EP1915461 - COMPOSITION AND METHOD FOR DETERMINATION OF CK19 EXPRESSION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 07.06.2019 Database last updated on 24.08.2024 | |
Former | The patent has been granted Status updated on 29.06.2018 | ||
Former | Grant of patent is intended Status updated on 22.02.2018 | ||
Former | Examination is in progress Status updated on 31.03.2017 | Most recent event Tooltip | 03.07.2020 | Lapse of the patent in a contracting state New state(s): CY | published on 05.08.2020 [2020/32] | Applicant(s) | For all designated states Dx4U GmbH Viktor Kaplan-Strasse 2 2700 Wiener Neustadt / AT | [2017/19] |
Former [2011/24] | For all designated states Lianidou, Evriklia Piperopoulou 19 145 75 Athens / GR | ||
For all designated states Stathopoulou, Aliki Hatziconstanti 31 115 24 Athens / GR | |||
For all designated states Mavroudis, Dimitrios Dimokratias 27 71 306 Herakleion / GR | |||
For all designated states Georgoulias, Vasileios Magnisias 12 71 305 Herakleion / GR | |||
Former [2008/18] | For all designated states Medexis S.A. 4, Asklipiou Str. Kryoneri 145 68 Athens / GR | Inventor(s) | 01 /
Mavroudis, Dimitros Dimokratias 27 71306 Heraklion, Crete / GR | 02 /
Georgoulias, Vasileios Gregoriou Theologou 5 11471 Athens / GR | 03 /
Lianidou, Evriklia Piperopoulou 19 14575 Athens / GR | 04 /
Stathopoulou, Aliki Aristotelous 27 15562 Holargos, Athens / GR | [2018/31] |
Former [2011/24] | 01 /
see applicant ... | ||
Former [2008/18] | 01 /
LIANIDOU, Evriklia Piperopoulou 19 GR-145 75 Athens / GR | ||
02 /
STATHOPOULOU, Aliki Hatziconstanti 31 GR-115 24 Athens / GR | |||
03 /
MAVROUDIS, Dimitrios Dimokratias 27 GR-71 306 Herakleion / GR | |||
04 /
GEORGOULIAS, Vasileios Magnisias 12 GR-71 305 Herakleion / GR | Representative(s) | Redl, Gerda, et al REDL Life Science Patent Attorneys Donau-City-Straße 11 1220 Wien / AT | [2018/31] |
Former [2013/15] | Redl, Gerda, et al REDL Life Science Patent Attorneys Tech Gate Vienna Donau-City-Straße 1 1220 Vienna / AT | ||
Former [2008/18] | Hiebl, Inge Elisabeth, et al Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15 80539 München / DE | Application number, filing date | 06776902.6 | 16.08.2006 | [2008/18] | WO2006EP08097 | Priority number, date | GR20050100430 | 17.08.2005 Original published format: GR 20050100430 | US20060795149P | 25.04.2006 Original published format: US 795149 P | [2008/18] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2007020081 | Date: | 22.02.2007 | Language: | EN | [2007/08] | Type: | A1 Application with search report | No.: | EP1915461 | Date: | 30.04.2008 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.02.2007 takes the place of the publication of the European patent application. | [2008/18] | Type: | B1 Patent specification | No.: | EP1915461 | Date: | 01.08.2018 | Language: | EN | [2018/31] | Search report(s) | International search report - published on: | EP | 22.02.2007 | Classification | IPC: | C12Q1/6886 | [2018/10] | CPC: |
C12Q1/6886 (EP,KR,US);
C12Q1/6876 (KR,US);
C12N15/09 (KR);
C12Q1/6804 (KR);
C12Q2600/118 (KR);
C12Q2600/158 (EP,US);
C12Q2600/16 (EP,KR,US)
(-)
|
Former IPC [2008/18] | C12Q1/68 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2018/31] |
Former [2008/18] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR | Extension states | AL | Not yet paid | BA | Not yet paid | HR | Not yet paid | MK | Not yet paid | RS | Not yet paid | Title | German: | ZUSAMMENSETZUNG UND VERFAHREN ZUR BESTIMMUNG DER CK19-EXPRESSION | [2008/18] | English: | COMPOSITION AND METHOD FOR DETERMINATION OF CK19 EXPRESSION | [2008/18] | French: | COMPOSITION ET METHODE POUR LA DETERMINATION DE L'EXPRESSION DE CK-19 | [2008/18] | Entry into regional phase | 12.02.2008 | National basic fee paid | 12.02.2008 | Designation fee(s) paid | 12.02.2008 | Examination fee paid | Examination procedure | 08.06.2007 | Request for preliminary examination filed International Preliminary Examining Authority: EP | 12.02.2008 | Amendment by applicant (claims and/or description) | 12.02.2008 | Examination requested [2008/18] | 01.04.2010 | Despatch of a communication from the examining division (Time limit: M06) | 15.12.2010 | Reply to a communication from the examining division | 01.03.2012 | Application deemed to be withdrawn, date of legal effect [2012/36] | 10.04.2017 | Despatch of a communication from the examining division (Time limit: M06) | deleted | Deletion: Application deemed to be withdrawn, date of legal effect [2017/18] | 11.04.2012 | Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2017/18] | 25.09.2017 | Reply to a communication from the examining division | 23.02.2018 | Communication of intention to grant the patent | 22.06.2018 | Fee for grant paid | 22.06.2018 | Fee for publishing/printing paid | 22.06.2018 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.04.2010 | Opposition(s) | 03.05.2019 | No opposition filed within time limit [2019/28] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 15.12.2010 | Request for further processing filed | 15.12.2010 | Full payment received (date of receipt of payment) Request granted | 29.12.2010 | Decision despatched | Request for re-establishment of rights: | 28.02.2013 | Date of receipt | Fees paid | Renewal fee | 14.08.2008 | Renewal fee patent year 03 | 27.08.2009 | Renewal fee patent year 04 | 13.08.2010 | Renewal fee patent year 05 | 28.02.2013 | Renewal fee patent year 06 | 28.02.2013 | Renewal fee patent year 07 | 20.02.2014 | Renewal fee patent year 08 | 25.08.2014 | Renewal fee patent year 09 | 24.07.2017 | Renewal fee patent year 10 | 24.07.2017 | Renewal fee patent year 11 | 22.08.2017 | Renewal fee patent year 12 | Penalty fee | Additional fee for renewal fee | 31.08.2011 | 06   M06   Fee paid on   28.02.2013 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 16.08.2006 | CY | 01.08.2018 | CZ | 01.08.2018 | DK | 01.08.2018 | EE | 01.08.2018 | ES | 01.08.2018 | FI | 01.08.2018 | LT | 01.08.2018 | LV | 01.08.2018 | MC | 01.08.2018 | NL | 01.08.2018 | PL | 01.08.2018 | PT | 01.08.2018 | RO | 01.08.2018 | SE | 01.08.2018 | SI | 01.08.2018 | SK | 01.08.2018 | TR | 01.08.2018 | IE | 16.08.2018 | LU | 16.08.2018 | BE | 31.08.2018 | CH | 31.08.2018 | LI | 31.08.2018 | FR | 01.10.2018 | BG | 01.11.2018 | IS | 01.12.2018 | [2020/32] |
Former [2020/30] | HU | 16.08.2006 | |
CZ | 01.08.2018 | ||
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
PT | 01.08.2018 | ||
RO | 01.08.2018 | ||
SE | 01.08.2018 | ||
SI | 01.08.2018 | ||
SK | 01.08.2018 | ||
TR | 01.08.2018 | ||
IE | 16.08.2018 | ||
LU | 16.08.2018 | ||
BE | 31.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
FR | 01.10.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2020/27] | HU | 16.08.2006 | |
CZ | 01.08.2018 | ||
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
PT | 01.08.2018 | ||
SE | 01.08.2018 | ||
SI | 01.08.2018 | ||
SK | 01.08.2018 | ||
TR | 01.08.2018 | ||
IE | 16.08.2018 | ||
LU | 16.08.2018 | ||
BE | 31.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
FR | 01.10.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2020/16] | CZ | 01.08.2018 | |
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
SI | 01.08.2018 | ||
SK | 01.08.2018 | ||
TR | 01.08.2018 | ||
IE | 16.08.2018 | ||
LU | 16.08.2018 | ||
BE | 31.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
FR | 01.10.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/38] | CZ | 01.08.2018 | |
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
SI | 01.08.2018 | ||
SK | 01.08.2018 | ||
IE | 16.08.2018 | ||
LU | 16.08.2018 | ||
BE | 31.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
FR | 01.10.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/37] | CZ | 01.08.2018 | |
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
SI | 01.08.2018 | ||
SK | 01.08.2018 | ||
IE | 16.08.2018 | ||
LU | 16.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/33] | CZ | 01.08.2018 | |
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
SK | 01.08.2018 | ||
IE | 16.08.2018 | ||
LU | 16.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/26] | CZ | 01.08.2018 | |
DK | 01.08.2018 | ||
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
SK | 01.08.2018 | ||
LU | 16.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/24] | CZ | 01.08.2018 | |
EE | 01.08.2018 | ||
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
MC | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
SK | 01.08.2018 | ||
LU | 16.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/22] | CZ | 01.08.2018 | |
ES | 01.08.2018 | ||
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
LU | 16.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/21] | ES | 01.08.2018 | |
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
LU | 16.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/12] | ES | 01.08.2018 | |
FI | 01.08.2018 | ||
LT | 01.08.2018 | ||
LV | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/10] | FI | 01.08.2018 | |
LT | 01.08.2018 | ||
NL | 01.08.2018 | ||
PL | 01.08.2018 | ||
SE | 01.08.2018 | ||
BG | 01.11.2018 | ||
IS | 01.12.2018 | ||
Former [2019/09] | FI | 01.08.2018 | |
LT | 01.08.2018 | ||
NL | 01.08.2018 | ||
IS | 01.12.2018 | ||
Former [2019/08] | FI | 01.08.2018 | |
LT | 01.08.2018 | ||
IS | 01.12.2018 | ||
Former [2019/07] | LT | 01.08.2018 | Cited in | International search | [X]WO9617080 (IMP CANCER RES TECH [GB], et al) [X] 1-39 * SEQ.ID.NO. 15;; example 1; table 1 *; | WO03097878 [ ] (SYSMEX CORP [JP], et al); | CA2464874 [ ] (VERIDEX LLC [US]) [ ] * SEQ ID NO 9 *; | US2004219534 [ ] (BELLY ROBERT [US], et al) [ ] * SEQ ID NO 9;; example 3 *; | EP1510587 [ ] (SYSMEX CORP [JP]) [ ] * SEQ ID 379;; claim 19 *; | EP1510587 [ ] (SYSMEX CORP [JP]) [ ] * SEQ ID 363;; claim 19 *; | EP1510587 [ ] (SYSMEX CORP [JP]) [ ] * SEQ ID NO 364;; claim 19 *; | [X]WO2005068612 (NOVAHEP AB [SE], et al) [X] 1-39 * SEQ.ID.NO:1;; example 1 *; | [ ] - "Cytokeratin 19 mRNA specific sense PCR primer", GENBANK, (19970127), Database accession no. AAT31783 [ ] * the whole document * | [ ] - "Sense primer for PCR of human CK-1, SEQ ID NO:1", GE, (20051006), Database accession no. AEB31032 [ ] * the whole document * | [X] - "Human cytokeratin 19-related R3 PCR primer - SEQ ID 379", GENBANK, (20040226), Database accession no. ADF92291, XP002408339 [X] 1-39 * the whole document * | [DY] - STATHOPOULOU ALIKI ET AL, "Real-time quantification of CK-19 mRNA-positive cells in peripheral blood of breast cancer patients using the lightcycler system.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. 1 NOV 2003, (20031101), vol. 9, no. 14, ISSN 1078-0432, pages 5145 - 5151, XP002407125 [DY] 1-39 * the whole document * | [DY] - STATHOPOULOU A ET AL, "Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance.", JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY. 15 AUG 2002, (20020815), vol. 20, no. 16, ISSN 0732-183X, pages 3404 - 3412, XP002407126 [DY] 1-39 * the whole document * DOI: http://dx.doi.org/10.1200/JCO.2002.08.135 | [Y] - XENIDIS N ET AL, "Peripheral blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer.", ANNALS OF ONCOLOGY : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY / ESMO. JUN 2003, (200306), vol. 14, no. 6, ISSN 0923-7534, pages 849 - 855, XP002407127 [Y] 1-39 * the whole document * DOI: http://dx.doi.org/10.1093/annonc/mdg259 | [Y] - AERTS J ET AL, "A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood.", ANNALS OF ONCOLOGY : OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY / ESMO. JAN 2001, (200101), vol. 12, no. 1, ISSN 0923-7534, pages 39 - 46, XP009074839 [Y] 1-39 * the whole document * DOI: http://dx.doi.org/10.1023/A:1008317512253 | [PX] - STATHOPOULOU ALIKI ET AL, "A highly specific real-time RT-PCR method for the quantitative determination of CK-19 mRNA positive cells in peripheral blood of patients with operable breast cancer.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. 1 OCT 2006, (20060517), vol. 119, no. 7, ISSN 0020-7136, pages 1654 - 1659, XP002407128 [PX] 1-39 * abstract * * page 1657 - page 1658 * DOI: http://dx.doi.org/10.1002/ijc.22017 | [A] - "Human cytokeratin 19-derived R1c DNA - SEQ ID 363", GENBANK, (20040226), Database accession no. ADF92275, XP002408340 [A] 1-39 * column A * | [A] - "Human cytokeratin 19-derived R1c DNA - SEQ ID 364", GENBANK, (20040226), Database accession no. ADF92276, XP002408341 [A] 1-39 * the whole document * | [A] - "Human prophobilinogen deaminase (PBGD) gene, PCR primer #4", GENBANK, (20050127), Database accession no. ADT93953, XP002408342 [A] 1-39 * the whole document * | [A] - "Intraoperative molecular diagnostic assay oligonucleotide #9", GENBANK, (20050210), Database accession no. ADV66394, XP002408343 [A] 1-39 * the whole document * | [A] - WERTHER K ET AL, "The use of the CELLection Kit@? in the isolation of carcinoma cells from mononuclear cell suspensions", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, (200004), vol. 238, no. 1-2, ISSN 0022-1759, pages 133 - 141, XP004195469 [A] 1-39 * the whole document * DOI: http://dx.doi.org/10.1016/S0022-1759(00)00150-2 | [A] - GUO JUNMING ET AL, "Combined use of positive and negative immunomagnetic isolation followed by real-time RT-PCR for detection of the circulating tumor cells in patients with colorectal cancers", JOURNAL OF MOLECULAR MEDICINE (BERLIN), (200411), vol. 82, no. 11, ISSN 0946-2716, pages 768 - 774, XP002407129 [A] 1-39 * the whole document * DOI: http://dx.doi.org/10.1007/s00109-004-0590-8 |