication from the examining division (Time limit: M04)
17.02.2009Reply to a communication from the examining division
15.09.2010Despatch of a communication from the examining division (Time limit: M06)
21.03.2011Reply to a communication from the examining division
06.07.2012Despatch of a communication from the examining division (Time limit: M06)
22.01.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
07.03.2013Reply to a communication from the examining division
03.01.2014Communication of intention to grant the patent
06.05.2014Fee for grant paid
06.05.2014Fee for publishing/printing paid
06.05.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.10.2008
Opposition(s)26.03.2015No opposition filed within time limit [2015/23]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
07.03.2013Request for further processing filed
07.03.2013Full payment received (date of receipt of payment)
Request granted
21.03.2013Decision despatched
Fees paidRenewal fee
27.03.2008Renewal fee patent year 03
26.03.2009Renewal fee patent year 04
25.03.2010Renewal fee patent year 05
29.03.2011Renewal fee patent year 06
26.03.2012Renewal fee patent year 07
27.03.2013Renewal fee patent year 08
27.03.2014Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.03.2006
AT25.06.2014
BE25.06.2014
BG25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
MC25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SI25.06.2014
SK25.06.2014
TR25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
GB14.03.2015
IE14.03.2015
LU14.03.2015
[2017/39]
Former [2016/07]AT25.06.2014
BE25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
MC25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SI25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
GB14.03.2015
IE14.03.2015
LU14.03.2015
Former [2015/50]AT25.06.2014
BE25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
MC25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SI25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
LU14.03.2015
Former [2015/47]AT25.06.2014
BE25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
MC25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
LU14.03.2015
Former [2015/46]AT25.06.2014
BE25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
MC25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
Former [2015/30]AT25.06.2014
BE25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
Former [2015/22]AT25.06.2014
CY25.06.2014
CZ25.06.2014
DK25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
IT25.06.2014
LT25.06.2014
LV25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
Former [2015/12]AT25.06.2014
CY25.06.2014
CZ25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
LT25.06.2014
LV25.06.2014
NL25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
IS25.10.2014
PT27.10.2014
Former [2015/11]CY25.06.2014
CZ25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
LT25.06.2014
LV25.06.2014
PL25.06.2014
RO25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
PT27.10.2014
Former [2015/10]CY25.06.2014
CZ25.06.2014
EE25.06.2014
ES25.06.2014
FI25.06.2014
LT25.06.2014
LV25.06.2014
SE25.06.2014
SK25.06.2014
GR26.09.2014
Former [2014/50]CY25.06.2014
FI25.06.2014
LT25.06.2014
LV25.06.2014
SE25.06.2014
GR26.09.2014
Former [2014/49]CY25.06.2014
FI25.06.2014
LT25.06.2014
Former [2014/48]CY25.06.2014
LT25.06.2014
Former [2014/47]CY25.06.2014
Cited inInternational search[X]US4337339  (FARINA PETER R, et al) [X] 1 * examples 4,5 *;
 [X]US2003162234  (JALLAD KARIM N [US], et al) [X] 39 * figure 3a *
 [X]  - MAKOTO N ET AL, "Development of an efficient intermediate, alpha-[2-(trimethylsilyl)et hoxycarbonyl]folic acid, for the synthesis of folate (gamma)-conjugates, and its application to the synthesis of folate-nucleoside conjugates", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, (20000811), vol. 65, no. 16, ISSN 0022-3263, pages 5016 - 5021, XP002314929 [X] 1 * page 5017, right column, first paragraph * * page 5021, synthesis of compound 21 *

DOI:   http://dx.doi.org/10.1021/jo000132a
 [X]  - PJ HARVISON, TI KALMAN, "Synthesis and Biological Activity of Novel Folic Acid Analogues: Pteroyl S-alkylhomocysteine Sulfoximines", JOURNAL OF MEDICINAL CHEMISTRY, (1992), vol. 35, XP002393707 [X] 1 * page 1229, right column, first paragraph *

DOI:   http://dx.doi.org/10.1021/jm00085a010
 [X]  - SCOTT, JOHN M., "Preparation and purification of pteroic acid from pteroylglutamic acid (folic acid)", METHODS IN ENZYMOLOGY , 66(VITAM. COENZYMES, PT. E), 657-60 CODEN: MENZAU; ISSN: 0076-6879, (1980), XP009070566 [X] 1 * page 658, paragraph LAST - page 660 *

DOI:   http://dx.doi.org/10.1016/0076-6879(80)66522-7
 [X]  - M.C. ARCHER, L.S. REED, "Separation of Folic Acid Derivatives and Pterins by High-Performance Liquid Chromatography", METHODS IN ENZYMOLOGY, (1980), vol. 66, pages 452 - 459, XP009070564 [X] 1 * page 453, paragraphs 1,2,AND * * examples *

DOI:   http://dx.doi.org/10.1016/0076-6879(80)66488-X
by applicantUS4337339
 US5108921
 US5416016
 US5635382
 US5688488
 US4713249
 US5266333
 US5417982
    - HOULIHAN ET AL., ANAL. BIOCHEM., (1972), vol. 46, pages 1 - 6
    - PRATT ET AL., J. BIOL. CHENA., (1968), vol. 243, page 6367
    - LEVY ET AL., J. BIOL. CHEM., (1967), vol. 242, page 2933
    - SCOTT, METHODS IN ENZYMOLOGY, (1980), vol. 66, pages 657 - 60
    - LEMON ET AL., "Conversion of pterolyglutamic acid to pteroic acid by bacterial degradation", ARCHIVES OFBIOCHEMISTRY, (1948), vol. 19, pages 311 - 16
    - HARVISON; KALMAN, J. MED. CHEM., (1992), vol. 35, pages 1227 - 33
    - NOMURA ET AL., J. ORG. CHEM., (2000), vol. 65, pages 5016 - 21
 US20010822379
 US20040765336
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.