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Extract from the Register of European Patents

EP About this file: EP2115159

EP2115159 - ASSAYS FOR MODULATORS OF PARKIN ACTIVITY USING NOVEL SUBSTRATES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.10.2012
Database last updated on 05.07.2024
Most recent event   Tooltip18.07.2014Lapse of the patent in a contracting state
New state(s): HU		published on 20.08.2014  [2014/34]
Applicant(s)For all designated states
Elan Pharma International Limited
800 Gateway Boulevard
South San Francisco, CA 94080 / US
[2009/46]
Inventor(s)01 / JOHNSTON, Jennifer, A.
889 Marin Drive
Mill Valley, CA 94941 / US
02 / GOLDBERG, Alfred
171 Crafts Road
Chestnut Hill, MA 02467 / US
 [2009/46]
Representative(s)Bullett, Rachel Margaret, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2009/46]Bullett, Rachel Margaret, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date08728753.831.01.2008
[2009/46]
WO2008US52700
Priority number, dateUS20070898947P31.01.2007         Original published format: US 898947 P
[2009/46]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008095126
Date:07.08.2008
Language:EN
[2008/32]
Type: A2 Application without search report 
No.:EP2115159
Date:11.11.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 07.08.2008 takes the place of the publication of the European patent application.
[2009/46]
Type: B1 Patent specification 
No.:EP2115159
Date:21.12.2011
Language:EN
[2011/51]
Search report(s)International search report - published on:EP31.12.2008
ClassificationIPC:C12Q1/25, G01N33/50
[2009/46]
CPC:
C12Q1/25 (EP,US); G01N2333/9015 (EP,US); G01N2500/02 (EP,US);
G01N2500/10 (EP,US); G01N2800/2835 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/46]
Extension statesAL28.08.2009
BA28.08.2009
MK28.08.2009
RS28.08.2009
TitleGerman:ASSAYS FÜR MODULATOREN DER PARKIN-AKTIVITÄT MITHILFE NEUARTIGER SUBSTRATE[2009/46]
English:ASSAYS FOR MODULATORS OF PARKIN ACTIVITY USING NOVEL SUBSTRATES[2009/46]
French:DOSAGES DE MODULATEURS DE L'ACTIVITE DE LA PARKINE UTILISANT DE NOUVEAUX SUBSTRATS[2011/26]
Former [2009/46]DOSAGES DE MODULATEURS DE L'ACTIVITE DE LA PARKINE UTLISANT DE NOUVEAUX SUBSTRATS
Entry into regional phase28.08.2009National basic fee paid 
28.08.2009Designation fee(s) paid 
28.08.2009Examination fee paid 
Examination procedure28.08.2009Amendment by applicant (claims and/or description)
28.08.2009Examination requested  [2009/46]
18.11.2009Despatch of a communication from the examining division (Time limit: M04)
29.03.2010Reply to a communication from the examining division
03.11.2010Despatch of a communication from the examining division (Time limit: M04)
10.03.2011Reply to a communication from the examining division
01.06.2011Communication of intention to grant the patent
15.09.2011Fee for grant paid
15.09.2011Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.11.2009
Opposition(s)24.09.2012No opposition filed within time limit [2012/48]
Fees paidRenewal fee
13.01.2010Renewal fee patent year 03
14.01.2011Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU31.01.2008
AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
FI21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
MT21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
TR21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
LU31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
ES01.04.2012
IS21.04.2012
PT23.04.2012
[2014/34]
Former [2014/27]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
FI21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
MT21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
TR21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
LU31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
ES01.04.2012
IS21.04.2012
PT23.04.2012
Former [2014/21]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
FI21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
MT21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
TR21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
ES01.04.2012
IS21.04.2012
PT23.04.2012
Former [2013/35]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
FI21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
MT21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
ES01.04.2012
IS21.04.2012
PT23.04.2012
Former [2013/29]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
FI21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
ES01.04.2012
IS21.04.2012
PT23.04.2012
Former [2013/22]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
ES01.04.2012
IS21.04.2012
PT23.04.2012
Former [2013/08]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
IE31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
PT23.04.2012
Former [2013/07]AT21.12.2011
BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
PT23.04.2012
Former [2012/50]BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
HR21.12.2011
IT21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
PT23.04.2012
Former [2012/49]BE21.12.2011
CY21.12.2011
CZ21.12.2011
DK21.12.2011
EE21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
CH31.01.2012
LI31.01.2012
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
PT23.04.2012
Former [2012/37]BE21.12.2011
CY21.12.2011
CZ21.12.2011
EE21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
PL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
MC31.01.2012
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
PT23.04.2012
Former [2012/36]BE21.12.2011
CY21.12.2011
CZ21.12.2011
EE21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
RO21.12.2011
SE21.12.2011
SI21.12.2011
SK21.12.2011
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
Former [2012/35]BE21.12.2011
CY21.12.2011
CZ21.12.2011
EE21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
SE21.12.2011
SI21.12.2011
BG21.03.2012
NO21.03.2012
GR22.03.2012
IS21.04.2012
Former [2012/34]BE21.12.2011
CY21.12.2011
CZ21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
SE21.12.2011
SI21.12.2011
NO21.03.2012
GR22.03.2012
IS21.04.2012
Former [2012/30]BE21.12.2011
CY21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
SE21.12.2011
SI21.12.2011
NO21.03.2012
GR22.03.2012
Former [2012/28]CY21.12.2011
HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
SE21.12.2011
SI21.12.2011
NO21.03.2012
GR22.03.2012
Former [2012/27]HR21.12.2011
LT21.12.2011
LV21.12.2011
NL21.12.2011
SE21.12.2011
SI21.12.2011
NO21.03.2012
GR22.03.2012
Former [2012/24]LT21.12.2011
LV21.12.2011
NL21.12.2011
SE21.12.2011
SI21.12.2011
NO21.03.2012
GR22.03.2012
Former [2012/20]LT21.12.2011
NO21.03.2012
Cited inInternational search[AY]  - IMAI YUZURU ET AL, "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.", MOLECULAR CELL JUL 2002, (200207), vol. 10, no. 1, ISSN 1097-2765, pages 55 - 67, XP002491457 [A] 1-15,18,19,25-28 * the whole document * * abstract * * page 62, column L, paragraph 2 * * figure 6B * * page 66, column L, paragraph 2 * [Y] 16,17,20-24

DOI:   http://dx.doi.org/10.1016/S1097-2765(02)00583-X
 [AY]  - TSAI YIEN CHE ET AL, "Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.", JOURNAL OF BIOLOGICAL CHEMISTRY, (20030613), vol. 278, no. 24, ISSN 0021-9258, pages 22044 - 22055, XP002491458 [A] 1-15,18,19,25-28 * the whole document * * abstract * * page 22046, column L, paragraph 2 * * page 22047, column R, paragraph 2 - paragraph 3; figure 4B * [Y] 16,17,20-24

DOI:   http://dx.doi.org/10.1074/jbc.M212235200
 [A]  - SATO SHIGETO ET AL, "14-3-3eta is a novel regulator of parkin ubiquitin ligase.", THE EMBO JOURNAL 11 JAN 2006, (20060111), vol. 25, no. 1, ISSN 0261-4189, pages 211 - 221, XP002491459 [A] 1-15,18,19,25-28 * the whole document * * abstract * * page 213, column R, paragraph 2; figure 3A * * page 213, column R, paragraph 3; figure 3B * * page 213, column R, paragraph 3; figure 3C * * figure 6B *

DOI:   http://dx.doi.org/10.1038/sj.emboj.7600774
 [A]  - TANAKA K ET AL, "Ubiquitin, proteasome and parkin", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20041129), vol. 1695, no. 1-3, ISSN 0167-4889, pages 235 - 247, XP004686287 [A] 1-15,18,19,25-28 * the whole document * * abstract * * section 5.6 "putative substrates", page 233, right column to page 234, right column *

DOI:   http://dx.doi.org/10.1016/j.bbamcr.2004.09.026
 [A]  - HATTORI ET AL, "Pathogenetic mechanisms of parkin in Parkinson's disease", LANCET THE, LANCET LIMITED. LONDON, GB, (20040821), vol. 364, no. 9435, ISSN 0140-6736, pages 722 - 724, XP005205008 [A] 1-15,18,19,25-28 * the whole document * * table on page 723 *

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)16901-8
 [A]  - SAKATA ERI ET AL, "Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain.", EMBO REPORTS, (200303), vol. 4, no. 3, ISSN 1469-221X, pages 301 - 306, XP002491479 [A] 1-9,18,25-27 * the whole document * * abstract *

DOI:   http://dx.doi.org/10.1038/sj.embor.embor764
 [Y]  - AUGERR K R ET AL, "Quantitative assays of mdm2 ubiquitin ligase activity and other ubiquitin-utilizing enzymes for inhibitor discovery", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, (20050101), vol. 399, ISSN 0076-6879, pages 701 - 717, XP008084920 [Y] 16,17,20-24 * the whole document * * abstract * * page 708, paragraph LAST - page 712, paragraph 1 * * page 712, paragraph L * * page 714, paragraph L - page 715, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0076-6879(05)99046-0
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.