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Extract from the Register of European Patents

EP About this file: EP2016101

EP2016101 - BINDING POLYPEPTIDES WITH OPTIMIZED SCAFFOLDS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  26.11.2010
Database last updated on 07.10.2024
Most recent event   Tooltip26.11.2010Application deemed to be withdrawnpublished on 29.12.2010  [2010/52]
Applicant(s)For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco, CA 94080-4990 / US
[N/P]
Former [2009/04]For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco CA 94080-4990 / US
Former [2008/38]For all designated states
Genentech, Inc.
1 DNA Way
South San Francisco, CA 94080 / US
Inventor(s)01 / BARTHELEMY, Pierre A.
1400 Floribunda Avenue, Apt. 305
Burlingame, California 94010 / US
02 / SIDHU, Sachdev, S.
135 Brunswick Avenue
Toronto, Ontario M5S 2M3 / CA
 [2009/04]
Representative(s)Kiddle, Simon John, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2009/04]Kiddle, Simon John, et al
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Application number, filing date07797370.908.05.2007
[2009/04]
WO2007US68469
Priority number, dateUS20060798812P09.05.2006         Original published format: US 798812 P
US20060866370P17.11.2006         Original published format: US 866370 P
US20070886994P29.01.2007         Original published format: US 886994 P
[2009/04]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2007134050
Date:22.11.2007
Language:EN
[2007/47]
Type: A2 Application without search report 
No.:EP2016101
Date:21.01.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 22.11.2007 takes the place of the publication of the European patent application.
[2009/04]
Search report(s)International search report - published on:EP25.09.2008
ClassificationIPC:C07K16/32
[2009/04]
CPC:
C07K16/005 (EP,US); C07K16/00 (US); C07K16/32 (EP,US);
C07K2317/24 (EP,US); C07K2317/56 (US); C07K2317/565 (EP,US);
C07K2317/567 (EP,US); C07K2317/569 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/04]
Extension statesAL18.11.2008
BA18.11.2008
HR18.11.2008
MK18.11.2008
RS18.11.2008
TitleGerman:BINDUNG VON POLYPEPTIDEN MIT OPTIMIERTEN GERÜSTEN[2009/04]
English:BINDING POLYPEPTIDES WITH OPTIMIZED SCAFFOLDS[2009/04]
French:POLYPEPTIDES DE LIAISON À SQUELETTES OPTIMISÉS[2009/04]
Entry into regional phase18.11.2008National basic fee paid 
18.11.2008Designation fee(s) paid 
18.11.2008Examination fee paid 
Examination procedure06.11.2008Amendment by applicant (claims and/or description)
18.11.2008Examination requested  [2009/04]
30.06.2009Despatch of a communication from the examining division (Time limit: M06)
07.01.2010Reply to a communication from the examining division
25.02.2010Despatch of a communication from the examining division (Time limit: M04)
08.07.2010Application deemed to be withdrawn, date of legal effect  [2010/52]
13.08.2010Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2010/52]
Fees paidRenewal fee
12.05.2009Renewal fee patent year 03
31.03.2010Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[A]WO2006030220  (DOMANTIS LTD [GB], et al) [A] 1-7,16,17,24,32,33,36,37,61-69 * sequences 9, 21-22, 26, 30-33, 45, 63, 76-77, 80, 285, 288 * * sequences 329, 337, 347, 356 *;
 [E]WO2007085815  (DOMANTIS LTD [GB], et al) [E] 1-7,16,17,24,32,33,36,37,61-69 * sequences 175, 176, 180, 190, 191, 199-204 * * sequences 206-222, 225-262, 264-293, 296-309 * * sequences 312-322, 326-330, 332, 334, 342, 346, 2435 * * table 16 *;
 [DX]  - JESPERS L ET AL, "Crystal Structure of HEL4, a Soluble, Refoldable Human VH Single Domain with a Germ-line Scaffold", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, (20040402), vol. 337, no. 4, ISSN 0022-2836, pages 893 - 903, XP004496018 [DX] 1-7,61-69 * page 897, column RIGHT - page 900, column LEFT *

DOI:   http://dx.doi.org/10.1016/j.jmb.2004.02.013
 [X]  - UEDA H ET AL, "Stabilization of antibody VH-domains by proteolytic selection", JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC, ELSEVIER, AMSTERDAM,, NL, (2004), vol. 28, ISSN 1381-1177, pages 173 - 179, XP003016163 [X] 1-5,61-69 * table 1 *

DOI:   http://dx.doi.org/10.1016/j.molcatb.2003.12.018
 [X]  - DAVIES J ET AL, "SINGLE ANTIBODY DOMAINS AS SMALL RECOGNITION UNITS: DESIGN AND IN VITRO ANTIGEN SELECTION OF CAMELIZED, HUMAN VH DOMAINS WITH IMPROVED PROTEIN STABILITY", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, (1996), vol. 9, no. 6, ISSN 0269-2139, pages 531 - 537, XP000971767 [X] 1-7,61-69 * the whole document *
 [A]  - RUDIKOFF S ET AL, "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, (198203), vol. 79, no. 6, ISSN 0027-8424, pages 1979 - 1983, XP002986051 [A] 1-7,16,17,24,32,33,36,37 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.79.6.1979
 [A]  - WILLUDA J ET AL, "High thermal stability is essential for tumor targeting of antibody fragments: Engineering of a humanized anti-epithelial glycoprotein-2 (epithelial cell adhesion molecule) single-chain Fv fragment", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, (19991115), vol. 59, no. 22, ISSN 0008-5472, pages 5758 - 5767, XP002249463 [A] * the whole document *
 [A]  - NIEBA L ET AL, "Disrupting the hydrophobic patches at the antibody variable/constant domain interface: Improved in vivo folding and physical characterization of an engineered scFv fragment", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, (1997), vol. 10, no. 4, ISSN 0269-2139, pages 435 - 444, XP002249462 [A] * the whole document *

DOI:   http://dx.doi.org/10.1093/protein/10.4.435
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.