EP2043685 - PREVENTION OF RASH IN PATIENTS UNDERGOING ANTI-EGFR THERAPY [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 28.10.2016 Database last updated on 03.06.2024 | Most recent event Tooltip | 17.08.2018 | Lapse of the patent in a contracting state New state(s): BG | published on 19.09.2018 [2018/38] | Applicant(s) | For all designated states Genmab A/S Bredgade 34 E 1260 Copenhagen K / DK | [2013/12] |
Former [2009/19] | For all designated states Genmab A/S Bredgade 34 P.O. Box 9068 1260 Copenhagen K / DK | ||
Former [2009/15] | For all designated states Genmab A/S Toldbodgade 33 1253 Copenhagen K / DK | Inventor(s) | 01 /
EDVARDSEN, Klaus Klampenborgvej 26 2930 Klampenborg / DK | 02 /
LISBY, Steen Nyelandsvej 83, 3.tv. 2000 Frederiksberg / DK | 03 /
BAADSGAARD, Ole Tuborg Sundpark 10, 1.tv 2900 Hellerup / DK | [2009/15] | Representative(s) | Genmab A/S Carl Jacobsens Vej 30 2500 Valby / DK | [N/P] |
Former [2015/52] | Genmab A/S Bredgade 34 E 1260 Copenhagen K / DK | ||
Former [2012/09] | Genmab A/S Bredgade 34 P.O. Box 9068 1260 Copenhagen K / DK | ||
Former [2010/11] | Jensen, Dorte Kold Genmab A/S Bredgade 34 P.O. Box 9068 1260 Copenhagen K / DK | ||
Former [2009/17] | Abildgren, Michael Padkjaer Genmab A/S Toldbodgade 33 P.O. Box 9068 DK-1253 Copenhagen K / DK | Application number, filing date | 07764464.9 | 03.07.2007 | [2009/15] | WO2007DK00334 | Priority number, date | DK20060000915 | 03.07.2006 Original published format: DK 200600915 | DK20070000727 | 15.05.2007 Original published format: DK 200700727 | DK20070000901 | 22.06.2007 Original published format: DK 200700901 | [2009/15] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2008003317 | Date: | 10.01.2008 | Language: | EN | [2008/02] | Type: | A1 Application with search report | No.: | EP2043685 | Date: | 08.04.2009 | Language: | EN | The application published by WIPO in one of the EPO official languages on 10.01.2008 takes the place of the publication of the European patent application. | [2009/15] | Type: | B1 Patent specification | No.: | EP2043685 | Date: | 23.12.2015 | Language: | EN | [2015/52] | Search report(s) | International search report - published on: | EP | 10.01.2008 | Classification | IPC: | A61P17/00, A61K39/395 | [2015/30] | CPC: |
C07K16/2863 (EP,US);
A61K39/3955 (EP,US);
A61K45/06 (EP,US);
A61P17/00 (EP);
A61P37/06 (EP);
C07K16/244 (EP,US);
A61K2039/507 (EP,US)
(-)
| C-Set: |
A61K39/3955, A61K2300/00 (EP,US)
|
Former IPC [2009/15] | A61K39/395 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2015/52] |
Former [2009/15] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR | Extension states | AL | 03.02.2009 | BA | 03.02.2009 | HR | 03.02.2009 | MK | 03.02.2009 | RS | 03.02.2009 | Title | German: | PRÄVENTION VON HAUTAUSSCHLAG BEI PATIENTEN IN ANTI-EGFR-THERAPIE | [2015/30] | English: | PREVENTION OF RASH IN PATIENTS UNDERGOING ANTI-EGFR THERAPY | [2009/15] | French: | PRÉVENTION D'UNE ÉRUPTION CUTANÉE SUR DES PATIENTS SUBISSANT UNE THÉRAPIE ANTI-EGFR | [2009/15] |
Former [2009/15] | PRÄVENTION VON HAUTAUSSCHLAG BEI PATIENTEN UNTER EINER ANTI-EGFR-THERAPIE | Entry into regional phase | 03.02.2009 | National basic fee paid | 03.02.2009 | Designation fee(s) paid | 03.02.2009 | Examination fee paid | Examination procedure | 03.02.2009 | Examination requested [2009/15] | 10.02.2009 | Amendment by applicant (claims and/or description) | 27.09.2013 | Despatch of a communication from the examining division (Time limit: M06) | 08.05.2014 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 10.07.2014 | Reply to a communication from the examining division | 18.06.2015 | Cancellation of oral proceeding that was planned for 06.07.2015 | 02.07.2015 | Communication of intention to grant the patent | 06.07.2015 | Date of oral proceedings (cancelled) | 28.10.2015 | Fee for grant paid | 28.10.2015 | Fee for publishing/printing paid | 28.10.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 27.09.2013 | Opposition(s) | 26.09.2016 | No opposition filed within time limit [2016/48] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 10.07.2014 | Request for further processing filed | 10.07.2014 | Full payment received (date of receipt of payment) Request granted | 22.07.2014 | Decision despatched | Fees paid | Renewal fee | 31.07.2009 | Renewal fee patent year 03 | 14.07.2010 | Renewal fee patent year 04 | 12.07.2011 | Renewal fee patent year 05 | 13.07.2012 | Renewal fee patent year 06 | 10.07.2013 | Renewal fee patent year 07 | 14.07.2014 | Renewal fee patent year 08 | 10.07.2015 | Renewal fee patent year 09 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 03.07.2007 | AT | 23.12.2015 | BE | 23.12.2015 | BG | 23.12.2015 | CY | 23.12.2015 | CZ | 23.12.2015 | DK | 23.12.2015 | EE | 23.12.2015 | ES | 23.12.2015 | FI | 23.12.2015 | IT | 23.12.2015 | LT | 23.12.2015 | LV | 23.12.2015 | MC | 23.12.2015 | NL | 23.12.2015 | PL | 23.12.2015 | RO | 23.12.2015 | SE | 23.12.2015 | SI | 23.12.2015 | SK | 23.12.2015 | TR | 23.12.2015 | GR | 24.03.2016 | IS | 23.04.2016 | PT | 26.04.2016 | IE | 03.07.2016 | LU | 03.07.2016 | CH | 31.07.2016 | LI | 31.07.2016 | MT | 31.07.2016 | [2018/38] |
Former [2018/33] | HU | 03.07.2007 | |
AT | 23.12.2015 | ||
BE | 23.12.2015 | ||
CY | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
MC | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SI | 23.12.2015 | ||
SK | 23.12.2015 | ||
TR | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
IE | 03.07.2016 | ||
LU | 03.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
MT | 31.07.2016 | ||
Former [2018/29] | HU | 03.07.2007 | |
AT | 23.12.2015 | ||
BE | 23.12.2015 | ||
CY | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
MC | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SI | 23.12.2015 | ||
SK | 23.12.2015 | ||
TR | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
IE | 03.07.2016 | ||
LU | 03.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
Former [2018/28] | HU | 03.07.2007 | |
AT | 23.12.2015 | ||
BE | 23.12.2015 | ||
CY | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
MC | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SI | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
IE | 03.07.2016 | ||
LU | 03.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
Former [2017/41] | AT | 23.12.2015 | |
BE | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
MC | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SI | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
IE | 03.07.2016 | ||
LU | 03.07.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
Former [2017/22] | AT | 23.12.2015 | |
BE | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
MC | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SI | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
CH | 31.07.2016 | ||
LI | 31.07.2016 | ||
Former [2017/13] | AT | 23.12.2015 | |
BE | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
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IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SI | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
Former [2017/03] | AT | 23.12.2015 | |
BE | 23.12.2015 | ||
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
Former [2016/46] | AT | 23.12.2015 | |
CZ | 23.12.2015 | ||
DK | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
Former [2016/38] | AT | 23.12.2015 | |
CZ | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
IS | 23.04.2016 | ||
PT | 26.04.2016 | ||
Former [2016/36] | AT | 23.12.2015 | |
CZ | 23.12.2015 | ||
EE | 23.12.2015 | ||
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
IT | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
PL | 23.12.2015 | ||
RO | 23.12.2015 | ||
SE | 23.12.2015 | ||
SK | 23.12.2015 | ||
GR | 24.03.2016 | ||
Former [2016/35] | CZ | 23.12.2015 | |
ES | 23.12.2015 | ||
FI | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
SE | 23.12.2015 | ||
GR | 24.03.2016 | ||
Former [2016/34] | CZ | 23.12.2015 | |
FI | 23.12.2015 | ||
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
SE | 23.12.2015 | ||
GR | 24.03.2016 | ||
Former [2016/26] | FI | 23.12.2015 | |
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
NL | 23.12.2015 | ||
SE | 23.12.2015 | ||
GR | 24.03.2016 | ||
Former [2016/25] | FI | 23.12.2015 | |
LT | 23.12.2015 | ||
LV | 23.12.2015 | ||
SE | 23.12.2015 | ||
GR | 24.03.2016 | ||
Former [2016/24] | FI | 23.12.2015 | |
LT | 23.12.2015 | ||
SE | 23.12.2015 | ||
GR | 24.03.2016 | ||
Former [2016/20] | LT | 23.12.2015 | Cited in | International search | [DXY]WO2004056847 (GENMAB AS [DK], et al) [DX] 42-44,46,47,42-44,46,47,42-44,46,47 * page 20 * * page 65, paragraph 4 * * figures 13,14 * * claims 7,19-24,42-47 * * page 20 * * page 65, paragraph 4 * * figures 13,14 * * claims 7,19-24,42-47 * * page 20 * * page 65, paragraph 4 * * figures 13,14 * * claims 7,19-24,42-47 * [Y] 1-35,45,1-35,45,1-35,45; | [DXY]WO2004058797 (MEDAREX INC [US], et al) [DX] 42-44,46,47,42-44,46,47,42-44,46,47 * page 45 * * example 2 * * claim 7 * * page 45 * * example 2 * * claim 7 * * page 45 * * example 2 * * claim 7 * [Y] 1-35,45,1-35,45,1-35,45; | [X] - SALCEDO ROSALBA ET AL, "Combined administration of antibodies to human interleukin 8 and epidermal growth factor receptor results in increased antimetastatic effects on human breast carcinoma xenografts.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AUG 2002, (200208), vol. 8, no. 8, ISSN 1078-0432, pages 2655 - 2665, XP002451870 [X] 1-47,1-47,1-47 * the whole document * * the whole document * * the whole document * | [ ] - GENESEQ, Derwent, (20040923), Database accession no. ADQ26403, URL: HTTP://WWW.EBI.AC.UK/CGI-BIN/EPO/EPOFETCH [ ] * column A * * column A * * column A * | [ ] - GENESEQ, Derwent, (20041007), Database accession no. ADQ75769, URL: HTTP://WWW.EBI.AC.UK/CGI-BIN/EPO/EPOFETCH [ ] * column A * * column A * * column A * | [ ] - GENESEQ, Derwent, (20041007), Database accession no. ADQ75777, URL: HTTP://WWW.EBI.AC.UK/CGI-BIN/EPO/EPOFETCH [ ] * column A * * column A * * column A * | [A] - PÉREZ-SOLER ROMÁN ET AL, "HER1/EGFR inhibitor-associated rash: future directions for management and investigation outcomes from the HER1/EGFR inhibitor rash management forum.", THE ONCOLOGIST MAY 2005, (200505), vol. 10, no. 5, ISSN 1083-7159, pages 345 - 356, XP002451871 [A] 1-47,1-47,1-47 * the whole document * * the whole document * * the whole document * DOI: http://dx.doi.org/10.1634/theoncologist.10-5-345 | [PX] - HOCHSTER H S ET AL, "Consensus report of the International Society of Gastrointestinal Oncology on therapeutic progress in advanced pancreatic cancer", CANCER 15 AUG 2006 UNITED STATES, (20060717), vol. 107, no. 4, ISSN 0008-543X 1097-0142, pages 676 - 685, XP002451872 [PX] 1-47,1-47,1-47 * the whole document * * the whole document * * the whole document * | [A] - MASCIA F ET AL, "Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, (200307), vol. 163, no. 1, ISSN 0002-9440, pages 303 - 312, XP002410413 [A] 1-47,1-47,1-47 * the whole document * * the whole document * * the whole document * | [A] - KARASHIMA T ET AL, "INHIBITION OF ANGIOGENESIS BY THE ANTIEPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY IMCLONE C225 IN ANDROGEN-INDEPENDENT PROSTATE CANCER GROWING ORTHOTOPICALLY IN NUDE MICE", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (200205), vol. 8, no. 4, ISSN 1078-0432, pages 1253 - 1264, XP001149163 [A] 1-47,1-47,1-47 * the whole document * * the whole document * * the whole document * | [A] - BRUNS C J ET AL, "EPIDERMAL GROWTH FACTOR RECEPTOR BLOCKADE WITH C225 PLUS GEMCITABINE RESULTS IN REGRESSION OF HUMAN PANCREATIC CARCINOMA GROWING ORTHOTOPICALLY IN NUDE MICE BY ANTIANGIOGENIC MECHANISMS", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (200005), vol. 6, ISSN 1078-0432, pages 1936 - 1948, XP002951102 [A] 1-47,1-47,1-47 * abstract * * abstract * * abstract * | [A] - ASAKUMA ET AL, "Modulation of Tumor Growth and Tumor Induced Angiogenesis After Epidermal Growth Factor Receptor Inhibition by ZD1839 in Renal Cell Carcinoma", JOURNAL OF UROLOGY, BALTIMORE, MD, US, (200402), vol. 171, no. 2, ISSN 0022-5347, pages 897 - 902, XP005532687 [A] 1-47,1-47,1-47 * abstract * * abstract * * abstract * DOI: http://dx.doi.org/10.1097/01.ju.0000095445.79222.ff | Examination | - Nannie Bangsgaard ET AL, "Neutralization of IL-8 Prevents the Induction of Dermatologic Adverse Events Associated with the Inhibition of Epidermal Growth Factor Receptor", PLoS ONE, (20120625), vol. 7, no. 6, doi:10.1371/journal.pone.0039706, page e39706, XP055172165 DOI: http://dx.doi.org/10.1371/journal.pone.0039706 |