blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2131852

EP2131852 - TREATMENT OF INFLAMMATION AND/OR ENDOTOXIC SHOCK [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.09.2018
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  29.09.2017
FormerGrant of patent is intended
Status updated on  02.11.2016
Most recent event   Tooltip05.06.2020Lapse of the patent in a contracting state
New state(s): HU, PT		published on 08.07.2020  [2020/28]
Applicant(s)For all designated states
Oxford University Innovation Limited
Buxton Court
3 West Way
Botley
Oxford OX2 0JB / GB
[2017/10]
Former [2016/32]For all designated states
Oxford University Innovation Limited
Buxton Court
3 West Way
Botley
Oxford OX2 0SZ / GB
Former [2009/51]For all designated states
ISIS Innovation Limited
Ewert Place, Ewert House Summertown
Oxford OX2 7SG / GB
Inventor(s)01 / GREAVES, David, R.
Sir William Dunn School of Phathology
University of Oxford
South Parks Road
Oxford OX1 3RE / GB
02 / RUSS, Andreas
Department of Biochemistry
University of Oxford
South Parks Road
Oxford OX1 3QU / GB
03 / CASH, Jenna, L.
Sir William Dunn School of Pathology
University of Oxford
South Parks Road
Oxford OX1 3RE / GB
 [2017/44]
Former [2009/51]01 / GREAVES, David, R.
Sir William Dunn School of Phathology University of Oxford South Parks Road
Oxford OX1 3RE / GB
02 / RUSS, Andreas
Department of Biochemistry University of Oxford South Parks Road
Oxford OX1 3QU / GB
03 / CASH, Jenna, L.
Sir William Dunn School of Pathology University of Oxford South Parks Road
Oxford OX1 3RE / GB
Representative(s)Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
[N/P]
Former [2017/44]Atkinson, Jennifer, et al
Barker Brettell LLP
100 Hagley Road
Edgbaston
Birmingham B16 8QQ / GB
Former [2009/51]Atkinson, Jennifer, et al
Barker Brettell LLP 138 Hagley Road Edgbaston Birmingham
B16 9PW / GB
Application number, filing date08718857.925.03.2008
[2009/51]
WO2008GB01020
Priority number, dateGB2007000548822.03.2007         Original published format: GB 0705488
[2009/51]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008114037
Date:25.09.2008
Language:EN
[2008/39]
Type: A1 Application with search report 
No.:EP2131852
Date:16.12.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 25.09.2008 takes the place of the publication of the European patent application.
[2009/51]
Type: B1 Patent specification 
No.:EP2131852
Date:01.11.2017
Language:EN
[2017/44]
Search report(s)International search report - published on:EP25.09.2008
ClassificationIPC:A61K38/04, A61P29/00, A61P31/00, C07K7/04
[2009/51]
CPC:
A61K38/08 (EP,US); A61K38/10 (US); A61P1/04 (EP);
A61P1/16 (EP); A61P11/00 (EP); A61P11/02 (EP);
A61P11/06 (EP); A61P13/12 (EP); A61P17/02 (EP);
A61P17/04 (EP); A61P17/06 (EP); A61P19/02 (EP);
A61P21/00 (EP); A61P25/00 (EP); A61P27/02 (EP);
A61P27/16 (EP); A61P29/00 (EP); A61P3/10 (EP);
A61P31/00 (EP); A61P31/04 (EP); A61P31/10 (EP);
A61P31/12 (EP); A61P31/18 (EP); A61P33/00 (EP);
A61P37/02 (EP); A61P37/06 (EP); A61P37/08 (EP);
A61P39/00 (EP); A61P39/02 (EP); A61P43/00 (EP);
A61P5/14 (EP); A61P7/04 (EP); A61P7/06 (EP);
C07K14/47 (EP,US); C07K7/06 (US); C07K7/08 (US);
A61K38/00 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/44]
Former [2009/51]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:BEHANDLUNG VON ENTZÜNDUNGEN UND/ODER ENDOTOXISCHEM SCHOCK[2016/38]
English:TREATMENT OF INFLAMMATION AND/OR ENDOTOXIC SHOCK[2009/51]
French:TRAITEMENT D'UNE INFLAMMATION ET/OU D'UN CHOC ENDOTOXIQUE[2009/51]
Former [2009/51]BEHANDLUNG VON ENTZÜNDUNG UND/ODER ENDOTOXISCHEM SCHOCK
Entry into regional phase01.10.2009National basic fee paid 
01.10.2009Designation fee(s) paid 
01.10.2009Examination fee paid 
Examination procedure01.10.2009Amendment by applicant (claims and/or description)
01.10.2009Examination requested  [2009/51]
01.02.2010Despatch of a communication from the examining division (Time limit: M04)
26.05.2010Reply to a communication from the examining division
07.06.2010Despatch of a communication from the examining division (Time limit: M06)
04.04.2011Reply to a communication from the examining division
27.09.2011Despatch of a communication from the examining division (Time limit: M04)
17.05.2012Reply to a communication from the examining division
12.04.2013Despatch of a communication from the examining division (Time limit: M06)
22.10.2013Reply to a communication from the examining division
13.10.2015Despatch of a communication from the examining division (Time limit: M04)
21.03.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
27.05.2016Reply to a communication from the examining division
03.11.2016Communication of intention to grant the patent
27.02.2017Fee for grant paid
27.02.2017Fee for publishing/printing paid
27.02.2017Receipt of the translation of the claim(s)
Divisional application(s)EP12152769.1  / EP2465522
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.02.2010
Opposition(s)02.08.2018No opposition filed within time limit [2018/41]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
27.05.2016Request for further processing filed
27.05.2016Full payment received (date of receipt of payment)
Request granted
08.06.2016Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
17.05.2012Request for further processing filed
17.05.2012Full payment received (date of receipt of payment)
Request granted
29.05.2012Decision despatched
The application is deemed to be withdrawn due to failure to reply to the examination report
04.04.2011Request for further processing filed
04.04.2011Full payment received (date of receipt of payment)
Request granted
15.04.2011Decision despatched
Fees paidRenewal fee
24.03.2010Renewal fee patent year 03
28.03.2011Renewal fee patent year 04
29.03.2012Renewal fee patent year 05
26.03.2013Renewal fee patent year 06
29.04.2014Renewal fee patent year 07
30.03.2015Renewal fee patent year 08
30.03.2016Renewal fee patent year 09
19.09.2017Renewal fee patent year 10
Penalty fee
Additional fee for renewal fee
31.03.201407   M06   Fee paid on   29.04.2014
31.03.201710   M06   Fee paid on   19.09.2017
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.03.2008
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
PT01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
TR01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
IE25.03.2018
LU25.03.2018
MT25.03.2018
BE31.03.2018
CH31.03.2018
LI31.03.2018
[2020/27]
Former [2020/16]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
TR01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
IE25.03.2018
LU25.03.2018
MT25.03.2018
BE31.03.2018
CH31.03.2018
LI31.03.2018
Former [2020/08]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
IE25.03.2018
LU25.03.2018
MT25.03.2018
BE31.03.2018
CH31.03.2018
LI31.03.2018
Former [2019/12]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
IE25.03.2018
LU25.03.2018
BE31.03.2018
CH31.03.2018
LI31.03.2018
Former [2019/09]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
IE25.03.2018
LU25.03.2018
Former [2019/04]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
LU25.03.2018
Former [2018/52]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/41]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
SE01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/39]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
SE01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/37]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
SE01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/35]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
SE01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/24]AT01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
SE01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/23]AT01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
NL01.11.2017
SE01.11.2017
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/22]FI01.11.2017
LT01.11.2017
NL01.11.2017
NO01.02.2018
Former [2018/21]FI01.11.2017
LT01.11.2017
NO01.02.2018
Cited inInternational search[X]  - WITTAMER ET AL, "The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2004), vol. 279, pages 9956 - 9962, XP002310263 [X] 23,26,27 * See page 9958 (Table 1 / peptides) *

DOI:   http://dx.doi.org/10.1074/jbc.M313016200
 [XD]  - WITTAMER ET AL, "Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids", JOURNAL OF EXPERIMENTAL MEDICINE, (2003), vol. 198, pages 977 - 985, XP002310262 [XD] 23,26,27 * See page 980 (Figure 2B) *

DOI:   http://dx.doi.org/10.1084/jem.20030382
 [XD]  - ZABEL ET AL, "Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2005), vol. 280, pages 34661 - 34666, XP002486778 [XD] 23,26,27 * See page 34661 (Abstract) and page 34664 (the peptide 141-155) *

DOI:   http://dx.doi.org/10.1074/jbc.M504868200
 [A]  - KULIG ET AL, "Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin", THE JOURNAL OF IMMUNOLOGY, (20070315), vol. 178, pages 3713 - 3720, XP002487265 [A] 1-28 * See pages 3715-3719 (Results and Discussion) *
 [PA]  - ROH ET AL, "Chemerin - a new adipokine that modulates adipogenesis via its own receptor", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (200708), vol. 362, pages 1013 - 1018, XP022249546 [PA] 1-28 * See page 1017 (right column, first paragraph) *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2007.08.104
by applicant   - COLMAN RW, BIOL CHEM., (200101), vol. 382, no. 1, pages 65 - 70
    - YAMASAKI K ET AL., FASEB J., (20061001), vol. 20, no. 12, pages 2068 - 2080
    - WITTAMER ET AL., J. BIOL. CHEM., (2004), vol. 279, no. 11, pages 9956 - 9962
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.