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Extract from the Register of European Patents

EP About this file: EP2078071

EP2078071 - RATIONALLY DESIGNED MEDIA FOR CELL CULTURE [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  25.03.2022
Database last updated on 17.08.2024
FormerThe patent has been granted
Status updated on  07.11.2017
Most recent event   Tooltip25.03.2022Revocation of patentpublished on 27.04.2022  [2022/17]
Applicant(s)For all designated states
Wyeth LLC
235 East 42nd Street
New York, NY 10017-5755 / US
[2014/10]
Former [2010/16]For all designated states
Wyeth LLC
Five Giralda Farms
Madison, NJ 07940 / US
Former [2009/29]For all designated states
Wyeth
5 Giralda Farms
Madison, NJ 07940 / US
Inventor(s)01 / LUAN, Yen-Tung
3 Armand Drive
Chelmsford, MA 01824 / US
02 / WANG, Wenge
1 Hollow Ridge Road
North Chelmsford, MA 01863 / US
03 / NOLAN, Ryan
71 Montvale Avenue, Apt.5
Stoneham, MA 02180 / US
04 / DRAPEAU, Denis
55 Old Farm Road
Salem, NH 03079 / US
 [2009/29]
Representative(s)Uexküll & Stolberg
Partnerschaft von
Patent- und Rechtsanwälten mbB
Beselerstraße 4
22607 Hamburg / DE
[N/P]
Former [2012/33]Pfizer
European Patent Department
23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
Former [2010/29]Pringot, Thomas, et al
Pfizer Limited European Patent Department Ramsgate Road
Sandwich, Kent CT13 9NJ / GB
Former [2009/29]Denholm, Anna Marie, et al
Wyeth Pharmaceuticals Huntercombe Lane South Taplow Maidenhead
Berkshire SL6 0PH / GB
Application number, filing date07868688.807.11.2007
[2009/29]
WO2007US83947
Priority number, dateUS20060858289P08.11.2006         Original published format: US 858289 P
[2009/29]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008063892
Date:29.05.2008
Language:EN
[2008/22]
Type: A2 Application without search report 
No.:EP2078071
Date:15.07.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 29.05.2008 takes the place of the publication of the European patent application.
[2009/29]
Type: B1 Patent specification 
No.:EP2078071
Date:18.03.2015
Language:EN
[2015/12]
Search report(s)International search report - published on:EP28.08.2008
ClassificationIPC:C12Q1/02, C12N5/00
[2014/42]
CPC:
A61P43/00 (EP); C12P21/00 (KR); C12Q1/02 (US);
C12N5/00 (KR); C12N5/0018 (EP,US); C12N2500/32 (EP,US)
Former IPC [2009/29]C12N5/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/29]
TitleGerman:RATIONAL ENTWORFENE MEDIEN FÜR ZELLKULTUR[2009/29]
English:RATIONALLY DESIGNED MEDIA FOR CELL CULTURE[2009/29]
French:MILIEUX CONÇUS RATIONNELLEMENT POUR UNE CULTURE CELLULAIRE[2009/29]
Entry into regional phase08.05.2009National basic fee paid 
08.05.2009Designation fee(s) paid 
08.05.2009Examination fee paid 
Examination procedure08.05.2009Examination requested  [2009/29]
23.09.2009Despatch of a communication from the examining division (Time limit: M06)
09.07.2010Reply to a communication from the examining division
06.02.2012Despatch of a communication from the examining division (Time limit: M06)
25.09.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
19.11.2012Reply to a communication from the examining division
17.03.2014Despatch of a communication from the examining division (Time limit: M06)
01.09.2014Reply to a communication from the examining division
13.10.2014Communication of intention to grant the patent
04.02.2015Fee for grant paid
04.02.2015Fee for publishing/printing paid
04.02.2015Receipt of the translation of the claim(s)
Divisional application(s)EP15159383.7  / EP2921552
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.09.2009
Opposition(s)Opponent(s)01  17.12.2015    ADMISSIBLE
F. Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 02  17.12.2015    ADMISSIBLE
Spencer, Matthew Peter
Boult Wade Tennant
Verulam Gardens
70 Gray's Inn Road
London WC1X 8BT / GB
Opponent's representative
Boult Wade Tennant LLP
Salisbury Square House
8 Salisbury Square
London EC4Y 8AP / GB
 [N/P]
Former [2016/03]
Opponent(s)01  17.12.2015    ADMISSIBLE
F.Hoffmann-La Roche AG
Grenzacherstrasse 124
4070 Basel / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 02  17.12.2015    ADMISSIBLE
Spencer, Matthew Peter
Boult Wade Tennant
Verulam Gardens
70 Gray's Inn Road
London WC1X 8BT / GB
Opponent's representative
Boult Wade Tennant
Verulam Gardens
70 Gray's Inn Road
London WC1X 8BT / GB
03.02.2016Invitation to proprietor to file observations on the notice of opposition
16.08.2016Reply of patent proprietor to notice(s) of opposition
06.10.2017Date of oral proceedings
08.11.2017Despatch of minutes of oral proceedings
08.11.2017Despatch of communication that the patent will be revoked
17.03.2022Legal effect of revocation of patent [2022/17]
Appeal following opposition09.01.2018Appeal received No.  T0079/18
19.03.2018Statement of grounds filed
17.03.2022Result of appeal procedure: appeal of the proprietor withdrawn
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
19.11.2012Request for further processing filed
19.11.2012Full payment received (date of receipt of payment)
Request granted
29.11.2012Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
09.07.2010Request for further processing filed
09.07.2010Full payment received (date of receipt of payment)
Request granted
23.07.2010Decision despatched
Fees paidRenewal fee
06.11.2009Renewal fee patent year 03
30.11.2010Renewal fee patent year 04
30.11.2011Renewal fee patent year 05
30.11.2012Renewal fee patent year 06
02.12.2013Renewal fee patent year 07
01.12.2014Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY18.03.2015
EE18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
MT18.03.2015
IS18.07.2015
[2017/40]
Former [2016/28]EE18.03.2015
LT18.03.2015
LV18.03.2015
MC18.03.2015
IS18.07.2015
Former [2015/51]EE18.03.2015
LT18.03.2015
LV18.03.2015
IS18.07.2015
Former [2015/49]EE18.03.2015
LT18.03.2015
LV18.03.2015
Former [2015/39]LT18.03.2015
LV18.03.2015
Former [2015/35]LT18.03.2015
Cited inInternational search[X]US5122469  (MATHER JENNIE P [US], et al) [X] 1-45 * "Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins" * * abstract * * column 2, line 48 - line 68 * * column 4, line 52 - column 7, line 44 * * tables 1-4 *;
 [DX]US2006121568  (DRAPEAU DENIS [US], et al) [DX] 1-45 * "Production of polypeptides" * * page 1, paragraph 5 * * page 10, paragraph 151 * * tables 1,11 * * page 31 - page 32; example 13; table 22 *;
 [XA]  - CASTRO P M L ET AL, "Application of a statistical design to the optimization of culture medium for recombinant interferon-gamma production by Chinese hamster ovary cells", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER VERLAG, BERLIN, DE, (19920101), vol. 38, no. 1, ISSN 0175-7598, pages 84 - 90, XP002995069 [X] 1,28,30,32,33 * the whole document * [A] 2-27,29,31,34-45

DOI:   http://dx.doi.org/10.1007/BF00169424
 [XA]  - SANDADI SANDEEPA ET AL, "Heuristic optimization of antibody production by Chinese hamster ovary cells.", BIOTECHNOLOGY PROGRESS 2005 SEP-OCT, (200509), vol. 21, no. 5, ISSN 8756-7938, pages 1537 - 1542, XP002484344 [X] 1,28,30,32,33 * the whole document * [A] 2-27,29,31,34-45

DOI:   http://dx.doi.org/10.1021/bp0501266
OppositionGB2251249
 WO9512664
 EP1229125
 WO2006026408
 US2006121568
 EP1686173
 WO2006099308
 US4282326
 US2005272124
 WO2006026445
 WO2006084826
 WO2008063892
    - LING et al., "CHEMICALLY CHARACTERIZED CONCENTRATED CORODIES FOR CONTINOUS CELL CULTURE (THE 7C'S CULTRURE MEDIA)", Experimental Cell Research, (19680000), vol. 52, pages 469 - 489, XP000990215

DOI:   http://dx.doi.org/10.1016/0014-4827(68)90489-8
    - DEMAIN et al., "Effective levels of tetanus toxin can be made in a production medium totally lacking both animal (e.g., brain heart infusion) and dairy proteins or digests (e.g., casein hydrolysates)", Vaccine, (20050502), vol. 23, pages 5420 - 5423, XP005158050

DOI:   http://dx.doi.org/10.1016/j.vaccine.2005.03.043
    - "QUEST INTERNATIONAL PRODUCT INFORMATION", (19980000), URL: http://www.sheffield-products.com , XP002156903
    - CHEN et al., "Effects of amino acid additions on ammonium stressed CHO cells", Journal of Biotechnology, (20050525), vol. 117, no. 3, pages 277 - 286, XP004872691

DOI:   http://dx.doi.org/10.1016/j.jbiotec.2005.02.003
    - LING et al., "Chemically characterized concentrated corodies for continuous cell culture (The 7C's culture media)", Experimental Cell Research, (19680000), vol. 52, pages 469 - 489, XP024792176

DOI:   http://dx.doi.org/10.1016/0014-4827(68)90489-8
    - MORGAN, J.F. et al., "Nutrition of Animal Cells in Tissue Culture. I. Initial Studies on a Synthetic Medium (17557)", Proceedings of the Society for Experimental Biology and Medicine, (19500100), vol. 73, no. 1, pages 1 - 8, XP055254255
    - WLASCHIN et al., "Fedbatch culture and dynamic nutrient feeding", Adv. Biochem Engin/Biotechnol, (20060610), vol. 101, pages 43 - 74, XP009092044
    - BUTLER, "Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals", Appl Microbiol Biotechnol, (20050416), vol. 68, pages 283 - 291, XP002457678

DOI:   http://dx.doi.org/10.1007/s00253-005-1980-8
    - BIRCH et al., "Antibody production", Advanced Drug Delivery Reviews, (20060522), vol. 58, pages 671 - 685, XP005611421

DOI:   http://dx.doi.org/10.1016/j.addr.2005.12.006
    - JAYAPAL et al., "Recombinant Protein Therapeutics from CHO Cells -- 20 Years and Counting", CHO consortium, SBE Special Section, (20071000), pages 40 - 47, XP055254248
    - Sigma Aldrich, "Medium 199, with Earle′s salts, L-glutamine and sodium bicarbonate, liquid, sterile-filtered, suitable for cell cultur", Technical information, pages 1 - 4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.