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Extract from the Register of European Patents

EP About this file: EP2010663

EP2010663 - EXOSOME TRANSFER OF NUCLEIC ACIDS TO CELLS [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  31.03.2023
Database last updated on 03.04.2025
Most recent event   Tooltip19.04.2024Lapse of the patent in a contracting state
New state(s): ES		published on 22.05.2024  [2024/21]
Applicant(s)For all designated states
Codiak BioSciences, Inc.
19 Presidential Way
Woburn, MA 01801 / US
[2016/20]
Former [2015/12]For all designated states
Lötvall, Jan Olof
Trädgårdsvägen 3A
435 35 Mölnlycke / SE
For all designated states
Valadi, Hadi
Östra Gunnesgärde 4D
417 49 Göteborg / SE
Former [2009/02]For all designated states
Lötvall, Jan Olof
Trädgårdsvägen 3A
435 35 Mölnlycke / SE
For all designated states
Valadi, Hadi
Östra Gunnesgärde 4D
417 49 Göteborg / SE
Inventor(s)01 / Lötvall, Jan Olof
Trädgårdsvägen 3A
435 35 Mölnlycke / SE
02 / Valadi, Hadi
Östra Gunnesgärde 4D
417 49 Göteborg / SE
[N/P]
Former [2009/02]01 / see applicant
...
Representative(s)Zwicker, Jörk
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[N/P]
Former [2013/01]Zakrisson, Ulrika
Awapatent AB
P.O. Box 45086
104 30 Stockholm / SE
Former [2012/08]Zakrisson, Ulrika
Awapatent AB
Box 11394
404 28 Göteborg / SE
Former [2009/02]Fagerlin, Heléne
Albihns AB P.O. Box 5581
114 85 Stockholm / SE
Application number, filing date07748459.002.05.2007
[2009/02]
WO2007SE50298
Priority number, dateUS20060797149P03.05.2006         Original published format: US 797149 P
US2007079914830.04.2007         Original published format: US 799148
[2009/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2007126386
Date:08.11.2007
Language:EN
[2007/45]
Type: A1 Application with search report 
No.:EP2010663
Date:07.01.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 08.11.2007 takes the place of the publication of the European patent application.
[2009/02]
Type: B1 Patent specification 
No.:EP2010663
Date:18.03.2015
Language:EN
[2015/12]
Search report(s)International search report - published on:SE08.11.2007
(Supplementary) European search report - dispatched on:EP18.10.2010
ClassificationIPC:C12N15/87, A61K48/00
[2009/02]
CPC:
C12N15/87 (EP,CN,US); A61K48/0033 (US); A61P31/00 (EP);
A61P35/00 (EP,US); C12N15/113 (US); A61K48/00 (EP,CN,US);
C12N2310/14 (US); C12N2320/32 (US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/02]
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:EXOSOMER TRANSFER VON NUKLEINSÄUREN AUF ZELLEN[2009/02]
English:EXOSOME TRANSFER OF NUCLEIC ACIDS TO CELLS[2009/02]
French:TRANSFERT D'EXOSOMES D'ACIDES NUCLÉIQUES À DES CELLULES[2009/02]
Entry into regional phase05.11.2008National basic fee paid 
05.11.2008Search fee paid 
05.11.2008Designation fee(s) paid 
05.11.2008Examination fee paid 
Examination procedure05.11.2008Examination requested  [2009/02]
03.05.2011Amendment by applicant (claims and/or description)
06.07.2011Despatch of a communication from the examining division (Time limit: M06)
16.01.2012Reply to a communication from the examining division
23.05.2012Observations by third parties
27.06.2012Despatch of a communication from the examining division (Time limit: M04)
06.11.2012Reply to a communication from the examining division
17.06.2013Despatch of a communication from the examining division (Time limit: M04)
23.10.2013Reply to a communication from the examining division
26.09.2014Cancellation of oral proceeding that was planned for 08.10.2014
08.10.2014Date of oral proceedings (cancelled)
23.10.2014Communication of intention to grant the patent
06.02.2015Fee for grant paid
06.02.2015Fee for publishing/printing paid
06.02.2015Receipt of the translation of the claim(s)
Divisional application(s)EP15158949.6  / EP2905339
EP18158203.2  / EP3378942
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.07.2011
Opposition(s)Opponent(s)01  17.12.2015  06.01.2016  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks, Kent TN13 1XR / GB
 02  18.12.2015  06.01.2016  ADMISSIBLE
Dr. H. Ulrich Dörries
Fünf Höfe, Theatinerstr. 16
80333 München / DE
Opponent's representative
Dörries, Hans Ulrich
Df-mp
Fünf Höfe
Theatinerstrasse 16
80333 München / DE
 [N/P]
Former [2018/51]
Opponent(s)01  17.12.2015  06.01.2016  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Elkington & Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks
Kent TN13 1XR / GB
 02  18.12.2015  06.01.2016  ADMISSIBLE
Dr. H. Ulrich Dörries
Fünf Höfe, Theatinerstr. 16
80333 München / DE
Opponent's representative
Dörries, Hans Ulrich
df-mp
Fünf Höfe
Theatinerstrasse 16
80333 München / DE
Former [2016/29]
Opponent(s)01  17.12.2015  06.01.2016  ADMISSIBLE
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Truscott, Glyn John
Elkington and Fife LLP
Thavies Inn House
3-4 Holborn Circus
London EC1N 2HA / GB
 02  18.12.2015  06.01.2016  ADMISSIBLE
Dr. H. Ulrich Dörries
Fünf Höfe, Theatinerstr. 16
80333 München / DE
Opponent's representative
Dörries, Hans Ulrich
df-mp
Fünf Höfe
Theatinerstrasse 16
80333 München / DE
Former [2016/04]
Opponent(s)01  17.12.2015   
James Poole Limited
One Southampton Row
London WC1B 5HA / GB
Opponent's representative
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
 02  18.12.2015    ADMISSIBLE
Dr. H. Ulrich Dörries
Fünf Höfe, Theatinerstr. 16
80333 München / DE
Opponent's representative
Dörries, Hans Ulrich
df-mp
Fünf Höfe
Theatinerstrasse 16
80333 München / DE
27.01.2016Invitation to proprietor to file observations on the notice of opposition
03.08.2016Reply of patent proprietor to notice(s) of opposition
29.11.2017Date of oral proceedings
24.05.2018Despatch of minutes of oral proceedings
25.05.2018Despatch of interlocutory decision in opposition
13.03.2023Despatch of communication that the patent will be revoked
23.03.2023Legal effect of revocation of patent [2023/18]
Appeal following opposition03.08.2018Appeal received No.  T1856/18
04.10.2018Statement of grounds filed
08.03.2023Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
13.03.2023Despatch of the decision of the Board of Appeal
17.07.2018Appeal received No.  T1856/18
04.10.2018Statement of grounds filed
08.03.2023Result of appeal procedure: REVOCATION OF PATENT AT PROPRIETOR'S REQUEST
13.03.2023Despatch of the decision of the Board of Appeal
Fees paidRenewal fee
05.11.2008Renewal fee patent year 03
24.05.2010Renewal fee patent year 04
20.05.2011Renewal fee patent year 05
05.05.2012Renewal fee patent year 06
08.05.2013Renewal fee patent year 07
28.03.2014Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU02.05.2007
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
TR18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
IE02.05.2022
ES03.05.2022
CH31.05.2022
FR31.05.2022
LI31.05.2022
DE01.12.2022
[2024/21]
Former [2023/23]HU02.05.2007
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
TR18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
IE02.05.2022
CH31.05.2022
FR31.05.2022
LI31.05.2022
DE01.12.2022
Former [2023/22]HU02.05.2007
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
TR18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
IE02.05.2022
CH31.05.2022
FR31.05.2022
LI31.05.2022
Former [2023/20]HU02.05.2007
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
TR18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
IE02.05.2022
CH31.05.2022
LI31.05.2022
Former [2023/09]HU02.05.2007
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
TR18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
CH31.05.2022
LI31.05.2022
Former [2017/39]HU02.05.2007
AT18.03.2015
BE18.03.2015
BG18.03.2015
CY18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
TR18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2017/03]AT18.03.2015
BE18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2016/37]AT18.03.2015
BE18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2016/12]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SI18.03.2015
SK18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2016/07]AT18.03.2015
CZ18.03.2015
DK18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2016/06]AT18.03.2015
CZ18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
LU02.05.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2015/51]AT18.03.2015
CZ18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2015/50]CZ18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
PL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
GR19.06.2015
IS18.07.2015
PT20.07.2015
Former [2015/49]CZ18.03.2015
EE18.03.2015
FI18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
RO18.03.2015
SE18.03.2015
SK18.03.2015
GR19.06.2015
PT20.07.2015
Former [2015/41]FI18.03.2015
LT18.03.2015
LV18.03.2015
NL18.03.2015
SE18.03.2015
GR19.06.2015
Former [2015/39]FI18.03.2015
LT18.03.2015
LV18.03.2015
SE18.03.2015
GR19.06.2015
Former [2015/37]FI18.03.2015
LT18.03.2015
SE18.03.2015
GR19.06.2015
Former [2015/36]FI18.03.2015
LT18.03.2015
SE18.03.2015
Former [2015/35]LT18.03.2015
Documents cited:Search[X]WO0136601  (CHIRON SPA [IT], et al) [X] 12,13 * claims 1,12 *;
 [X]WO03016522  (ANOSYS INC [US], et al) [X] 12-14* claims 1,21,23 *;
 [XI]US2004028692  (ZITVOGEL LAURENCE [FR], et al) [X] 1,3,4,6-14 * paragraphs [0105] - [0109] - [0348]; claims 5,9,34-37; table 1 * [I] 2,5;
 [XI]WO2005121369  (SOURCEPHARM INC [US], et al) [X] 1,3,4,6-14 * page 15, lines 15-20 * * page 17, line 5 - page 19, line 21 * * page 23, line 19 - page 25, line 9 * [I] 2,5;
 [XI]  - RATAJCZAK J ET AL, "Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery", LEUKEMIA, MACMILLAN PRESS LTD, US LNKD- DOI:10.1038/SJ.LEU.2404132, (20060501), vol. 20, no. 5, ISSN 0887-6924, pages 847 - 856, XP002456317 [X] 12,13 * page 852, column 1, paragraph 2 * * page 852, column 2, paragraph 2; figure 4; table 3 * * page 852, column 2, paragraph 1 - page 853, column 2, paragraph 1 * [I] 1-11,14

DOI:   http://dx.doi.org/10.1038/sj.leu.2404132
 [X]  - COUZIN JENNIFER, "Cell biology: The ins and outs of exosomes.", SCIENCE (NEW YORK, N.Y.) 24 JUN 2005 LNKD- PUBMED:15976285, (20050624), vol. 308, no. 5730, ISSN 1095-9203, pages 1862 - 1863, XP002603035 [X] 1,3,5-10,12-14 * page 1863, column 1, paragraph 1 *
International search[A]WO0136601  (CHIRON SPA [IT], et al);
 [A]WO03016522  (ANOSYS INC [US], et al);
 [A]  - DELCAYRE A. ET AL., "Exosomes as novel therapeutic nanodevices", CURRENT OPINION IN MOLECULAR THERAPEUTICS, (2006), vol. 8, no. 1, pages 31 - 38, XP008074288
 [T]  - VALADI H. ET AL., "Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells", NATURE CELL BIOLOGY, (20070606), vol. 9, no. 6, pages 654 - 659, XP003016816

DOI:   http://dx.doi.org/10.1038/ncb1596
 [A]  - BAJ-KRZYWORZEKA M. ET AL., "Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes", CANCER IMMUNOL. IMMUNOTHER., (2006), vol. 55, pages 808 - 818, XP019333260

DOI:   http://dx.doi.org/10.1007/s00262-005-0075-9
ExaminationWO2010119256
    - GEHL J, "Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research.", ACTA PHYSIOLOGICA SCANDINAVICA APR 2003, (200304), vol. 177, no. 4, ISSN 0001-6772, pages 437 - 447
    - J. WAHLGREN ET AL, "Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes", NUCLEIC ACIDS RESEARCH, (20120522), vol. 40, no. 17, doi:10.1093/nar/gks463, ISSN 0305-1048, pages e130 - e130, XP055099539

DOI:   http://dx.doi.org/10.1093/nar/gks463
by applicantWO0136601
 WO03016522
 US2004028693
 WO2005121369
    - J. RATAJCZAK ET AL., LEUKEMIA, (2006), vol. 20, pages 847 - 856
    - J. COUZIN, "The Ins and Outs of Exosomes", SCIENCE, (2005), vol. 308, no. 5730, pages 1862 - 1863, XP002603035
otherWO2010119256
Opposition   - VAN DER POL, E. et al., Pharmacol Rev, (20120000), vol. 64, no. 3, pages 676 - 705, XP055155968

DOI:   http://dx.doi.org/10.1124/pr.112.005983
    - LÖTVALL, J. et al., J Extracell Vesicles, (20140000), vol. 3, pages 26913-1 - 26913-6, XP055341684

DOI:   http://dx.doi.org/10.3402/jev.v3.26913
    - LENER T. et al., J Extracell Vesicles, (20151231), vol. 4, pages 30087-1 - 30087-31, XP055336989

DOI:   http://dx.doi.org/10.3402/jev.v4.30087
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.