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Extract from the Register of European Patents

EP About this file: EP1972638

EP1972638 - Remedies for juvenile chronic arthritis and related diseases [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  14.07.2017
Database last updated on 14.03.2026
Most recent event   Tooltip14.07.2017Refusal of applicationpublished on 16.08.2017  [2017/33]
Applicant(s)For all designated states
Chugai Seiyaku Kabushiki Kaisha
5-1 Ukima 5-chome Kita-ku Tokyo
115-8543 / JP
[N/P]
Former [2008/39]For all designated states
Chugai Seiyaku Kabushiki Kaisha
5-1 Ukima 5-chome Kita-ku Tokyo
115-8543 / JP
Inventor(s)01 / Yoshizaki, Kazuyuki
3-8-4, Midori-cho
Ashiya-shi Hyogo 659-0059 / JP
02 / Nishimoto, Norihiro
4-6-9-804, Nyoidani
Minoo-shi Osaka 562-0011 / JP
03 / Iwamoto, Masahiro
16-7, Utsukushigaoka 2-chome
Oyama-shi Tochigi 329-0207 / JP
04 / Minota, Seiji
37-7-908, Minamisenju 6-chome Arakawa-ku
Tokyo 116-0003 / JP
05 / Yokota, Shumpei
4-2-6, Nakakaigan
Chigasaki-shi Kanagawa 253-0055 / JP
06 / Miyamae, Takako
38-210 Takenomaru Naka-ku
Yokohama-shi Kanagawa-231-0847 / JP
 [2009/19]
Former [2009/08]01 / Yoshizaki, Kazuyuki
3-8-4, Midori-cho
Ashiya-shi Hyogo 659-0059 / JP
02 / Nishimoto, Norihiro
4-6-9-804, Nyoidani
Minoo-shi Osaka 562-0011 / JP
03 / Iwamoto, Masahiro
16-7, Utsukushigaoka 2-chome
Oyama-shi Tochigi 329-0207 / JP
04 / Minota, Seiji
37-7-908, Minamisenju 6-chome Arakawa-ku
Tokyo 116-0003 / JP
05 / Yokota, Shumpei
4-2-6, Nakakaigan
Chigasaki-shi Kanagawa 253-0055 / JP
06 / Miyamae, Takako
Nishitakenomaru Naka-ku
Yokohama-shi Kanagawa-231-0852 / JP
Former [2008/39]01 / Yoshizaki, Kazuyuki
3-8-4, Midori-cho
Ashiya-shi Hyogo 659-0059 / JP
02 / Nishimoto, Norihiro
4-6-9-804, Nyoidani
Minoo-shi Osaka 562-0011 / JP
03 / Iwamoto, Masahiro
16-7, Utsukushigaoka 2-chome
Oyama-shi Tochigi 329-0207 / JP
04 / Minota, Seiji
37-7-908, Minamisenju 6-chome Arakawa-ku
Tokyo 116-0003 / JP
05 / Yokota, Shumpei
4-2-6, Nakakaigan
Chigasaki-shi Kanagawa 253-0055 / JP
06 / Miyamae, Takako
85-1-305, Nishitakenomaru Naka-ku
Yokohama-shi Kanagawa-231-0852 / JP
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [2011/36]Jaenichen, Hans-Rainer, et al
Vossius & Partner Postfach 86 07 67
81634 München / DE
Former [2008/39]Harding, Charles Thomas, et al
D Young & Co 120 Holborn
London EC1N 2DY / GB
Application number, filing date08010046.402.04.2002
[2008/39]
Priority number, dateJP2001010362702.04.2001         Original published format: JP 2001103627
JP2001010913106.04.2001         Original published format: JP 2001109131
[2008/39]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP1972638
Date:24.09.2008
Language:EN
[2008/39]
Search report(s)(Supplementary) European search report - dispatched on:EP11.08.2008
ClassificationIPC:C07K16/28, A61K45/00, A61K39/395, A61P19/02
[2008/39]
CPC:
C07K16/2866 (EP,US); A61K39/395 (KR); A61K39/3955 (US);
A61K45/06 (US); A61K9/0019 (US); A61P19/02 (EP);
A61P29/00 (EP); A61P37/02 (EP); A61P43/00 (EP);
C07K16/248 (EP,US); A61K2039/505 (EP,US); C07K2317/14 (US);
C07K2317/24 (EP,US); C07K2317/76 (US) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2008/39]
Extension statesAL15.07.2008
LT01.07.2008
LV01.07.2008
MK15.07.2008
RO01.07.2008
SI01.07.2008
TitleGerman:Mittel zur Behandlung von juveniler chronischer Arthritis und verwandte Krankheiten[2008/39]
English:Remedies for juvenile chronic arthritis and related diseases[2008/39]
French:Remèdes pour le traitement de l'arthrite chronique juvenile et des maladies apparentées[2008/39]
Examination procedure01.07.2008Examination requested  [2008/39]
08.04.2009Despatch of a communication from the examining division (Time limit: M06)
08.10.2009Reply to a communication from the examining division
04.12.2009Despatch of a communication from the examining division (Time limit: M06)
14.06.2010Reply to a communication from the examining division
30.09.2011Date of oral proceedings
04.11.2011Despatch of communication that the application is refused, reason: substantive examination [2017/33]
04.11.2011Minutes of oral proceedings despatched
08.12.2016Application refused, date of legal effect [2017/33]
Appeal following examination15.12.2011Appeal received No.  T0652/12
07.03.2012Statement of grounds filed
08.12.2016Result of appeal procedure: appeal of the applicant was rejected
08.12.2016Date of oral proceedings
10.02.2017Minutes of oral proceedings despatched
Parent application(s)   TooltipEP02708772.5  / EP1374900
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20020708772) is  16.02.2006
Fees paidRenewal fee
01.07.2008Renewal fee patent year 03
01.07.2008Renewal fee patent year 04
01.07.2008Renewal fee patent year 05
01.07.2008Renewal fee patent year 06
01.07.2008Renewal fee patent year 07
15.04.2009Renewal fee patent year 08
17.03.2010Renewal fee patent year 09
21.04.2011Renewal fee patent year 10
27.03.2012Renewal fee patent year 11
23.04.2013Renewal fee patent year 12
13.03.2014Renewal fee patent year 13
23.04.2015Renewal fee patent year 14
30.03.2016Renewal fee patent year 15
24.04.2017Renewal fee patent year 16
Opt-out from the exclusive  Tooltip
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Documents cited:Search[A] EP0783893  (CHUGAI PHARMACEUTICAL CO LTD et al.)
 [A] EP0983767  (CHUGAI PHARMACEUTICAL CO LTD et al.)
 [Y]   DE BENEDETTI F ET AL: "Is systemic juvenile rheumatoid arthritis an interleukin 6 mediated disease?", JOURNAL OF RHEUMATOLOGY, TORONTO, CA, vol. 25, no. 2, 1 February 1998 (1998-02-01), pages 203 - 207, XP009103922, ISSN: 0315-162X
 [Y]   ARKACHAISRI T ET AL: "USE OF BIOLOGICS IN THE TREATMENT OF CHILDHOOD RHEUMATIC DISEASES", CURRENT RHEUMATOLOGY REPORTS, CURRENT SCIENCE, PHILADELPHIA, PA, US, vol. 2, no. 4, 1 August 2000 (2000-08-01), pages 330 - 336, XP009031120, ISSN: 1523-3774
 [Y]   YILMAZ M ET AL: "Cytokine levels in serum of patients with juvenile rheumatoid arthritis.", CLINICAL RHEUMATOLOGY 2001, vol. 20, no. 1, January 2001 (2001-01-01), pages 30 - 35, XP009104083, ISSN: 0770-3198

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 [Y]   MANGGE HARALD ET AL: "Cytokines in juvenile rheumatoid arthritis (JRA)", CYTOKINE, vol. 10, no. 6, June 1998 (1998-06-01), pages 471 - 480, XP002281430, ISSN: 1043-4666

DOI:   http://dx.doi.org/10.1006/cyto.1997.0306
 [Y]   YOSHIZAKI K ET AL: "THERAPY OF RHEUMATOID ARTHRITIS BY BLOCKING IL-6 SIGNAL TRANSDUCTION WITH A HUMANIZED ANTI-IL-6 RECEPTOR ANTIBODY", SPRINGER SEMINARS IN IMMUNOPATHOLOGY, SPRINGER, BERLIN, DE, vol. 20, no. 1/2, 1998, pages 247 - 259, XP001069950, ISSN: 0172-6641
 [Y]   MIHARA M ET AL: "HUMINIZED ANTIBODY TO HUMAN INTERLEUKIN-6 RECEPTOR INHIBITS THE DEVELOPMENT OF COLLAGEN ARTHRITIS IN CYNOMOLGUS MONKEYS", CLINICAL IMMUNOLOGY, ACADEMIC PRESS,, US, vol. 98, no. 3, March 2001 (2001-03-01), pages 319 - 326, XP001069970, ISSN: 1521-6616

DOI:   http://dx.doi.org/10.1006/clim.2000.4989
 [Y]   DE BENEDETTI FABRIZIO ET AL: "Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I: A model for stunted growth in children with chronic inflammation", JOURNAL OF CLINICAL INVESTIGATION, vol. 99, no. 4, 1997, pages 643 - 650, XP002281431, ISSN: 0021-9738

DOI:   http://dx.doi.org/10.1172/JCI119207
 [Y]   TAKAGI N ET AL: "BLOCKAGE OF INERLEUKIN-6 RECEPTOR AMELIORATES JOINT DISEASE IN MURINE COLLAGEN-INDUCED ARTHRITIS", ARTHRITIS AND RHEUMATISM, LIPPINCOTT, PHILADELPHIA, US, vol. 41, no. 12, December 1998 (1998-12-01), pages 2117 - 2121, XP001069955, ISSN: 0004-3591

DOI:   http://dx.doi.org/10.1002/1529-0131(199812)41:12<2117::AID-ART6>3.0.CO;2-P
 [A]   MANGGE H ET AL: "Long-term follow-up of cytokines and soluble cytokine receptors in peripheral blood of patients with juvenile rheumatoid arthritis.", JOURNAL OF INTERFERON & CYTOKINE RESEARCH : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR INTERFERON AND CYTOKINE RESEARCH SEP 1999, vol. 19, no. 9, September 1999 (1999-09-01), pages 1005 - 1010, XP009104085, ISSN: 1079-9907

DOI:   http://dx.doi.org/10.1089/107999099313217
 [A]   GALLAGHER K T ET AL: "JUVENILE RHEUMATOID ARTHRITIS", CURRENT OPINION IN RHEUMATOLOGY, CURRENT SCIENCE, LONDON, GB, vol. 11, no. 5, 1 January 1999 (1999-01-01), pages 372 - 376, XP009031046, ISSN: 1040-8711

DOI:   http://dx.doi.org/10.1097/00002281-199909000-00008
 [A]   KEUL R ET AL: "A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis.", CYTOKINE SEP 1998, vol. 10, no. 9, September 1998 (1998-09-01), pages 729 - 734, XP009104086, ISSN: 1043-4666

DOI:   http://dx.doi.org/10.1006/cyto.1997.0343
 [A]   FISHMAN D ET AL: "THE EFFECT OF NOVEL POLYMORPHISMS IN THE INTERLEUKIN-6 (IL-6) GENE ON IL-6 TRANSCRIPTION AND PLASMA IL-6 LEVELS AND AN ASSOCIATION WITH SYSTEMIC-ONSET JUVENILE CHRONIC ARTHRITIS", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, 1 October 1998 (1998-10-01), pages 1369 - 1376, XP002952078, ISSN: 0021-9738

DOI:   http://dx.doi.org/10.1172/JCI2629
Examination  SATO K ET AL: "Reshaping a human antibody to inhibit the interleukin 6 -dependent tumor cell growth", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER REREARCH, US, vol. 53, 15 February 1993 (1993-02-15), pages 851 - 856, XP002119558, ISSN: 0008-5472
by applicantWO9509873
 FR2694767
 US5216128
 WO9219759
 EP0325474
 JPH03155795
 JPH03219894
 US5571513
 JPH08291199
 EP0411946
 JPH0159878
 WO9312227
 WO9203918
 WO9402602
 WO9425585
 WO9634096
 WO9633735
 JPH03139293
 EP0125023
 EP0239400
 WO9201047
 WO9220791
 WO9306213
 WO9311236
 WO9319172
 WO9501438
 WO9515388
 WO9630394
 WO9411523
 WO9618648
 WO9617869
 JPH02188600
 JPH07324097
 JPH08311098
 US5210075
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