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Extract from the Register of European Patents

EP About this file: EP2117422

EP2117422 - A METHOD AND SYSTEM FOR DETERMINING A CEREBROVASCULAR AUTOREGULATION STATE OF A PATIENT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.10.2016
Database last updated on 24.04.2024
Most recent event   Tooltip17.08.2018Lapse of the patent in a contracting state
New state(s): BG		published on 19.09.2018  [2018/38]
Applicant(s)For all designated states
The Johns Hopkins University
3400 North Charles Street
Baltimore, MD 21218 / US
[2015/50]
Former [2010/18]For all designated states
The Johns Hopkins University
3400 North Charles Street
Baltimore MD 21218 / US
Former [2009/47]For all designated states
Johns Hopkins University
3400 North Charles Street
Baltimore MD 21218 / US
Inventor(s)01 / BRADY, Ken, M.
Johns Hopkins University School of Medicine
Department of Anesthesiology
Division of Pediatric Anethesiology and Critical Care Medicine
600 North Wolfe Street, Blalock 904 Baltimore, Maryland 21287 / US
 [2015/50]
Former [2009/47]01 / BRADY, Ken, M.
Johns Hopkins University School of Medicine Department of Anesthesiology Division of Pediatric Anethesiology and Critical Care Medicine
600 North Wolfe Street, Blalock 904 Baltimore, Maryland 21287 / US
Representative(s)Wright, Howard Hugh Burnby, et al
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
[N/P]
Former [2015/50]Wright, Howard Hugh Burnby, et al
Withers & Rogers LLP
4 More London Riverside
London
SE1 2AU / GB
Former [2009/47]Wright, Howard Hugh Burnby, et al
Withers & Rogers LLP Goldings House 2 Hays Lane London
SE1 2HW / GB
Application number, filing date08713011.804.01.2008
[2009/47]
WO2008US00170
Priority number, dateUS20070899146P02.02.2007         Original published format: US 899146 P
[2009/47]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008097411
Date:14.08.2008
Language:EN
[2008/33]
Type: A1 Application with search report 
No.:EP2117422
Date:18.11.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 14.08.2008 takes the place of the publication of the European patent application.
[2009/47]
Type: B1 Patent specification 
No.:EP2117422
Date:09.12.2015
Language:EN
[2015/50]
Search report(s)International search report - published on:US14.08.2008
(Supplementary) European search report - dispatched on:EP13.08.2012
ClassificationIPC:A61B5/02, A61B5/145, G01N33/49, G06Q50/00, A61B5/021, // A61B5/026, A61B5/03
[2015/24]
CPC:
A61B5/02 (KR); A61B5/02028 (EP,US); A61B5/021 (EP,US);
A61B5/0261 (EP,US); A61B5/14 (KR); A61B5/14553 (EP,US);
A61B5/4064 (EP,US); A61B5/022 (EP,US); A61B5/031 (EP,US);
A61B5/1459 (EP,US) (-)
Former IPC [2009/47]A61B5/02, G01N33/49, G06Q50/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/50]
Former [2009/47]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERFAHREN UND SYSTEM ZUR BESTIMMUNG EINES ZEREBROVASKULÄREN AUTOREGULATIONSZUSTANDS EINES PATIENTEN[2009/47]
English:A METHOD AND SYSTEM FOR DETERMINING A CEREBROVASCULAR AUTOREGULATION STATE OF A PATIENT[2009/47]
French:PROCÉDÉ ET SYSTÈME POUR DÉTERMINER UN ÉTAT D'AUTORÉGULATION CÉRÉBROVASCULAIRE D'UN PATIENT[2009/47]
Entry into regional phase02.09.2009National basic fee paid 
02.09.2009Search fee paid 
02.09.2009Designation fee(s) paid 
02.09.2009Examination fee paid 
Examination procedure02.12.2008Request for preliminary examination filed
International Preliminary Examining Authority: US
02.09.2009Examination requested  [2009/47]
08.03.2013Amendment by applicant (claims and/or description)
17.06.2015Communication of intention to grant the patent
21.10.2015Fee for grant paid
21.10.2015Fee for publishing/printing paid
21.10.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.06.2015
Opposition(s)12.09.2016No opposition filed within time limit [2016/46]
Fees paidRenewal fee
25.01.2010Renewal fee patent year 03
25.01.2011Renewal fee patent year 04
25.01.2012Renewal fee patent year 05
25.01.2013Renewal fee patent year 06
27.01.2014Renewal fee patent year 07
27.01.2015Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU04.01.2008
AT09.12.2015
BE09.12.2015
BG09.12.2015
CY09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
HR09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
TR09.12.2015
IE04.01.2016
LU04.01.2016
CH31.01.2016
LI31.01.2016
MT31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
[2018/38]
Former [2018/31]HU04.01.2008
AT09.12.2015
BE09.12.2015
CY09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
HR09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
TR09.12.2015
IE04.01.2016
LU04.01.2016
CH31.01.2016
LI31.01.2016
MT31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2018/28]HU04.01.2008
AT09.12.2015
BE09.12.2015
CY09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
HR09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
MT09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
IE04.01.2016
LU04.01.2016
CH31.01.2016
LI31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2017/47]AT09.12.2015
BE09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
MT09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
IE04.01.2016
LU04.01.2016
CH31.01.2016
LI31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2017/07]AT09.12.2015
BE09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
IE04.01.2016
LU04.01.2016
CH31.01.2016
LI31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2017/03]AT09.12.2015
BE09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
LU04.01.2016
CH31.01.2016
LI31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2016/49]AT09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
PL09.12.2015
RO09.12.2015
SE09.12.2015
SI09.12.2015
SK09.12.2015
LU04.01.2016
BE31.01.2016
CH31.01.2016
LI31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2016/46]AT09.12.2015
CZ09.12.2015
DK09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
RO09.12.2015
SE09.12.2015
SK09.12.2015
LU04.01.2016
BE31.01.2016
CH31.01.2016
LI31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2016/42]AT09.12.2015
CZ09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
MC09.12.2015
NL09.12.2015
RO09.12.2015
SE09.12.2015
SK09.12.2015
LU04.01.2016
BE31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2016/39]AT09.12.2015
CZ09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
NL09.12.2015
RO09.12.2015
SE09.12.2015
SK09.12.2015
LU04.01.2016
BE31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2016/38]AT09.12.2015
CZ09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
NL09.12.2015
RO09.12.2015
SE09.12.2015
SK09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
IS09.04.2016
PT11.04.2016
Former [2016/36]AT09.12.2015
CZ09.12.2015
EE09.12.2015
ES09.12.2015
FI09.12.2015
IS09.12.2015
IT09.12.2015
LT09.12.2015
LV09.12.2015
NL09.12.2015
RO09.12.2015
SE09.12.2015
SK09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
Former [2016/34]CZ09.12.2015
ES09.12.2015
FI09.12.2015
IS09.12.2015
LT09.12.2015
LV09.12.2015
NL09.12.2015
SE09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
Former [2016/31]ES09.12.2015
FI09.12.2015
IS09.12.2015
LT09.12.2015
LV09.12.2015
NL09.12.2015
SE09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
Former [2016/26]ES09.12.2015
FI09.12.2015
LT09.12.2015
LV09.12.2015
NL09.12.2015
SE09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
Former [2016/25]ES09.12.2015
FI09.12.2015
LT09.12.2015
LV09.12.2015
SE09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
Former [2016/24]ES09.12.2015
FI09.12.2015
LT09.12.2015
SE09.12.2015
BE31.01.2016
NO09.03.2016
GR10.03.2016
Former [2016/23]ES09.12.2015
LT09.12.2015
SE09.12.2015
NO09.03.2016
Former [2016/21]ES09.12.2015
LT09.12.2015
NO09.03.2016
Former [2016/20]ES09.12.2015
LT09.12.2015
Documents cited:Search[Y]US6802812  (WALKER STEPHEN D [US], et al) [Y] 1-8 * abstract * * column 4, lines 18-19,56-57 * * column 8, lines 59-61 * * column 11, lines 38-55 *;
 [Y]DE10331027  (SELEON GMBH [DE]) [Y] 1-8 * abstract * * paragraphs [0017] , [0018] , [0037] , [0038] *;
 [A]US2006094964  (RAGAUSKAS ARMINAS [LT], et al) [A] 1,6,8 * abstract * * paragraphs [0006] , [0036] , [0053] *;
 [IY]  - JAEGER MATTHIAS ET AL, "Continuous assessment of cerebrovascular autoregulation after traumatic brain injury using brain tissue oxygen pressure reactivity", CRITICAL CARE MEDICINE, WILLIAMS AND WILKINGS COMPANY, BALTIMORE, MA, US, (20060101), vol. 34, no. 6, ISSN 0090-3493, pages 1783 - 1788, XP009161683 [I] 1,5,6,8 * the whole document * [Y] 1-8

DOI:   http://dx.doi.org/10.1097/01.CCM.0000218413.51546.9E
 [IY]  - RALF STEINMEIER ET AL, "Slow Rhythmic Oscillations of Blood Pressure, Intracranial Pressure, Microcirculation, and Cerebral Oxygenation", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, (19961201), vol. 27, no. 12, doi:10.1161/?01.STR.27.12.2236, ISSN 0039-2499, pages 2236 - 2243, XP009161681 [I] 1-3,5-8 * the whole document * [Y] 1-8

DOI:   http://dx.doi.org/10.1161/?01.STR.27.12.2236
 [A]  - LANG ERHARD W ET AL, "Tissue oxygen reactivity and cerebral autoregulation after severe traumatic brain injury", CRITICAL CARE MEDICINE, WILLIAMS AND WILKINGS COMPANY, BALTIMORE, MA, US, (20030101), vol. 31, no. 1, ISSN 0090-3493, pages 267 - 271, XP009161682 [A] 1,6,8 * the whole document *

DOI:   http://dx.doi.org/10.1097/00003246-200301000-00042
 [A]  - JES F SCHMIDT ET AL, "Computerized analysis of cerebral blood flow autoregulation in humans: validation of a method for pharmaceutical studies", JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, (19900101), vol. 15, pages 983 - 988, XP055034580 [A] 1,6,8 * the whole document *

DOI:   http://dx.doi.org/10.1097/00005344-199006000-00017
International search[Y]US2006094964  (RAGAUSKAS ARMINAS [LT], et al);
 [Y]US6802812  (WALKER STEPHEN D [US], et al)
by applicantUS6802812
 DE10331027
    - CZOSNYKA M; SMIELEWSKI P; KIRKPATRICK P; MENON DK; PICKARD JD, "Monitoring of cerebral autoregulation in head-injured patients", STROKE, (1996), vol. 27, no. 10, pages 1829 - 1834
    - LAM JM; HSIANG JN; POON WS., "Monitoring of autoregulation using laser doppler flowmetry in patients with head injury.", J NEUROSURG., (1997), vol. 86, no. 3, pages 438 - 445
    - LANG EW; CZOSNYKA M; MEHDOM HM., "Tissue oxygen reactivity and cerebral autoregulation after severe traumatic brain injury.", CRIT CARE MED., (2003), vol. 31, no. 1, doi:doi:10.1097/00003246-200301000-00042, pages 267 - 271, XP009161682

DOI:   http://dx.doi.org/10.1097/00003246-200301000-00042
    - JAEGER M; SCHUHMANN MU; SOEHLE M; MEIXENSBERGER J., "Continuous assessment of cerebrovascular autoregulation after traumatic brain injury using brain tissue oxygen pressure reactivity.", CRIT CARE MED., (2006), vol. 34, no. 6, doi:doi:10.1097/01.CCM.0000218413.51546.9E, pages 1783 - 1788, XP009161683

DOI:   http://dx.doi.org/10.1097/01.CCM.0000218413.51546.9E
    - TSUJI M; SAUL JP; DU PLESSIS A ET AL., "Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants.", PEDIATRICS, (2000), vol. 106, no. 4, pages 625 - 632
    - CZOSNYKA M; SMIELEWSKI P; KIRKPATRICK P; LAING RJ; MENON D; PICKARD JD, "Continuous assessment of the cerebral vasomotor reactivity in head injury.", NEUROSURGERY, (1997), vol. 41, no. 1, pages 11 - 7,17-9
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.