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Extract from the Register of European Patents

EP About this file: EP2069476

EP2069476 - METABOLIC ENGINEERING OF ARABINOSE- FERMENTING YEAST CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.06.2017
Database last updated on 24.03.2026
Most recent event   Tooltip20.07.2018Lapse of the patent in a contracting state
New state(s): MT		published on 22.08.2018  [2018/34]
Applicant(s)For all designated states
DSM IP Assets B.V.
Het Overloon 1
6411 TE Heerlen / NL
[2009/38]
Former [2009/25]For all designated states
DSM IP Assets B.V.
Het Overloon 1
6411 TE Heerlen / NL
Inventor(s)01 / VAN MARIS, Antonius, Jeroen, Adriaan
Koornmarkt 42, apt. 13
NL-2611 EH Delft / NL
02 / PRONK, Jacobus, Thomas
Bark 5
NL-2636 DD Schipluiden / NL
03 / WISSELINK, Hendrik, Wouter
Gelddijk 32
NL-4105 AE Culemborg / NL
04 / VAN DIJKEN, Johannes, Pieter
Spotvogellaan 38
NL-2261 CP Leidschendam / NL
05 / WINKLER, Aaron, Adriaan
Purperreigerstraat 28
NL-2492 TD Den Haag / NL
06 / DE WINDE, Johannes, Hendrik
Saffraanweg 51
NL-2215 WC Voorhout / NL
 [2009/25]
Representative(s)Kleiborn, Paul Erik, et al
DSM Intellectual Property
P.O. Box 4
6100 AA Echt / NL
[2016/32]
Former [2011/11]Kleiborn, Paul Erik, et al
DSM Intellectual Property P.O. Box 130
6100 AC Echt / NL
Former [2009/25]Kleiborn, Paul Erik, et al
DSM Intellectual Property DSM IP Assets B.V. Delft Office (600-0240) P.O. Box 1
NL-2600 MA Delft / NL
Application number, filing date07834562.601.10.2007
[2009/25]
WO2007NL00246
Priority number, dateEP2006012163302.10.2006         Original published format: EP 06121633
US20060848357P02.10.2006         Original published format: US 848357 P
[2009/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008041840
Date:10.04.2008
Language:EN
[2008/15]
Type: A1 Application with search report 
No.:EP2069476
Date:17.06.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 10.04.2008 takes the place of the publication of the European patent application.
[2009/25]
Type: B1 Patent specification 
No.:EP2069476
Date:10.08.2016
Language:EN
[2016/32]
Search report(s)International search report - published on:EP10.04.2008
ClassificationIPC:C12N1/18, C12P7/08
[2009/25]
CPC:
C12N9/90 (EP,US); C12N9/1205 (EP,US); C12P7/08 (EP,US);
Y02E50/10 (EP,US); Y02E50/30 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/32]
Former [2009/25]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesALNot yet paid
BANot yet paid
HRNot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:STOFFWECHSELTECHNISCHE HERSTELLUNG VON ARABINOSE VERGÄRENDEN HEFEZELLEN[2009/25]
English:METABOLIC ENGINEERING OF ARABINOSE- FERMENTING YEAST CELLS[2009/25]
French:GÉNIE MÉTABOLIQUE DE CELLULES DE LEVURE INDUISANT LA FERMENTATION DE L'ARABINOSE[2009/25]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase03.04.2009National basic fee paid 
03.04.2009Designation fee(s) paid 
03.04.2009Examination fee paid 
Examination procedure29.09.2008Observations by third parties
03.04.2009Examination requested  [2009/25]
17.01.2011Despatch of a communication from the examining division (Time limit: M06)
14.07.2011Reply to a communication from the examining division
28.06.2012Despatch of a communication from the examining division (Time limit: M04)
07.11.2012Reply to a communication from the examining division
08.01.2014Despatch of a communication from the examining division (Time limit: M06)
27.03.2014Observations by third parties
15.07.2014Reply to a communication from the examining division
09.09.2014Despatch of a communication from the examining division (Time limit: M04)
13.01.2015Reply to a communication from the examining division
11.03.2016Communication of intention to grant the patent
16.06.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
16.06.2016Fee for grant paid
16.06.2016Fee for publishing/printing paid
01.07.2016Information about intention to grant a patent
01.07.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.01.2011
Opposition(s)11.05.2017No opposition filed within time limit [2017/29]
Fees paidRenewal fee
26.10.2009Renewal fee patent year 03
25.10.2010Renewal fee patent year 04
25.10.2011Renewal fee patent year 05
11.10.2012Renewal fee patent year 06
14.10.2013Renewal fee patent year 07
14.10.2014Renewal fee patent year 08
12.10.2015Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.10.2007
AT10.08.2016
BE10.08.2016
CY10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
MC10.08.2016
RO10.08.2016
SE10.08.2016
SI10.08.2016
SK10.08.2016
TR10.08.2016
IE01.10.2016
LU01.10.2016
CH31.10.2016
LI31.10.2016
MT31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
[2018/32]
Former [2018/29]HU01.10.2007
AT10.08.2016
BE10.08.2016
CY10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
MC10.08.2016
RO10.08.2016
SE10.08.2016
SI10.08.2016
SK10.08.2016
TR10.08.2016
IE01.10.2016
LU01.10.2016
CH31.10.2016
LI31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2018/28]HU01.10.2007
AT10.08.2016
BE10.08.2016
CY10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
MC10.08.2016
RO10.08.2016
SE10.08.2016
SI10.08.2016
SK10.08.2016
IE01.10.2016
LU01.10.2016
CH31.10.2016
LI31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/51]AT10.08.2016
BE10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
RO10.08.2016
SE10.08.2016
SI10.08.2016
SK10.08.2016
IE01.10.2016
LU01.10.2016
CH31.10.2016
LI31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/43]AT10.08.2016
BE10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
RO10.08.2016
SE10.08.2016
SI10.08.2016
SK10.08.2016
LU01.10.2016
CH31.10.2016
LI31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/37]AT10.08.2016
BE10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
RO10.08.2016
SE10.08.2016
SI10.08.2016
SK10.08.2016
CH31.10.2016
LI31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/35]AT10.08.2016
BE10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
RO10.08.2016
SE10.08.2016
SK10.08.2016
CH31.10.2016
LI31.10.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/23]AT10.08.2016
BE10.08.2016
CZ10.08.2016
EE10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
RO10.08.2016
SE10.08.2016
SK10.08.2016
BG10.11.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/13]AT10.08.2016
FI10.08.2016
LT10.08.2016
LV10.08.2016
SE10.08.2016
BE31.10.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/11]AT10.08.2016
FI10.08.2016
LT10.08.2016
SE10.08.2016
BE31.10.2016
GR11.11.2016
IS10.12.2016
PT12.12.2016
Former [2017/10]FI10.08.2016
LT10.08.2016
SE10.08.2016
BE31.10.2016
IS10.12.2016
Former [2017/07]LT10.08.2016
Cited inInternational search[DY]   BECKER JESSICA ET AL: "A modified Saccharomyces cerevisiae strain that consumes L-arabinose and produces ethanol.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 69, no. 7, July 2003 (2003-07-01), pages 4144 - 4150, XP009080581, ISSN: 0099-2240

DOI:   http://dx.doi.org/10.1128/AEM.69.7.4144-4150.2003
 [Y]   KLEEREBEZEM MICHIEL ET AL: "Complete genome sequence of Lactobacillus plantarum WCFS1", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 4, 18 February 2003 (2003-02-18), pages 1990 - 1995, XP002285325, ISSN: 0027-8424

DOI:   http://dx.doi.org/10.1073/pnas.0337704100
 [Y]   DATABASE UniProt [online] 1 June 2003 (2003-06-01), "L-arabinose isomerase (EC 5.3.1.4)", XP002463086, retrieved from EBI accession no. UNIPROT:Q88S84 Database accession no. Q88S84
 [Y]   DATABASE UniProt [online] 1 June 2003 (2003-06-01), "L-ribulokinase (Putative) (EC 2.7.1.16).", XP002425138, retrieved from EBI accession no. UNIPROT:Q88S82 Database accession no. Q88S82 * page 4148, column 2, paragraph 2 - page 4149; figure 4 *
 [Y]   DATABASE UniProt [online] 1 June 2003 (2003-06-01), "L-ribulose 5-phosphate 4-epimerase (EC 5.1.3.4).", XP002425139, retrieved from EBI accession no. UNIPROT:Q88S83 Database accession no. Q88S83 * the whole document *
 [Y]   SEDLAK MIROSLAV ET AL: "Expression of E. coli araBAD operon encoding enzymes for metabolizing L-arabinose in Saccharomyces cerevisiae", ENZYME AND MICROBIAL TECHNOLOGY, vol. 28, no. 1, 2 January 2001 (2001-01-02), pages 16 - 24, XP002950458, ISSN: 0141-0229

DOI:   http://dx.doi.org/10.1016/S0141-0229(00)00282-9
 [Y]   DEANDA KRISTINE ET AL: "Development of an arabinose-fermenting Zymomonas mobilis strain by metabolic pathway engineering", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 62, no. 12, 1996, pages 4465 - 4470, XP002912122, ISSN: 0099-2240
Examination  KARHUMAA KAISA ET AL: "Co-utilization of L-arabinose and D-xylose by laboratory and industrial Saccharomyces cerevisiae strains", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL, vol. 5, no. 1, 18, 10 April 2006 (2006-04-10), pages 1 - 11, XP021017778, ISSN: 1475-2859, DOI: DOI:10.1186/1475-2859-5-18

DOI:   http://dx.doi.org/10.1186/1475-2859-5-18
   WISSELINK H WOUTER ET AL: "Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of L-arabinose", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 73, no. 15, 1 August 2007 (2007-08-01), pages 4881 - 4891, XP009090726, ISSN: 0099-2240, DOI: DOI:10.1128/AEM.00177-07 [P]

DOI:   http://dx.doi.org/10.1128/AEM.00177-07
by applicant  ALTSCHUL, S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
   ALTSCHUL, S. ET AL.: "BLAST Manual", NCBI NLM NIH BETHESDA
other  KARHUMAA K. ET AL: "Co-utilization of L-arabinose and D-xylose by laboratory and industrial Saccharomyces cerevisiae strains", MICROBIAL CELL FACTORIES, vol. 5, no. 1, XP021017778

DOI:   http://dx.doi.org/10.1186/1475-2859-5-18
   WISSELINK H. ET AL: "Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of L-arabinose", APPL. ENVIRON MICROBIOL, vol. 73, no. 15, 1 June 2007 (2007-06-01), pages 4881 - 4891, XP002454725 [P]

DOI:   http://dx.doi.org/10.1128/AEM.00177-07
   DATABASE PROTEIN [online] XP003033527, accession no. NCBI Database accession no. WP_021356821
   DATABASE PROTEIN [online] "LIFE WITH 600 GENES", XP003033528, accession no. NCBI Database accession no. NP_012414
   GOFFEAU A. ET AL, SCIENCE, vol. 274, no. 5287, 1996, pages 546
   BECKER J. ET AL.,: "A MODIFIED SACCHAROMYCES CEREVISIAE STRAIN THAT CONSUMES L-ARABINOSE AND PRODUCES ETHANOL", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 69, no. 7, 2003, pages 4144 - 4150, XP009080581

DOI:   http://dx.doi.org/10.1128/AEM.69.7.4144-4150.2003
   SEDLAK ET AL.,: "EXPRESSION OF E. COLI ARABAD OPERON ENCODING ENZYMES FOR METABOLIZING L-ARABINOSE IN SACCHAROMYCES CEREVISIAE", ENZYME ENVIRON MICROBIOL., vol. 28, no. 1, 2 January 2001 (2001-01-02), pages 16 - 24, XP000295045
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.