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Extract from the Register of European Patents

EP About this file: EP1917368

EP1917368 - METHODS AND KITS FOR EVALUATING DNA METHYLATION [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 10.08.2012 Database last updated on 26.06.2024
Most recent event Tooltip	10.08.2012	Application deemed to be withdrawn	published on 12.09.2012 [2012/37]
Applicant(s)	For all designated states Life Technologies Corporation 5823 Newton Drive Carlsbad, CA 92008 / US
	[N/P]
Former [2010/21]	For all designated states Life Technologies Corporation 5791 Van Allen Way Carlsbad, CA 92008 / US
Former [2010/18]	For all designated states Life Technologies Corporation 5791 Van Alley Way Carlsbad, CA 92008 / US
Former [2010/16]	For all designated states Applied Biosystems, LLC 5791 Van Allen Way Carlsbad, CA 92008 / US
Former [2008/19]	For all designated states Applera Corporation 850 Lincoln Centre Drive Foster City, CA 94404 / US
Inventor(s)	01 / BOYD, Victoria 199 Fir Street San Carlos, CA 94070 United States of America / US
	02 / LIVAK, Kenneth 1148 Polk Lane San Jose, CA 95117 United States of America / US
	03 / ZON, Gerald 199 Fir Street San Carlos, CA 94070 United States of America / US
	[2008/20]
Former [2008/19]	01 / BOYD, Victoria 199 Fir Street San Carlos, CA 94070 / US
	02 / LIVAK, Kenneth 1148 Polk Lane San Jose, CA 95117 / US
	03 / ZON, Gerald 199 Fir Street San Carlos, CA 94070 / US
Representative(s)	Grund, Martin Grund Intellectual Property Group Patentanwälte und Solicitor PartG mbB Steinsdorfstraße 2 80538 München / DE
	[N/P]
Former [2008/19]	Grund, Martin GRUND Intellectual Property Group Postfach 44 05 16 80754 München / DE
Application number, filing date	06851402.5	16.06.2006
	[2008/19]
	WO2006US23669
Priority number, date	US20050691608P	16.06.2005 Original published format: US 691608 P
	US20060424224	14.06.2006 Original published format: US 424224
	[2008/19]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2008018855
	Date:	14.02.2008
	Language:	EN
	[2008/07]
	Type:	A2 Application without search report
	No.:	EP1917368
	Date:	07.05.2008
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 14.02.2008 takes the place of the publication of the European patent application.
	[2008/19]
Search report(s)	International search report - published on:	US	04.12.2008
	(Supplementary) European search report - dispatched on:	EP	23.11.2009
Classification	IPC:	C12Q1/68	[2009/08]
	CPC:	C12Q1/686 (EP,US)
	C-Set:	C12Q1/686, C12Q2565/125, C12Q2523/125 (EP,US)
	Former IPC [2008/20]	C12Q1/68, C12P19/34
	Former IPC [2008/19]	C12Q1/68
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2008/19]
Extension states	AL	Not yet paid
	BA	Not yet paid
	HR	Not yet paid
	MK	Not yet paid
	RS	Not yet paid
Title	German:	VERFAHREN UND KITS ZUR BEURTEILUNG VON DNA-METHYLIERUNG	[2008/19]
	English:	METHODS AND KITS FOR EVALUATING DNA METHYLATION	[2008/19]
	French:	PROCÉDÉS ET TROUSSES POUR L'ÉVALUATION DE LA MÉTHYLATION DE L'ADN	[2008/19]
Entry into regional phase	10.01.2008	National basic fee paid
	10.01.2008	Search fee paid
	29.05.2009	Designation fee(s) paid
	29.05.2009	Examination fee paid
Examination procedure	29.05.2009	Examination requested [2009/28]
	02.03.2010	Despatch of a communication from the examining division (Time limit: M06)
	01.09.2010	Reply to a communication from the examining division
	11.01.2012	Despatch of a communication from the examining division (Time limit: M02)
	22.03.2012	Application deemed to be withdrawn, date of legal effect [2012/37]
	27.04.2012	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2012/37]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 02.03.2010
Fees paid	Renewal fee
	31.03.2008	Renewal fee patent year 03
	26.06.2009	Renewal fee patent year 04
	25.06.2010	Renewal fee patent year 05
	27.06.2011	Renewal fee patent year 06
	Penalty fee
	Additional fee for renewal fee
	30.06.2012	07 M06 Not yet paid
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[X]US6013435 (NUSBAUM NEIL J [US]) [X] 39-41 * column 16, line 62 - column 17, line 18 *;
		[DXY]US6265171 (HERMAN JAMES G [US], et al) [DX] 39,41 * the whole document * [Y] 1-38,40;
		[X]US6399304 (KILGER CHRISTIAN [DE], et al) [X] 39,41 * paragraph [0090] - paragraph [0091] *;
		[X]EP1457556 (TAKEDA CHEMICAL INDUSTRIES LTD [JP]) [X] 39,41 * page 4, paragraph 17 *;
		[PX]WO2005071106 (EPIGENOMICS AG [DE], et al) [PX] 1-41* the whole document *;
		[DXY] - YAMAMOTO T ET AL, "METHYLATION ASSAY BY NUCLEOTIDE INCORPORATION: A QUANTITATIVE ASSAY FOR REGIONAL CPG METHYLATION DENSITY", BIOTECHNIQUES, INFORMA LIFE SCIENCES PUBLISHING, WESTBOROUGH, MA, US, (20040101), vol. 36, no. 5, ISSN 0736-6205, pages 846 - 854, XP001247943 [DX] 1-4,7,9-14,17,18 * the whole document * [Y] 19-38
		[DY] - BOYD V L AND ZON G, "Bisulfite conversion of genomic DNA for methylation analysis: protocol simplification with higher recovery applicable to limited samples and increased throughput", ANALYTICAL BIOCHEMISTRY, (2004), vol. 326, pages 278 - 280, XP002553975 [DY] 1-41 * the whole document * DOI: http://dx.doi.org/10.1016/j.ab.2003.11.020
		[DY] - XIONG Z AND LAIRD P W, "COBRA: a sensitive and quantitative DNA methylation assay", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, (19970101), vol. 25, no. 12, ISSN 0305-1048, pages 2532 - 2534, XP002106407 [DY] 1-41 * the whole document * DOI: http://dx.doi.org/10.1093/nar/25.12.2532
		[DY] - HERMAN J G ET AL, "METHYLATION-SPECIFIC PCR: A NOVEL PCR ASSAY FOR METHYLATION STATUS OF CPG ISLANDS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, (19960901), vol. 93, ISSN 0027-8424, pages 9821 - 9826, XP002910406 [DY] 1-38 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.93.18.9821
		[DY] - GHADESSY F J ET AL, "Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20040601), vol. 22, no. 6, ISSN 1087-0156, pages 755 - 759, XP002320329 [DY] 40 * the whole document * DOI: http://dx.doi.org/10.1038/nbt974
		[DA] - LI L-C ET AL, "MethPrimer: designing primers for methylation PCRs", BIOINFORMATICS, OXFORD UNIVERSITY PRESS, SURREY, GB, (20021101), vol. 18, no. 11, ISSN 1367-4803, pages 1427 - 1431, XP003004907 [DA] * the whole document * DOI: http://dx.doi.org/10.1093/bioinformatics/18.11.1427
		[DA] - COUVERT P ET AL, "DHPLC-BASED METHOD FOR DNA METHYLATION ANALYSIS OF DIFFERENTIAL METHYLATED REGIONS FROM IMPRINTED GENES", BIOTECHNIQUES, INFORMA LIFE SCIENCES PUBLISHING, WESTBOROUGH, MA, US, (20030201), vol. 34, no. 2, ISSN 0736-6205, pages 356 - 362, XP009039901 [DA] * abstract *
		[DA] - BROWNSTEIN M J ET AL, "MODULATION OF NON-TEMPLATED NUCLEOTIDE ADDITION BY TAQ DNA POLYMERASE: PRIMER MODIFICATIONS THAT FACILITATE GENOTYPING", BIOTECHNIQUES, INFORMA LIFE SCIENCES PUBLISHING, WESTBOROUGH, MA, US, (19960601), vol. 20, no. 6, ISSN 0736-6205, page 1004,1006,1008, XP002027777 [DA] * the whole document *
	International search	[Y]US4879214 (KORNHER JOHN S [US], et al);
		[Y]US6331393 (LAIRD PETER W [US], et al);
		[Y]US2004101843 (ZON GERALD [US]);
		[X]US2005095623 (ZON GERALD [US], et al);
		[Y] - EADS C.A. ET AL., "MethylLight: a high-throughput assay to measure DNA methylation", NUCLEIC ACIDS RESEARCH, (20000415), vol. 28, no. 8, pages E32-I - E32-VIII, XP002341618 DOI: http://dx.doi.org/10.1093/nar/28.8.e32
		[Y] - FACKLER ET AL., "Quantitative Multiplex Methylation-Specific PCR Assay for the Detection of Promoter Hypermethylation in Multiple Genes in Breast Cancer", CANCER RESEARCH, (20040701), vol. 64, pages 4442 - 4452
		[AP] - BOYD V.L. ET AL., "Methylation-dependent fragment separation: Direct detection of DNA methylation by capillary electrophoresis of PCR products from bisulfite-converted genomic DNA", ANALYTICAL BIOCHEMISTRY, (2006), vol. 354, pages 266 - 273, XP024942130 DOI: http://dx.doi.org/10.1016/j.ab.2006.04.009

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