blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP1785422

EP1785422 - Micronised crystalline tiotropium bromide [Right-click to bookmark this link]
StatusOpposition rejected
Status updated on  15.12.2023
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  20.05.2019
Most recent event   Tooltip15.12.2023Opposition rejectedpublished on 17.01.2024  [2024/03]
Applicant(s)For all designated states
Boehringer Ingelheim Pharma GmbH & Co. KG
Binger Strasse 173
55216 Ingelheim / DE
[2007/20]
Inventor(s)01 / Trunk, Michael
Im Bruehl 5
55218 Ingelheim / DE
02 / Walz, Michael
Prizrenstr. 22
55411 Bingen / DE
03 / Bender, Helmut
Dudenstrasse 52
65193 Wiesbaden / DE
04 / Graebner, Hagen
Stauferring 42
55218 Ingelheim / DE
05 / Schindler, Konrad
Magdeburger Straße 24
55218 Ingelheim / DE
 [2017/18]
Former [2007/20]01 / Trunk, Michael
Im Bruehl 5
55218, Ingelheim / DE
02 / Walz, Michael
Prizrenstr. 22
55411, Bingen / DE
03 / Bender, Helmut
Dudenstrasse 52
65193, Wiesbaden / DE
04 / Graebner, Hagen
Stauferring 42
55218, Ingelheim / DE
05 / Schindler, Konrad
Magdeburger Straße 24
55218, Ingelheim / DE
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2016/46]
Former [2012/24]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastraße 4
81925 München / DE
Former [2008/43]Klusmann, Peter, et al
Hoffmann - Eitle Patent- und Rechtsanwälte Arabellastrasse 4
81925 München / DE
Former [2007/20]Hammann, Heinz, et al
Boehringer Ingelheim Pharma GmbH & Co. KG Binger Strasse 173
55216 Ingelheim am Rhein / DE
Application number, filing date07102206.510.03.2003
[2007/20]
Priority number, dateDE2002101226420.03.2002         Original published format: DE 10212264
[2007/20]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report 
No.:EP1785422
Date:16.05.2007
Language:DE
[2007/20]
Type: A8 Corrected patent application 
No.:EP1785422
Date:23.06.2010
[2010/25]
Type: B1 Patent specification 
No.:EP1785422
Date:16.11.2016
Language:DE
[2016/46]
Search report(s)(Supplementary) European search report - dispatched on:EP05.04.2007
ClassificationIPC:C07D451/10, A61P11/00, A61K31/40
[2007/20]
CPC:
A61K9/0075 (EP); A61K31/40 (NO); C07D451/10 (EP,KR,NO);
A61K31/439 (EP); A61K9/0073 (NO); A61P11/00 (EP);
A61P11/06 (EP); A61P43/00 (EP); C07D491/08 (KR) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2016/46]
Former [2010/24]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IT,  LI,  LU,  MC,  NL,  PT,  RO,  SE,  SI,  SK,  TR 
Former [2007/20]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesLT16.11.2007
LV16.11.2007
TitleGerman:Kristallines Mikronisat des Tiotropiumbromids[2007/20]
English:Micronised crystalline tiotropium bromide[2007/20]
French:Micronisat crystallin de bromure de tiotropium[2007/20]
Examination procedure16.11.2007Examination requested  [2008/01]
29.01.2008Despatch of a communication from the examining division (Time limit: M06)
31.07.2008Reply to a communication from the examining division
14.12.2015Despatch of a communication from the examining division (Time limit: M04)
10.03.2016Reply to a communication from the examining division
20.04.2016Despatch of a communication from the examining division (Time limit: M04)
27.04.2016Reply to a communication from the examining division
11.08.2016Communication of intention to grant the patent
26.09.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
26.09.2016Fee for grant paid
26.09.2016Fee for publishing/printing paid
07.10.2016Information about intention to grant a patent
07.10.2016Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP03708206.2  / EP1487832
Divisional application(s)EP16159836.2  / EP3053921
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030708206) is  17.03.2006
Opposition(s)Opponent(s)01  15.08.2017  22.08.2017  ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
 02  15.08.2017  22.08.2017  ADMISSIBLE
HEXAL PHARMA AG
Industriestrasse 25
83607 Holzkirchen / DE
Opponent's representative
Ter Meer Steinmeister & Partner
Patentanwälte mbB
Nymphenburger Straße 4
80335 München / DE
 03  16.08.2017  22.08.2017  ADMISSIBLE
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor
08028 Barcelona / ES
Opponent's representative
Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
 04  16.08.2017  22.08.2017  WITHDRAWN
Jump, Timothy John Simon
200 Aldersgate
London EC1A 4HD / GB
Opponent's representative
Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
 [2022/39]
Former [2020/17]
Opponent(s)01  15.08.2017  22.08.2017  ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
 02  15.08.2017  22.08.2017  ADMISSIBLE
HEXAL PHARMA AG
Industriestrasse 25
83607 Holzkirchen / DE
Opponent's representative
Ter Meer Steinmeister & Partner
Patentanwälte mbB
Nymphenburger Straße 4
80335 München / DE
 03  16.08.2017  22.08.2017  ADMISSIBLE
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor
08028 Barcelona / ES
Opponent's representative
Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
 04  16.08.2017  22.08.2017  ADMISSIBLE
Jump, Timothy John Simon
200 Aldersgate
London EC1A 4HD / GB
Opponent's representative
Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
Former [2019/15]
Opponent(s)01  15.08.2017  22.08.2017  ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
 02  15.08.2017  22.08.2017  ADMISSIBLE
Hexal AG / Sandoz International GmbH
Industriestrasse 25
83607 Holzkirchen / DE
Opponent's representative
Ter Meer Steinmeister & Partner
Patentanwälte mbB
Nymphenburger Straße 4
80335 München / DE
 03  16.08.2017  22.08.2017  ADMISSIBLE
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor
08028 Barcelona / ES
Opponent's representative
Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
 04  16.08.2017  22.08.2017  ADMISSIBLE
Jump, Timothy John Simon
200 Aldersgate
London EC1A 4HD / GB
Opponent's representative
Elkington & Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
Former [2018/52]
Opponent(s)01  15.08.2017  22.08.2017  ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
 02  15.08.2017  22.08.2017  ADMISSIBLE
Hexal AG / Sandoz International GmbH
Industriestrasse 25
83607 Holzkirchen / DE
Opponent's representative
Schust, Jochen
Sandoz International GmbH
Industriestraße 25
83607 Holzkirchen / DE
 03  16.08.2017  22.08.2017  ADMISSIBLE
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor
08028 Barcelona / ES
Opponent's representative
Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
 04  16.08.2017  22.08.2017  ADMISSIBLE
Jump, Timothy John Simon
200 Aldersgate
London EC1A 4HD / GB
Opponent's representative
Elkington & Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
Former [2018/38]
Opponent(s)01  15.08.2017  22.08.2017  ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm&Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
 02  15.08.2017  22.08.2017  ADMISSIBLE
Hexal AG / Sandoz International GmbH
Industriestrasse 25
83607 Holzkirchen / DE
Opponent's representative
Schust, Jochen
Sandoz International GmbH
Industriestraße 25
83607 Holzkirchen / DE
 03  16.08.2017  22.08.2017  ADMISSIBLE
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor
08028 Barcelona / ES
Opponent's representative
Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
 04  16.08.2017  22.08.2017  ADMISSIBLE
Jump, Timothy John Simon
200 Aldersgate
London EC1A 4HD / GB
Opponent's representative
Gillard, Richard Edward
Elkington and Fife LLP
Thavies Inn House
3-4 Holborn Circus
London EC1N 2HA / GB
Former [2017/39]
Opponent(s)01  15.08.2017  22.08.2017  ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm & Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
 02  15.08.2017  22.08.2017  ADMISSIBLE
Hexal AG / Sandoz International GmbH
Industriestrasse 25
83607 Holzkirchen / DE
Opponent's representative
Schust, Jochen
Sandoz International GmbH
Industriestraße 25
83607 Holzkirchen / DE
 03  16.08.2017  22.08.2017  ADMISSIBLE
Laboratorios Liconsa, S.A.
Gran Via Carlos III, 98, 7th floor
08028 Barcelona / ES
Opponent's representative
Schön, Christoph
Dr. Schön, Neymeyr & Partner mbB
Bavariaring 26
80336 München / DE
 04  16.08.2017  22.08.2017  ADMISSIBLE
Jump, Timothy John Simon
200 Aldersgate
London EC1A 4HD / GB
Opponent's representative
Jump, Timothy John Simon
Venner Shipley LLP
200 Aldersgate
London EC1A 4HD / GB
Former [2017/38]
Opponent(s)01  15.08.2017    ADMISSIBLE
Alfred E. Tiefenbacher (GmbH & Co. KG)
Van-der-Smissen-Straße 1
22767 Hamburg / DE
Opponent's representative
Hamm & Wittkopp Patentanwälte PartmbB
Jungfernstieg 38
20354 Hamburg / DE
26.09.2017Invitation to proprietor to file observations on the notice of opposition
06.04.2018Reply of patent proprietor to notice(s) of opposition
02.04.2019Date of oral proceedings
21.05.2019Despatch of minutes of oral proceedings
21.05.2019Date of despatch of rejection of opposition
30.06.2023Legal effect of rejection of opposition [2024/03]
Appeal following opposition23.07.2019Appeal received No.  T1989/19
30.09.2019Statement of grounds filed
30.06.2023Result of appeal procedure: appeal of the opponent was rejected
12.12.2023Despatch of the decision of the Board of Appeal
12.07.2019Appeal received No.  T1989/19
30.09.2019Statement of grounds filed
30.06.2023Result of appeal procedure: appeal of the opponent was rejected
12.12.2023Despatch of the decision of the Board of Appeal
11.07.2019Appeal received No.  T1989/19
30.09.2019Statement of grounds filed
30.06.2023Result of appeal procedure: appeal of the opponent was rejected
12.12.2023Despatch of the decision of the Board of Appeal
09.07.2019Appeal received No.  T1989/19
30.09.2019Statement of grounds filed
30.06.2023Result of appeal procedure: appeal of the opponent was rejected
12.12.2023Despatch of the decision of the Board of Appeal
30.06.2023Date of oral proceedings
Fees paidRenewal fee
13.06.2007Renewal fee patent year 03
13.06.2007Renewal fee patent year 04
13.06.2007Renewal fee patent year 05
31.03.2008Renewal fee patent year 06
30.03.2009Renewal fee patent year 07
16.03.2010Renewal fee patent year 08
25.03.2011Renewal fee patent year 09
15.03.2012Renewal fee patent year 10
20.03.2013Renewal fee patent year 11
18.03.2014Renewal fee patent year 12
23.03.2015Renewal fee patent year 13
14.03.2016Renewal fee patent year 14
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipGB09.03.2023
CZ10.03.2023
IE10.03.2023
SK10.03.2023
ES11.03.2023
SI11.03.2023
PT21.03.2023
[2023/33]
Former [2023/27]GB09.03.2023
CZ10.03.2023
SK10.03.2023
SI11.03.2023
PT21.03.2023
Former [2023/25]CZ10.03.2023
SK10.03.2023
SI11.03.2023
PT21.03.2023
Former [2023/23]CZ10.03.2023
SK10.03.2023
PT21.03.2023
Former [2023/22]CZ10.03.2023
PT21.03.2023
Documents cited:Search[Y]EP0418716  (BOEHRINGER INGELHEIM KG [DE], et al) [Y] 1-26 * the whole document *;
 [Y]FR2779347  (GUERRY ARLETTE [FR], et al) [Y] 1-26* page 1, line 1 - line 13 *
ExaminationWO0047200
by applicantUS4570630
 DE3625685
 EP0418716
 WO9428958
OppositionEP0418716
 WO9505805
 US5610163
 WO0047200
 WO0069468
 CA2368583
 WO0230928
 EP1401445
 US2006094703
 WO2007068655
 US2008292563
 CN102127069
 US5874063
 CA2338680
 WO02098874
 EP1238661
 US7309707
    - X.-M. ZENG et al., Particulate interactions in dry powder formulations for inhalation, (20010000), pages 133 - 138, XP055412006
    - G.H. WARD et al., "PROCESS-INDUCED CRYSTALLINITY CHANGES IN ALBUTEROL SULFATE AND ITS EFFECT ON POWDER PHYSICAL STABILITY", Pharmaceut. Res., (19950000), vol. 12, no. 5, pages 773 - 779, XP000891782

DOI:   http://dx.doi.org/10.1023/A:1016232230638
    - B.C. HANCOCK et al., "CHARACTERISTICS AND SIGNIFICANCE OF THE AMORPHOUS STATE IN PHARMACEUTICAL SYSTEMS", J. Pharm. Sci., (19970100), vol. 86, no. 1, pages 1 - 12, XP000929450

DOI:   http://dx.doi.org/10.1021/js9601896
    - Furniss et al, Vogel's Textbook of Practical Organic Chemistry, 5th ed., (19890000), pages 135 - 153, XP055412009
    - X.-M. ZENG et al., Particlulate interactions in dry powder formulations for inhalation, (20010000), pages 86 - 95, XP055412020
    - "Module 3: Characteristics of Particles - Aerodynamic Diameter", (20080404), URL: http://www.epa.gov/apti/bces/module3/diameter/diameter.htm, XP055412026
    - Muscarinic Receptors in Airways Diseases, (20010000), pages 236 - 243, XP055412044
    - S. BRYN et al., "Review - Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", Pharmaceutical Research, (19950000), vol. 12, no. 7, XP000996386

DOI:   http://dx.doi.org/10.1023/A:1016241927429
    - X.-M. ZENG et al., Particulate Interactions in Dry Powder Formulations for Inhalation, (20010000), pages 220 - 224, XP055412049
    - The Merck Index, 12th ed., (19960000), pages 1614 - 1615, XP055412050
    - "International Nonproprietary Names for Pharmaceutical Substances", WHO Drug Information, (19930000), vol. 7, no. 3, pages 135 - 144, XP055412057
    - "Parts <696> and <941>", US Pharmacopoeia, (20120000), pages 1 - 3, 414, XP055412060
    - X.-M. ZENG et al., Particulate interactions in dry powder formulations for inhalation, (20010000), pages 150 - 156, XP055412061
    - G.H. WARD et al., "PROCESS-INDUCED CRYSTABILLINITY CHANGES IN ALBUTEROL SULFATE AND ITS EFFECT ON POWDER PHYSICAL STABILITY", Pharmaceut. Res., (19950000), vol. 12, pages 773 - 779, XP000891782

DOI:   http://dx.doi.org/10.1023/A:1016232230638
    - B. C. HANCOCK et al., "CHARACTERISTICS AND SIGNIFICANCE OF THE AMORPHOUS STATE IN PHARMACEUTICAL SYSTEMS", J. Pharm. Sci., (19970100), vol. 86, no. 1, pages 1 - 12, XP000929450

DOI:   http://dx.doi.org/10.1021/js9601896
    - X.-M. ZENG et al., Particulate interactions in dry powder formulations for inhalation, (20010000), pages 86 - 95, XP055412020
    - "Spiriva 18microg, inhalation powder in hard capsules", Public Assessment Report for RVG 26191 (SPIRIVA®), (20020521), pages 1 - 28, URL: https://db.cbg-meb.nl/Pars/h26191.pdf, XP055073045
    - New Zealand Gazette, (20011018), page 3565, 3594, XP055412142
    - "Tiotropium Bromide", Drugs of the Future, (20000000), vol. 25, no. 7, pages 693 - 699, XP055227955

DOI:   http://dx.doi.org/10.1358/dof.2000.025.07.584825
    - A. LEUSCH et al., "Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog", Biopharm. Drug Dispos., (20010000), vol. 22, pages 199 - 212, XP055412147

DOI:   http://dx.doi.org/10.1002/bdd.280
    - X.M. ZENG et al., Particulate Interactions in Dry Powder Formulations for Inhalation, (20110000), pages 30-31, 86-89, 136 - 138, 163-164, XP055412151
    - "Metered Dose Inhaler (MDI) and Dry Powder Inhaler (DPI) Drug Products", Draft Guidance for Industry, (19981000), pages 1 - 62, XP002510894
    - ELENA BOLDYREVA et al., Reactivity of Molecular Solids, (19990000), pages 241 - 242, XP055412154
    - Vogel's textbook of practical organic chemistry, (19890000), pages 135 - 153, XP055412009
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.