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Extract from the Register of European Patents

EP About this file: EP1915461

EP1915461 - COMPOSITION AND METHOD FOR DETERMINATION OF CK19 EXPRESSION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.06.2019
Database last updated on 24.08.2024
FormerThe patent has been granted
Status updated on  29.06.2018
FormerGrant of patent is intended
Status updated on  22.02.2018
FormerExamination is in progress
Status updated on  31.03.2017
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Dx4U GmbH
Viktor Kaplan-Strasse 2
2700 Wiener Neustadt / AT
[2017/19]
Former [2011/24]For all designated states
Lianidou, Evriklia
Piperopoulou 19
145 75 Athens / GR
For all designated states
Stathopoulou, Aliki
Hatziconstanti 31
115 24 Athens / GR
For all designated states
Mavroudis, Dimitrios
Dimokratias 27
71 306 Herakleion / GR
For all designated states
Georgoulias, Vasileios
Magnisias 12
71 305 Herakleion / GR
Former [2008/18]For all designated states
Medexis S.A.
4, Asklipiou Str. Kryoneri
145 68 Athens / GR
Inventor(s)01 / Mavroudis, Dimitros
Dimokratias 27
71306 Heraklion, Crete / GR
02 / Georgoulias, Vasileios
Gregoriou Theologou 5
11471 Athens / GR
03 / Lianidou, Evriklia
Piperopoulou 19
14575 Athens / GR
04 / Stathopoulou, Aliki
Aristotelous 27
15562 Holargos, Athens / GR
 [2018/31]
Former [2011/24]01 / see applicant
...
Former [2008/18]01 / LIANIDOU, Evriklia
Piperopoulou 19
GR-145 75 Athens / GR
02 / STATHOPOULOU, Aliki
Hatziconstanti 31
GR-115 24 Athens / GR
03 / MAVROUDIS, Dimitrios
Dimokratias 27
GR-71 306 Herakleion / GR
04 / GEORGOULIAS, Vasileios
Magnisias 12
GR-71 305 Herakleion / GR
Representative(s)Redl, Gerda, et al
REDL Life Science Patent Attorneys
Donau-City-Straße 11
1220 Wien / AT
[2018/31]
Former [2013/15]Redl, Gerda, et al
REDL Life Science Patent Attorneys Tech Gate Vienna Donau-City-Straße 1
1220 Vienna / AT
Former [2008/18]Hiebl, Inge Elisabeth, et al
Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15
80539 München / DE
Application number, filing date06776902.616.08.2006
[2008/18]
WO2006EP08097
Priority number, dateGR2005010043017.08.2005         Original published format: GR 20050100430
US20060795149P25.04.2006         Original published format: US 795149 P
[2008/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2007020081
Date:22.02.2007
Language:EN
[2007/08]
Type: A1 Application with search report 
No.:EP1915461
Date:30.04.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 22.02.2007 takes the place of the publication of the European patent application.
[2008/18]
Type: B1 Patent specification 
No.:EP1915461
Date:01.08.2018
Language:EN
[2018/31]
Search report(s)International search report - published on:EP22.02.2007
ClassificationIPC:C12Q1/6886
[2018/10]
CPC:
C12Q1/6886 (EP,KR,US); C12Q1/6876 (KR,US); C12N15/09 (KR);
C12Q1/6804 (KR); C12Q2600/118 (KR); C12Q2600/158 (EP,US);
C12Q2600/16 (EP,KR,US) (-)
Former IPC [2008/18]C12Q1/68
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/31]
Former [2008/18]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:ZUSAMMENSETZUNG UND VERFAHREN ZUR BESTIMMUNG DER CK19-EXPRESSION[2008/18]
English:COMPOSITION AND METHOD FOR DETERMINATION OF CK19 EXPRESSION[2008/18]
French:COMPOSITION ET METHODE POUR LA DETERMINATION DE L'EXPRESSION DE CK-19[2008/18]
Entry into regional phase12.02.2008National basic fee paid 
12.02.2008Designation fee(s) paid 
12.02.2008Examination fee paid 
Examination procedure08.06.2007Request for preliminary examination filed
International Preliminary Examining Authority: EP
12.02.2008Amendment by applicant (claims and/or description)
12.02.2008Examination requested  [2008/18]
01.04.2010Despatch of a communication from the examining division (Time limit: M06)
15.12.2010Reply to a communication from the examining division
01.03.2012Application deemed to be withdrawn, date of legal effect  [2012/36]
10.04.2017Despatch of a communication from the examining division (Time limit: M06)
deletedDeletion: Application deemed to be withdrawn, date of legal effect  [2017/18]
11.04.2012Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2017/18]
25.09.2017Reply to a communication from the examining division
23.02.2018Communication of intention to grant the patent
22.06.2018Fee for grant paid
22.06.2018Fee for publishing/printing paid
22.06.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.04.2010
Opposition(s)03.05.2019No opposition filed within time limit [2019/28]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
15.12.2010Request for further processing filed
15.12.2010Full payment received (date of receipt of payment)
Request granted
29.12.2010Decision despatched
Request for re-establishment of rights:28.02.2013Date of receipt
Fees paidRenewal fee
14.08.2008Renewal fee patent year 03
27.08.2009Renewal fee patent year 04
13.08.2010Renewal fee patent year 05
28.02.2013Renewal fee patent year 06
28.02.2013Renewal fee patent year 07
20.02.2014Renewal fee patent year 08
25.08.2014Renewal fee patent year 09
24.07.2017Renewal fee patent year 10
24.07.2017Renewal fee patent year 11
22.08.2017Renewal fee patent year 12
Penalty fee
Additional fee for renewal fee
31.08.201106   M06   Fee paid on   28.02.2013
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.08.2006
CY01.08.2018
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
PT01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
IE16.08.2018
LU16.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
FR01.10.2018
BG01.11.2018
IS01.12.2018
[2020/32]
Former [2020/30]HU16.08.2006
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
PT01.08.2018
RO01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
IE16.08.2018
LU16.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
FR01.10.2018
BG01.11.2018
IS01.12.2018
Former [2020/27]HU16.08.2006
CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
PT01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
IE16.08.2018
LU16.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
FR01.10.2018
BG01.11.2018
IS01.12.2018
Former [2020/16]CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
TR01.08.2018
IE16.08.2018
LU16.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
FR01.10.2018
BG01.11.2018
IS01.12.2018
Former [2019/38]CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
IE16.08.2018
LU16.08.2018
BE31.08.2018
CH31.08.2018
LI31.08.2018
FR01.10.2018
BG01.11.2018
IS01.12.2018
Former [2019/37]CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
SI01.08.2018
SK01.08.2018
IE16.08.2018
LU16.08.2018
CH31.08.2018
LI31.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/33]CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
SK01.08.2018
IE16.08.2018
LU16.08.2018
CH31.08.2018
LI31.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/26]CZ01.08.2018
DK01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
SK01.08.2018
LU16.08.2018
CH31.08.2018
LI31.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/24]CZ01.08.2018
EE01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
MC01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
SK01.08.2018
LU16.08.2018
CH31.08.2018
LI31.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/22]CZ01.08.2018
ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
LU16.08.2018
CH31.08.2018
LI31.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/21]ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
LU16.08.2018
CH31.08.2018
LI31.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/12]ES01.08.2018
FI01.08.2018
LT01.08.2018
LV01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/10]FI01.08.2018
LT01.08.2018
NL01.08.2018
PL01.08.2018
SE01.08.2018
BG01.11.2018
IS01.12.2018
Former [2019/09]FI01.08.2018
LT01.08.2018
NL01.08.2018
IS01.12.2018
Former [2019/08]FI01.08.2018
LT01.08.2018
IS01.12.2018
Former [2019/07]LT01.08.2018
Cited inInternational search[X]WO9617080  (IMP CANCER RES TECH [GB], et al) [X] 1-39 * SEQ.ID.NO. 15;; example 1; table 1 *;
 WO03097878  [ ] (SYSMEX CORP [JP], et al);
 CA2464874  [ ] (VERIDEX LLC [US]) [ ] * SEQ ID NO 9 *;
 US2004219534  [ ] (BELLY ROBERT [US], et al) [ ] * SEQ ID NO 9;; example 3 *;
 EP1510587  [ ] (SYSMEX CORP [JP]) [ ] * SEQ ID 379;; claim 19 *;
 EP1510587  [ ] (SYSMEX CORP [JP]) [ ] * SEQ ID 363;; claim 19 *;
 EP1510587  [ ] (SYSMEX CORP [JP]) [ ] * SEQ ID NO 364;; claim 19 *;
 [X]WO2005068612  (NOVAHEP AB [SE], et al) [X] 1-39 * SEQ.ID.NO:1;; example 1 *;
    [ ] - "Cytokeratin 19 mRNA specific sense PCR primer", GENBANK, (19970127), Database accession no. AAT31783 [ ] * the whole document *
    [ ] - "Sense primer for PCR of human CK-1, SEQ ID NO:1", GE, (20051006), Database accession no. AEB31032 [ ] * the whole document *
 [X]  - "Human cytokeratin 19-related R3 PCR primer - SEQ ID 379", GENBANK, (20040226), Database accession no. ADF92291, XP002408339 [X] 1-39 * the whole document *
 [DY]  - STATHOPOULOU ALIKI ET AL, "Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 1 NOV 2003, (20031101), vol. 9, no. 14, ISSN 1078-0432, pages 5145 - 5151, XP002407125 [DY] 1-39 * the whole document *
 [DY]  - STATHOPOULOU A ET AL, "Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY. 15 AUG 2002, (20020815), vol. 20, no. 16, ISSN 0732-183X, pages 3404 - 3412, XP002407126 [DY] 1-39 * the whole document *

DOI:   http://dx.doi.org/10.1200/JCO.2002.08.135
 [Y]  - XENIDIS N ET AL, "Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer.", ANNALS OF ONCOLOGY : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY / ESMO. JUN 2003, (200306), vol. 14, no. 6, ISSN 0923-7534, pages 849 - 855, XP002407127 [Y] 1-39 * the whole document *

DOI:   http://dx.doi.org/10.1093/annonc/mdg259
 [Y]  - AERTS J ET AL, "A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood.", ANNALS OF ONCOLOGY : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY / ESMO. JAN 2001, (200101), vol. 12, no. 1, ISSN 0923-7534, pages 39 - 46, XP009074839 [Y] 1-39 * the whole document *

DOI:   http://dx.doi.org/10.1023/A:1008317512253
 [PX]  - STATHOPOULOU ALIKI ET AL, "A highly specific real-time RT-PCR method for the quantitative determination of CK-19 mRNA positive cells in peripheral blood of patients with operable breast cancer.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. 1 OCT 2006, (20060517), vol. 119, no. 7, ISSN 0020-7136, pages 1654 - 1659, XP002407128 [PX] 1-39 * abstract * * page 1657 - page 1658 *

DOI:   http://dx.doi.org/10.1002/ijc.22017
 [A]  - "Human cytokeratin 19-derived R1c DNA - SEQ ID 363", GENBANK, (20040226), Database accession no. ADF92275, XP002408340 [A] 1-39 * column A *
 [A]  - "Human cytokeratin 19-derived R1c DNA - SEQ ID 364", GENBANK, (20040226), Database accession no. ADF92276, XP002408341 [A] 1-39 * the whole document *
 [A]  - "Human prophobilinogen deaminase (PBGD) gene, PCR primer #4", GENBANK, (20050127), Database accession no. ADT93953, XP002408342 [A] 1-39 * the whole document *
 [A]  - "Intraoperative molecular diagnostic assay oligonucleotide #9", GENBANK, (20050210), Database accession no. ADV66394, XP002408343 [A] 1-39 * the whole document *
 [A]  - WERTHER K ET AL, "The use of the CELLection Kit@? in the isolation of carcinoma cells from mononuclear cell suspensions", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, (200004), vol. 238, no. 1-2, ISSN 0022-1759, pages 133 - 141, XP004195469 [A] 1-39 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0022-1759(00)00150-2
 [A]  - GUO JUNMING ET AL, "Combined use of positive and negative immunomagnetic isolation followed by real-time RT-PCR for detection of the circulating tumor cells in patients with colorectal cancers", JOURNAL OF MOLECULAR MEDICINE (BERLIN), (200411), vol. 82, no. 11, ISSN 0946-2716, pages 768 - 774, XP002407129 [A] 1-39 * the whole document *

DOI:   http://dx.doi.org/10.1007/s00109-004-0590-8
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.