EP2147979 - Fluorescently or spin-labeled kinases for rapid screening and identification of novel kinase inhibitor scaffolds [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 17.12.2010 Database last updated on 19.10.2024 | Most recent event Tooltip | 17.12.2010 | Application deemed to be withdrawn | published on 19.01.2011 [2011/03] | Applicant(s) | For all designated states Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hofgartenstrasse 8 80539 München / DE | [N/P] |
Former [2010/04] | For all designated states Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Hofgartenstrasse 8 80539 München / DE | Inventor(s) | 01 /
Rauh, Daniel Wasserturmstrasse 16 67549 Worms / DE | [2010/04] | Representative(s) | Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE | [N/P] |
Former [2010/04] | Vossius & Partner Siebertstrasse 4 81675 München / DE | Application number, filing date | 08013340.8 | 24.07.2008 | [2010/04] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2147979 | Date: | 27.01.2010 | Language: | EN | [2010/04] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 24.11.2008 | Classification | IPC: | C12Q1/48 | [2010/04] | CPC: |
C12Q1/485 (EP);
G01N2333/9121 (EP);
G01N2500/00 (EP)
| Designated contracting states | (deleted) [2010/39] |
Former [2010/04] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR | Title | German: | Fluoreszent- oder spinmarkierte Kinasen zum schnellen Screening und Identifizieren von neuartigen Kinasehemmergerüsten | [2010/04] | English: | Fluorescently or spin-labeled kinases for rapid screening and identification of novel kinase inhibitor scaffolds | [2010/04] | French: | Kinases étiquetées à rotation et de manière fluorescente pour un criblage et une identification rapides des nouveaux échafaudages d'inhibiteur de kinase | [2010/04] | Examination procedure | 28.07.2010 | Application deemed to be withdrawn, date of legal effect [2011/03] | 02.09.2010 | Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time [2011/03] | Fees paid | Penalty fee | Additional fee for renewal fee | 31.07.2010 | 03   M06   Not yet paid |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A] - KAPAHI PANKAJ ET AL, "Inhibition of NF-kappaB activation by arsenite through reaction with a critical cysteine in the activation loop of IkappaB kinase", JOURNAL OF BIOLOGICAL CHEMISTRY, (200011), vol. 275, no. 46, ISSN 0021-9258, pages 36062 - 36066, XP002503167 [A] 1-16 * abstract * DOI: http://dx.doi.org/10.1074/JBC.M007204200 | [A] - FIRST E A ET AL, "SELECTIVE MODIFICATION OF THE CATALYTIC SUBUNIT OF CAMP-DEPENDENT PROTEIN KINASE WITH SULFHYDRYL-SPECIFIC FLUORESCENT PROBES", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON, PA.; US, (19890101), vol. 28, no. 8, ISSN 0006-2960, pages 3598 - 3605, XP002073139 [A] 1-16 * abstract * DOI: http://dx.doi.org/10.1021/bi00434a067 | [A] - PURI R N ET AL, "Adenosine cyclic 3',5'-monophosphate dependent protein kinase: fluorescent affinity labeling of the catalytic subunit from bovine skeletal muscle with o-phthalaldehyde.", BIOCHEMISTRY 5 NOV 1985, (19851105), vol. 24, no. 23, ISSN 0006-2960, pages 6499 - 6508, XP002503168 [A] 1-16 * abstract * DOI: http://dx.doi.org/10.1021/bi00344a029 | [X] - LANGER THOMAS ET AL, "NMR backbone assignment of a protein kinase catalytic domain by a combination of several approaches: application to the catalytic subunit of cAMP-dependent protein kinase.", CHEMBIOCHEM : A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY 5 NOV 2004, (20041105), vol. 5, no. 11, ISSN 1439-4227, pages 1508 - 1516, XP002503169 [X] 1-16 * page 1509; figure 5 * DOI: http://dx.doi.org/10.1002/CBIC.200400129 | [X] - MANLEY PAUL W ET AL, "Bcr-Abl binding modes of dasatinib, imatinib and nilotinib: An NMR study.", BLOOD, & 48TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ORLANDO, FL, USA; DECEMBER 09 -12, 2006, (200611), vol. 108, no. 11, Part 1, ISSN 0006-4971, page 224A, XP002503170 [X] 1-16 * abstract * | by applicant | - HOLZGRABE; BECHTOLD, DEUTSCHE APOTHEKER ZEITUNG, (2000), vol. 140, no. 8, pages 813 - 823 | - ANDERSEN, C.B. ET AL., "Discovery of selective aminothiazole aurora kinase inhibitors", ACS CHEM BIOL, (2008), vol. 3, no. 3, pages 180 - 92 | - ANNIS, D. A. ET AL., "A general technique to rank protein-ligand binding affinities and determine allosteric versus direct binding site competition in compound mixtures", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2004), vol. 126, pages 15495 - 15503 | - ASKARI, N. ET AL., "Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2007), vol. 282, pages 91 - 99 | - AVITZOUR, M. ET AL., "Intrinsically active variants of all human p38 isoforms", THE PEBS JOURNAL, (2007), vol. 274, pages 963 - 975 | - CAPUTO GA; LONDON E., "Cumulative effects of amino acid substitutions and hydrophobic mismatch upon the transmembrane stability and conformation of hydrophobic alpha-helices", BIOCHEMISTRY, (20030325), vol. 42, no. 11, pages 3275 - 85 | - DE LORIMIER, R. M. ET AL., "Construction of a fluorescent biosensor family", PROTEIN SCI, (2002), vol. 11, pages 2655 - 2675 | - DUMAS, J. ET AL., "1-Phenyl-5-pyrazolyl ureas: potent and selective p38 kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2000), vol. 10, pages 2051 - 2054 | - DUMAS, J. ET AL., "Discovery of a new class of p38 kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2000), vol. 10, pages 2047 - 2050 | - HIBBS, R. E.; TALLEY, T. T.; TAYLOR, P., "Acrylodan-conjugated cysteine side chains reveal conformational state and ligand site locations of the acetylcholine- binding protein", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2004), vol. 279, pages 28483 - 28491 | - JOHNSON, L. N.; LEWIS, R. J., "Structural basis for control by phosphorylation", CHEM. REV., (2001), vol. 101, no. 40, pages 2209 - 2242 | - JOHNSON, L. N.; NOBLE, M. E. M.; OWEN, D. J., "Active and inactive protein kinases : structural basis for regulation", CELL, (1996), vol. 85, pages 149 - 158 | - LEVINSON, N.M. ET AL., "Structural basis for the recognition of c-Src by its inactivator Csk", CELL, (2008), vol. 134, pages 124 - 134 | - MOSS, N. ET AL., "New modifications to the area of pyrazole- naphthyl urea based p38 MAP kinase inhibitors that bind to the adenine/ATP site", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2007), vol. 17, pages 4242 - 4247 | - OHREN, J. F. ET AL., "Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition", NATURE STRUCTURAL & MOLECULAR BIOLOGY, (2004), vol. 11, pages 1192 - 1197 | - PARGELLIS, C. ET AL., "Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site", NATURE STRUCTURAL BIOLOGY, (2002), vol. 9, pages 268 - 272 | - "Rapid and Sensitive Sequence Comparison with FASTP and FASTA", W. A PEARSON, Methods in Enzymology, ACADEMIC PRESS, (1990), vol. 183, pages 63 - 98 | - REGAN, J. ET AL., "Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate", JOURNAL OF MEDICINAL CHEMISTRY, (2002), vol. 45, pages 2994 - 3008 | - REGAN, J. ET AL., "The kinetics of binding to p38MAP kinase by analogues of BIRB 796", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2003), vol. 13, pages 3101 - 3104 | - RICHIERI, G. V.; OGATA, R. T.; KLEINFELD, A. M., "The measurement of free fatty acid concentration with the fluorescent probe ADIFAB: a practical guide for the use of the ADIFAB probe", MOLECULAR AND CELLULAR BIOCHEMISTRY, (1999), vol. 192, pages 87 - 94 | - SULLIVAN, J. E. ET AL., "Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase", BIOCHEMISTRY, (2005), vol. 44, pages 16475 - 16490 | - TAYLOR, S. S.; RADZIO-ANDZELM, E., "Three protein kinase structures define a common motif", STRUCTURE, (1994), vol. 2, no. 43, pages 345 - 355 | - "NMR characterization of kinase p38 dynamics in free and ligand-bound forms", VOGTHERR, M. ET AL., Angewandte Chemie, (2006), vol. 45, pages 993 - 997 | - YEM, A. W. ET AL., "Site-specific chemical modification of interleukin-1 beta by acrylodan at cysteine 8 and lysine 103", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (1992), vol. 267, pages 3122 - 3128 | - YOUNG, P.R. ET AL., "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site", J BIOL CHEM, (1997), vol. 272, no. 18, pages 12116 - 21 | - KARAMAN, M.W. ET AL., "A quantitative analysis of kinase inhibitor selectivity", NAT BIOTECHNOL, (2008), vol. 26, no. 1, pages 127 - 32 |