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Extract from the Register of European Patents

EP About this file: EP1924281

EP1924281 - MODIFIED INFLUENZA VIRUS FOR MONITORING AND IMPROVING VACCINE EFFICIENCY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.03.2020
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  05.04.2019
FormerGrant of patent is intended
Status updated on  18.02.2019
FormerExamination is in progress
Status updated on  07.01.2019
FormerGrant of patent is intended
Status updated on  08.08.2018
FormerExamination is in progress
Status updated on  15.03.2017
Most recent event   Tooltip02.07.2021Lapse of the patent in a contracting state
New state(s): IS		published on 04.08.2021  [2021/31]
Applicant(s)For all designated states
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
262 Danny Thomas Place
Memphis, TN 38105 / US
[2019/04]
Former [2008/22]For all designated states
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
332 N. Lauderdale Street
Memphis, TN 38105-2794 / US
Inventor(s)01 / HOFFMANN, Erich
3102 Cove View Blvd.
Apt. M104
Galveston, TX 77554 / US
02 / LIPATOV, Aleksandr, S.
c/o MAKAROVA, Natalia PhD
2804 Galahad Dr. NE
Atlanta, GA 30345 / US
03 / WEBSTER, Robert, G.
295 Richbriar Street
Memphis, TN 38120 / US
04 / WEBBY, Richard, J.
2211 College Rd
Southaven, MS 38672 / US
05 / GOVORKOVA, Elena, A.
7591 Dexter Hills Drive
Cordova, TN 38016 / US
 [2019/19]
Former [2008/38]01 / HOFFMANN, Erich
1061 Natchez Point N° 179
Memphis, TN 38103 / US
02 / LIPATOV, Aleksandr, S.
1704 Grayson Parkway
Grayson, GA 30017 / US
03 / WEBSTER, Robert, G.
295 Richbriar Street
Memphis, TN 38120 / US
04 / WEBBY, Richard, J.
233 N. McNeil St.
Memphis, TN 38112 / US
05 / GOVORKOVA, Elena, A.
7591 Dexter Hills Drive
Cordova, TN 38016 / US
Former [2008/22]01 / HOFFMANN, Erich
1061 Natchez Point N° 179
Memphis, TN 38103 / US
02 / LIPATOV, Aleksandr, S.
1309 Greenbrook Bend, Apt. 8
Bartlett, TN 38134 / US
03 / WEBSTER, Robert, G.
295 Richbriar Street
Memphis, TN 38120 / US
04 / WEBBY, Richard, J.
233 N. McNeil St.
Memphis, TN 38112 / US
05 / GOVORKOVA, Elena, A.
7591 Dexter Hills Drive
Cordova, TN 38016 / US
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2019/19]
Former [2008/35]Vossius & Partner
Siebertstrasse 3
81675 München / DE
Former [2008/22]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date06813248.928.07.2006
[2008/22]
WO2006US29575
Priority number, dateUS20050705808P04.08.2005         Original published format: US 705808 P
[2008/22]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007019094
Date:15.02.2007
Language:EN
[2007/07]
Type: A2 Application without search report 
No.:EP1924281
Date:28.05.2008
Language:EN
The application published by WIPO in one of the EPO official languages on 15.02.2007 takes the place of the publication of the European patent application.
[2008/22]
Type: B1 Patent specification 
No.:EP1924281
Date:08.05.2019
Language:EN
[2019/19]
Search report(s)International search report - published on:US12.07.2007
(Supplementary) European search report - dispatched on:EP02.12.2013
ClassificationIPC:A61K39/145, C12Q1/70, C07H21/04, C12N7/00, C07K14/11
[2008/22]
CPC:
A61K39/12 (EP,US); C12N15/86 (KR); C12Q1/02 (US);
A61K39/145 (EP,US); A61P31/16 (EP); A61P37/04 (EP);
C07K14/005 (EP,US); C07K16/1018 (EP,US); C12N5/06 (KR);
C12N7/00 (EP,KR,US); G01N33/56983 (EP,US); A61K2039/525 (EP,US);
A61K2039/5254 (EP,US); A61K39/00 (EP,KR,US); C12N2760/16122 (EP,US);
C12N2760/16134 (EP,US); C12N2760/16161 (EP,US); G01N2333/11 (EP,US);
G01N2469/20 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2019/19]
Former [2008/22]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesAL03.03.2008
BA03.03.2008
HR03.03.2008
MK03.03.2008
RS03.03.2008
TitleGerman:MODIFIZIERTES INFLUENZA-VIRUS ZUR ÜBERWACHUNG UND VERBESSERUNG DER IMPFSTOFFWIRKSAMKEIT[2008/22]
English:MODIFIED INFLUENZA VIRUS FOR MONITORING AND IMPROVING VACCINE EFFICIENCY[2008/22]
French:VIRUS DE LA GRIPPE MODIFIÉ UTILISÉ POUR SURVEILLER ET AMÉLIORER L'EFFICACITÉ D'UN VACCIN[2008/22]
Entry into regional phase03.03.2008National basic fee paid 
03.03.2008Search fee paid 
03.03.2008Designation fee(s) paid 
03.03.2008Examination fee paid 
Examination procedure03.03.2008Examination requested  [2008/22]
25.04.2014Amendment by applicant (claims and/or description)
26.02.2016Despatch of a communication from the examining division (Time limit: M06)
23.08.2016Reply to a communication from the examining division
06.03.2017Despatch of a communication from the examining division (Time limit: M04)
14.07.2017Reply to a communication from the examining division
23.02.2018Despatch of a communication from the examining division (Time limit: M04)
03.07.2018Reply to a communication from the examining division
09.08.2018Communication of intention to grant the patent
19.12.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
19.12.2018Fee for grant paid
19.12.2018Fee for publishing/printing paid
19.12.2018Receipt of the translation of the claim(s)
19.02.2019Communication of intention to grant the patent
01.04.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.02.2016
Opposition(s)11.02.2020No opposition filed within time limit [2020/16]
Fees paidRenewal fee
25.08.2008Renewal fee patent year 03
28.07.2009Renewal fee patent year 04
26.07.2010Renewal fee patent year 05
25.07.2011Renewal fee patent year 06
25.07.2012Renewal fee patent year 07
29.07.2013Renewal fee patent year 08
28.07.2014Renewal fee patent year 09
27.07.2015Renewal fee patent year 10
27.07.2016Renewal fee patent year 11
27.07.2017Renewal fee patent year 12
27.07.2018Renewal fee patent year 13
Penalty fee
Additional fee for renewal fee
31.07.200803   M06   Fee paid on   25.08.2008
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT08.05.2019
CY08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
MC08.05.2019
RO08.05.2019
SE08.05.2019
SI08.05.2019
SK08.05.2019
TR08.05.2019
IE28.07.2019
LU28.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
BG08.08.2019
IS08.09.2019
PT08.09.2019
[2021/31]
Former [2021/26]AT08.05.2019
CY08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
MC08.05.2019
RO08.05.2019
SE08.05.2019
SI08.05.2019
SK08.05.2019
TR08.05.2019
IE28.07.2019
LU28.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
BG08.08.2019
PT08.09.2019
Former [2020/36]AT08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
MC08.05.2019
RO08.05.2019
SE08.05.2019
SI08.05.2019
SK08.05.2019
TR08.05.2019
IE28.07.2019
LU28.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
BG08.08.2019
PT08.09.2019
Former [2020/25]AT08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
MC08.05.2019
RO08.05.2019
SE08.05.2019
SI08.05.2019
SK08.05.2019
TR08.05.2019
LU28.07.2019
BE31.07.2019
CH31.07.2019
LI31.07.2019
BG08.08.2019
PT08.09.2019
Former [2020/17]AT08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
MC08.05.2019
RO08.05.2019
SE08.05.2019
SK08.05.2019
TR08.05.2019
BG08.08.2019
PT08.09.2019
Former [2020/14]AT08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
MC08.05.2019
RO08.05.2019
SE08.05.2019
SK08.05.2019
BG08.08.2019
PT08.09.2019
Former [2020/11]AT08.05.2019
CZ08.05.2019
DK08.05.2019
EE08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
RO08.05.2019
SE08.05.2019
SK08.05.2019
BG08.08.2019
PT08.09.2019
Former [2020/10]AT08.05.2019
CZ08.05.2019
DK08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
RO08.05.2019
SE08.05.2019
BG08.08.2019
PT08.09.2019
Former [2020/09]CZ08.05.2019
DK08.05.2019
FI08.05.2019
LT08.05.2019
LV08.05.2019
SE08.05.2019
BG08.08.2019
PT08.09.2019
Former [2019/52]FI08.05.2019
LT08.05.2019
LV08.05.2019
SE08.05.2019
BG08.08.2019
PT08.09.2019
Former [2019/48]FI08.05.2019
LT08.05.2019
SE08.05.2019
PT08.09.2019
Former [2019/47]FI08.05.2019
LT08.05.2019
Documents cited:Search[X]  - LIPATOV ALEKSANDR S ET AL, "Efficacy of H5 influenza vaccines produced by reverse genetics in a lethal mouse model", JOURNAL OF INFECTIOUS DISEASES, (200504), vol. 191, no. 8, pages 1216 - 1220, XP002716580 [X] 1-6,10-13,16,18,24,28,29,31-36 * the whole document *

DOI:   http://dx.doi.org/10.1086/428951
 [XP]  - HOFFMANN ERICH ET AL, "ROLE OF SPECIFIC HEMAGGLUTININ AMINO ACIDS IN THE IMMUNOGENICITY AND PROTECTION OF H5N1 INFLUENZA VIRUS VACCINES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES - PNAS, NATIONAL ACADEMY OF SCIENCES, US, (20050901), vol. 102, no. 36, doi:10.1073/PNAS.0506416102, ISSN 0027-8424, pages 12915 - 12920, XP009084967 [XP] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.0506416102
 [A]  - WEBBY R ET AL, "Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines", THE LANCET, LANCET LIMITED. LONDON, GB, (20040403), vol. 363, no. 9415, doi:10.1016/S0140-6736(04)15892-3, ISSN 0140-6736, pages 1099 - 1103, XP004852899 [A] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)15892-3
 [A]  - SUBBARAO K ET AL, "Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics", VIROLOGY, ELSEVIER, AMSTERDAM, NL, (20030105), vol. 305, no. 1, doi:10.1006/VIRO.2002.1742, ISSN 0042-6822, pages 192 - 200, XP002314284 [A] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1006/viro.2002.1742
 [A]  - HOFFMANN E ET AL, "Eight-plasmid system for rapid generation of influenza virus vaccines", VACCINE, ELSEVIER LTD, GB, (20020819), vol. 20, no. 25-26, doi:10.1016/S0264-410X(02)00268-2, ISSN 0264-410X, pages 3165 - 3170, XP004374556 [A] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0264-410X(02)00268-2
 [A]  - LIU M ET AL, "Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics", VIROLOGY, ELSEVIER, AMSTERDAM, NL, (20030930), vol. 314, no. 2, doi:10.1016/S0042-6822(03)00458-6, ISSN 0042-6822, pages 580 - 590, XP004462749 [A] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0042-6822(03)00458-6
 [A]  - MARTIN J ET AL, "Studies of the Binding Properties of Influenza Hemagglutinin Receptor-Site Mutants", VIROLOGY, ELSEVIER, AMSTERDAM, NL, (19980201), vol. 241, no. 1, doi:10.1006/VIRO.1997.8958, ISSN 0042-6822, pages 101 - 111, XP004446009 [A] 1-36 * the whole document *

DOI:   http://dx.doi.org/10.1006/viro.1997.8958
 [A]  - KAVERIN NIKOLAI V ET AL, "Structure of antigenic sites on the haemagglutinin molecule of H5 avian influenza virus and phenotypic variation of escape mutants", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, (20021001), vol. 83, no. Pt 10, ISSN 0022-1317, pages 2497 - 2505, XP002547472 [A] 1-36 * the whole document *
International search[Y]US6719979  (PEETERS BERNARDUS PETRUS HUBER [NL], et al);
 [Y]US6740325  (ARNON RUTH [IL], et al);
 [X]  - BOTH G.W. ET AL., "Hemagglutinin of Swine Influenza Virus: A Single Amino Acid Change Pleiotropically Affects Viral Antigenicity and Replication", PNAS, (198311), vol. 0, pages 6996 - 7000, XP003015260

DOI:   http://dx.doi.org/10.1073/pnas.80.22.6996
 [Y]  - GAMBARYANA A. ET AL., "Receptor specificity of influenza viruses from birds and mammals: New data on involvement of the inner fragments of the carbohydrate chain", VIROLOGY, (200502), vol. 334, pages 276 - 283, XP004796057

DOI:   http://dx.doi.org/10.1016/j.virol.2005.02.003
 [Y]  - HOFFMANN E. ET AL., "A DNA transfection system for generation of influenza A virus from eight plasmids", PNAS, (200005), vol. 97, pages 6108 - 6113, XP000982038

DOI:   http://dx.doi.org/10.1073/pnas.100133697
 [Y]  - GOVORKOVA E.A. ET AL., "Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004", J. VIROLOGY, (200502), vol. 79, no. 4, pages 2191 - 2198, XP002434799

DOI:   http://dx.doi.org/10.1128/JVI.79.4.2191-2198.2005
Examination   - GAMBARYAN A ET AL, "Evolution of the receptor binding phenotype of influenza A (H5) viruses", VIROLOGY, ELSEVIER, AMSTERDAM, NL, vol. 344, no. 2, doi:10.1016/J.VIROL.2005.08.035, ISSN 0042-6822, (20060120), pages 432 - 438, (20060120), XP024896840

DOI:   http://dx.doi.org/10.1016/j.virol.2005.08.035
    - HA YA ET AL, "X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, (20010925), vol. 98, no. 20, doi:10.1073/PNAS.201401198, ISSN 0027-8424, pages 11181 - 11186, XP002593759

DOI:   http://dx.doi.org/10.1073/PNAS.201401198
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.