blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP1978098

EP1978098 - Use of multiple recombination sites with unique specificity in recombinational cloning [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  31.03.2017
Database last updated on 02.07.2024
FormerGrant of patent is intended
Status updated on  13.12.2016
Most recent event   Tooltip31.03.2017Application deemed to be withdrawnpublished on 03.05.2017  [2017/18]
Applicant(s)For all designated states
Life Technologies Corporation
5823 Newton Drive
Carlsbad, CA 92008 / US
[2016/47]
Former [2009/30]For all designated states
Life Technologies Corporation
5791 Van Allen Way
Carlsbad, CA 92008 / US
Former [2008/41]For all designated states
INVITROGEN CORPORATION
1600 Faraday Avenue
Carlsbad, CA 92008 / US
Inventor(s)01 / Cheo, David
4307 Ambler Drive
Kensington MD 20895 / US
02 / Brasch, Michael A.
20931 Sunnyacres Road
Gaithersburg MD 20882 / US
03 / Temple, Gary F.
114 Ridge Road
Washington Grove MD 20880 / US
04 / Hartley, James L.
7409 Hillside Drive
Frederick MD 21702 / US
05 / Byrd, Devon R.N.
51 Cornwallis Drive
Fredericksburg, VA 22405 / US
 [2009/37]
Former [2008/41]01 / Cheo, David
4307 Ambler Drive
Kensington MD 20895 / US
02 / Brasch, Michael A.
20931 Sunnyacres Road
Gaithersburg MD 20882 / US
03 / Temple, Gary F.
114 Ridge Road
Washington Grove MD 20880 / US
04 / Hartley, James L.
7409 Hillside Drive
Frederick MD 21702 / US
05 / Byrd, Devon R.N.
9511 Briar Glenn Way
Montgomery Village, MD 20886 / US
Representative(s)Weber, Birgit
Life Technologies GmbH
Frankfurter Strasse 129 B
64293 Darmstadt / DE
[N/P]
Former [2012/09]Weber, Birgit
Life Technologies GmbH Frankfurter Strasse 129 B
64293 Darmstadt / DE
Former [2010/09]Harrison Goddard Foote
4th Floor Merchant Exchange 17-19 Whitworth Street West Manchester
M1 5WG / GB
Former [2008/41]Harrison Goddard Foote
Orlando House 11c Compstall Road Marple Bridge Stockport
SK6 5HH / GB
Application number, filing date08153538.711.12.2000
[2008/41]
Priority number, dateUS20000188020P09.03.2000         Original published format: US 188020 P
US19990169983P10.12.1999         Original published format: US 169983 P
[2008/41]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP1978098
Date:08.10.2008
Language:EN
[2008/41]
Type: A3 Search report 
No.:EP1978098
Date:18.02.2009
[2009/08]
Search report(s)(Supplementary) European search report - dispatched on:EP16.01.2009
ClassificationIPC:C12N15/64, C12N15/10, C07K14/47, C12N9/00, C12N15/66
[2009/08]
CPC:
C12N15/10 (EP,US); C07K14/47 (EP,US); C12N15/102 (EP,US);
C12N15/64 (EP,US); C12N15/66 (EP,US); C12N9/00 (EP,US)
Former IPC [2008/41]C12N15/64, C07K14/47, C12N15/66, C12N9/00
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE,   TR [2008/41]
TitleGerman:Verwendung von mehrfachen Rekombinationsstellen mit einzigartiger Spezifizität beim Rekombinationsklonen[2008/41]
English:Use of multiple recombination sites with unique specificity in recombinational cloning[2008/41]
French:Utilisation de sites à recombinaison multiples avec une spécificité unique de clonage recombinatoire[2008/41]
Examination procedure05.08.2009Examination requested  [2009/38]
07.09.2009Despatch of a communication from the examining division (Time limit: M06)
29.06.2010Reply to a communication from the examining division
05.07.2011Despatch of a communication from the examining division (Time limit: M06)
13.01.2012Reply to a communication from the examining division
02.05.2013Despatch of a communication from the examining division (Time limit: M06)
08.11.2013Reply to a communication from the examining division
14.07.2015Despatch of a communication from the examining division (Time limit: M04)
12.11.2015Reply to a communication from the examining division
15.12.2015Despatch of a communication from the examining division (Time limit: M04)
15.04.2016Reply to a communication from the examining division
24.06.2016Communication of intention to grant the patent
05.11.2016Application deemed to be withdrawn, date of legal effect  [2017/18]
14.12.2016Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2017/18]
Parent application(s)   TooltipEP00984184.2  / EP1250453
Divisional application(s)EP10151112.9  / EP2210948
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20000984184) is  19.01.2007
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
29.06.2010Request for further processing filed
29.06.2010Full payment received (date of receipt of payment)
Fees paidRenewal fee
28.03.2008Renewal fee patent year 03
28.03.2008Renewal fee patent year 04
28.03.2008Renewal fee patent year 05
28.03.2008Renewal fee patent year 06
28.03.2008Renewal fee patent year 07
28.03.2008Renewal fee patent year 08
24.12.2008Renewal fee patent year 09
28.12.2009Renewal fee patent year 10
27.12.2010Renewal fee patent year 11
27.12.2011Renewal fee patent year 12
26.12.2012Renewal fee patent year 13
27.12.2013Renewal fee patent year 14
29.12.2014Renewal fee patent year 15
10.12.2015Renewal fee patent year 16
Penalty fee
Additional fee for renewal fee
31.12.201617   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XY]WO9640724  (LIFE TECHNOLOGIES INC [US], et al) [X] 1,6,8-10,12-15,17 * the whole document * [Y] 2,3,7,16;
 [X]WO9921977  (LIFE TECHNOLOGIES INC [US]) [X] 1-8,11-15,17 * the whole document *;
 [E]EP1227147  (INVITROGEN CORP [US]) [E] 1-8,11-15,17 * the whole document *;
 [X]  - TSURUSHITA N ET AL, "Phage display vectors for in vivo recombination of immunoglobulin heavy and light chain genes to make large combinatorial libraries", GENE, ELSEVIER, AMSTERDAM, NL, (19960612), vol. 172, no. 1, ISSN 0378-1119, pages 59 - 63, XP004042709 [X] 1-8,10-15,17-26 * figure 1 *

DOI:   http://dx.doi.org/10.1016/0378-1119(96)00170-9
 [XY]  - THORPE HELENA M ET AL, "In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, May 12, 1998, (19980512), vol. 95, no. 10, ISSN 0027-8424, pages 5505 - 5510, XP002268753 [X] 1,4-6,11-15,17 * the whole document * [Y] 2,3,7,16

DOI:   http://dx.doi.org/10.1073/pnas.95.10.5505
 [PX]  - WALHOUT A J M ET AL, "GATEWAY RECOMBINATIONAL CLONING: APPLICATION TO THE CLONING OF LARGE NUMBERS OF OPEN READING FRAMES OR ORFEOMES", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, (20000101), vol. 328, ISSN 0076-6879, pages 575 - 592, XP001056139 [PX] 1-8,10,12-15,17 * page 579 - page 582; figure 2 *

DOI:   http://dx.doi.org/10.1016/S0076-6879(00)28419-X
ExaminationUS5851808
by applicantUS4683195
 US4683202
 US4736866
 US4800159
 EP0329822
 US4873191
 US4874748
 US4889818
 US4960707
 US4962022
 US4965188
 US4980286
 US5000333
 US5047342
 US5063155
 US5079352
 US5082784
 US5098839
 US5098837
 WO9206180
 WO9206188
 WO9206200
 US5139942
 US5143854
 US5147800
 US5149639
 WO9220316
 WO9222635
 US5179015
 US5192675
 US5200333
 US5202248
 WO9313663
 WO9314188
 US5231021
 US5244797
 US5248605
 US5252743
 WO9320221
 US5270179
 WO9407921
 US5304480
 WO9408598
 US5312746
 WO9412649
 US5328984
 US5334526
 US5334575
 US5374553
 WO9508548
 US5409818
 US5412087
 WO9516028
 US5436146
 US5436149
 US5436327
 US5445934
 US5455166
 US5464764
 US5470740
 EP0684315
 US5498523
 WO9610640
 US5512462
 WO9617053
 US5534428
 WO9640968
 WO9702358
 WO9702357
 US5599695
 WO9709451
 US5614365
 US5631153
 US5667973
 US5672491
 US5677170
 WO9743450
 US5712146
 WO9806736
 US5733743
 WO9820967
 US5763170
 US5766891
 US5770435
 WO9827203
 US5800992
 WO9847912
 US5837832
 US5843772
 US5851808
 US5858657
 WO9905574
 WO9905591
 US5871907
 US5888732
 US5888795
 US5889165
 WO9940105
 US5965796
 US5998205
 US6040435
 US6110372
 WO0052027
 US6120814
 US6143557
 US6270969
 US6277608
 US6451602
 US2003100110
 US6964861
    - LANDY, A., CURRENT OPINION IN BIOTECHNOLOGY, (1993), vol. 3, pages 699 - 707
    - HOESS ET AL., NUCLEIC ACIDS RESEARCH, (1986), vol. 14, no. 6, page 2287
    - ABREMSKI ET AL., J BIOL. CHEM., (1986), vol. 261, no. 1, page 391
    - CAMPBELL, J BACTERIOL., (1992), vol. 174, no. 23, page 7495
    - QIAN ET AL., J BIOL. CHEM., (1992), vol. 267, no. 11, page 7794
    - ARAKI ET AL., J MOL. BIOL., (1992), vol. 225, no. 1, page 25
    - MAESER; KAHNMANN, MOL. GEN. GENET, (1991), vol. 230, pages 170 - 176
    - ESPOSITO ET AL., NUCL. ACIDS RES, (1997), vol. 25, no. 18, page 3605
    - ARGOS ET AL., EMBO J., (1986), vol. 5, pages 433 - 440
    - VOZIYANOV ET AL., NUCL. ACIDS RES., (1999), vol. 27, no. 930
    - LANDY, A, CURRENT OPINIONS IN GENETICS AND DEVEL., (1993), vol. 3, pages 699 - 707
    - HOESS; ABREMSKI, Nucleic Acids and Molecular Biology, SPRINGER-VERLAG, (1990), vol. 4, pages 90 - 109
    - BROACH ET AL., CELL, (1982), vol. 29, pages 227 - 234
    - STELLWAGEN, A.E.; CRAIG, N.L., TRENDS IN BIOCHEMICAL SCIENCES, (1998), vol. 23, pages 486 - 490
    - LUCKLOW ET AL., J. VIROL, (1993), vol. 67, pages 4566 - 4579
    - YORK ET AL., NUCLEIC ACIDS RESEARCH, (1998), vol. 26, no. 8, pages 1927 - 1933
    - DEVINE ET AL., NUCLEIC ACIDS RESEARCH, (1994), vol. 22, pages 3765 - 3772
    - FRANCIA ET AL., J. BACTERIOLOGY, (1999), vol. 181, no. 21, pages 6844 - 6849
    - SAUER, B., CURR. OPIN. BIOTECH, (1994), vol. 5, pages 521 - 527
    - LANDY, CURR. OPIN. BIOTECH, (1993), vol. 3, pages 699 - 707
    - S. MOTTAGUI-TABAR, NAR, (1998), vol. 26, no. 11, page 2789
    - EGGERTSSON ET AL., MICROBIOLOGICAL REVIEW, (1988), vol. 52, no. 3, pages 354 - 374
    - "Escherichia coli and Salmonella Cellular and Molecular Biology", ENGLEERG-KUKLA ET AL., Escherichia coli and Salmonella Cellular and Molecular Biology, ASM PRESS, (1996), pages 909 - 921
    - CAPONE ET AL., MOLECULAR AND CELLULAR BIOLOGY, (1986), vol. 6, no. 9, pages 3059 - 3067
    - SEDIVY ET AL., CELL, (1987), vol. 50, pages 379 - 389
    - PHILLIPS-JONES ET AL., MOLECULAR AND CELLULAR BIOLOGY, (1995), vol. 15, no. 12, pages 6593 - 6600
    - MARTIN ET AL., BIOCHEMICAL SOCIETY TRANSACTIONS, (1993), vol. 21
    - TEMPLE ET AL., NATURE, (1982), vol. 296, no. 5857, pages 537 - 40
    - ROBINSON ET AL., HUMAN GENE THERAPY, (1995), vol. 6, pages 137 - 143
    - FERGUSON, J. ET AL., GENE, (1981), vol. 16, page 191
    - HASHIMOTO-GOTOH, T. ET AL., GENE, (1986), vol. 41, page 125
    - SAUER, B., CURRENT OPINION IN BIOTECHNOLOGY, (1994), vol. 5, pages 521 - 527
    - LANDY, CURRENT OPINION IN BIOTECHNOLOGY, (1993), vol. 3, pages 699 - 707
    - LIU, Q. ET AL., CURR. BIOL, (1998), vol. 8, pages 1300 - 1309
    - WILSON, G.G., NUCL. ACIDS RES, (1991), vol. 19, pages 2539 - 2566
    - LUNNEN, K.D. ET AL., GENE, (1988), vol. 74, pages 25 - 32
    - SAUER, B., CURRENT OPINIONS IN BIOTECHNOLOGY, (1994), vol. 5, pages 521 - 527
    - LANDY, A., ANN. REV. BIOCHEM., (1989), vol. 58, pages 913 - 949
    - WATERHOUSE ET AL., NUCLEIC ACIDS RES., (1993), vol. 21, no. 9, pages 2265 - 2266
    - TSURUSHITA ET AL., GENE, (1996), vol. 172, no. 1, pages 59 - 63
    - PERSSON, INT. REV. IMMUNOL., (1993), vol. 10, no. 2-3, pages 153 - 63
    - CHANOCK ET AL., INFECT AGENTS DIS, (19930602), vol. 3, pages 118 - 31
    - BURIONI ET AL., RES VIROL, (199703), vol. 148, no. 2, pages 161 - 4
    - LEUNG, THROMB. HAEMOST, (199507), vol. 74, no. 1, pages 373 - 6
    - SANDHU, CRIT. REV. BIOTECHNOL, (1992), vol. 12, no. 5-6, pages 437 - 62
    - SMITH; WATERMAN, ADVANCES IN APPLIED MATHEMATICS, (1981), vol. 2, pages 482 - 489
    - OURY ET AL., J. BIOL. CHEM., (2000), vol. 275, pages 22611 - 22614
    - MCNELLIS ET AL., PLANT CELL, (1996), vol. 8, pages 1491 - 1503
    - MAEMURA ET AL., J BIOL. CHEM., (1999), vol. 274, pages 31565 - 31570
    - KIM ET AL., APPL. ENVIRON. MICROBIOL, (2000), vol. 66, pages 788 - 793
    - STASSI ET AL., PROC. NATL. ACAD. SCI. USA, (1998), vol. 95, pages 7305 - 7309
    - MARTIN, APPL. MICROBIOL. BIOTECHNOL, (1998), vol. 50, no. 1, pages 1 - 15
    - KOMIYAMA ET AL., BIOL. PHARM. BULL, (1998), vol. 21, no. 10, pages 1013 - 1019
    - HANCOCK ET AL., PROC. NATL. ACAD SCI. USA, (2000), vol. 97, pages 8856 - 8861
    - SAITO ET AL., GENE, (1997), vol. 203, no. 2, pages 241 - 250
    - FLORES ET AL., PROC. NATL. ACAD SCI. USA, (1999), vol. 96, no. 14, pages 7815 - 7820
    - WOLD, F., POST-TRANSLATIONAL PROTEIN MODIFICATIONS: PERSPECTIVES AND PROSPECTS, ACADEMIC PRESS, (1983), pages 1 - 12
    - SEIFTER ET AL., "Analysis for Protein Modifications and Nonprotein Cofactors", METH. ENZYMOL, (1990), vol. 182, doi:doi:10.1016/0076-6879(90)82049-8, pages 626 - 646, XP009082492

DOI:   http://dx.doi.org/10.1016/0076-6879(90)82049-8
    - RATTAN ET AL., "Protein Synthesis: Post-translational Modifications and Aging", ANN. NYACAD SCI, (1992), vol. 663, pages 48 - 62
    - SKRALY ET AL., APPL. ENVIRON MICROBIOL., (1998), vol. 64, pages 98 - 105
    - DENG ET AL., APPL. ENVIRON. MICROBIOL, (1999), vol. 65, pages 523 - 528
    - MADISON ET AL., MICROBIOL. MOLEC. BIOL, (1999), vol. 63, pages 21 - 53
    - "The Common Pathway to Lysine, Methionine and Threonine", G.N. COHEN, Amino Acids: Biosynthesis and Genetic Regulation, ADDISON-WELESLEY PUBLISHING CO., INC., (1983), pages 147 - 171
    - JARVIS ET AL., CURR. OPIN. BIOTECHNOL, (1998), vol. 9, pages 528 - 533
    - STANLEY, "glycosylation engineering", GLYCOBIOLOGY, (1992), vol. 2, doi:doi:10.1093/glycob/2.2.99, pages 99 - 107, XP001018791

DOI:   http://dx.doi.org/10.1093/glycob/2.2.99
    - KHOLODENKO ET AL., BIOTECHNOL. BIOENG., (1997), vol. 59, pages 239 - 247
    - FU ET AL., BIOCHEMISTRY, (1994), vol. 33, pages 9321 - 9326
    - MCDANIEL ET AL., SCIENCE, (1993), vol. 262, pages 1546 - 1550
    - ROHR, ANGEW. CHEM. INT. ED ENGL, (1995), vol. 34, pages 881 - 888
    - PANKE ET AL., APPL. ENVIRON. MICROBIOL., (1998), vol. 64, pages 748 - 751
    - MILLER, "Bacterial Detoxification of Hg(II) and Organomercurials", ESSAYS BIOCHEM., (1999), vol. 34, pages 17 - 30
    - O'GARA ET AL., APPL. ENVIRON. MICROBIOL, (1997), vol. 63, no. 12, pages 4713 - 4720
    - CORBETT, "Phytochelatin Biosynthesis and Function in Heavy-Metal Detoxification", CURR. OPIN. PLANT BIOL., (2000), vol. 3, no. 3, pages 211 - 216, XP004793024
    - SCHNEPFETAL., MICROBIOL. MOLEC. BIOL. REV, (1998), vol. 62, pages 775 - 806
    - GOLDSPIEL ET AL., CLINICAL PHARMACY, (1993), vol. 12, pages 488 - 505
    - WU; WU, BIOTHERAPY, (1991), vol. 3, pages 87 - 95
    - TOLSTOSHEV, ARM. REV. PHARMACOL. TOXICOL, (1993), vol. 32, pages 573 - 596
    - MULLIGAN, SCIENCE, (1993), vol. 260, pages 926 - 932
    - MORGAN; ANDERSON, ANN. REV. BIOCHEM., (1993), vol. 62, pages 191 - 217
    - MAY, TIBTECH, (1993), vol. 11, no. 5, pages 155 - 215
    - WU; WU, J BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432
    - KOLLER; SMITHIES, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 8932 - 8935
    - ZIJLSTRA ET AL., NATURE, (1989), vol. 342, pages 435 - 438
    - MILLER ET AL., METH. ENZYMOL., (1993), vol. 217, pages 581 - 599
    - BOESEN ET AL., BIOTHERAPY, (1994), vol. 6, pages 291 - 302
    - CLOWES ET AL., J. CLIN. INVEST., (1994), vol. 93, pages 644 - 651
    - KIEM ET AL., BLOOD, (1994), vol. 83, pages 1467 - 1473
    - SALMONS; GUNZBERG, HUMAN GENE THERAPY, (1993), vol. 4, pages 129 - 141
    - GROSSMAN; WILSON, CURR. OPIN. IN GENETICS AND DEVEL, (1993), vol. 3, pages 110 - 114
    - KOZARSKY; WILSON, CURRENT OPINION IN GENETICS AND DEVELOPMENT, (1993), vol. 3, pages 499 - 503
    - BOUT ET AL., HUMAN GENE THERAPY, (1994), vol. 5, pages 3 - 10
    - ROSENFELD ET AL., SCIENCE, (1991), vol. 252, pages 431 - 434
    - ROSENFELD ET AL., CELL, (1992), vol. 68, pages 143 - 155
    - MASTRANGELI ET AL., J. CLIN. INVEST, (1993), vol. 91, pages 225 - 234
    - WANG ET AL., GENE THERAPY, (1995), vol. 2, pages 775 - 783
    - WALSH ET AL., PROC. SOC. EXP. BIOL. MED, (1993), vol. 204, pages 289 - 300
    - WAGSTAFF ET AL., GENE THER, (1998), vol. 5, pages 1566 - 70
    - LOEFFLER; BEHR, METH. ENZYMOL, (1993), vol. 217, pages 599 - 618
    - COHEN ET AL., METH. ENZYMOL, (1993), vol. 217, pages 618 - 644
    - CLINE, PHARMAC. THER., (1985), vol. 29, pages 69 - 92
    - STEMPLE; ANDERSON, CELL, (1992), vol. 71, pages 973 - 985
    - RHEINWALD, METH. CELL BIO., (1980), vol. 21A, page 229
    - PITTELKOW; SCOTT, MAYO CLINIC PROC, (1986), vol. 61, page 771
    - PATERSON ET AL., APPL. MICROBIOL. BIOTECHNOL., (1994), vol. 40, pages 691 - 698
    - CARVER ET AL., BIOTECHNOLOGY (NY, (1993), vol. 11, pages 1263 - 1270
    - WRIGHT ET AL., BIOTECHNOLOGY (NY, (1991), vol. 9, pages 830 - 834
    - VAN DER PUTTEN, PROC. NATL. ACAD. SCI., (1985), vol. 82, pages 6148 - 6152
    - THOMPSON ET AL., CELL, (1989), vol. 56, pages 313 - 321
    - LO, MOL. CELL. BIOL., (1983), vol. 3, pages 1803 - 1814
    - ULMER ET AL., SCIENCE, (1993), vol. 259, page 1745
    - LAVITRANO ET AL., CELL, (1989), vol. 57, pages 717 - 723
    - GORDON, "Transgenic Animals", INTL. REV. CYTOL, (1989), vol. 115, pages 171 - 229
    - CAMPELL ET AL., NATURE, (1996), vol. 380, pages 64 - 66
    - WILMUT ET AL., NATURE, (1997), vol. 385, pages 810 - 813
    - LASKO ET AL., PROC. NATL. ACAD SCI. USA, (1992), vol. 89, pages 6232 - 6236
    - GU ET AL., SCIENCE, (1994), vol. 265, pages 103 - 106
    - SAMBROOK, J. ET AL., Molecular Cloning, a Laboratory Manual, COLD SPRING HARBOR LABORATORY PRESS, (1989), pages 16.30 - 16.55
    - WATSON, J.D. ET AL., Recombinant DNA, W.H. FREEMAN AND CO., (1992), pages 213 - 234
    - ASTATKE, M. ET AL., J. MOL. BIOL., (1998), vol. 278, pages 147 - 165
    - BARNES, W.M., GENE, (1992), vol. 112, pages 29 - 35
    - LAWYER, F.C. ET AL., PCR METH. APPL, (1993), vol. 2, pages 275 - 287
    - FLAMAN, J.-M ET AL., NUCL. ACIDS RES, (1994), vol. 22, no. 15, pages 3259 - 3260
    - SAIKI, R.K. ET AL., SCIENCE, (1988), vol. 239, pages 487 - 491
    - KOTEWICZ, M.L. ET AL., NUCL. ACIDS RES, (1988), vol. 16, page 265
    - GERARD, G.F. ET AL., FOCUS, (1992), vol. 14, no. 5, page 91
    - HOUTS, G.E. ET AL., J. VIROL, (1979), vol. 29, page 517
    - KOTEWICZ, M.L. ET AL., NUCL. ACIDS RES., (1988), vol. 16, page 265
    - SOLTIS, D.A.; SKALKA, A.M., PROC. NATL. ACAD SCI. USA, (1988), vol. 85, pages 3372 - 3376
    - ROGERS ET AL., ANAL. BIOCHEM., (1999), vol. 266, pages 23 - 30
    - ALDRIAN-HERRADA ET AL., J. PEPT. SCI., (1998), vol. 4, pages 266 - 281
    - SYKES ET AL., NATURE BIOTECHNOLOGY, (1999), vol. 17, pages 355 - 359
    - TAWFIK ET AL., NATURE BIOTECHNOLOGY, (1998), vol. 16, pages 652 - 656
    - ENCAMACION, CURRENT OPINION IN BIOTECHNOLOGY, (1999), vol. 10, pages 458 - 464
    - METTE ET AL., EMBO J, (2000), vol. 19, pages 5194 - 5201
    - CHUANG ET AL., PROC. NATL. ACAD SCI. (USA, (2000), vol. 97, pages 4985 - 4990
    - ROSS; LANDY, CELL, (1983), vol. 33, pages 261 - 272
    - R. REED, CURR. OPIN. GENET. DEVEL., (1996), vol. 6, pages 215 - 220
    - S. MOUNT, NUCL. ACIDS. RES, (1982), vol. 10, pages 459 - 472
    - P. SHARP, CELL, (1994), vol. 77, pages 805 - 815
    - K. NELSON; M. GREEN, GENES AND DEVEL, (1988), vol. 23, pages 319 - 329
    - T. COOPER; W. MATTOX, AM. J HUM. GENET., (1997), vol. 61, pages 259 - 266
    - DERBYSHIRE ET AL., PROC. NATL. ACAD SCI, (1998), vol. 95, pages 1356 - 1357
    - PERLER, NUCLEIC ACIDS RES., (1999), vol. 2, no. 7, pages 346 - 347
    - CHONG ET AL., GENE, (1997), vol. 192, pages 271 - 281
 US19950486139
 US19970065930
 US19980177387
 US19980108324
 US19990122392
 US19990122389
 US19990126049
 US19990136744
 US19990161403
 US20000517466
 US20000518188
 US20000695065
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.