blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP1937286

EP1937286 - COMPOSITIONS COMPRISING DIMETHYL SULFOXIDE (DMSO) [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.01.2017
Database last updated on 14.09.2024
Most recent event   Tooltip13.07.2018Lapse of the patent in a contracting state
New state(s): TR		published on 15.08.2018  [2018/33]
Applicant(s)For all designated states
Abela Pharmaceuticals, Inc.
25181 Midcrest Drive
Lake Forest, CA 92630 / US
[2016/10]
Former [2008/27]For all designated states
Abela Pharmaceuticals, Inc.
25181 Midcrest Drive
Lake Forest, CA 92630 / US
Inventor(s)01 / DE LA TORRE, Jack
3416 80th Ave., Ct. NW
Gig Harbor, Washington 98335 / US
 [2008/27]
Representative(s)Rees, Kerry
WP Thompson
138 Fetter Lane
London EC4A 1BT / GB
[N/P]
Former [2016/10]Rees, Kerry
WP Thompson
55 Drury Lane
London WC2B 5SQ / GB
Former [2008/27]Brand, Thomas Louis
W.P. Thompson & Co. 55 Drury Lane
London WC2B 5SQ / GB
Application number, filing date06803336.411.09.2006
[2008/27]
WO2006US35320
Priority number, dateUS20050716335P12.09.2005         Original published format: US 716335 P
[2008/27]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007033082
Date:22.03.2007
Language:EN
[2007/12]
Type: A2 Application without search report 
No.:EP1937286
Date:02.07.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 22.03.2007 takes the place of the publication of the European patent application.
[2008/27]
Type: B1 Patent specification 
No.:EP1937286
Date:09.03.2016
Language:EN
[2016/10]
Search report(s)International search report - published on:US11.10.2007
(Supplementary) European search report - dispatched on:EP21.10.2008
ClassificationIPC:A61K33/14, A61K31/198, A61K31/10, A61K31/17, A61P25/28
[2008/47]
CPC:
A61K31/17 (EP,US); A61K31/10 (EP,US); A61K31/198 (EP,US);
A61P25/28 (EP)
C-Set:
A61K31/10, A61K2300/00 (EP,US);
A61K31/17, A61K2300/00 (US,EP);
A61K31/198, A61K2300/00 (US,EP)
Former IPC [2008/27]A61K33/14
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/10]
Former [2008/27]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:ZUSAMMENSETZUNGEN AUS DIMETHYLSULFOXID (DMSO)[2008/27]
English:COMPOSITIONS COMPRISING DIMETHYL SULFOXIDE (DMSO)[2008/27]
French:COMPOSITIONS COMPRENANT DU DIMÉTHYLSULFOXYDE (DMSO)[2008/27]
Entry into regional phase08.04.2008National basic fee paid 
08.04.2008Search fee paid 
08.04.2008Designation fee(s) paid 
08.04.2008Examination fee paid 
Examination procedure08.04.2008Amendment by applicant (claims and/or description)
08.04.2008Examination requested  [2008/27]
17.02.2009Despatch of a communication from the examining division (Time limit: M06)
21.08.2009Reply to a communication from the examining division
15.10.2010Despatch of a communication from the examining division (Time limit: M06)
05.04.2011Reply to a communication from the examining division
28.03.2012Despatch of a communication from the examining division (Time limit: M04)
01.08.2012Reply to a communication from the examining division
08.02.2013Despatch of a communication from the examining division (Time limit: M06)
16.08.2013Reply to a communication from the examining division
16.03.2015Despatch of a communication from the examining division (Time limit: M04)
15.07.2015Reply to a communication from the examining division
19.08.2015Communication of intention to grant the patent
24.12.2015Fee for grant paid
24.12.2015Fee for publishing/printing paid
24.12.2015Receipt of the translation of the claim(s)
Divisional application(s)EP11154666.9  / EP2324838
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.02.2009
Opposition(s)12.12.2016No opposition filed within time limit [2017/07]
Fees paidRenewal fee
08.04.2008Renewal fee patent year 03
11.09.2009Renewal fee patent year 04
14.09.2010Renewal fee patent year 05
29.09.2011Renewal fee patent year 06
12.09.2012Renewal fee patent year 07
12.09.2013Renewal fee patent year 08
12.09.2014Renewal fee patent year 09
11.09.2015Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.09.2006
AT09.03.2016
BE09.03.2016
CY09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
TR09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
IE11.09.2016
LU11.09.2016
CH30.09.2016
FR30.09.2016
LI30.09.2016
[2018/29]
Former [2018/28]HU11.09.2006
AT09.03.2016
BE09.03.2016
CY09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
IE11.09.2016
LU11.09.2016
CH30.09.2016
FR30.09.2016
LI30.09.2016
Former [2017/41]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
IE11.09.2016
LU11.09.2016
CH30.09.2016
FR30.09.2016
LI30.09.2016
Former [2017/37]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
IE11.09.2016
CH30.09.2016
FR30.09.2016
LI30.09.2016
Former [2017/31]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/20]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/07]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/03]AT09.03.2016
BE09.03.2016
CZ09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2016/51]AT09.03.2016
CZ09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2016/50]AT09.03.2016
CZ09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
Former [2016/49]EE09.03.2016
ES09.03.2016
FI09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
IS09.07.2016
Former [2016/48]ES09.03.2016
FI09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
IS09.07.2016
Former [2016/40]ES09.03.2016
FI09.03.2016
LT09.03.2016
LV09.03.2016
NL09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
Former [2016/39]ES09.03.2016
FI09.03.2016
LT09.03.2016
LV09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
Former [2016/36]ES09.03.2016
FI09.03.2016
LT09.03.2016
PL09.03.2016
GR10.06.2016
Former [2016/35]ES09.03.2016
FI09.03.2016
GR10.06.2016
Documents cited:Search[Y]EP0827744  (JAPAN SCIENCE & TECH CORP [JP], et al) [Y] 1-15 * column 3, lines 30,56 * * column 2, lines 46-49 *;
 [Y]WO03015760  (HADASIT MED RES SERVICE [IL], et al) [Y] 1-15 * page 12, paragraphs 4,5; claim 1 *;
 [YD]  - CHERIAN LEELA ET AL, "L-arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in rats.", JOURNAL OF NEUROTRAUMA, (200301), vol. 20, no. 1, ISSN 0897-7151, pages 77 - 85, XP009106134 [YD] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1089/08977150360517209
 [Y]  - KUBOTA M ET AL, "Beneficial effect of l-arginine for stroke-like episode in MELAS", BRAIN AND DEVELOPMENT, AMSTERDAM, NL, (20041001), vol. 26, no. 7, ISSN 0387-7604, pages 481 - 483, XP004692525 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.braindev.2004.01.006
 [Y]  - ROBERTSON C S ET AL, "L-arginine reduces neuronal damage after traumatic brain injury in the mouse", JOURNAL OF NEUROTRAUMA, & EIGHTEENTH ANNUAL NATIONAL NEUROTRAUMA SOCIETY SYMPOSIUM; NEW ORLEANS, LOUISIANA, USA; NOVEMBER 03-04, 2000, (200010), vol. 17, no. 10, ISSN 0897-7151, page 945, XP009106221 [Y] 1-15 * abstract *
International search[X]US4296104  (HERSCHLER ROBERT J);
 [X]US2005031651  (GERVAIS FRANCINE [CA], et al);
 [X]US6479488  (DI-FABIO ROMANO [IT], et al)
Examination   - DE LA TORRE J C ET AL, "DIMETHYL SULFOXIDE IN CENTRAL NERVOUS SYSTEM TRAUMA", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, (19750101), vol. 243, doi:10.1111/J.1749-6632.1975.TB25377.X, ISSN 0077-8923, pages 362 - 389, XP009106146

DOI:   http://dx.doi.org/10.1111/j.1749-6632.1975.tb25377.x
    - DE LA TORRE J C ET AL, "DEXAMETHASONE AND DI METHYL SULFOXIDE IN EXPERIMENTAL TRANS ORBITAL CEREBRAL INFARCTION", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, (19761101), vol. 7, no. 6, ISSN 0039-2499, pages 577 - 583, XP009106150
by applicant   - NARAYAN K, "NIH Collaborative Committee. Clinical trials in head injury", J NEUROTRAUMA, (2002), vol. 19, no. 5, pages 503 - 57
    - MONCADA, S.; PALMER,R.M.; HIGGS,E.A., "Nitric oxide: physiology, pathophysiology, and pharmacology", PHARMACOL. REV, (1991), vol. 43, pages 109 - 142, XP009007593
    - IGNARRO L; NAPOLI C, "Novel features of nitric oxide, endothelial nitric oxide synthase, and atherosclerosis", CURR ATHEROSCLER REP., (200407), vol. 6, no. 4, pages 281 - 7
    - BARBUL A, "Arginine: biochemistry, physiology, and therapeutic implications", J PARENT ENTERAL NUTR, (1986), vol. 10, pages 227 - 238, XP009071908
    - CHERIAN L, "L-Arginine and Free Radical Scavengers Increase Cerebral Blood Flow and Brain Tissue Nitric Oxide Concentrations after Controlled Cortical Impact Injury in Rats", JOURNAL OF NEUROTRAUMA, (200301), vol. 20, no. 1, doi:doi:10.1089/08977150360517209, pages 77 - 85, XP009106134

DOI:   http://dx.doi.org/10.1089/08977150360517209
    - HLATKY R., "The Role of Endothelial Nitric Oxide Synthase in the Cerebral Hemodynamics after Controlled Cortical Impact Injury in Mice", JOURNAL OF NEUROTRAUMA, (2003), vol. 20, no. 10, pages 995 - 1006
    - PIATTI P; FRAGASSO G; MONTI LD; SETOLA E; LUCOTTI P; FERMO I; PARONI R; GALLUCCIO E; POZZA G; CHIERCHIA S, "Acute intravenous L-arginine infusion decreases endothelin-1 levels and improves endothelial function in patients with angina pectoris and normal coronary arteriograms: correlation with asymmetric dimethylarginine levels", CIRCULATION, (2003), vol. L07, no. 3, pages 429 - 36
    - KUBES P.; GRANGER,D.N., "Nitric oxide modulates microvascular permeability", AM. J. PHYSIOL., (1992), vol. 262, pages H611 - H615
    - KUBES P.; KANWAR S.; NIU X.F., "Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cells", FASEB J., (1993), vol. 7, pages 1293 - 1299
    - DE LA TORRE JC; STEFANO GB, "Evidence that Alzheimer's disease is a microvascular disorder: Role of constitutive nitric oxide", BRAIN RES REV., (2000), vol. 34, pages 119 - 136
    - VISSER JJ; HOEKMAN K, "Arginine supplementation in the prevention and treatment of osteoporosis", MED HYPOTHESES., (199411), vol. 43, no. 5, doi:doi:10.1016/0306-9877(94)90113-9, pages 339 - 42, XP026308807

DOI:   http://dx.doi.org/10.1016/0306-9877(94)90113-9
    - DE LA TORRE, J.C.; SURGEON, J.W., "Dexamethasone and DMSO in cerebral infarction", STROKE, (1976), vol. 7, pages 577 - 583
    - DE LA TORRE, J.C.; KAWANAGA, H.M.; GOODE, D.J.; JOHNSON, C.M.; KAJIHARA, K.; ROWED, D.W.; MULLAN, S., "Dimethyl sulfoxide in CNS trauma", ANN. N.Y. ACAD. SCI., (1975), vol. 243, doi:doi:10.1111/j.1749-6632.1975.tb25377.x, pages 362 - 389, XP009106146

DOI:   http://dx.doi.org/10.1111/j.1749-6632.1975.tb25377.x
    - BROWN FD; JOHNS LM; MULLAN S, "Dimethyl sulfoxide in experimental brain injury, with comparison to mannitol", J NEUROSURG., (198007), vol. 53, no. L, pages 58 - 62
    - KARACA M; KILIC E; YAZICI B; DEMIR S; DE LA TORRE JC, "Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate compound", NEUROL RES, (2002), vol. 24, pages 73 - 80
    - KARACA, M.; BILGIN, U.; AKAR, M.; DE LA TORRE, J.C., "Dimethyl sulfoxide lowers ICP after closed head trauma", EUR. J. CLIN. PHARMACOL., (1991), vol. 40, pages 113 - 114
    - BENVENISTE H; DREJER J; SCHOUSBOE A; DIEMER NH, "Elevation of the extracellular concentrations of glutamate and aspartate in rat. hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis.", J NEUROCHEM, (1984), vol. 43, pages 1369 - 74
    - KRISTIAN T; SIESJO; BK, "Calcium in ischemic cell death", STROKE, (1998), vol. 29, pages 705 - 18
    - ROSSI DJ; OSHIMA T; ATTWELL D, "Glutamate release in severe brain ischaemia is mainly by reversed uptake", NATURE, (2000), vol. 403, pages 316 - 21
    - BEZZI P; CARMIGNOTO, G; PASTI L; VESCE S; ROSSI D; RIZZINI BL; POZZAN T; VOLTERRA A, "Prostaglandins stimulate calcium-dependent glutamate release in astrocytes", NATURE, (1998), vol. 391, pages 281 - 292
    - LU, C.; M.P. MATTSON, "Dimethyl sulfoxide suppresses NMDA- and AMPA-induced ion currents and calcium influx and protects against excitotoxic death in hippocampal neurons", EXP NEUROL, (200107), vol. 170, pages 180 - 185
    - MARSHALL LF; CAMP P; BOWERS S, "Dimethyl sulfoxide for the treatment of intracranial hypertension", J NEUROSURG, (1984), vol. 14, pages 659 - 664
    - ROBERTSON C.S. ET AL., JOURNAL OF NEUROTRAUMA, (200010), vol. 17, no. 10, page 945
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.