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Extract from the Register of European Patents

EP About this file: EP2117586

EP2117586 - TREATMENT OR PROPHYLAXIS OF ASTHMA [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.06.2019
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  06.07.2018
FormerGrant of patent is intended
Status updated on  07.03.2018
FormerExamination is in progress
Status updated on  03.01.2017
Most recent event   Tooltip09.07.2021Lapse of the patent in a contracting state
New state(s): HU		published on 11.08.2021  [2021/32]
Applicant(s)For all designated states
Hunter Immunology Pty Ltd
Level 3, 35 Lime Street
Sydney NSW 2000 / AU
[2018/31]
Former [2009/47]For all designated states
Hunter Immunology Limited
Suite 209 18 Rodborough RoadFrenchs Forest
Sydney, New South Wales 2086 / AU
Inventor(s)01 / DUNKLEY, Margaret
80 Dangerfield Drive
Elermore Vale New South Wales 2287 / AU
02 / CLANCY, Robert
4 Neutral Street
North Sydney New South Wales 2060 / AU
03 / CRIPPS, Allan William
33 Geraldton Drive
Robina Queensland 4226 / AU
04 / OTCZYK, Diana Christine
33 Geraldton Drive
Robina Queensland 4226 / AU
 [2009/47]
Representative(s)Roberts, Michael Austin
Reddie & Grose LLP The White Chapel Building
10 Whitechapel High Street
London E1 8QS / GB
[2018/32]
Former [2009/47]Roberts, Michael Austin
Reddie & Grose 16 Theobalds Road London
WC1X 8PL / GB
Application number, filing date08714405.114.03.2008
[2009/47]
WO2008AU00358
Priority number, dateAU2007901326P15.03.2007         Original published format: AU 2007901326 P
[2009/47]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008109956
Date:18.09.2008
Language:EN
[2008/38]
Type: A1 Application with search report 
No.:EP2117586
Date:18.11.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.2008 takes the place of the publication of the European patent application.
[2009/47]
Type: B1 Patent specification 
No.:EP2117586
Date:08.08.2018
Language:EN
[2018/32]
Search report(s)International search report - published on:AU18.09.2008
(Supplementary) European search report - dispatched on:EP30.05.2011
ClassificationIPC:A61K39/102
[2018/11]
CPC:
A61K39/102 (EP,KR,US); A61K39/145 (KR); A61K39/395 (KR);
A61P11/00 (EP); A61P11/06 (EP); Y02A50/30 (EP,US)
Former IPC [2009/47]A61K39/102, A61P11/00, A61P11/06
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/32]
Former [2009/47]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:BEHANDLUNG ODER PROPHYLAXE VON ASTHMA[2009/47]
English:TREATMENT OR PROPHYLAXIS OF ASTHMA[2009/47]
French:TRAITEMENT OU PROPHYLAXIE DE L'ASTHME[2009/47]
Entry into regional phase21.09.2009National basic fee paid 
21.09.2009Search fee paid 
21.09.2009Designation fee(s) paid 
21.09.2009Examination fee paid 
Examination procedure15.09.2008Request for preliminary examination filed
International Preliminary Examining Authority: AU
21.09.2009Examination requested  [2009/47]
22.12.2011Amendment by applicant (claims and/or description)
04.07.2012Despatch of a communication from the examining division (Time limit: M04)
05.11.2012Reply to a communication from the examining division
23.04.2013Despatch of a communication from the examining division (Time limit: M04)
03.09.2013Reply to a communication from the examining division
25.03.2014Despatch of a communication from the examining division (Time limit: M06)
22.12.2014Reply to a communication from the examining division
26.06.2015Despatch of a communication from the examining division (Time limit: M04)
08.10.2015Reply to a communication from the examining division
18.03.2016Despatch of a communication from the examining division (Time limit: M06)
26.10.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
21.12.2016Reply to a communication from the examining division
08.03.2018Communication of intention to grant the patent
25.06.2018Fee for grant paid
25.06.2018Fee for publishing/printing paid
25.06.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.07.2012
Opposition(s)09.05.2019No opposition filed within time limit [2019/29]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
21.12.2016Request for further processing filed
21.12.2016Full payment received (date of receipt of payment)
Request granted
11.01.2017Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
22.12.2014Request for further processing filed
22.12.2014Full payment received (date of receipt of payment)
Request granted
16.01.2015Decision despatched
Fees paidRenewal fee
07.01.2010Renewal fee patent year 03
24.03.2011Renewal fee patent year 04
23.03.2012Renewal fee patent year 05
26.03.2013Renewal fee patent year 06
12.03.2014Renewal fee patent year 07
12.03.2015Renewal fee patent year 08
02.03.2016Renewal fee patent year 09
29.09.2017Renewal fee patent year 10
27.02.2018Renewal fee patent year 11
Penalty fee
Additional fee for renewal fee
31.03.201710   M06   Fee paid on   29.09.2017
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.03.2008
AT08.08.2018
CY08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
PT08.12.2018
IE14.03.2019
LU14.03.2019
MT14.03.2019
BE31.03.2019
[2021/32]
Former [2021/26]AT08.08.2018
CY08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
PT08.12.2018
IE14.03.2019
LU14.03.2019
MT14.03.2019
BE31.03.2019
Former [2020/29]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
PT08.12.2018
IE14.03.2019
LU14.03.2019
MT14.03.2019
BE31.03.2019
Former [2020/16]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
TR08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
IE14.03.2019
LU14.03.2019
BE31.03.2019
Former [2020/12]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
IE14.03.2019
LU14.03.2019
BE31.03.2019
Former [2020/09]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
IE14.03.2019
LU14.03.2019
Former [2020/01]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
LU14.03.2019
Former [2019/46]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
MC08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/37]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SI08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/26]AT08.08.2018
CZ08.08.2018
DK08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/24]AT08.08.2018
CZ08.08.2018
EE08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
SK08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/22]AT08.08.2018
CZ08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
RO08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/21]AT08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
IT08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/12]AT08.08.2018
ES08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
LV08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/11]AT08.08.2018
FI08.08.2018
HR08.08.2018
LT08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/10]AT08.08.2018
FI08.08.2018
LT08.08.2018
NL08.08.2018
PL08.08.2018
SE08.08.2018
BG08.11.2018
NO08.11.2018
GR09.11.2018
IS08.12.2018
Former [2019/09]FI08.08.2018
LT08.08.2018
NL08.08.2018
NO08.11.2018
IS08.12.2018
Former [2019/08]FI08.08.2018
LT08.08.2018
NO08.11.2018
IS08.12.2018
Former [2019/07]LT08.08.2018
Documents cited:Search[XY]  - FOXWELL AR, CRIPPS AW, DEAR KBG, "Haemophilus influenzae oral whole cell vaccination for preventing acute exacerbations of chronic bronchitis", COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (200307), no. 3, doi:10.1002/14651858.cd001958, XP002634660 [X] 1-4,7,11-13 * abstract * * page 4, column r, paragraphs 3-5 * [Y] 5,6,8-10

DOI:   http://dx.doi.org/10.1002/14651858.CD001958
 [XY]  - ARANDJUS ET AL, "Oral bacterial vaccines for the prevention of acute exacerbations in chronic obstructive pulmonary disease and chronic bronchitis", RESPIRATORY MEDICINE, BAILLIERE TINDALL, LONDON, GB, (20061001), vol. 100, no. 10, doi:10.1016/J.RMED.2006.06.029, ISSN 0954-6111, pages 1671 - 1681, XP005626604 [X] 1-4,7,11-13 * page 1674, column r, paragraph 3 - page 1675, column l, paragraph 2 * [Y] 5,6,8-10

DOI:   http://dx.doi.org/10.1016/j.rmed.2006.06.029
 [Y]  - ESMAILY FARHAD ET AL, "Efficacy of immunization with outer membrane proteins for induction of pulmonary clearance of nontypeable Haemophilus influenzae in a rat respiratory model.", IRANIAN JOURNAL OF ALLERGY, ASTHMA, AND IMMUNOLOGY JUN 2006 LNKD- PUBMED:17237577, (200606), vol. 5, no. 2, ISSN 1735-1502, pages 57 - 61, XP002634661 [Y] 1-13 * page 60, column l, paragraph last - column r, paragraph 3 *
 [Y]  - KOYAMA JUN ET AL, "Strain-specific pulmonary defense achieved after repeated airway immunizations with non-typeable Haemophilus influenzae in a mouse model", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, (200701), vol. 211, no. 1, ISSN 0040-8727, pages 63 - 74, XP002634662 [Y] 1-13 * abstract *

DOI:   http://dx.doi.org/10.1620/tjem.211.63
 [YD]  - PAUWELS R ET AL, "IgE antibodies to bacteria in patients with bronchial asthma.", ALLERGY DEC 1980 LNKD- PUBMED:6971585, (198012), vol. 35, no. 8, ISSN 0105-4538, pages 665 - 669, XP002634663 [YD] 5,6,8-10 * page 667, column r, paragraph 2 - page 668, column r, paragraph 4 *
 [YD]  - CLEMENTSEN P ET AL, "ENDOTOXIN FROM HAEMOPHILUS-INFLUENZAE ENHANCES IGE-MEDIATED AND NONIMMUNOLOGICAL HISTAMINE RELEASE", ALLERGY (COPENHAGEN), (1990), vol. 45, no. 1, ISSN 0105-4538, pages 10 - 17, XP002634664 [YD] 5,6,8-10 * page 15, column l, paragraph 3 - page 16, column l, paragraph 3 *

DOI:   http://dx.doi.org/10.1111/j.1398-9995.1990.tb01078.x
International search[A]WO02074328  (UNIV MONASH [AU], et al);
 [A]WO2004019979  (GLAXO GROUP LTD [GB], et al)
 [X]  - CLANCY R. ET AL., "Oral immunisation with killed Haemophilus influenza for protection agains acute bronchitis in chronic obstructive lung disease", LANCET, (1985), vol. 2, no. 8469-70, pages 1395 - 1397, XP008116635

DOI:   http://dx.doi.org/10.1016/S0140-6736(85)92559-0
 [X]  - ARANDJUS C. ET AL., "Oral bacterial vaccines for the prevention of acute exacerbations in chronic obstructive pulmonary disease and chronic bronchitis", RESPIRATORY MEDICINE, (2006), vol. 100, pages 1671 - 1681, XP005626604

DOI:   http://dx.doi.org/10.1016/j.rmed.2006.06.029
 [A]  - SCHREURS A.J. ET AL., "Haemophilus-influenza induced loss of lung beta adrenoceptor binding sites and modulation by changes in peripheral catecholaminergic input", EUROPEAN JOURNAL OF PHARMACOLOGY, (1982), vol. 77, no. 2-3, pages 95 - 102, XP023742234

DOI:   http://dx.doi.org/10.1016/0014-2999(82)90002-4
 [A]  - SCHREURS A.J. ET AL., "Involvement of catecholamines in Haemophilus influenzae induced decrase of beta-adrenoceptor function", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, (1982), vol. 320, no. 3, pages 235 - 239, XP008116478

DOI:   http://dx.doi.org/10.1007/BF00510134
 [A]  - ZIMMERMAN R.K. ET AL., "Childhood immunization guidelines: current and future", PRIMARY CARE, (1994), vol. 21, no. 4, pages 693 - 715, XP008116479
Examination   - CLANCY,RL; CRIPPS, AW; GEBSKI, V, "protection against recurrent acute bronchitis after oral immunization with killed Haemophilus influenzae", MEDICAL JOURNAL OF AUSTRALIA, AU, (1990), vol. 152, no. 8, ISSN 0025-729X, pages 413 - 416, XP008153163
    - L L Kjaergard ET AL, "Basophil-bound IgE and serum IgE directed against Hmmphilus influenzae and Streptococcus pneumniae in patients with chronic bronchitis during acute exacerbations", APMIS, (19960101), vol. 104, pages 61 - 67, XP055060069
    - Masakazu Ichinose ET AL, "Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways", American Journal of Respiratory and Critical Care Medicine, (20000801), vol. 162, no. 2, doi:10.1164/ajrccm.162.2.9908132, ISSN 1073-449X, pages 701 - 706, XP055197130

DOI:   http://dx.doi.org/10.1164/ajrccm.162.2.9908132
    - LACOSTE J-Y ET AL, "EOSINOPHILIC AND NEUTROPHILIC INFLAMMATION IN ASTHAM, CHRONIC BRONCHITIS, AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, (19931001), vol. 92, no. 4, doi:10.1016/0091-6749(93)90078-T, ISSN 0091-6749, pages 537 - 548, XP009070364

DOI:   http://dx.doi.org/10.1016/0091-6749(93)90078-T
    - SCHREURS A J M ET AL, "Haemophilus influenzae induced loss of lung beta-adrenoceptor binding sites and modulation by changes in peripheral catecholaminergic input", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 77, no. 2-3, doi:10.1016/0014-2999(82)90002-4, ISSN 0014-2999, (19820122), pages 95 - 102, (19820122), XP023742234

DOI:   http://dx.doi.org/10.1016/0014-2999(82)90002-4
    - SCHREURS A J ET AL, "Involvement of catecholamines in Haemophilus influenzae induced decrase of beta-adrenoceptor function", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY,, (19820101), vol. 320, no. 3, doi:10.1007/BF00510134, pages 235 - 239, XP008116478

DOI:   http://dx.doi.org/10.1007/BF00510134
    - M. Johnson, "Interactions between Corticosteroids and  2-Agonists in Asthma and Chronic Obstructive Pulmonary Disease", AMERICAN THORACIC SOCIETY. PROCEEDINGS, US, (20041101), vol. 1, no. 3, doi:10.1513/pats.200402-010MS, ISSN 1546-3222, pages 200 - 206, XP055447180

DOI:   http://dx.doi.org/10.1513/pats.200402-010MS
    - BENNETT W D ET AL, "Effect of salmeterol on mucociliary and cough clearance in chronic bronchitis", PULMORNARY PHARMACOLOGY & THERAPEUTICS, ACADEMIC PRESS, GB, vol. 19, no. 2, doi:10.1016/J.PUPT.2005.04.001, ISSN 1094-5539, (20060401), pages 96 - 100, (20060401), XP024946860

DOI:   http://dx.doi.org/10.1016/j.pupt.2005.04.001
    - STEFANO GUERRA, "Asthma and chronic obstructive pulmonary disease :", CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, US, (20091001), vol. 9, no. 5, doi:10.1097/ACI.0b013e3283300baf, ISSN 1528-4050, pages 409 - 416, XP055448668

DOI:   http://dx.doi.org/10.1097/ACI.0b013e3283300baf
by applicant   - ABE Y; MURPHY TF; SETHI S; FADEN HS; DMOCHOWSKI J; HARAUCHI Y; THANAVALA YM, "Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease", AM J RESPIR CRIT CARE MED, (2002), vol. 165, pages 967 - 71
    - ARANDJUS C; BLACK PN; POOLE PJ; WOOD BAKER R; STEURER-STEY C, "Oral bacterial vaccines for the prevention of acute exacerbations in chronic obstructive pulmonary disease and chronic bronchitis", RESPIR MED, (2006), vol. 100, doi:doi:10.1016/j.rmed.2006.06.029, pages 1671 - 1681, XP005626604

DOI:   http://dx.doi.org/10.1016/j.rmed.2006.06.029
    - CLANCY RL; CRIPPS AW; GEBSKI V, "Protection against recurrent acute bronchitis after oral immunization with killed Haemophilus influenzae", LLED J AUST, (1990), vol. 152, pages 413 - 416, XP008153163
    - CLEMENTSEN P; MILMAN N; KILIAN M ET AL., "Endotoxin from Haemophilus influenzae enhances IgE-mediated and non-immunological histamine release", ALLERGY, (1990), vol. 45, pages 10 - 17
    - COURCOL RJ; DAMIEN JM; RAMON P; C VOISIN C; MARTIN GR, "Presence of alveolar macrophages as a criterion for determining the suitability of sputum specimens for bacterial culture", EUR J CLIN MICROBIOL, (1985), vol. 3, pages 122 - 25
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