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Extract from the Register of European Patents

EP About this file: EP1985631

EP1985631 - Demannosylated recombinant factor VIII for the treatment of patients with hemophiila A [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  02.12.2011
Database last updated on 19.10.2024
Most recent event   Tooltip02.12.2011Application deemed to be withdrawnpublished on 04.01.2012  [2012/01]
Applicant(s)For all designated states
LFB Biotechnologies
3 Avenue des Tropiques
91940 Les Ulis / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
101, rue de Tolbiac
75654 Paris Cedex 13 / FR
[N/P]
Former [2008/48]For all designated states
LFB Biotechnologies
3 Avenue des Tropiques
91940 Les Ulis / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
101, Rue de Tolbiac
75654 Paris Cedex 13 / FR
Former [2008/44]For all designated states
LFB Biotechnologies
3 Avenue des Tropiques
91940 Les Ulis / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
UMR 872 (équipe 16) Centre de Recherche des Cordeliers 15, rue de l'Ecole de Médecine
75006 Paris / FR
Inventor(s)01 / Chtourou, Abdessatar Sami
20 avenue du Chateau
78990 Elancourt / FR
02 / Desmazes, Sebastien Lacroix
5 Promenade Robinson
92130 Issy-les-Moulineaux / FR
03 / Kaveri, Srinavas
15 rue Gerber
92240 Malakoff / FR
04 / Dasgupta, Suryasarathi, Brigham and Women's Hospital
Channing Lab., 6th Floor, 181 Longwood Avenue
Boston, MA 02115 / US
05 / Bayry, Jagaadeesh
4 Promenade Robinson
92130 Issy-les-Moulineaux / FR
 [2008/44]
Representative(s)Hirsch & Associés
154 Boulevard Haussmann
75008 Paris / FR
[N/P]
Former [2008/44]Hirsch & Associés
58, avenue Marceau
75008 Paris / FR
Application number, filing date07290495.620.04.2007
[2008/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1985631
Date:29.10.2008
Language:EN
[2008/44]
Search report(s)(Supplementary) European search report - dispatched on:EP10.10.2007
ClassificationIPC:C07K14/755, A61K38/37, C12N15/12
[2011/08]
CPC:
C07K14/755 (EP,KR,US); A61K38/37 (KR); A61P43/00 (EP);
A61P7/00 (EP); A61P7/02 (EP); A61P7/04 (EP);
C12N15/11 (KR); C12N15/63 (KR); A61K38/00 (EP,US) (-)
Former IPC [2008/44]C07K14/755, C12N15/12, A61K38/37, C12P21/00, // C12N5/10, C12N1/21, C12N1/15, A01K67/027
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2008/44]
TitleGerman:Entmannosierter rekombinanter Faktor VIII zur Behandlung von Patienten mit Hämophilie A[2008/44]
English:Demannosylated recombinant factor VIII for the treatment of patients with hemophiila A[2008/44]
French:Facteur VIII recombinant demannosylé pour le traitement de patients atteints de l'hémophilie A[2008/44]
Examination procedure29.04.2009Examination requested  [2009/24]
10.06.2009Despatch of a communication from the examining division (Time limit: M06)
18.12.2009Reply to a communication from the examining division
12.04.2010Despatch of a communication from the examining division (Time limit: M06)
07.10.2010Reply to a communication from the examining division
28.02.2011Communication of intention to grant the patent
11.07.2011Fee for grant paid
11.07.2011Fee for publishing/printing paid
12.07.2011Application deemed to be withdrawn, date of legal effect  [2012/01]
17.08.2011Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2012/01]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.06.2009
Fees paidRenewal fee
28.04.2009Renewal fee patent year 03
03.05.2010Renewal fee patent year 04
02.05.2011Renewal fee patent year 05
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Documents cited:Search[DX]US5633150  (WOOD WILLIAM I [US], et al) [DX] 21 * abstract *;
 [X]WO02096454  (D COLLEN RES FOUNDATION VZW [BE], et al) [X] 3,10,21-34 * abstract *;
 [A]US6759216  (LOLLAR JOHN S [US]) [A] 1-34 * the whole document *;
 [X]US2005100990  (SAENKO EVGUENI L [US], et al) [X] 1-3,6,7,10,21-34 * the whole document *;
 [X]  - MIAO HONGZHI Z ET AL, "Bioengineering of coagulation factor VIII for improved secretion", BLOOD, (20040501), vol. 103, no. 9, ISSN 0006-4971, pages 3412 - 3419, XP002452857 [X] 1,2,6,7,10,21-34 * the whole document *

DOI:   http://dx.doi.org/10.1182/blood-2003-10-3591
 [X]  - BARROW RACHEL T ET AL, "Antigenicity of putative phospholipid membrane-binding residues in factor VIII", BLOOD, (20010101), vol. 97, no. 1, ISSN 0006-4971, pages 169 - 174, XP002452858 [X] 3,10,21-34 * abstract *

DOI:   http://dx.doi.org/10.1182/blood.V97.1.169
 [A]  - BOVENSCHEN N ET AL, "The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor.", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH JUN 2005, (200506), vol. 3, no. 6, ISSN 1538-7933, pages 1257 - 1265, XP002452859 [A] 1-34 * abstract *

DOI:   http://dx.doi.org/10.1111/j.1538-7836.2005.01389.x
 [A]  - SAENKO E L ET AL, "The future of recombinant coagulation factors", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, BLACKWELL PUBLISHING, OXFORD, GB, (200305), vol. 1, no. 5, ISSN 1538-7933, pages 922 - 930, XP002320944 [A] 1-34 * the whole document *

DOI:   http://dx.doi.org/10.1046/j.1538-7836.2003.00196.x
 [PX]  - DASGUPTA SURYASARATHI ET AL, "A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+T lymphocytes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, online, (20070514), vol. 104, no. 21, ISSN 0027-8424, pages 8965 - 8970, XP002452860 [PX] 1-34 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.0702120104
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