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Extract from the Register of European Patents

EP About this file: EP2126073

EP2126073 - GENE SILENCING BY SINGLE-STRANDED POLYNUCLEOTIDES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  16.09.2011
Database last updated on 25.09.2024
Most recent event   Tooltip16.09.2011Application deemed to be withdrawnpublished on 19.10.2011  [2011/42]
Applicant(s)For all designated states
Genesegues, Inc.
3180 High Point Drive
Chaska, MN 55318 / US
[2009/49]
Inventor(s)01 / UNGER, Gretchen M.
3180 High Point Drive
Chaska, Minnesota 55318 / US
 [2009/49]
Representative(s)Lucas, Brian Ronald
Lucas & Co.
135 Westhall Road
Warlingham, Surrey CR6 9HJ / GB
[N/P]
Former [2009/49]Lucas, Brian Ronald
Lucas & Co. 135 Westhall Road Warlingham
Surrey CR6 9HJ / GB
Application number, filing date08728878.301.02.2008
[2009/49]
WO2008US52863
Priority number, dateUS20070898674P01.02.2007         Original published format: US 898674 P
[2009/49]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008095192
Date:07.08.2008
Language:EN
[2008/32]
Type: A2 Application without search report 
No.:EP2126073
Date:02.12.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 07.08.2008 takes the place of the publication of the European patent application.
[2009/49]
Search report(s)International search report - published on:KR05.03.2009
(Supplementary) European search report - dispatched on:EP17.09.2010
ClassificationIPC:C12N15/10, C12N15/09
[2009/49]
CPC:
A61K31/7125 (EP,US); C12N15/111 (EP,US); C12N15/113 (EP,US);
G01N33/5308 (US); C12N2310/11 (EP,US); C12N2310/14 (EP,US);
C12N2310/315 (EP,US); C12N2310/321 (EP,US); C12N2310/51 (EP,US);
C12N2320/32 (US) (-)
C-Set:
C12N2310/321, C12N2310/3521 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/49]
TitleGerman:GEN-SILENCING MITHILFE EINSTRÄNGIGER POLYNUKLEOTIDE[2009/49]
English:GENE SILENCING BY SINGLE-STRANDED POLYNUCLEOTIDES[2009/49]
French:BLOCAGE DE GENE PAR POLY(NUCLEOTIDES) MONOBRINS[2009/49]
Entry into regional phase01.09.2009National basic fee paid 
01.09.2009Search fee paid 
01.09.2009Designation fee(s) paid 
01.09.2009Examination fee paid 
Examination procedure01.09.2009Examination requested  [2009/49]
23.10.2009Amendment by applicant (claims and/or description)
16.04.2011Application deemed to be withdrawn, date of legal effect  [2011/42]
22.06.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2011/42]
Fees paidRenewal fee
20.01.2010Renewal fee patent year 03
Penalty fee
Additional fee for renewal fee
28.02.201104   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2006066154  (UNIV MINNESOTA [US]; SLATON JOEL W [US]; AHMED KHALIL [US]; UNGER GRET) [Y] 1-15 * the whole document * * examples 6-7; table 5; sequences 5-6 *;
 [A]WO2005097993  (COLEY PHARM GROUP INC [US]; COLEY PHARM GMBH [DE]; LIPFORD GRAYSON B [) [A] 1-15 * the whole document *;
 [Y]  - AHMAD KASHIF A ET AL, "Targeting CK2 for cancer therapy", ANTI-CANCER DRUGS, LIPPINCOTT WILLIAMS & WILKINS, US; NL LNKD- DOI:10.1097/00001813-200511000-00001, (20051101), vol. 16, no. 10, ISSN 0959-4973, pages 1037 - 1043, XP009104787 [Y] 1-6,8-15 * the whole document *

DOI:   http://dx.doi.org/10.1097/00001813-200511000-00001
 [Y]  - GUIXIA WANG ET AL, "Downregulation of CK2 induces apoptosis in cancer cells - A potential approach to cancer therapy", MOLECULAR AND CELLULAR BIOCHEMISTRY, KLUWER ACADEMIC PUBLISHERS, BO, (20050601), vol. 274, no. 1-2, ISSN 1573-4919, pages 77 - 84, XP019288784 [Y] 1-6,8-15 * the whole document *
 [Y]  - SIMEONI F ET AL, "Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB LNKD- DOI:10.1093/NAR/GKG385, (20030313), vol. 31, no. 11, ISSN 0305-1048, pages 2717 - 2724, XP002984580 [Y] 7 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/gkg385
 [A]  - PEPPERKOK R ET AL, "Cell growth stimulation by EGF: Inhibition through antisense-oligodeoxynucleotides demonstrates important role of casein kinase II", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US LNKD- DOI:10.1016/0014-4827(91)90429-X, vol. 197, no. 2, ISSN 0014-4827, (19911201), pages 245 - 253, (19911201), XP024791949 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/0014-4827(91)90429-X
 [A]  - OHRT THOMAS ET AL, "In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5", NUCLEIC ACIDS RESEARCH, (2006), vol. 34, no. 5, ISSN 0305-1048, pages 1369 - 1380, XP002598041 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/gkl001
 [A]  - GRUENWELLER ARNOLD ET AL, "Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.", NUCLEIC ACIDS RESEARCH, (20030615), vol. 31, no. 12, ISSN 0305-1048, pages 3185 - 3193, XP002598042 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/gkg409
 [A]  - KANDIMALLA EKAMBAR R ET AL, "Mixed backbone antisense oligonucleotides: Design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments", NUCLEIC ACIDS RESEARCH, (1997), vol. 25, no. 2, ISSN 0305-1048, pages 370 - 378, XP002598043 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/25.2.370
 [T]  - UI-TEI KUMIKO ET AL, "Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect", NUCLEIC ACIDS RESEARCH, (200804), vol. 36, no. 7, ISSN 0305-1048, pages 2136 - 2151, XP002598044 [T] * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/gkn042
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.