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Extract from the Register of European Patents

EP About this file: EP1928461

EP1928461 - PYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.11.2012
Database last updated on 26.06.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
Janssen Pharmaceutica NV
Turnhoutseweg 30
2340 Beerse / BE
[2008/24]
Inventor(s)01 / DVORAK, Curt, A.
7657 Angeleno Road
San Diego, CA 92126 / US
02 / RUDOLPH, Dale, A.
12721 Alondra Court
San Diego, CA 92128 / US
03 / SHIREMAN, Brock, T.
3819 Creststone Place
San Diego, CA 92130 / US
 [2008/24]
Representative(s)Warner, James Alexander, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2009/51]Warner, James Alexander, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Former [2008/24]Warner, James Alexander, et al
Carpmaels & Ransford 43-45 Bloomsbury Square London
WC1A 2RA / GB
Application number, filing date06788808.127.07.2006
[2008/24]
WO2006US29437
Priority number, dateUS20050705719P04.08.2005         Original published format: US 705719 P
[2008/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2007019083
Date:15.02.2007
Language:EN
[2007/07]
Type: A1 Application with search report 
No.:EP1928461
Date:11.06.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 15.02.2007 takes the place of the publication of the European patent application.
[2008/24]
Type: B1 Patent specification 
No.:EP1928461
Date:04.01.2012
Language:EN
[2012/01]
Search report(s)International search report - published on:EP15.02.2007
ClassificationIPC:A61K31/505, C07D487/04, C07D239/74, C07D239/26, C07D471/18, C07D487/18, C07D471/04, A61K31/506, A61K31/517, A61K31/519
[2008/24]
CPC:
C07D471/04 (EP,KR,NO); C07D239/26 (EP,KR,NO); A61K31/505 (KR);
A61P1/00 (EP); A61P1/08 (EP); A61P1/10 (EP);
A61P1/12 (EP); A61P1/14 (EP); A61P13/02 (EP);
A61P13/12 (EP); A61P15/10 (EP); A61P15/12 (EP);
A61P25/00 (EP); A61P25/04 (EP); A61P25/06 (EP);
A61P25/14 (EP); A61P25/16 (EP); A61P25/18 (EP);
A61P25/20 (EP); A61P25/22 (EP); A61P25/24 (EP);
A61P25/28 (EP); A61P25/32 (EP); A61P25/36 (EP);
A61P27/02 (EP); A61P29/00 (EP); A61P3/00 (EP);
A61P3/04 (EP); A61P43/00 (EP); A61P5/00 (EP);
A61P7/00 (EP); A61P9/02 (EP); A61P9/08 (EP);
A61P9/10 (EP); A61P9/12 (EP); C07D239/74 (EP,NO);
C07D487/04 (EP,NO); C07D487/18 (KR) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/24]
Extension statesAL04.03.2008
BA04.03.2008
HR04.03.2008
MK04.03.2008
RS04.03.2008
TitleGerman:PYRIMIDIN-VERBINDUNGEN ALS SEROTONIN-REZEPTOR-MODULATOREN[2008/24]
English:PYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS[2008/24]
French:COMPOSES DE PYRIMIDINE UTILES COMME MODULATEURS DES RECEPTEURS DE LA SEROTONINE[2008/24]
Entry into regional phase04.03.2008National basic fee paid 
04.03.2008Designation fee(s) paid 
04.03.2008Examination fee paid 
Examination procedure04.03.2008Amendment by applicant (claims and/or description)
04.03.2008Examination requested  [2008/24]
27.07.2009Despatch of a communication from the examining division (Time limit: M04)
04.12.2009Reply to a communication from the examining division
22.06.2011Communication of intention to grant the patent
02.11.2011Fee for grant paid
02.11.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  27.07.2009
Opposition(s)05.10.2012No opposition filed within time limit [2012/50]
Fees paidRenewal fee
04.03.2008Renewal fee patent year 03
10.07.2009Renewal fee patent year 04
14.07.2010Renewal fee patent year 05
12.07.2011Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.07.2006
AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
TR04.01.2012
BG04.04.2012
GR05.04.2012
ES15.04.2012
IS04.05.2012
PT04.05.2012
IE27.07.2012
LU27.07.2012
CH31.07.2012
LI31.07.2012
MC31.07.2012
[2014/34]
Former [2014/27]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
TR04.01.2012
BG04.04.2012
GR05.04.2012
ES15.04.2012
IS04.05.2012
PT04.05.2012
IE27.07.2012
LU27.07.2012
CH31.07.2012
LI31.07.2012
MC31.07.2012
Former [2014/21]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
TR04.01.2012
BG04.04.2012
GR05.04.2012
ES15.04.2012
IS04.05.2012
PT04.05.2012
IE27.07.2012
CH31.07.2012
LI31.07.2012
MC31.07.2012
Former [2013/33]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
BG04.04.2012
GR05.04.2012
ES15.04.2012
IS04.05.2012
PT04.05.2012
IE27.07.2012
CH31.07.2012
LI31.07.2012
MC31.07.2012
Former [2013/22]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
BG04.04.2012
GR05.04.2012
ES15.04.2012
IS04.05.2012
PT04.05.2012
CH31.07.2012
LI31.07.2012
MC31.07.2012
Former [2013/20]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
CH31.07.2012
LI31.07.2012
MC31.07.2012
Former [2013/11]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
MC31.07.2012
Former [2013/07]AT04.01.2012
BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/50]BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
SK04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/49]BE04.01.2012
CY04.01.2012
CZ04.01.2012
DK04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
RO04.01.2012
SE04.01.2012
SI04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/48]BE04.01.2012
CY04.01.2012
EE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
SE04.01.2012
SI04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/41]BE04.01.2012
CY04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
SI04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/39]BE04.01.2012
FI04.01.2012
LT04.01.2012
LV04.01.2012
NL04.01.2012
PL04.01.2012
SI04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/37]BE04.01.2012
FI04.01.2012
LT04.01.2012
NL04.01.2012
PL04.01.2012
SI04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
PT04.05.2012
Former [2012/36]BE04.01.2012
LT04.01.2012
NL04.01.2012
SI04.01.2012
BG04.04.2012
GR05.04.2012
IS04.05.2012
Former [2012/35]BE04.01.2012
LT04.01.2012
NL04.01.2012
SI04.01.2012
BG04.04.2012
IS04.05.2012
Former [2012/34]BE04.01.2012
LT04.01.2012
SI04.01.2012
IS04.05.2012
Former [2012/33]BE04.01.2012
LT04.01.2012
SI04.01.2012
Former [2012/25]SI04.01.2012
Cited inInternational search[X]US3969355  (SCHWAN THOMAS J) [X] 1,33 * claim 1 *;
 [X]JPH03148265  (SUMITOMO CHEMICAL CO) [X] 1 * Table on page 832, compounds for which X=CH2 *;
 [DX]US5137890  (SANFILIPPO PAULINE J [US], et al) [DX] 1,33,34,36 * claim 1 *;
 [A]WO9529909  (PFIZER [US], et al) [A] 1,33,34 * claim 1 *;
 [A]WO9747601  (YOSHITOMI PHARMACEUTICAL [JP], et al) [A] 1,33,34 * claim 1, definition of X1-X2-X3 and Z-D-R *;
 [X]WO0059510  (PFIZER PROD INC [US], et al) [X] 1 * examples 86,step,D *;
 [X]EP1211246  (KUMIAI CHEMICAL INDUSTRY CO [JP], et al) [X] 1 * compounds 6-29 * * claim 6 *;
 [X]WO02072558  (BOEHRINGER INGELHEIM PHARMA [DE], et al) [X] 1 * example 8a *;
 [A]EP1264820  (FUJISAWA PHARMACEUTICAL CO [JP]) [A] 1,33,34 * page 1, paragraph 1 *;
 [X]  - HERRERA A ET AL, "On the mechanism of reaction between ketones and nitriles. Unexpected results from benzyl nitriles", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20020506), vol. 58, no. 19, ISSN 0040-4020, pages 3755 - 3764, XP004350399 [X] 1 * Scheme 10, compound 23 *

DOI:   http://dx.doi.org/10.1016/S0040-4020(02)00327-7
 [X]  - DUBE, HENRY ET AL, "Synthesis of chiral .alpha.-aminoalkylpyrimidines using an enantioselective three-component reaction", SYNTHESIS , (12), 2015-2025 CODEN: SYNTBF; ISSN: 0039-7881, (2004), XP002411606 [X] 1 * Scheme 4, compound 10 *

DOI:   http://dx.doi.org/10.1055/s-2004-829129
 [X]  - KAWAMURA, SHINICHI ET AL, "Fused heterocycles, furo[3,2-d]pyrimidines and dihydrocylopenta[d]pyrimidines, as potential new herbicides", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY , 56(11), 1897-9 CODEN: BBBIEJ; ISSN: 0916-8451, (1992), XP009076153 [X] 1 * compounds 15,18 *
 [X]  - HERRERA, ANTONIO ET AL, "1H and 13C NMR spectral assignments of 2,4-diaryl-substituted cycloalkyl[d]pyrimidines", MAGNETIC RESONANCE IN CHEMISTRY , 40(4), 293-299 CODEN: MRCHEG; ISSN: 0749-1581, (2002), XP001248275 [X] 1 * Scheme 1, compounds 2a-2c, 3b-c, 4a-c *

DOI:   http://dx.doi.org/10.1002/mrc.1002
 [X]  - VOITENKO, Z. V. ET AL, "Conversions of 2-(2-oxocyclohexylcarbonyl)benzoic acid derivatives to pyrazolo[5,1-a]isoindole and pyrimidine rings", PHOSPHORUS, SULFUR AND SILICON AND THE RELATED ELEMENTS , 180(1), 163-177 CODEN: PSSLEC; ISSN: 1042-6507, (2005), XP001248745 [X] 1 * Scheme 7, compounds XIIa-b *

DOI:   http://dx.doi.org/10.1080/104265090508127
 [X]  - APPELL, MICHAEL ET AL, "An Analysis of the Binding of Cocaine Analogues to the Monoamine Transporters Using Tensor Decomposition 3-D QSAR", BIOORGANIC & MEDICINAL CHEMISTRY , 10(5), 1197-1206 CODEN: BMECEP; ISSN: 0968-0896, (2002), XP002411608 [X] 1 * Compound 3e *

DOI:   http://dx.doi.org/10.1016/S0968-0896(01)00389-3
 [A]  - BONHAUS D W ET AL, "RS-127445: A SELECTIVE, HIGH AFFINITY, ORALLY BIOAVAILABLE 5-HT 2B RECEPTOR ANTAGONIST", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, (199907), vol. 127, no. 5, ISSN 0007-1188, pages 1075 - 1082, XP000980373 [A] 1,33,34 * the whole document *

DOI:   http://dx.doi.org/10.1038/sj.bjp.0702632
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.