EP1963276 - N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 26.04.2013 Database last updated on 19.10.2024 | Most recent event Tooltip | 18.07.2014 | Lapse of the patent in a contracting state New state(s): HU | published on 20.08.2014 [2014/34] | Applicant(s) | For all designated states Decode Genetics EHF Sturlugata 8 101 Reykjavik / IS | [2008/36] | Inventor(s) | 01 /
SANDANAYAKA, Vincent deCODE Chemistry, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | 02 /
SINGH, Jasbir deCODE Chemistry, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | 03 /
ZHAO, Lei c/o deCODE Chemistry, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | 04 /
GURNEY, Mark deCODE Genetics, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | [2012/25] |
Former [2008/36] | 01 /
SANDANAYAKA, Vincent deCODE Chemistry, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | ||
02 /
SINGH, Jasbir deCODE Chemistry, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | |||
03 /
ZHAO, Lei c/o deCODE Chemistry, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | |||
04 /
GURNEY, Mark deCODE Genetics, Inc. 2501 Davey Road Woodridge, Illinois 60517 / US | Representative(s) | Graf von Stosch, Andreas, et al Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22 80538 München / DE | [N/P] |
Former [2009/29] | Graf von Stosch, Andreas, et al Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22 80538 München / DE | ||
Former [2008/52] | Graf von Stosch, Andreas, et al Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22 80538 München / DE | ||
Former [2008/40] | Graf von Stosch, Andreas, et al Bosch Graf von Stosch Jehle Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22 80538 München / DE | ||
Former [2008/36] | Graf von Stosch, Andreas, et al Bosch, Graf v. Stosch, Jehle Patentanwaltsgesellschaft mbH Flüggenstrasse 13 80639 München / DE | Application number, filing date | 06789243.0 | 03.08.2006 | [2008/36] | WO2006US30185 | Priority number, date | US20050752658P | 21.12.2005 Original published format: US 752658 P | [2008/36] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2007073405 | Date: | 28.06.2007 | Language: | EN | [2007/26] | Type: | A1 Application with search report | No.: | EP1963276 | Date: | 03.09.2008 | Language: | EN | The application published by WIPO in one of the EPO official languages on 28.06.2007 takes the place of the publication of the European patent application. | [2008/36] | Type: | B1 Patent specification | No.: | EP1963276 | Date: | 20.06.2012 | Language: | EN | [2012/25] | Type: | B9 Corrected patent specification | No.: | EP1963276 | Date: | 26.09.2012 | [2012/39] | Search report(s) | International search report - published on: | EP | 28.06.2007 | Classification | IPC: | C07D231/56, C07D209/48, C07D209/44, C07D401/12, C07D403/12, C07D471/04, A61K31/416, A61K31/4035, A61P29/00 | [2011/48] | CPC: |
C07D209/44 (EP,US);
A61P29/00 (EP);
C07D209/48 (EP,US);
C07D231/56 (EP,US);
C07D401/12 (EP,US);
C07D403/12 (EP,US);
C07D471/04 (EP,US)
(-)
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Former IPC [2008/36] | C07D231/56, C07D209/48, C07D209/44, C07D471/04, A61K31/416, A61K31/4035, A61P29/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2008/36] | Extension states | AL | 16.07.2008 | BA | 16.07.2008 | HR | 16.07.2008 | MK | 16.07.2008 | RS | 16.07.2008 | Title | German: | N-GEBUNDENE ARYLHETEROARYLINHIBITOREN VON LTA4H ZUR BEHANDLUNG VON ENZÜNDUNGEN | [2008/36] | English: | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | [2008/36] | French: | INHIBITEURS ARYLE HETEROARYLE A LIAISON AZOTE DE LTA4H UTILISES DANS LE TRAITEMENT DE L'INFLAMMATION | [2008/36] | Entry into regional phase | 27.06.2008 | National basic fee paid | 27.06.2008 | Designation fee(s) paid | 27.06.2008 | Examination fee paid | Examination procedure | 27.06.2008 | Amendment by applicant (claims and/or description) | 27.06.2008 | Examination requested [2008/36] | 27.08.2009 | Despatch of a communication from the examining division (Time limit: M06) | 08.03.2010 | Reply to a communication from the examining division | 26.01.2011 | Despatch of a communication from the examining division (Time limit: M04) | 23.05.2011 | Reply to a communication from the examining division | 19.12.2011 | Communication of intention to grant the patent | 10.04.2012 | Fee for grant paid | 10.04.2012 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 27.08.2009 | Opposition(s) | 21.03.2013 | No opposition filed within time limit [2013/22] | Fees paid | Renewal fee | 27.06.2008 | Renewal fee patent year 03 | 13.07.2009 | Renewal fee patent year 04 | 12.07.2010 | Renewal fee patent year 05 | 22.07.2011 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 03.08.2006 | AT | 20.06.2012 | BE | 20.06.2012 | CY | 20.06.2012 | CZ | 20.06.2012 | DK | 20.06.2012 | EE | 20.06.2012 | FI | 20.06.2012 | IT | 20.06.2012 | LT | 20.06.2012 | LV | 20.06.2012 | NL | 20.06.2012 | PL | 20.06.2012 | RO | 20.06.2012 | SE | 20.06.2012 | SI | 20.06.2012 | SK | 20.06.2012 | TR | 20.06.2012 | IE | 03.08.2012 | LU | 03.08.2012 | CH | 31.08.2012 | FR | 31.08.2012 | LI | 31.08.2012 | MC | 31.08.2012 | BG | 20.09.2012 | GB | 20.09.2012 | GR | 21.09.2012 | ES | 01.10.2012 | IS | 20.10.2012 | PT | 22.10.2012 | DE | 01.03.2013 | [2014/34] |
Former [2014/27] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
TR | 20.06.2012 | ||
IE | 03.08.2012 | ||
LU | 03.08.2012 | ||
CH | 31.08.2012 | ||
FR | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
BG | 20.09.2012 | ||
GB | 20.09.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
DE | 01.03.2013 | ||
Former [2014/21] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
TR | 20.06.2012 | ||
IE | 03.08.2012 | ||
CH | 31.08.2012 | ||
FR | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
BG | 20.09.2012 | ||
GB | 20.09.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
DE | 01.03.2013 | ||
Former [2013/40] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
IE | 03.08.2012 | ||
CH | 31.08.2012 | ||
FR | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
BG | 20.09.2012 | ||
GB | 20.09.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
DE | 01.03.2013 | ||
Former [2013/35] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
IE | 03.08.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
BG | 20.09.2012 | ||
GB | 20.09.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
DE | 01.03.2013 | ||
Former [2013/34] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
IE | 03.08.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
BG | 20.09.2012 | ||
GB | 20.09.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/33] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
IE | 03.08.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/22] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
GR | 21.09.2012 | ||
ES | 01.10.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/21] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
DK | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/20] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
CH | 31.08.2012 | ||
LI | 31.08.2012 | ||
MC | 31.08.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/16] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
MC | 31.08.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/15] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
NL | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/13] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
PT | 22.10.2012 | ||
Former [2013/11] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
IT | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
PL | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
Former [2013/10] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
CY | 20.06.2012 | ||
CZ | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
RO | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
SK | 20.06.2012 | ||
GR | 21.09.2012 | ||
IS | 20.10.2012 | ||
Former [2013/09] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
EE | 20.06.2012 | ||
FI | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
GR | 21.09.2012 | ||
Former [2013/07] | AT | 20.06.2012 | |
BE | 20.06.2012 | ||
FI | 20.06.2012 | ||
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
GR | 21.09.2012 | ||
Former [2012/51] | FI | 20.06.2012 | |
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
SE | 20.06.2012 | ||
SI | 20.06.2012 | ||
GR | 21.09.2012 | ||
Former [2012/50] | FI | 20.06.2012 | |
LT | 20.06.2012 | ||
LV | 20.06.2012 | ||
SE | 20.06.2012 | ||
GR | 21.09.2012 | ||
Former [2012/48] | FI | 20.06.2012 | |
LT | 20.06.2012 | ||
SE | 20.06.2012 | ||
Former [2012/47] | LT | 20.06.2012 | Cited in | International search | [X]US4448784 (GLAMKOWSKI EDWARD J [US], et al) [X] 1,11 * claim 1 * * example 4 * * table 1 *; | [X]EP0418385 (SHIONOGI & CO [JP]) [X] 1,11 * claim 1 * * example 4 *; | [X]US2002077329 (AUDOLY LAURENT [US], et al) [X] 1,11 * examples 37(7),39(7),42(7),43(6),49(3),51(7),53(7),55(7) *; | [X]WO2004065370 (CRYSTALGENOMICS INC [KR], et al) [X] 1,11 * example 79 *; | [X]US2004157849 (LEE CHIH-HUNG [US], et al) [X] 1,11 * example 350b *; | [DY]US2005043378 (AXE FRANK U [US], et al) [DY] 1-17 * claim - *; | [DY]US2005043379 (AXE FRANK U [US], et al) [DY] 1-17 * claim - *; | [X]WO2005042496 (IMCLONE SYSTEMS INC [US], et al) [X] 1,11 * example 8 *; | [X] - FRAY M JONATHAN ET AL, "Novel Antagonists of Platelet-Activating Factor: 1. Synthesis and Structure-Activity Relationships of Benzodiazepine and Benzazepine Derivatives of 2-Methyl-1-phenylimidazo(4,5-c)pyridine", JOURNAL OF MEDICINAL CHEMISTRY, (1995), vol. 38, no. 18, ISSN 0022-2623, pages 3514 - 3523, XP002414336 [X] 1,11 * compound 27 * DOI: http://dx.doi.org/10.1021/jm00018a011 | [X] - MASSIMO G ET AL, "BIOLOGICAL STUDIES ON 1 2 BENZISOTHIAZOLE DERIVATIVES III. EVALUATION OF ANTIBACTERIAL ANTIFUNGAL AND DNA-DAMAGING ACTIVITIES OF 1 2 BENZISOTHIAZOLIN-3-ONES", FARMACO (ROME), (1990), vol. 45, no. 4, ISSN 0014-827X, pages 439 - 446, XP009077002 [X] 1,11 * compounds 55,57 * | [X] - BEILSTEIN, Beilstein Institit zur Foerderung der chemischen Wissenschaft, Frankfurt am Main, DE, Database accession no. 8581995(BRN), XP002414338 [X] 1,11 * column A * | [ ] - ARIEF M.M.H; AMINE M.S.; EISSA A. M. F., EGYPT. J. CHEM., (1999), vol. 42, no. 6, pages 563 - 572 | [X] - ARTICO M ET AL, "RESEARCH ON COMPOUNDS WITH ANTIBLASTIC ACTIVITY NOTE XXXVI - DERIVATIVES OF 3-P-AMINOPHENYL-2-OXAZOLIDINONE: SYNTHESIS AND ANTINEOPLASTIC ACTIVITIES", FARMACO, EDIZIONE SCIENTIFICA, SOCIETA CHIMICA ITALIANA, PAVIA, IT, (1969), vol. 2, no. 24, ISSN 0430-0920, pages 179 - 190, XP001070657 [X] 1,11 * page 183; compound X * | [Y] - PENNING T D, "INHIBITORS OF LEUKOTRIENE A4 (LTA4) HYDROLASE AS POTENTIAL ANTI-INFLAMMATORY AGENTS", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, SCHIPHOL, NL, (200102), vol. 7, no. 3, ISSN 1381-6128, pages 163 - 179, XP001205198 [Y] 1-17 * table 2 * DOI: http://dx.doi.org/10.2174/1381612013398248 | [Y] - PENNING THOMAS D ET AL, "Structure-Activity Relationship Studies on 1-[2-(4- Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, (2000), vol. 43, ISSN 0022-2623, pages 721 - 725, XP002197495 [Y] 1-17 * table 2 * DOI: http://dx.doi.org/10.1021/jm990496z |