EP1863816 - SYNTHESIS AND PURIFICATION OF PTEROIC ACID AND CONJUGATES THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 01.05.2015 Database last updated on 22.08.2024 | Most recent event Tooltip | 13.10.2017 | Lapse of the patent in a contracting state New state(s): BG, HU, TR | published on 15.11.2017 [2017/46] | Applicant(s) | For all designated states Endocyte, Inc. 3000 Kent Avenue West Lafayette, IN 47906 / US | [2007/50] | Inventor(s) | 01 /
XU, Le-Cun 2845 Ashland Street West Lafayette, IN 47906 / US | 02 /
VLAHOV, Iontcho, Radoslavov 1041 Shooting Strar Court West Lafayette, IN 47906 / US | 03 /
LEAMON, Christopher, Paul 5830 Farm Ridge Road West Lafayette, IN 47906 / US | 04 /
SANTHAPURAM, Hari, Krishna 1704 Sandpiper Drive South West Lafayette, IN 47906 / US | 05 /
LI, Chunhong 15 Crimson King Drive Bear, DE 19701 / US | [2007/50] | Representative(s) | Elsy, David, et al Withers & Rogers LLP 2 London Bridge London SE1 9RA / GB | [N/P] |
Former [2014/26] | Elsy, David, et al Withers & Rogers LLP 4 More London Riverside London SE1 2AU / GB | ||
Former [2007/50] | Elsy, David, et al Withers & Rogers LLP Goldings House, 2 Hays Lane London SE1 2HW / GB | Application number, filing date | 06738235.8 | 14.03.2006 | [2007/50] | WO2006US09153 | Priority number, date | US20050662277P | 16.03.2005 Original published format: US 662277 P | [2007/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2006101845 | Date: | 28.09.2006 | Language: | EN | [2006/39] | Type: | A2 Application without search report | No.: | EP1863816 | Date: | 12.12.2007 | Language: | EN | The application published by WIPO in one of the EPO official languages on 28.09.2006 takes the place of the publication of the European patent application. | [2007/50] | Type: | B1 Patent specification | No.: | EP1863816 | Date: | 25.06.2014 | Language: | EN | [2014/26] | Search report(s) | International search report - published on: | EP | 29.03.2007 | Classification | IPC: | C07D475/08, A61K31/519, A61K31/00 | [2007/50] | CPC: |
C07D475/08 (EP,US);
A61P31/00 (EP);
A61P31/04 (EP);
A61P31/10 (EP);
A61P31/12 (EP);
A61P31/14 (EP);
A61P31/16 (EP);
A61P31/20 (EP);
A61P31/22 (EP);
A61P33/02 (EP);
A61P33/10 (EP);
A61P33/12 (EP);
A61P33/14 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P43/00 (EP)
(-)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2007/50] | Title | German: | SYNTHESE UND AUFREINIGUNG VON PTEROINSÄURE UND KONJUGATEN DAVON | [2007/50] | English: | SYNTHESIS AND PURIFICATION OF PTEROIC ACID AND CONJUGATES THEREOF | [2007/50] | French: | SYNTHESE ET PURIFICATION D'ACIDE PTEROIQUE ET DES CONJUGUES DE CELUI-CI | [2007/50] | Entry into regional phase | 05.10.2007 | National basic fee paid | 05.10.2007 | Designation fee(s) paid | 05.10.2007 | Examination fee paid | Examination procedure | 05.10.2007 | Examination requested [2007/50] | 23.11.2007 | Amendment by applicant (claims and/or description) | 16.10.2008 | Despatch of a communication from the examining division (Time limit: M04) | 17.02.2009 | Reply to a communication from the examining division | 15.09.2010 | Despatch of a communication from the examining division (Time limit: M06) | 21.03.2011 | Reply to a communication from the examining division | 06.07.2012 | Despatch of a communication from the examining division (Time limit: M06) | 22.01.2013 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 07.03.2013 | Reply to a communication from the examining division | 03.01.2014 | Communication of intention to grant the patent | 06.05.2014 | Fee for grant paid | 06.05.2014 | Fee for publishing/printing paid | 06.05.2014 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 16.10.2008 | Opposition(s) | 26.03.2015 | No opposition filed within time limit [2015/23] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 07.03.2013 | Request for further processing filed | 07.03.2013 | Full payment received (date of receipt of payment) Request granted | 21.03.2013 | Decision despatched | Fees paid | Renewal fee | 27.03.2008 | Renewal fee patent year 03 | 26.03.2009 | Renewal fee patent year 04 | 25.03.2010 | Renewal fee patent year 05 | 29.03.2011 | Renewal fee patent year 06 | 26.03.2012 | Renewal fee patent year 07 | 27.03.2013 | Renewal fee patent year 08 | 27.03.2014 | Renewal fee patent year 09 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 14.03.2006 | AT | 25.06.2014 | BE | 25.06.2014 | BG | 25.06.2014 | CY | 25.06.2014 | CZ | 25.06.2014 | DK | 25.06.2014 | EE | 25.06.2014 | ES | 25.06.2014 | FI | 25.06.2014 | IT | 25.06.2014 | LT | 25.06.2014 | LV | 25.06.2014 | MC | 25.06.2014 | NL | 25.06.2014 | PL | 25.06.2014 | RO | 25.06.2014 | SE | 25.06.2014 | SI | 25.06.2014 | SK | 25.06.2014 | TR | 25.06.2014 | GR | 26.09.2014 | IS | 25.10.2014 | PT | 27.10.2014 | GB | 14.03.2015 | IE | 14.03.2015 | LU | 14.03.2015 | [2017/39] |
Former [2016/07] | AT | 25.06.2014 | |
BE | 25.06.2014 | ||
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CZ | 25.06.2014 | ||
DK | 25.06.2014 | ||
EE | 25.06.2014 | ||
ES | 25.06.2014 | ||
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LT | 25.06.2014 | ||
LV | 25.06.2014 | ||
MC | 25.06.2014 | ||
NL | 25.06.2014 | ||
PL | 25.06.2014 | ||
RO | 25.06.2014 | ||
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SK | 25.06.2014 | ||
GR | 26.09.2014 | ||
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PT | 27.10.2014 | ||
GB | 14.03.2015 | ||
IE | 14.03.2015 | ||
LU | 14.03.2015 | ||
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GR | 26.09.2014 | ||
IS | 25.10.2014 | ||
PT | 27.10.2014 | ||
LU | 14.03.2015 | ||
Former [2015/47] | AT | 25.06.2014 | |
BE | 25.06.2014 | ||
CY | 25.06.2014 | ||
CZ | 25.06.2014 | ||
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GR | 26.09.2014 | ||
IS | 25.10.2014 | ||
PT | 27.10.2014 | ||
LU | 14.03.2015 | ||
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CY | 25.06.2014 | ||
CZ | 25.06.2014 | ||
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PT | 27.10.2014 | ||
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GR | 26.09.2014 | ||
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PT | 27.10.2014 | ||
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PT | 27.10.2014 | ||
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PT | 27.10.2014 | ||
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Former [2014/48] | CY | 25.06.2014 | |
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Former [2014/47] | CY | 25.06.2014 | Cited in | International search | [X]US4337339 (FARINA PETER R, et al) [X] 1 * examples 4,5 *; | [X]US2003162234 (JALLAD KARIM N [US], et al) [X] 39 * figure 3a * | [X] - MAKOTO N ET AL, "Development of an efficient intermediate, alpha-[2-(trimethylsilyl)et hoxycarbonyl]folic acid, for the synthesis of folate (gamma)-conjugates, and its application to the synthesis of folate-nucleoside conjugates", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, (20000811), vol. 65, no. 16, ISSN 0022-3263, pages 5016 - 5021, XP002314929 [X] 1 * page 5017, right column, first paragraph * * page 5021, synthesis of compound 21 * DOI: http://dx.doi.org/10.1021/jo000132a | [X] - PJ HARVISON, TI KALMAN, "Synthesis and Biological Activity of Novel Folic Acid Analogues: Pteroyl S-alkylhomocysteine Sulfoximines", JOURNAL OF MEDICINAL CHEMISTRY, (1992), vol. 35, XP002393707 [X] 1 * page 1229, right column, first paragraph * DOI: http://dx.doi.org/10.1021/jm00085a010 | [X] - SCOTT, JOHN M., "Preparation and purification of pteroic acid from pteroylglutamic acid (folic acid)", METHODS IN ENZYMOLOGY , 66(VITAM. COENZYMES, PT. E), 657-60 CODEN: MENZAU; ISSN: 0076-6879, (1980), XP009070566 [X] 1 * page 658, paragraph LAST - page 660 * DOI: http://dx.doi.org/10.1016/0076-6879(80)66522-7 | [X] - M.C. ARCHER, L.S. REED, "Separation of Folic Acid Derivatives and Pterins by High-Performance Liquid Chromatography", METHODS IN ENZYMOLOGY, (1980), vol. 66, pages 452 - 459, XP009070564 [X] 1 * page 453, paragraphs 1,2,AND * * examples * DOI: http://dx.doi.org/10.1016/0076-6879(80)66488-X | by applicant | US4337339 | US5108921 | US5416016 | US5635382 | US5688488 | US4713249 | US5266333 | US5417982 | - HOULIHAN ET AL., ANAL. BIOCHEM., (1972), vol. 46, pages 1 - 6 | - PRATT ET AL., J. BIOL. CHENA., (1968), vol. 243, page 6367 | - LEVY ET AL., J. BIOL. CHEM., (1967), vol. 242, page 2933 | - SCOTT, METHODS IN ENZYMOLOGY, (1980), vol. 66, pages 657 - 60 | - LEMON ET AL., "Conversion of pterolyglutamic acid to pteroic acid by bacterial degradation", ARCHIVES OFBIOCHEMISTRY, (1948), vol. 19, pages 311 - 16 | - HARVISON; KALMAN, J. MED. CHEM., (1992), vol. 35, pages 1227 - 33 | - NOMURA ET AL., J. ORG. CHEM., (2000), vol. 65, pages 5016 - 21 | US20010822379 | US20040765336 |