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Extract from the Register of European Patents

EP About this file: EP2042504

EP2042504 - Fused azole-pyrimidine derivatives [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.04.2012
Database last updated on 26.06.2024
Most recent event   Tooltip10.04.2012No opposition filed within time limitpublished on 09.05.2012  [2012/19]
Applicant(s)For all designated states
Bayer Pharma Aktiengesellschaft
Müllerstrasse 178
13353 Berlin / DE
[2011/34]
Former [2009/38]For all designated states
Bayer Schering Pharma Aktiengesellschaft
Müllerstrasse 178
13353 Berlin / DE
Former [2009/37]For all designated states
Bayer Schering Pharma AG
Müllerstrasse 178
13353 Berlin / DE
Former [2009/14]For all designated states
Bayer HealthCare AG
51368 Leverkusen / DE
Inventor(s)01 / Murata, Toshiki
1-3-501, Nakano-cho
Ikoma-shi, 360-0267 / JP
02 / Yamauchi, Megumi
1-7-3-603, Akuwanishi, Seya-ku Yokohama-shi
Kanagawa, 246-0025 / JP
03 / Kikuchi, Tetsuo
c/o Bayer Yakuhin Ltd. 121-1, Toriino Koka-cho, Koka
Shiga, 520-3493 / JP
04 / Yoshino, Takashi
2-13-501, Honcho, Sakado
Saitama, 350-0226 / JP
05 / Omori, Naoki
12-4, Sagisu 5-chome Fukushima-ku
Osaka, 553-0002 / JP
06 / Miura, Mami
1-1365-3-202, Daiwa-cho, Gakuen
Nara-ken, 631-0041 / JP
07 / Tsujishita, Hideki
1-37-2-522, Seikadai, Seika-cho Soraku-gun
Kyoto-fu, 619-0238 / JP
08 / Shimazaki, Makoto
5-5-3-1, Kunimidai, Kizugawa
Kyoto, 619-0216 / JP
09 / Urbahns, Klaus, Dr.
c/o Bayer Yakuhin Ltd. Ichisaka, Kezu-cho, Sayara-Gun
Kyoto 619-02 / JP
10 / Fuchikami, Kinji
c/o Mitsui Ventures MVC Corporation KDDI Otemachi Bldg. 16F 1-8-1, Otemachi, Chiyoda-ku
Tokyo 100-0004 / JP
11 / Matsukawa, Satoko
2-33-3, Numa, Yao-shi
Osaka, 581-0036 / JP
12 / Gantner, Florian
Kristinusstrasse 29
88171 Weiler / DE
13 / Bacon, Kevin
5025 Seagrove Cove
San Diego, California, 92130 / US
 [2009/24]
Former [2009/14]01 / Murata, Toshiki
1-3-501, Nakano-cho
Ikoma-shi, 360-0267 / JP
02 / Yamauchi, Megumi
9-1-506, Minamiuoya-cho
Nara-ken, 630-8355 / JP
03 / Kikuchi, Tetsuo
5-4-12-205, Daianji, Nara-shi
Nara-ken, 630-8133 / JP
04 / Yoshino, Takashi
1-1-17-101, Saidaiji-Nogami-cho
Nara-ken, 631-0833 / JP
05 / Omori, Naoki
A102-1-4-8, Umemidai, Kizo-cho, Soraku-gun
Kyoto-fu, 619-0213 / JP
06 / Miura, Mami
1-1365-3-202, Daiwa-cho, Gakuen
Nara-ken, 631-0041 / JP
07 / Tsujishita, Hideki
1-37-2-522, Seikadai, Seika-cho Soraku-gun
Kyoto-fu, 619-0238 / JP
08 / Shimazaki, Makoto
5-5-3-1, Kunimidai, Kizo-cho Soraku-gun
Kyoto-fu, 619-0216 / JP
09 / Urbahns, Klaus, Dr.
6-3-1-301, Kusugaoka-cho, Nada-ku, Kobe-shi
Hyogo-ken, 657-0024 / JP
10 / Fuchikami, Kinji
7-1-8-A103, Umemidai, Kizu-cho Soraku-gun
Kyoto-fu, 619-0215 / JP
11 / Matsukawa, Satoko
3-149, Nishiyuuge, Yao-shi
Osaka-fu, 581-0035 / JP
12 / Gantner, Florian
Kristinusstrasse 29
88171 Weiler / DE
13 / Bacon, Kevin
5-15-912, Koyo-cho, Naka, Higashinada-ku, Kobe-shi
Hyogo-ken, 658-0032 / JP
Representative(s)(deleted)
[2011/34]
Former [2009/37]Williams, Paul Howard
Bayer Schering Pharma AG Patents and Licensing Müllerstrasse 178
13342 Berlin / DE
Former [2009/14]Williams, Paul Howard
Bayer Schering Pharma Aktiengesellschaft Müllerstrasse 178
13353 Berlin / DE
Application number, filing date08075839.418.09.2003
[2009/14]
Priority number, dateEP2002002186130.09.2002         Original published format: EP 02021861
[2009/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2042504
Date:01.04.2009
Language:EN
[2009/14]
Type: B1 Patent specification 
No.:EP2042504
Date:01.06.2011
Language:EN
[2011/22]
Search report(s)(Supplementary) European search report - dispatched on:EP11.02.2009
ClassificationIPC:C07D471/14, C07D487/04, C07D519/00, A61K31/435, A61P29/00
[2009/14]
CPC:
C07D471/14 (EP,US); C07D487/04 (EP,KR,US); A61P11/02 (EP);
A61P11/06 (EP); A61P13/12 (EP); A61P19/02 (EP);
A61P25/00 (EP); A61P25/28 (EP); A61P29/00 (EP);
A61P3/10 (EP); A61P35/00 (EP); A61P37/00 (EP);
A61P37/02 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P5/14 (EP); A61P9/00 (EP); A61P9/04 (EP);
A61P9/10 (EP); A61P9/12 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2009/14]
TitleGerman:Kondensierte Azol-Pyrimidin-Derivate[2009/14]
English:Fused azole-pyrimidine derivatives[2009/14]
French:Dérivés de pyrimidine d'azole fusionné[2009/14]
Examination procedure25.04.2009Examination requested  [2009/24]
08.07.2009Despatch of a communication from the examining division (Time limit: M06)
15.01.2010Reply to a communication from the examining division
22.11.2010Communication of intention to grant the patent
17.03.2011Fee for grant paid
17.03.2011Fee for publishing/printing paid
Parent application(s)   TooltipEP03788908.6  / EP1549652
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030788908) is  10.07.2006
Opposition(s)02.03.2012No opposition filed within time limit [2012/19]
Fees paidRenewal fee
17.10.2008Renewal fee patent year 03
17.10.2008Renewal fee patent year 04
17.10.2008Renewal fee patent year 05
17.10.2008Renewal fee patent year 06
30.09.2009Renewal fee patent year 07
27.09.2010Renewal fee patent year 08
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[DA]US3644354  (HARDTMANN GOETZ E, et al) [DA] 1-21 * column 1, line 37 - column 1, line 49; examples 1-5; claim - *;
 [DA]  - VLAHOS C J ET AL, "A SPECIFIC INHIBITOR OF PHOSPHATIDYLINOSITOL 3-KINASE, 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE (LY294002)", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,; US, (19940218), vol. 269, no. 7, ISSN 0021-9258, pages 5241 - 5248, XP002023636 [DA] 1-21 * the whole document *
 [DA]  - UI M ET AL, "Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase", TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER, HAYWARDS, GB, (19950801), vol. 20, no. 8, ISSN 0968-0004, pages 303 - 307, XP004222293 [DA] 1-21 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0968-0004(00)89056-8
by applicantUS3644354
 US4287341
    - FRUMAN DA; MEYERS RE; CANTLEY LC, "Phosphoinositide kinases", ANNU. REV. BIOCHEM., (1998), vol. 67, doi:doi:10.1146/annurev.biochem.67.1.481, pages 481 - 507, XP009006080

DOI:   http://dx.doi.org/10.1146/annurev.biochem.67.1.481
    - WYMANN MP; PIROLA L, "Structure and function of phosphoinositide 3-kinases", BIOCHIM. BIOPHYS. ACTA, (1998), vol. 1436, doi:doi:10.1016/S0005-2760(98)00139-8, pages 127 - 150, XP004277222

DOI:   http://dx.doi.org/10.1016/S0005-2760(98)00139-8
    - SOTSIOS Y; WARD SG, "Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines", IMMUNOL. REV., (2000), vol. 177, pages 217 - 235
    - TOKER A; CANTLEY LC, "Signalling through the lipid products of phosphoinositide-3-OH kinase", NATURE, (1997), vol. 387, pages 673 - 676
    - STEPHENS LR; JACKSON TR; HAWKINS PT, "Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system?", BIOCHIM. BIOPHYS. ACTA, (1993), vol. 1179, doi:doi:10.1016/0167-4889(93)90072-W, pages 27 - 75, XP023474566

DOI:   http://dx.doi.org/10.1016/0167-4889(93)90072-W
    - STEPHENS LR ET AL., "The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101", CELL, (1997), vol. 89, doi:doi:10.1016/S0092-8674(00)80187-7, pages 105 - 114, XP002121210

DOI:   http://dx.doi.org/10.1016/S0092-8674(00)80187-7
    - STOYANOV B ET AL., "Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase", SCIENCE, (1995), vol. 269, doi:doi:10.1126/science.7624799, pages 690 - 693, XP000615903

DOI:   http://dx.doi.org/10.1126/science.7624799
    - KRUGMANN S ET AL., "Characterizing the interactions between the two subunits of the p101/p11 Ogamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits", J. BIOL. CHEM., (1999), vol. 274, pages 17152 - 17158
    - SASAKI T ET AL., "Phosphoinositide 3-kinases in immunity: lessons from knockout mice", J. BIOCHEM., (2002), vol. 131, pages 495 - 501
    - SASAKI T ET AL., "Function of PI3Ky in thymocyte development, T cell activation, and neutrophil migration", SCIENCE, (2000), vol. 287, doi:doi:10.1126/science.287.5455.1040, pages 1040 - 1046, XP002214938

DOI:   http://dx.doi.org/10.1126/science.287.5455.1040
    - LI Z ET AL., "Roles ofPLC-beta2 and - beta3 and PI3Ky in chemoattractant-mediated signal transduction", SCIENCE, (2000), vol. 287, pages 1046 - 1049
    - HIRSCH E ET AL., "Central role for G protein- coupled phosphoinositide 3-kinase y in inflammation", SCIENCE, (2000), vol. 287, pages 1049 - 1053
    - MICHAEL A. CRACKOWER ET AL., "Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways", CELL, (2002), vol. 110, pages 737 - 749
    - EMILIO HIRSCH; OMELLA BOSCO ET AL., "Resistance to thromboembolism in PI3Ky-deficient mice", THE FASEB JOURNAL., (2001), vol. 15, pages 2019 - 2021
    - UI M ET AL., "Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase", TRENDS BIOCHEM. SCI., (1995), vol. 20, doi:doi:10.1016/S0968-0004(00)89056-8, pages 303 - 307, XP004222293

DOI:   http://dx.doi.org/10.1016/S0968-0004(00)89056-8
    - VLAHOS CJ ET AL., "A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholino)-8-phenyl-4H-1-benzopyran-4-one (LY294002", J. BIOL. CHEM., (1994), vol. 269, pages 5241 - 5248
    - WYMANN MP ET AL., "Lipids on the move: phosphoinositide 3-kinases in leukocyte function", IMMUNOL. TODAY, (2000), vol. 6, doi:doi:10.1016/S0167-5699(00)01649-2, pages 260 - 264, XP004200089

DOI:   http://dx.doi.org/10.1016/S0167-5699(00)01649-2
    - STEIN RC; WATERFIELD MD, "PI3-kinase inhibition: a target for drug development?", MOL. MED. TODAY., (2000), vol. 6, doi:doi:10.1016/S1357-4310(00)01770-6, pages 347 - 357, XP002351307

DOI:   http://dx.doi.org/10.1016/S1357-4310(00)01770-6
    - SEAN A. WEAVER; STEPHEN G. WARD, "Phosphoinositide 3-kinases in the gut: a link between inflammation and cancer?", TRENDS IN MOLECULAR MEDICINE, (2001), vol. 7, doi:doi:10.1016/S1471-4914(01)02107-4, pages 455 - 462, XP008079381

DOI:   http://dx.doi.org/10.1016/S1471-4914(01)02107-4
    - VANHAESEBROECK B ET AL., "Phosphoinositide 3-kinases: a conserved family of signal transducers", TRENDS BIOCHEM. SCI., (1997), vol. 22, doi:doi:10.1016/S0968-0004(97)01061-X, pages 267 - 272, XP004081595

DOI:   http://dx.doi.org/10.1016/S0968-0004(97)01061-X
    - J. EXP. MED., (1996), vol. 183, pages 2437 - 2448
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