EP2083011 - PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.04.2015 Database last updated on 02.09.2024 | Most recent event Tooltip | 15.07.2016 | Lapse of the patent in a contracting state New state(s): MT | published on 17.08.2016 [2016/33] | Applicant(s) | For all designated states Tianjin Hemay Bio-Tech Co., Ltd Xiao Yuan Xin Cun 31-101 Teda Tianjin 300457 / CN | [N/P] |
Former [2014/22] | For all designated states Tianjin Hemay Bio-Tech Co., Ltd. Xiao Yuan Xin Cun 31-101 Teda Tianjin 300457 / CN | ||
Former [2009/31] | For all designated states Tian Jin Hemay Bio-Tech Co., Ltd. Xiao Yuan Xin Cun 31-101 Teda Tianjin 300457 / CN | Inventor(s) | 01 /
ZHANG, Hesheng Xiao Yuan Xin Cun 31-101 Teda Tianjin 300457 / CN | [2014/23] |
Former [2009/31] | 01 /
ZHANG, Hesheng Xiao Yuan Xin Cun 31-101 Teda Tianjin 300457 / CN | Representative(s) | Korga, Leokadia Kancelaria Rzecznika Patentowego ul. Bereniki 6/7 44-117 Gliwice / PL | [N/P] |
Former [2014/23] | Korga, Leokadia Kancelaria Rzecznika Patentowego ul. Bereniki 6/7 44-117 Gliwice / PL | ||
Former [2009/31] | Korga, Leokadia Kancelaria Rzecznika Patentowego ul. Bereniki 6/7 44-117 Gliwice / PL | Application number, filing date | 07816579.2 | 16.10.2007 | [2009/31] | WO2007CN02965 | Priority number, date | CN200610129421 | 15.11.2006 Original published format: CN200610129421 | [2009/31] | Filing language | ZH | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2008058448 | Date: | 22.05.2008 | Language: | ZH | [2008/21] | Type: | A1 Application with search report | No.: | EP2083011 | Date: | 29.07.2009 | Language: | EN | [2009/31] | Type: | B1 Patent specification | No.: | EP2083011 | Date: | 04.06.2014 | Language: | EN | [2014/23] | Search report(s) | International search report - published on: | CN | 22.05.2008 | (Supplementary) European search report - dispatched on: | EP | 09.02.2011 | Classification | IPC: | C07D495/04, C07D487/04, A61K31/4365, A61K31/437, A61P35/00, A61P31/00, A61P37/00, A61P9/00, A61P9/10, A61P5/00 | [2009/31] | CPC: |
C07D487/04 (EP,KR,US);
C07D495/04 (EP,KR,US);
A61K31/4365 (KR);
A61P1/00 (EP);
A61P1/16 (EP);
A61P13/12 (EP);
A61P17/06 (EP);
A61P19/02 (EP);
A61P25/00 (EP);
A61P29/00 (EP);
A61P31/00 (EP);
A61P31/04 (EP);
A61P33/06 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/00 (EP);
A61P37/06 (EP);
A61P39/00 (EP);
A61P43/00 (EP);
A61P5/00 (EP);
A61P7/00 (EP);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2009/31] | Extension states | AL | 15.06.2009 | BA | 15.06.2009 | HR | 15.06.2009 | MK | 15.06.2009 | RS | 15.06.2009 | Title | German: | PYRROLINDERIVATE GEGEN TUMORNEKROSEFAKTOR FREISETZENDE ZELLEN, HERSTELLUNGSVERFAHREN UND ANWENDUNGEN DAVON | [2009/31] | English: | PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF | [2009/31] | French: | DÉRIVÉS DE PYRROLINE AGISSANT CONTRE LES CELLULES LIBÉRANT LE FACTEUR DE NÉCROSE TUMORALE, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS ASSOCIÉS | [2009/31] | Entry into regional phase | 15.06.2009 | Translation filed | 31.03.2009 | National basic fee paid | 31.03.2009 | Search fee paid | 31.03.2009 | Designation fee(s) paid | 31.03.2009 | Examination fee paid | Examination procedure | 31.03.2009 | Examination requested [2009/31] | 28.10.2011 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time | 16.12.2011 | Amendment by applicant (claims and/or description) | 01.02.2012 | Despatch of a communication from the examining division (Time limit: M04) | 01.06.2012 | Reply to a communication from the examining division | 09.01.2013 | Despatch of a communication from the examining division (Time limit: M04) | 12.04.2013 | Reply to a communication from the examining division | 11.12.2013 | Communication of intention to grant the patent | 08.04.2014 | Receipt of the translation of the claim(s) | 09.04.2014 | Fee for grant paid | 09.04.2014 | Fee for publishing/printing paid | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.02.2012 | Opposition(s) | 05.03.2015 | No opposition filed within time limit [2015/20] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 13.12.2011 | Request for further processing filed | 13.12.2011 | Full payment received (date of receipt of payment) Request granted | 30.12.2011 | Decision despatched | Fees paid | Renewal fee | 20.10.2009 | Renewal fee patent year 03 | 09.10.2010 | Renewal fee patent year 04 | 28.09.2011 | Renewal fee patent year 05 | 10.10.2012 | Renewal fee patent year 06 | 31.10.2013 | Renewal fee patent year 07 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 16.10.2007 | AT | 04.06.2014 | BE | 04.06.2014 | BG | 04.06.2014 | CY | 04.06.2014 | CZ | 04.06.2014 | DK | 04.06.2014 | EE | 04.06.2014 | FI | 04.06.2014 | LT | 04.06.2014 | LV | 04.06.2014 | MC | 04.06.2014 | MT | 04.06.2014 | NL | 04.06.2014 | PL | 04.06.2014 | RO | 04.06.2014 | SE | 04.06.2014 | SI | 04.06.2014 | SK | 04.06.2014 | TR | 04.06.2014 | GR | 05.09.2014 | IS | 04.10.2014 | PT | 06.10.2014 | IE | 16.10.2014 | LU | 16.10.2014 | CH | 31.10.2014 | LI | 31.10.2014 | [2016/33] |
Former [2016/32] | HU | 16.10.2007 | |
AT | 04.06.2014 | ||
BE | 04.06.2014 | ||
BG | 04.06.2014 | ||
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
DK | 04.06.2014 | ||
EE | 04.06.2014 | ||
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
LV | 04.06.2014 | ||
MC | 04.06.2014 | ||
NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
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SI | 04.06.2014 | ||
SK | 04.06.2014 | ||
TR | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
IE | 16.10.2014 | ||
LU | 16.10.2014 | ||
CH | 31.10.2014 | ||
LI | 31.10.2014 | ||
Former [2016/25] | AT | 04.06.2014 | |
BG | 04.06.2014 | ||
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
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EE | 04.06.2014 | ||
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SI | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
IE | 16.10.2014 | ||
LU | 16.10.2014 | ||
CH | 31.10.2014 | ||
LI | 31.10.2014 | ||
Former [2015/46] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
DK | 04.06.2014 | ||
EE | 04.06.2014 | ||
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
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MC | 04.06.2014 | ||
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SI | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
IE | 16.10.2014 | ||
LU | 16.10.2014 | ||
CH | 31.10.2014 | ||
LI | 31.10.2014 | ||
Former [2015/36] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
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EE | 04.06.2014 | ||
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MC | 04.06.2014 | ||
NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
SE | 04.06.2014 | ||
SI | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
LU | 16.10.2014 | ||
CH | 31.10.2014 | ||
LI | 31.10.2014 | ||
Former [2015/33] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
DK | 04.06.2014 | ||
EE | 04.06.2014 | ||
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
LV | 04.06.2014 | ||
MC | 04.06.2014 | ||
NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
SE | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
LU | 16.10.2014 | ||
CH | 31.10.2014 | ||
LI | 31.10.2014 | ||
Former [2015/27] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
DK | 04.06.2014 | ||
EE | 04.06.2014 | ||
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
LV | 04.06.2014 | ||
MC | 04.06.2014 | ||
NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
SE | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
LU | 16.10.2014 | ||
Former [2015/26] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
DK | 04.06.2014 | ||
EE | 04.06.2014 | ||
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NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
SE | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
LU | 16.10.2014 | ||
Former [2015/22] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
DK | 04.06.2014 | ||
EE | 04.06.2014 | ||
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
LV | 04.06.2014 | ||
NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
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SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
Former [2015/12] | AT | 04.06.2014 | |
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CZ | 04.06.2014 | ||
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LV | 04.06.2014 | ||
NL | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
SE | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
IS | 04.10.2014 | ||
PT | 06.10.2014 | ||
Former [2015/11] | AT | 04.06.2014 | |
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CZ | 04.06.2014 | ||
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LV | 04.06.2014 | ||
PL | 04.06.2014 | ||
RO | 04.06.2014 | ||
SE | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
PT | 06.10.2014 | ||
Former [2015/10] | AT | 04.06.2014 | |
CY | 04.06.2014 | ||
CZ | 04.06.2014 | ||
EE | 04.06.2014 | ||
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
LV | 04.06.2014 | ||
SE | 04.06.2014 | ||
SK | 04.06.2014 | ||
GR | 05.09.2014 | ||
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LT | 04.06.2014 | ||
LV | 04.06.2014 | ||
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GR | 05.09.2014 | ||
Former [2014/50] | CY | 04.06.2014 | |
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LV | 04.06.2014 | ||
SE | 04.06.2014 | ||
GR | 05.09.2014 | ||
Former [2014/49] | CY | 04.06.2014 | |
FI | 04.06.2014 | ||
LT | 04.06.2014 | ||
Former [2014/48] | CY | 04.06.2014 | |
LT | 04.06.2014 | ||
Former [2014/47] | CY | 04.06.2014 | Documents cited: | Search | [X]EP0220051 (AMERICAN HOME PROD [US]) [X] 1,3,4,6-9 * examples 10, 12 *; | [X]US4929616 (BINDER DIETER [AT], et al) [X] 1,3-5,8,12,13 * claims 1,4 * * example 1 *; | [X]US5380742 (SEVRIN MIREILLE [FR], et al) [X] 1-9,11-13 * claims 1, 8 * * tables I, II * * column 1, line 4 - line 5 *; | [I]WO9723457 (CELGENE CORP [US], et al) [I] 1-17 * claims 1, 6, 8 * * page 1, lines 7-10 * * page 8, line 19 - line 33 * * page 12, line 1 - line 11 ** example 5 *; | [X]EP1260512 (MITSUBISHI PHARMA CORP [JP]) [X] 1-9,11 * example 22f *; | [XP]WO2007084455 (SCHERING CORP [US], et al) [XP] 1-5,7-9,11-15 * claims 1, 93, 97 * * page 1, paragraph 1 * * page 114; compound 26 *; | [E]EP1964842 (TIAN JIN HEMAY BIO TECH CO LTD [CN]) [E] 1-5,7-11 * example 10.1 *; | [X] - BENACHENHOU, F.; MESLI, M.A.; BORAI, M. 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SMALLHEER, "Synthesis of 1,5-dimethyl-1,4-dihydropyrrolo[3,4-b]-pyrrol-6(5H)-one by intramolecular Diels-Alder reaction to the imidazole nucleus", TETRAHEDRON LETTERS, (1992), vol. 33, no. 39, pages 5697 - 5698, XP002609370 [X] 1,2,4,5,7-11 * page 5697; figure 1; compound 3 * | [X] - UNTERHALT B ET AL, "Reactions of condensed 2,3-dihydro-3-thioxo-isothiazole 1,1-dioxides with diazomethane and diazoethane", ARCHIV DER PHARMAZIE, DE, (1989), vol. 322, no. 11, ISSN 0365-6233, pages 829 - 830, XP002609989 [X] 1,3-5,8-11 * starting material of compounds 1a and 1b; page 829, column 2 * | [X] - UNTERHALT B ET AL, "Umsetzungen von 2,3-Dihydro-3-thioxo-thienoisothiazol-1,1-dioxiden mit Diazomethan und Diazoethan", PHARMAZIE, (1994), vol. 49, no. 5, ISSN 0031-7144, pages 317 - 319, XP001525628 [X] 1,3-5,7-11 * page 317, column 2; compounds 5, 6 * | [X] - LAZER E S ET AL, "Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.", JOURNAL OF MEDICINAL CHEMISTRY, (19970314), vol. 40, no. 6, ISSN 0022-2623, pages 980 - 989, XP002609990 [X] 1,3-5,7-11 * intermediates for synthesis of compounds 72, 75 and 77 * DOI: http://dx.doi.org/10.1021/jm9607010 | [X] - ARRANZ E ET AL, "Novel 1,1,3-trioxo- 2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, (19981008), vol. 41, no. 21, doi:10.1021/JM9802012, ISSN 0022-2623, pages 4109 - 4117, XP002179390 [X] 1,3-5,8-11 * scheme 2; page 4110; compound 9 * DOI: http://dx.doi.org/10.1021/jm9802012 | [X] - D. J. ZWANENBURG, HANS WYNBERG, "Steric inhibition of intramolecular cyclizations by ortho substituents. Synthesis of 1H,3H-thieno[3,4-c]thiophene, its 2,2-dioxide, and 5-ethyl-5,6-dihydro-4H-thieno[3,4-c]pyrrole", JOURNAL OF ORGANIC CHEMISTRY, (196902), vol. 34, no. 2, pages 333 - 340, XP002609991 [X] 1-11 * scheme IV; page 336; compound 28 * | [X] - NIELSEN C B ET AL, "New Regiosymmetrical Dioxopyrrolo- and Dihydropyrrolo-Functionalized Polythiophenes", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, (20040820), vol. 6, no. 19, doi:10.1021/OL048659N, ISSN 1523-7060, pages 3381 - 3384, XP007905481 [X] 1-8,10,11,16,17 * schemes 1-3,; page 3382; compounds 4a, 5a, 6a, 7a * DOI: http://dx.doi.org/10.1021/ol048659n | [X] - MALINKA W ET AL, "Synthesis and analgesic action of N-(substituted-ethyl)pyrrole-3,4-di carboximides", IL FARMACO, IT, (20050101), vol. 60, no. 1, doi:10.1016/J.FARMAC.2004.10.002, ISSN 0014-827X, pages 15 - 22, XP004709723 [X] 1,2,4-6,8,9,11-13 * compounds 4a, 4b, 4d, 3e * DOI: http://dx.doi.org/10.1016/j.farmac.2004.10.002 | [X] - W. MALINKA, "Synthesis and pharmacological properties of N-(4-substituted-1-piperazinylalkyl)-1-butyl-2,5-dimethylpyrrole-3,4-dicarboximide derivatives", IL FARMACO, (1993), vol. 48, no. 7, ISSN 0014-827X, pages 933 - 947, XP009141312 [X] 1,2,4,5,7-9,11-13 * tables I, II; compounds 2a-e, 3a-l * | [X] - ABOU-GHARBIA M ET AL, "SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF SUBSTITUTED TETRAHYDRO- AND HEXAHYDRO-1,2-BENZISOTHIAZOL-3-ONE 1,1-DIOXIDES AND THIADIAZINONES: POTENTIAL ANXIOLYTIC AGENTS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, (19890101), vol. 32, no. 5, doi:10.1021/JM00125A016, ISSN 0022-2623, pages 1024 - 1033, XP002021028 [X] 1,3-5,7-9 * page 1029; table II; compounds 51-54 * DOI: http://dx.doi.org/10.1021/jm00125a016 | [X] - MALINKA W ET AL, "Synthesis and pharmacological screening of some N-(4-substituted-piperazin-1-ylalkyl)-3,4-pyrroledicarboximides.", IL FARMACO, (19990630), vol. 54, no. 6, ISSN 0014-827X, pages 390 - 401, XP002609993 [X] 1-5,8,9,11 * page 391; table 1; compounds 3a, 4a, 4c, 5e * | [X] - UNTERHALT B ET AL, "REAKTIONEN MIT 2,3-DIHYDRO-3-OXOTHIENO[3,4-D]ISOTHIAZOL-1,1-DIOXID", ARCHIV DER PHARMAZIE, (19870101), vol. 320, no. 11, pages 854 - 856, XP002609371 [X] 1,3-5,7-11 * page 854; compound 2 * | [X] - OHNMACHT C J ET AL, "SYNTHESIS AND CARBON-13 NMR STUDY OF 2-BENZYL, 2-METHYL, 2-ARYLOCTAHYDROPYRROLOÚ3,4-C 3/4 PYRROLES AND THE 1,2,3,5-TETRAHYDROPYRROLOÚ3,4-C 3/4 PYRROLE RING SYSTEM", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, US, (19830301), vol. 20, doi:10.1002/JHET.5570200212, ISSN 0022-152X, pages 321 - 329, XP000563767 [X] 1,2,4,5,7-11 * page 323; table II; compound 7'a * DOI: http://dx.doi.org/10.1002/jhet.5570200212 | [X] - MALINKA W ET AL, "Rearrangement of some N-substituted pyrrolo[3,4-c]pyrroles to corresponding pyrrolo[3,4-c]pyridines", POLISH JOURNAL OF CHEMISTRY, POLISH CHEMICAL SOCIETY, (19950101), vol. 69, no. 1, pages 95 - 102, XP002996902 [X] 1,2,4,5,8-11 * page 97; table 1; compound 2b * | [X] - QING T. 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