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Extract from the Register of European Patents

EP About this file: EP2125031

EP2125031 - LIPIDS AND LIPID ASSEMBLIES COMPRISING TRANSFECTION ENHANCER ELEMENTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.09.2018
Database last updated on 08.06.2024
FormerThe patent has been granted
Status updated on  29.09.2017
FormerGrant of patent is intended
Status updated on  13.12.2016
Most recent event   Tooltip29.05.2020Lapse of the patent in a contracting state
New state(s): PT		published on 01.07.2020  [2020/27]
Applicant(s)For all designated states
Marina Biotech, Inc.
3830 Monte Villa Parkway
Bothell WA 98021-7266 / US
[2017/44]
Former [2010/49]For all designated states
Marina Biotech, Inc.
3830 Monte Villa Parkway
Bothell WA 98021-7266 / US
Former [2009/49]For all designated states
novosom AG
Weinbergweg 22
06120 Halle / DE
Inventor(s)01 / PANZNER, Steffen
Herweghstr. 7
06114 Halle / DE
02 / LUTZ, Silke
Schleiermacherstr. 33
06114 Halle / DE
03 / SIEPI, Evgenios
Georg-Schumann-Strasse 78
04155 Leipzig / DE
04 / REINSCH, Christian
Beesener Str. 7
06110 Halle / DE
05 / MULLER, Claudia
Markt 11
04685 Nerchau / DE
 [2009/49]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2017/44]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2013/24]Srinivasan, Ravi Chandran
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2010/48]Mathys & Squire LLP
120 Holborn London
EC1N 2SQ / GB
Former [2009/49]Haile, Alison Victoria, et al
Mintz Levin, Cohn, Ferris, Glovsky and Popeo IP, LLP Alder Castle 10 Noble Street
London EC2V 7JX / GB
Application number, filing date07856910.019.12.2007
[2009/49]
WO2007EP11187
Priority number, dateEP2006025645019.12.2006         Original published format: EP 06256450
US2006064234719.12.2006         Original published format: US 642347
EP2007011718925.09.2007         Original published format: EP 07117189
[2009/49]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008074487
Date:26.06.2008
Language:EN
[2008/26]
Type: A2 Application without search report 
No.:EP2125031
Date:02.12.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 26.06.2008 takes the place of the publication of the European patent application.
[2009/49]
Type: B1 Patent specification 
No.:EP2125031
Date:01.11.2017
Language:EN
[2017/44]
Search report(s)International search report - published on:EP23.04.2009
ClassificationIPC:A61K47/28
[2017/44]
CPC:
A61K9/1272 (EP,US); A61K31/7052 (EP,US); A61K47/542 (EP,US);
A61K47/544 (EP,US); A61K47/545 (EP,US); A61K47/554 (EP,US);
A61K47/6911 (EP,US); A61K48/0008 (EP,US); A61K48/0025 (EP,US);
A61K48/0033 (EP,US); A61K48/0041 (EP,US); A61K9/127 (EP,US);
A61P29/00 (EP); A61P31/04 (EP); A61P35/00 (EP);
A61P37/00 (EP); A61P37/02 (EP); A61P37/06 (EP);
A61P43/00 (EP); C07C229/24 (EP,US); C12N15/88 (EP,US);
Y02P20/582 (EP,US) (-)
Former IPC [2009/49]A61K48/00, A61K47/48
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/44]
Former [2009/49]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:LIPIDE UND LIPIDANORDNUNGEN MIT TRANSFEKTIONSVERSTÄRKUNGSELEMENTEN[2009/49]
English:LIPIDS AND LIPID ASSEMBLIES COMPRISING TRANSFECTION ENHANCER ELEMENTS[2009/49]
French:LIPIDES ET ENSEMBLES LIPIDIQUES COMPRENANT DES ÉLÉMENTS D'AMÉLIORATION DE LA TRANSFECTION[2009/49]
Entry into regional phase20.07.2009National basic fee paid 
20.07.2009Designation fee(s) paid 
20.07.2009Examination fee paid 
Examination procedure20.07.2009Amendment by applicant (claims and/or description)
20.07.2009Examination requested  [2009/49]
10.08.2012Despatch of a communication from the examining division (Time limit: M06)
11.06.2013Reply to a communication from the examining division
23.10.2013Despatch of a communication from the examining division (Time limit: M06)
02.05.2014Reply to a communication from the examining division
17.12.2014Communication of intention to grant the patent
13.03.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
13.03.2015Receipt of the translation of the claim(s)
17.04.2015Communication of intention to grant the patent
15.12.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
29.01.2016Communication of intention to grant the patent
21.09.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
14.12.2016Communication of intention to grant the patent
02.06.2017Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
31.07.2017Fee for grant paid
31.07.2017Fee for publishing/printing paid
31.07.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.08.2012
Opposition(s)02.08.2018No opposition filed within time limit [2018/41]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
31.07.2017Request for further processing filed
31.07.2017Full payment received (date of receipt of payment)
Request granted
21.08.2017Decision despatched
The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
21.09.2016Request for further processing filed
21.09.2016Full payment received (date of receipt of payment)
Request granted
06.10.2016Decision despatched
The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
15.12.2015Request for further processing filed
15.12.2015Full payment received (date of receipt of payment)
Request granted
07.01.2016Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
11.06.2013Request for further processing filed
11.06.2013Full payment received (date of receipt of payment)
Request granted
24.06.2013Decision despatched
Fees paidRenewal fee
23.12.2009Renewal fee patent year 03
19.11.2010Renewal fee patent year 04
29.12.2011Renewal fee patent year 05
26.12.2012Renewal fee patent year 06
12.02.2014Renewal fee patent year 07
11.12.2014Renewal fee patent year 08
10.12.2015Renewal fee patent year 09
26.06.2017Renewal fee patent year 10
Penalty fee
Additional fee for renewal fee
31.12.201307   M06   Fee paid on   12.02.2014
31.12.201610   M06   Fee paid on   26.06.2017
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Lapses during opposition  TooltipHU19.12.2007
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
PL01.11.2017
PT01.11.2017
RO01.11.2017
SI01.11.2017
SK01.11.2017
TR01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
[2020/27]
Former [2020/16]HU19.12.2007
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
PL01.11.2017
RO01.11.2017
SI01.11.2017
SK01.11.2017
TR01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2019/31]HU19.12.2007
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
PL01.11.2017
RO01.11.2017
SI01.11.2017
SK01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2019/30]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
PL01.11.2017
RO01.11.2017
SI01.11.2017
SK01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/52]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
PL01.11.2017
RO01.11.2017
SI01.11.2017
SK01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/50]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
PL01.11.2017
RO01.11.2017
SK01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/45]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
PL01.11.2017
RO01.11.2017
SK01.11.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/43]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
PL01.11.2017
RO01.11.2017
SK01.11.2017
LU19.12.2017
MT19.12.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/42]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
PL01.11.2017
RO01.11.2017
SK01.11.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/37]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
PL01.11.2017
SK01.11.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/35]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
SK01.11.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/24]AT01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
LV01.11.2017
BG01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/23]AT01.11.2017
ES01.11.2017
FI01.11.2017
LT01.11.2017
GR02.02.2018
IS01.03.2018
Former [2018/22]ES01.11.2017
FI01.11.2017
LT01.11.2017
Cited inInternational search[X]WO9605218  (COMMW SCIENT IND RES ORG [AU], et al) [X] 1-63 * page 1, line 3 - line 10 * * page 1, line 21 - page 3, line 17 * * page 4, line 35 - page 5, line 2 *;
 [X]US5206027  (KITAGUCHI HIROSHI [JP]) [X] 1-63 * column 2, lines 1-44 * * columns 9-10 *;
 [X]WO03070735  (NOVOSOM AG [DE], et al) [X] 1-63 * claims 1,9 *;
 [X]EP0422543  (GREEN CROSS CORP [JP]) [X] 1-63 * claim 1 *;
 [X]WO0059474  (ISIS PHARMACEUTICALS INC [US], et al) [X] 1-63 * claim 1 * * claims 47-53 *;
 [X]WO9719675  (VICAL INC [US]) [X] 1-63 * claim 1 * * pages 26,36 *;
 [X]EP0178624  (CIBA GEIGY AG [CH]) [X] 1-63 * claim 1 *;
 [X]EP0099068  (MAX PLANCK GESELLSCHAFT [DE]) [X] 1-17 * claim 1 *;
 [X]US2004241858  (MATSUURA EIJI [JP], et al) [X] 1-17 * pages 1-2; claim 1 *;
 [X]WO2006107098  (FUJI PHOTO FILM CO LTD [JP], et al) [X] 1-17 * claim 1 *;
 [PX]EP1764090  (NOVOSOM AG [DE]) [PX] 1-63 * claim 1 * * pages 5-6 *;
 [E]EP1938843  (NOVOSOM AG [DE]) [E] 1-63 * claim - *;
 [X]WO03070220  (NOVOSOM AG [DE], et al) [X] 1-63 * pages 8-10 *;
 [X]WO02066490  (NOVOSOM AG [DE], et al) [X] 1-63 * page 6 *;
 [X]WO02096390  (ALZA CORP [US]) [X] 1-63 * pages 9-10 *;
 [X]WO2004100927  (NOVOSOM AG [DE], et al) [X] 1-63 * page 6; claim 1 *;
 [X]WO2006053646  (NOVOSOM AG [DE], et al) [X] 1-63 * pages 6,8 *;
 [X]WO02066012  (NOVOSOM AG [DE], et al) [X] 1-63 * page 6 * * claim 1 *;
 [X]WO9918933  (INEX PHARMACEUTICALS CORP [CA], et al) [X] 1-63 * page 18 *;
 [PX]WO2007064857  (PRONAI THERAPEUTICS INC [US], et al) [PX] 1-63 * claim - *;
 [PX]WO2007107304  (NOVOSOM AG [DE], et al) [PX] 1-63 * claim - *
 [X]  - FATTAL E ET AL, "Smart delivery of antisense oligonucleotides by anionic pH-sensitive liposomes", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, (20040423), vol. 56, no. 7, ISSN 0169-409X, pages 931 - 946, XP002454176 [X] 1-63 * page 937, column L *

DOI:   http://dx.doi.org/10.1016/j.addr.2003.10.037
 [X]  - ZI CHEN LI ET AL, "SYNTHESIS OF CHOLESTEROL DERIVATIVES WITH AMINO ACID AS HYDROPHILIC GROUP AND THE VESICLES PREPARED THEREFROM", CHINESE CHEMICAL LETTERS, XX, XX, (19990101), vol. 12, no. 10, ISSN 1001-8417, pages 1007 - 1010, XP008005314 [X] 1-17 * page 1008 *
 [X]  - HAGSTROM J E ET AL, "COMPLEXES OF NON-CATIONIC LIPOSOMES AND HISTONE H1 MEDIATE EFFICIENT TRANSFECTION OF DNA WITHOUT ENCAPSULATION", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, (19960101), vol. 1284, ISSN 0005-2736, pages 47 - 55, XP001024646 [X] 1-63 * page 48, column L *

DOI:   http://dx.doi.org/10.1016/0005-2736(96)00106-X
 [X]  - REDDY J A ET AL, "Enhanced folate receptor mediated gene therapy using a novel pH-sensitive lipid formulation", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (20000201), vol. 64, no. 1-3, ISSN 0168-3659, pages 27 - 37, XP004185090 [X] 1-63 * page 31 *

DOI:   http://dx.doi.org/10.1016/S0168-3659(99)00135-2
 [X]  - WONG F M P ET AL, "Phosphatidylethanolamine mediated destabilization of lipid-based pDNA delivery systems.", INTERNATIONAL JOURNAL OF PHARMACEUTICS (KIDLINGTON), (20030414), vol. 255, no. 1-2, ISSN 0378-5173, pages 117 - 127, XP002514040 [X] 1-63 * page 119, column L *

DOI:   http://dx.doi.org/10.1016/S0378-5173(03)00051-6
 [X]  - CHEUNG CHARLES Y ET AL, "A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, (20011101), vol. 12, no. 6, ISSN 1043-1802, pages 906 - 910, XP002454175 [X] 1-63 * page 906 *

DOI:   http://dx.doi.org/10.1021/bc0100408
 [X]  - GUO W ET AL, "Characterization of a novel diolein-based LPDII vector for gene delivery", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (20020918), vol. 83, no. 1, ISSN 0168-3659, pages 121 - 132, XP004380065 [X] 1-63 * page 122 *

DOI:   http://dx.doi.org/10.1016/S0168-3659(02)00167-0
ExaminationUS4042330
 JPH0834725
 EP0554897
    - HAPIOT F, "IMPROVEMENT OF THE DOPANT COMPATIBILITY IN A CHIRAL LC MIXTURE BY STRUCTURAL MODIFICATION OF LANTHANIDE COMPLEXES", LIQUID CRYSTALS: AN INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY, TAYLOR & FRANCIS, GB, (20060801), vol. 33, no. 8, doi:10.1080/02678290500277995, ISSN 0267-8292, pages 921 - 927, XP001246012

DOI:   http://dx.doi.org/10.1080/02678290500277995
    - DATABASE WPI, 1, Derwent World Patents Index, vol. 1996, no. 15, Database accession no. 1996-146877, & JPH0834725 A 19960206 (KAO CORP)
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.