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Extract from the Register of European Patents

EP About this file: EP2134690

EP2134690 - 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE MGLUR2 -RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.10.2013
Database last updated on 11.04.2026
Most recent event   Tooltip01.07.2016Lapse of the patent in a contracting state
New state(s): IS		published on 03.08.2016  [2016/31]
Applicant(s)For all designated states
Janssen Pharmaceuticals, Inc.
1125 Trenton-Harbourton Road
Titusville, NJ 08560 / US
For all designated states
ADDEX Pharma S.A.
12, Chemin des Aulx
1228 Plan-les-Ouates (Geneva) / CH
[N/P]
Former [2012/22]For all designated states
Janssen Pharmaceuticals, Inc.
1125 Trenton-Harbourton Road
Titusville, NJ 08560 / US
For all designated states
ADDEX Pharma S.A.
12, Chemin des Aulx
1228 Plan-lès-Ouates (Geneva) / CH
Former [2009/52]For all designated states
Ortho-McNeil-Janssen Pharmaceuticals, Inc.
1125 Trenton-Harbourton Road
Titusville, NJ 08560 / US
For all designated states
ADDEX Pharma S.A.
12, Chemin des Aulx
1228 Plan-lès-Ouates (Geneva) / CH
Inventor(s)01 / CID-NÚÑEZ, José, Maria
c/o Johnson & Johnson
Pharmaceutical Research and Development
Division of Janssen-Cilag, S.A
Calle Jarama, 75
Poligono Industrial E-45007 Toledo / ES
02 / TRABANCO-SUÁREZ, Andrés, Avelino
c/o Johnson & Johnson
Pharmaceutical Research and Development
Division of Janssen-Cilag, S.A
Calle Jarama, 75
Poligono Industrial / ES
03 / MACDONALD, Gregor, James
c/o Janssen Pharmaceutica NV
Turnhoutseweg 30
B-2340 Beerse / BE
04 / DUVEY, Guillaume, Albert, Jacques
c/o ADDEX Pharma S.A.
12, Chemin des Aulx
CH-1228 Plan-lès-Ouates / CH
05 / LÜTJENS, Robert, Johannes
c/o ADDEX Pharma S.A.
12, Chemin des Aulx
CH-1228 Plan-lès-Ouates / CH
 [2012/48]
Former [2009/52]01 / CID-NÚÑEZ, José, Maria
c/o Johnson & Johnson Pharmaceutical Research and Development Division of Janssen-Cilag, S.A Calle Jarama, 75
Poligono Industrial E-45007 Toledo / ES
02 / TRABANCO-SUÁREZ, Andrés, Avelino
c/o Johnson & Johnson Pharmaceutical Research and Development Division of Janssen-Cilag, S.A Calle Jarama, 75
Poligono Industrial / ES
03 / MACDONALD, Gregor, James
c/o Janssen Pharmaceutica NV Turnhoutseweg 30
B-2340 Beerse / BE
04 / DUVEY, Guillaume, Albert, Jacques
c/o ADDEX Pharma S.A. 12, Chemin des Aulx
CH-1228 Plan-lès-Ouates / CH
05 / LÜTJENS, Robert, Johannes
c/o ADDEX Pharma S.A. 12, Chemin des Aulx
CH-1228 Plan-lès-Ouates / CH
Representative(s)Campbell, Neil Boyd
Dehns
St Bride's House
10 Salisbury Square
London
EC4Y 8JD / GB
[N/P]
Former [2012/48]Campbell, Neil Boyd
Dehns St Bride's House 10 Salisbury Square London
EC4Y 8JD / GB
Former [2009/52]Campbell, Neil Boyd
Frank B. Dehn & Co. St Bride's House 10 Salisbury Square London
EC4Y 8JD / GB
Application number, filing date08717514.707.03.2008
[2009/52]
WO2008EP52767
Priority number, dateEP2007010365407.03.2007         Original published format: EP 07103654
WO2007EP5244215.03.2007         Original published format: PCT/EP2007/052442
EP2007011640214.09.2007         Original published format: EP 07116402
[2009/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008107480
Date:12.09.2008
Language:EN
[2008/37]
Type: A1 Application with search report 
No.:EP2134690
Date:23.12.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 12.09.2008 takes the place of the publication of the European patent application.
[2009/52]
Type: B1 Patent specification 
No.:EP2134690
Date:28.11.2012
Language:EN
[2012/48]
Search report(s)International search report - published on:EP12.09.2008
ClassificationIPC:C07D213/85, C07D401/04, A61K31/4412, A61K31/4418, C07D409/04, A61K31/443, A61K31/4436, A61K31/4439, A61K31/444, A61P25/22, C07D401/06, C07D401/10, C07D401/12, C07D401/14, C07D405/06
[2009/52]
CPC:
C07D213/85 (EP,US); C07D409/04 (KR); A61K31/198 (EP,US);
A61K31/4412 (KR); A61K31/444 (EP,US); A61P1/14 (EP);
A61P25/00 (EP); A61P25/06 (EP); A61P25/08 (EP);
A61P25/18 (EP); A61P25/22 (EP); A61P25/24 (EP);
A61P25/28 (EP); A61P25/32 (EP); A61P25/34 (EP);
A61P25/36 (EP); A61P3/04 (EP); A61P9/10 (EP);
C07D401/14 (KR) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/52]
Extension statesAL06.10.2009
BA06.10.2009
MK06.10.2009
RS06.10.2009
TitleGerman:1,4-DISUBSTITUIERTE 3-CYANOPYRIDONDERIVATE UND IHRE VERWENDUNG ALS POSITIVE MODULATOREN DES MGLUR2-REZEPTORS[2009/52]
English:1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE MGLUR2 -RECEPTOR MODULATORS[2009/52]
French:DÉRIVÉS DE 3-CYANO-PYRIDONE 1,4 DISUBSTITUÉS ET LEUR UTILISATION COMME MODULATEURS POSITIFS DES RÉCEPTEURS MGLUR2[2009/52]
Entry into regional phase06.10.2009National basic fee paid 
06.10.2009Designation fee(s) paid 
06.10.2009Examination fee paid 
Examination procedure06.10.2009Amendment by applicant (claims and/or description)
06.10.2009Examination requested  [2009/52]
28.06.2010Despatch of a communication from the examining division (Time limit: M06)
07.01.2011Reply to a communication from the examining division
14.04.2011Despatch of a communication from the examining division (Time limit: M04)
01.08.2011Reply to a communication from the examining division
03.02.2012Communication of intention to grant the patent
29.03.2012Fee for grant paid
29.03.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.06.2010
Opposition(s)29.08.2013No opposition filed within time limit [2013/45]
Fees paidRenewal fee
24.03.2010Renewal fee patent year 03
28.03.2011Renewal fee patent year 04
26.03.2012Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.03.2008
AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
IS28.11.2012
LT28.11.2012
LV28.11.2012
MT28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
TR28.11.2012
DK26.02.2013
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
LU07.03.2013
MC31.03.2013
HR31.07.2013
[2016/31]
Former [2015/34]HU07.03.2008
AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
MT28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
TR28.11.2012
DK26.02.2013
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
LU07.03.2013
MC31.03.2013
HR31.07.2013
Former [2015/32]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
MT28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
TR28.11.2012
DK26.02.2013
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
MC31.03.2013
HR31.07.2013
Former [2015/09]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
MT28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
DK26.02.2013
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
MC31.03.2013
HR31.07.2013
Former [2014/32]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
MT28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
MC31.03.2013
HR31.07.2013
Former [2014/09]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
MC31.03.2013
HR31.07.2013
Former [2014/07]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
IE07.03.2013
MC31.03.2013
Former [2013/47]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
MC31.03.2013
Former [2013/37]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
RO28.11.2012
SI28.11.2012
SK28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
Former [2013/35]AT28.11.2012
CY28.11.2012
CZ28.11.2012
EE28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
SI28.11.2012
SK28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
Former [2013/34]AT28.11.2012
CY28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
SI28.11.2012
BG28.02.2013
NO28.02.2013
GR01.03.2013
Former [2013/31]AT28.11.2012
CY28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
SI28.11.2012
NO28.02.2013
GR01.03.2013
Former [2013/26]CY28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
SI28.11.2012
NO28.02.2013
GR01.03.2013
Former [2013/24]CY28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
NO28.02.2013
GR01.03.2013
Former [2013/23]CY28.11.2012
FI28.11.2012
LT28.11.2012
LV28.11.2012
PL28.11.2012
NO28.02.2013
Former [2013/22]FI28.11.2012
LT28.11.2012
NO28.02.2013
Former [2013/20]LT28.11.2012
NO28.02.2013
Cited inInternational search[A]   F. AL-OMRAN ET. AL.: "Studies with Polyfunctionally Substituted Heteroaromatics. New Routes for the Synthesis of Polyfunctionally Substituted Pyridines and 1,2,4-Triazolo[1,5-a]pyridines.", HETEROATOM CHEMISTRY, vol. 6, 1995, pages 545 - 551, XP002394951 [A] 1-37 * page 546, compounds 11a-11c *

DOI:   http://dx.doi.org/10.1002/hc.520060609
 [A]   R. JAIN ET. AL.: "A One-Step Preparation of Functionalized 3-Cyano-2-Pyridones.", TETRAHEDRON LETTERS, vol. 36, 1995, pages 3307 - 3310, XP004028117 [A] 1-37 * table 1 *

DOI:   http://dx.doi.org/10.1016/0040-4039(95)00615-J
 [A]   S. KAMBE ET. AL.: "A Convenient Method for the Preparation of 2-Pyridone Derivatives.", SYNTHESIS, no. 12, 1977, pages 841 - 842, XP002394957 [A] 1-37 * table 1 *

DOI:   http://dx.doi.org/10.1055/s-1977-24596
 [A]   V. MUTEL: "Therapeutic potential of non-competitive, substype selective, metabotropic glutamate receptor ligands.", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 12, 2002, pages 1845 - 1852, XP002394958 [A] 1-37 * page 1849, column 2 - page 1851, column 2 *

DOI:   http://dx.doi.org/10.1517/13543776.12.12.1845
 [A]   H. M. EISA ET. AL.: "Synthesis of some novel tetrazole derivatives as potential antimicrobial agents.", PAKISTAN JOURNAL OF SCIENTIFIC AND INDUSTRIAL RESEARCH, vol. 33, 1990, pages 417 - 420, XP009101636 [A] 1-37 * page 418, scheme 1, compounds Va to VIIIb *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.