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Extract from the Register of European Patents

EP About this file: EP2138571

EP2138571 - Process for the preparation of multicellular spheroids [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.02.2018
Database last updated on 07.10.2024
FormerThe patent has been granted
Status updated on  10.03.2017
FormerGrant of patent is intended
Status updated on  03.03.2017
Most recent event   Tooltip29.05.2020Lapse of the patent in a contracting state
New state(s): PT		published on 01.07.2020  [2020/27]
Applicant(s)For all designated states
SpheroTec GmbH
Am Klopferspitz 19
82152 Martinsried / DE
[2010/01]
Inventor(s)01 / Mayer, Barbara
Altbachweg 7
87700 Memmingen / DE
 [2010/14]
Representative(s)Stolmár & Partner Patentanwälte PartG mbB
Blumenstraße 17
80331 München / DE
[2017/15]
Former [2010/01]Stolmár, Matthias, et al
Stolmár Scheele & Partner Patentanwälte Blumenstrasse 17
80331 München / DE
Application number, filing date08011629.626.06.2008
[2010/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2138571
Date:30.12.2009
Language:EN
[2009/53]
Type: B1 Patent specification 
No.:EP2138571
Date:12.04.2017
Language:EN
[2017/15]
Search report(s)(Supplementary) European search report - dispatched on:EP12.12.2008
ClassificationIPC:C12N5/00
[2010/01]
CPC:
C12N5/0062 (EP,US); C12N2503/02 (EP,US); C12N2513/00 (US);
C12N2533/78 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/15]
Former [2010/43]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Former [2010/42]AT,  BE,  BG,  CH,  CY,  CZ,  LI 
Former [2010/39]AT,  BE,  BG,  CH,  CY,  LI 
Former [2010/36]
Former [2010/01]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Verfahren zur Herstellung mehrzelliger Sphäroide[2010/01]
English:Process for the preparation of multicellular spheroids[2010/01]
French:Procédé de préparation de sphéroïdes multicellulaires[2010/01]
Examination procedure25.01.2010Despatch of communication that the application is refused, reason: Examination on filing A.90(5) {1}
31.05.2010Examination requested  [2010/39]
11.11.2010Despatch of a communication from the examining division (Time limit: M04)
21.03.2011Reply to a communication from the examining division
26.03.2013Despatch of a communication from the examining division (Time limit: M06)
26.09.2013Reply to a communication from the examining division
30.10.2014Despatch of a communication from the examining division (Time limit: M04)
06.03.2015Reply to a communication from the examining division
26.02.2016Despatch of a communication from the examining division (Time limit: M06)
05.09.2016Reply to a communication from the examining division
19.10.2016Communication of intention to grant the patent
28.02.2017Fee for grant paid
28.02.2017Fee for publishing/printing paid
28.02.2017Receipt of the translation of the claim(s)
Appeal following examination19.02.2010Appeal received
19.02.2010Statement of grounds filed
21.04.2010Interlocutory revision of appeal
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  11.11.2010
Opposition(s)15.01.2018No opposition filed within time limit [2018/12]
Fees paidRenewal fee
22.06.2010Renewal fee patent year 03
30.06.2011Renewal fee patent year 04
27.06.2012Renewal fee patent year 05
01.07.2013Renewal fee patent year 06
22.12.2014Renewal fee patent year 07
30.06.2015Renewal fee patent year 08
30.06.2016Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
30.06.201407   M06   Fee paid on   22.12.2014
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.06.2008
AT12.04.2017
CY12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
PT12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
TR12.04.2017
IE26.06.2017
LU26.06.2017
MT26.06.2017
BE30.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
[2020/27]
Former [2020/15]HU26.06.2008
AT12.04.2017
CY12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
TR12.04.2017
IE26.06.2017
LU26.06.2017
MT26.06.2017
BE30.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2019/46]HU26.06.2008
AT12.04.2017
CY12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
IE26.06.2017
LU26.06.2017
MT26.06.2017
BE30.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2019/31]HU26.06.2008
AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
IE26.06.2017
LU26.06.2017
MT26.06.2017
BE30.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/43]AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
IE26.06.2017
LU26.06.2017
MT26.06.2017
BE30.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/39]AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
IE26.06.2017
LU26.06.2017
BE30.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/23]AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SI12.04.2017
SK12.04.2017
IE26.06.2017
LU26.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/21]AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SK12.04.2017
LU26.06.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/11]AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
IT12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SK12.04.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/10]AT12.04.2017
CZ12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
NL12.04.2017
PL12.04.2017
RO12.04.2017
SE12.04.2017
SK12.04.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2018/09]AT12.04.2017
DK12.04.2017
EE12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
NL12.04.2017
PL12.04.2017
SE12.04.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2017/50]AT12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
NL12.04.2017
PL12.04.2017
SE12.04.2017
BG12.07.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2017/49]AT12.04.2017
ES12.04.2017
FI12.04.2017
HR12.04.2017
LT12.04.2017
NL12.04.2017
NO12.07.2017
GR13.07.2017
IS12.08.2017
Former [2017/48]NL12.04.2017
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 [XY]  - YAMADA K. ET AL., "Efficient induction of hepatocyte spheroids in a suspension culture using a water-soluble synthetic polymer as an artificial Matrix", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY / OUP, TOKYO, JP, (19980101), vol. 123, no. 6, ISSN 0021-924X, pages 1017 - 1023, XP002955752 [X] 1-10,12,13,15-20 * the whole document * [Y] 11,14
 [XY]  - PARK K-H, "Improved long-term culture of hepatocytes in a hydrogel containing Arg-Gly-Asp (RGD)", BIOTECHNOLOGY LETTERS, (2002), vol. 24, pages 1131 - 1135, XP009108470 [X] 1-10,12,13,15-20 * the whole document * [Y] 11,14
 [Y]  - VINATIER C. ET AL., "A silanized hydroxypropyl methylcellulose hydrogel for the three-dimensional culture of chondrocytes", BIOMATERIALS, (200511), vol. 26, no. 33, ISSN 0142-9612, pages 6643 - 6651, XP004989121 [Y] 11 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2005.04.057
 [Y]  - YAMADA K. ET AL., "Enhanced cell aggregation and liver functions using polymers modified with a cell-specific ligand in primary hepatocyte cultures", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, (199911), vol. 88, no. 5, ISSN 1389-1723, pages 557 - 562, XP002503414 [Y] 14 * the whole document *

DOI:   http://dx.doi.org/10.1016/S1389-1723(00)87675-6
 [A]  - XU F. ET AL., "Three-dimensional polymeric systems for cancer cell studies", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, (20070731), vol. 54, no. 3, ISSN 1573-0778, pages 135 - 143, XP019525901 [A] * the whole document *

DOI:   http://dx.doi.org/10.1007/s10616-007-9065-4
ExaminationUS6368858
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    - MAYER K ET AL, "631 Tumor associated fibroblasts have a profound impact on drug sensitivity of gastric cancer cells", EUROPEAN JOURNAL OF CANCER. SUPPLEMENT, PERGAMON, OXFORD, GB, (20040901), vol. 2, no. 8, doi:10.1016/S1359-6349(04)80639-6, ISSN 1359-6349, page 191, XP004640075

DOI:   http://dx.doi.org/10.1016/S1359-6349(04)80639-6
    - JOKA M ET AL, "prediction of the therapeutic repsonse in colorectal cancer patients using spheroid microtumor technology", JOURNAL OF CLINICAL ONCOLOGY, vol. 26, no. 15S, ISSN 0732-183X, page 22178, URL: http://meeting.ascopubs.org/cgi/content/abstract/26/15_suppl/22178, (20090108), XP002509449
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    - A. MOSCANA, "Cell suspensions from organ rudiments of chick embryos", EXP. CELL RES., (1952), vol. 3, doi:doi:10.1016/0014-4827(52)90077-3, pages 535 - 539, XP024861130

DOI:   http://dx.doi.org/10.1016/0014-4827(52)90077-3
    - A. MOSCANA, "The development in vitro of chimeric aggregates of dissociated embryonic chick and mouse cells", PROC. NATL. ACAD. SCI. (USA, (1957), vol. 43, pages 184 - 104
    - W. MUELLER-KLIESER, "Multicellular Spheroids", J. CANCER RES. CLIN. ONCOL., (1986), vol. 12, pages 101 - 122
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.