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Extract from the Register of European Patents

EP About this file: EP2046727

EP2046727 - POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF DICLOFENAC WITH VERY FAST SKIN PENETRATION RATE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.01.2015
Database last updated on 20.07.2024
Most recent event   Tooltip08.07.2016Lapse of the patent in a contracting state
New state(s): HU		published on 10.08.2016  [2016/32]
Applicant(s)For all designated states
Techfields Biochem Co. Ltd
Techfields Biochem 2399 Jinqiu Road 129
Shanghai N/A 200444 / CN
For all designated states
Yu, Chongxi
Techfields Biochem 12952 Stockton Avenue
Plainfield, Illinois 60585 / US
[2014/11]
Former [2009/16]For all designated states
Techfields Biochem Co. Ltd
Techfields Biochem 2399 Jinqiu Road 129
Shanghai N/A 200444 / CN
For all designated states
Yu, Chongxi
Techfields Biochem 12952 Stockton Avenue
Plainfield, Illinois 60585 / US
Inventor(s)01 / YU, Chongxi
Techfields Biochem
12952 Stockton Ave.
Plainfield IL 60585 / US
02 / XU, Lina
Techfields Biochem Co. Ltd.
2399 JinQiu Road No. 129
N/A 200444 Shanghai / CN
 [2014/11]
Former [2009/16]01 / YU, Chongxi
Techfields Biochem 12952 Stockton Ave.
Plainfield IL 60585 / US
02 / XU, Lina
Techfields Biochem Co. Ltd. 2399 JinQiu Road No. 129
N/A 200444 Shanghai / CN
Representative(s)Viering, Jentschura & Partner mbB Patent- und Rechtsanwälte
Hamborner Straße 53
40472 Düsseldorf / DE
[N/P]
Former [2014/11]Viering, Jentschura & Partner Patent- und Rechtsanwälte
Kennedydamm 55 / Roßstrasse
40476 Düsseldorf / DE
Former [2011/21]Viering, Jentschura & Partner
Kennedydamm 55/Roßstr.
40476 Düsseldorf / DE
Former [2009/30]Viering, Jentschura & Partner
Postfach 22 14 43
80504 München / DE
Former [2009/16]Viering, Jentschura & Partner
Grillparzerstrasse 14
81675 München / DE
Application number, filing date06780202.525.07.2006
[2009/16]
WO2006IB52549
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008012602
Date:31.01.2008
Language:EN
[2008/05]
Type: A1 Application with search report 
No.:EP2046727
Date:15.04.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 31.01.2008 takes the place of the publication of the European patent application.
[2009/16]
Type: B1 Patent specification 
No.:EP2046727
Date:12.03.2014
Language:EN
[2014/11]
Search report(s)International search report - published on:KR31.01.2008
(Supplementary) European search report - dispatched on:EP30.07.2010
ClassificationIPC:C07C215/40, C07C215/42, A61K31/216, A61P29/00, A61P43/00
[2010/34]
CPC:
C07C229/42 (EP); A61P1/04 (EP); A61P11/06 (EP);
A61P15/08 (EP); A61P17/02 (EP); A61P17/10 (EP);
A61P19/02 (EP); A61P25/06 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P43/00 (EP);
C07C237/20 (EP) (-)
Former IPC [2009/16]C07C215/40, C07C215/42
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/16]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:POSITIV GELADENE, WASSERLÖSLICHE PRODRUGS VON DICLOFENAC MIT SEHR SCHNELLER HAUTPENETRATIONSGESCHWINDIGKEIT[2009/16]
English:POSITIVELY CHARGED WATER-SOLUBLE PRODRUGS OF DICLOFENAC WITH VERY FAST SKIN PENETRATION RATE[2009/16]
French:PROMÉDICAMENTS HYDROSOLUBLES À CHARGE POSITIVE DU DICLOFÉNAC PRÉSENTANT UNE VITESSE DE PÉNÉTRATION CUTANÉE TRÈS RAPIDE[2009/16]
Entry into regional phase09.02.2009National basic fee paid 
09.02.2009Search fee paid 
09.02.2009Designation fee(s) paid 
09.02.2009Examination fee paid 
Examination procedure09.02.2009Examination requested  [2009/16]
22.02.2011Amendment by applicant (claims and/or description)
31.10.2012Despatch of a communication from the examining division (Time limit: M04)
05.03.2013Reply to a communication from the examining division
27.09.2013Communication of intention to grant the patent
08.01.2014Fee for grant paid
08.01.2014Fee for publishing/printing paid
Divisional application(s)EP14158789.9  / EP2756843
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  31.10.2012
Opposition(s)15.12.2014No opposition filed within time limit [2015/08]
Fees paidRenewal fee
09.02.2009Renewal fee patent year 03
09.02.2009Renewal fee patent year 04
14.07.2010Renewal fee patent year 05
12.07.2011Renewal fee patent year 06
13.07.2012Renewal fee patent year 07
10.07.2013Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.07.2006
AT12.03.2014
CY12.03.2014
CZ12.03.2014
DK12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
MC12.03.2014
RO12.03.2014
SI12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
IE25.07.2014
LU25.07.2014
[2016/32]
Former [2016/21]AT12.03.2014
CY12.03.2014
CZ12.03.2014
DK12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
MC12.03.2014
RO12.03.2014
SI12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
IE25.07.2014
LU25.07.2014
Former [2015/37]AT12.03.2014
CY12.03.2014
CZ12.03.2014
DK12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SI12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
IE25.07.2014
LU25.07.2014
Former [2015/36]AT12.03.2014
CY12.03.2014
CZ12.03.2014
DK12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SI12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
LU25.07.2014
Former [2015/13]AT12.03.2014
CY12.03.2014
CZ12.03.2014
DK12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
LU25.07.2014
Former [2015/08]AT12.03.2014
CY12.03.2014
CZ12.03.2014
DK12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
Former [2015/02]AT12.03.2014
CY12.03.2014
CZ12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
PT14.07.2014
Former [2014/51]AT12.03.2014
CY12.03.2014
CZ12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
Former [2014/50]CY12.03.2014
CZ12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
SK12.03.2014
BG12.06.2014
IS12.07.2014
Former [2014/49]CY12.03.2014
CZ12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
RO12.03.2014
BG12.06.2014
IS12.07.2014
Former [2014/48]CY12.03.2014
CZ12.03.2014
EE12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
BG12.06.2014
Former [2014/41]CY12.03.2014
FI12.03.2014
LT12.03.2014
LV12.03.2014
Former [2014/37]CY12.03.2014
FI12.03.2014
LT12.03.2014
Former [2014/36]LT12.03.2014
Documents cited:Search[Y]WO02085297  (EPIGENESIS PHARMACEUTICALS INC [US], et al) [Y] 7 * claims 43-47,63 * * page 31, paragraphs 3-4 *
 [XY]  - NEDIOGLU D ET AL, "Synthesis and in vitro anti-inflammatory activities of some new diaryl amine derivatives as prodrug of diclofenac", JOURNAL OF FACULTY OF PHARMACY OF GAZI UNIVERSITY, GAZI UNIVERSITY, ANKARA, TR, (19930101), vol. 10, no. 1, ISSN 1015-9592, pages 69 - 81, XP008110133 [X] 1-3 * page 79; compounds 2a-2h * [Y] 6-8
 [Y]  - J.-L. MAGNETTE ET AL, "Diclofenac systemic exposure is not increased when topical diclofenac is applied to ultraviolet-induced erythema", EUR. J. CLIN. PHARMACOL., (2004), vol. 60, pages 591 - 594, XP002590780 [Y] 6 * the whole document *

DOI:   http://dx.doi.org/10.1007/S00228-004-0832-2
 [Y]  - L. APT ET AL, "A randomized clinical trial of the nonsteroidal eyedrop diclofenac after strabismus surgery", OPHTHALMOLOGY, (199808), vol. 105, no. 8, pages 1448 - 1454, XP002590781 [Y] 8 * the whole document *
International search[X]US4640911  (BASCHANG GERHARD [CH], et al);
 [X]EP0289262  (SYNTEX PHARMA INT [BM]);
 [X]  - TUNCA GUL ALTUNTAS ET AL., "A stud on the interation between p60c-src receptor tyrosine kinase and arylcarboxylic and arylacetic acid derivatives based on docking modes and in vitro activity", BIOL. PHARM. BULL., (2004), vol. 27, no. 1, pages 61 - 65, XP008102356

DOI:   http://dx.doi.org/10.1248/bpb.27.61
 [Y]  - CEVC G. AND BLUME G., "New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, transersomes", BIOCHIM. BIOPHYS. ACTA, (2001), vol. 1514, no. 2, pages 191 - 205, XP004319625

DOI:   http://dx.doi.org/10.1016/S0005-2736(01)00369-8
 [Y]  - PRIYABJA ARORA AND BISWAJIT MUKHERJEE, "Design, development, physicochemical, and in vitro and in vivo evaluation of transdermal patches containing diclofenac diethylammonium salt", JOURNAL OF PHARMACEUTICAL SCIENCES, (2002), vol. 91, no. 9, pages 2076 - 2089, XP008102312

DOI:   http://dx.doi.org/10.1002/jps.10200
by applicantUS4640911
 EP0289262
    - NEDIOGLU, D. ET AL., JOURNAL OF FACULTY OF PHARMACY OF GAZI UNIVERSITY, (1993), vol. 10, page 1
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.