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Extract from the Register of European Patents

EP About this file: EP2139485

EP2139485 - METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  10.04.2019
Database last updated on 03.04.2025
Most recent event   Tooltip12.04.2019Revocation of patentpublished on 15.05.2019  [2019/20]
Applicant(s)For all designated states
BioMarin Pharmaceutical Inc.
105 Digital Drive
Novato, CA 94949 / US
[N/P]
Former [2012/42]For all designated states
BioMarin Pharmaceutical Inc.
105 Digital Drive
Novato, CA 94949 / US
Former [2010/01]For all designated states
BioMarin Pharmaceutical Inc.
105 Digital Drive
Novato, CA 94949 / US
Inventor(s)01 / OPPENHEIMER, Daniel, I.
4516 Hillsborough Drive
Castro Valley, CA 94546 / US
02 / DORENBAUM, Alejandro
120 Stanford Avenue
Mill Valley, CA 94941 / US
03 / OKHAMAFE, Augustus
5310 Crystyl Ranch Drive
Concord, CA 94521 / US
04 / FOEHR, Erik
1554 Buchanan Street
Novato, CA 94947 / US
05 / CASTILLO, Sianna
400 25th Avenue, 5
San Francisco, CA 94121 / US
06 / KOSTEL, Paul, John
2623 Cactus Avenue
Santa Rosa, CA 95405 / US
 [2010/01]
Representative(s)Weber, Martin, et al
Jones Day
Rechtsanwälte Attorneys-at-Law Patentanwälte
Prinzregentenstrasse 11
80538 München / DE
[N/P]
Former [2014/17]Neuefeind, Regina, et al
Maiwald Patentanwalts GmbH
Elisenhof
Elisenstrasse 3
80335 München / DE
Former [2012/24]Benz, Jürgen, et al
Merck Patent GmbH Frankfurter Strasse 250
64293 Darmstadt / DE
Former [2012/16]Williams, Aylsa, et al
D Young & Co LLP 120 Holborn
London EC1N 2DY / GB
Former [2010/01]Dempster, Robert Charles
D Young & Co 120 Holborn
London EC1N 2DY / GB
Application number, filing date08745614.111.04.2008
[2010/01]
WO2008US60041
Priority number, dateUS20070922821P11.04.2007         Original published format: US 922821 P
US2008001975308.01.2008         Original published format: US 19753
[2010/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008128049
Date:23.10.2008
Language:EN
[2008/43]
Type: A2 Application without search report 
No.:EP2139485
Date:06.01.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 23.10.2008 takes the place of the publication of the European patent application.
[2010/01]
Type: B1 Patent specification 
No.:EP2139485
Date:17.10.2012
Language:EN
[2012/42]
Search report(s)International search report - published on:EP19.11.2009
ClassificationIPC:A61K31/519, A61K45/06, A61P3/02, A61P3/00, A61P25/16
[2010/01]
CPC:
A61K31/519 (EP,KR,US); A61K45/06 (EP,US); A61K9/0019 (EP,KR,US);
A61K9/0053 (KR,US); A61K9/0065 (EP,US); A61K9/0095 (EP,US);
A61K9/08 (US); A61K9/20 (KR); A61K9/2027 (EP,US);
A61K9/2054 (EP,US); A61K9/48 (KR); A61K9/4808 (EP,US);
A61K9/4858 (EP,US); A61K9/4891 (EP,US); A61P25/00 (EP);
A61P25/06 (EP); A61P25/16 (EP); A61P25/18 (EP);
A61P25/24 (EP); A61P25/28 (EP); A61P3/00 (EP);
A61P3/02 (EP); A61P43/00 (EP); A61P7/06 (EP);
A61P9/00 (EP); A61P9/10 (EP); C07B63/00 (EP,US);
C07D487/04 (EP,US); G01N33/6848 (US); A61K9/1652 (EP,US);
A61K9/2086 (EP,US); G01N30/7233 (EP,US); H01J49/004 (US);
Y10T436/147777 (EP,US) (-)
C-Set:
A61K31/519, A61K2300/00 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/01]
TitleGerman:VERFAHREN ZUR VERABREICHUNG VON TETRAHYDROBIOPTERIN, ASSOZIIERTEN ZUSAMMENSETZUNGEN UND MESSVERFAHREN[2010/01]
English:METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING[2010/01]
French:PROCÉDÉS D'ADMINISTRATION DE LA TÉTRAHYDROBIOPTÉRINE, COMPOSITIONS ASSOCIÉES ET PROCÉDÉS DE MESURE[2010/01]
Entry into regional phase26.10.2009National basic fee paid 
26.10.2009Designation fee(s) paid 
26.10.2009Examination fee paid 
Examination procedure15.10.2009Amendment by applicant (claims and/or description)
26.10.2009Examination requested  [2010/01]
29.07.2010Despatch of a communication from the examining division (Time limit: M06)
08.12.2010Reply to a communication from the examining division
11.01.2011Despatch of a communication from the examining division (Time limit: M02)
10.03.2011Reply to a communication from the examining division
12.08.2011Despatch of a communication from the examining division (Time limit: M02)
12.10.2011Reply to a communication from the examining division
20.02.2012Despatch of a communication from the examining division (Time limit: M02)
29.02.2012Reply to a communication from the examining division
02.05.2012Communication of intention to grant the patent
18.08.2012Fee for grant paid
18.08.2012Fee for publishing/printing paid
Divisional application(s)EP12005352.5  / EP2545939
EP18205446.0  / EP3461503
EP22154751.6  / EP4029519
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.07.2010
Opposition(s)Opponent(s)01  17.07.2013    ADMISSIBLE
Generics [UK] Limited
(trading as Mylan)
Albany Gate
Darkes Lane
Potters Bar
Hertfordshire EN6 1AG / GB
Opponent's representative
Elend, Almut Susanne, et al, et al
Venner Shipley LLP
406 Cambridge Science Park
Milton Road
Cambridge CB4 0WW / GB
 [N/P]
Former [2013/34]
Opponent(s)01  17.07.2013    ADMISSIBLE
Generics [UK] Limited
(trading as Mylan)
Albany Gate
Darkes Lane
Potters Bar
Hertfordshire EN6 1AG / GB
Opponent's representative
Elend, Almut Susanne, et al, et al
Venner Shipley LLP
Byron House
Cambridge Business Park
Cowley Road
Cambridge, Cambridgeshire CB4 0WZ / GB
04.09.2013Invitation to proprietor to file observations on the notice of opposition
14.03.2014Reply of patent proprietor to notice(s) of opposition
09.12.2014Date of oral proceedings
20.01.2015Despatch of interlocutory decision in opposition
20.01.2015Despatch of minutes of oral proceedings
09.11.2018Legal effect of revocation of patent [2019/20]
29.03.2019Despatch of communication that the patent will be revoked
Appeal following opposition30.03.2015Appeal received No.  T0605/15
01.06.2015Statement of grounds filed
10.01.2019Result of appeal procedure: revocation of the patent
18.03.2015Appeal received No.  T0605/15
01.06.2015Statement of grounds filed
10.01.2019Result of appeal procedure: revocation of the patent
Fees paidRenewal fee
26.04.2010Renewal fee patent year 03
25.04.2011Renewal fee patent year 04
28.03.2012Renewal fee patent year 05
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Cited inInternational search[X]US4550109  (FOLKERS KARL [US], et al) [X] 1-9 * Briding paragraph of; columns 8-9 * * column 1, paragraph 1 *;
 [X]WO2004058268  (BIOCRATES LIFE SCIENCES GMBH [AT], et al) [X] 1-9 * page 39, paragraph 2 * * page 35, paragraph 1 *;
 [A]US2006194808  (RICHARDSON KENNETH T [US], et al) [A] * claim 1 *
Examination   - PONZONE A ET AL, "Hyperphenylalaninemia and pterin metabolism in serum and erythrocytes.", CLINICA CHIMICA ACTA; INTERNATIONAL JOURNAL OF CLINICAL CHEMISTRY 16 JUL 1993 LNKD- PUBMED:8222274, (19930716), vol. 216, no. 1-2, ISSN 0009-8981, pages 63 - 71
by applicantUS4550109
 US2006040946
 WO2006055511
 EP1757293
    - "Disorders oftetrahydrobiopterin and related biogenic amines", BLAU ET AL., The Metabolic and Molecular Bases of Inherited Disease, MCGRAW-HILL, (2001), pages 1275 - 1776
    - FIEGE ET AL., MOLECULAR GENETICS AND METABOLISM, (2004), vol. 81, pages 45 - 51
    - DAVIS ET AL., EUR. J. BIOCHEM., (1988), vol. 173, pages 345 - 351
    - KIRSCH ET AL., J. BIOL. CHEM., (2003), vol. 278, pages 24481 - 24490
    - Remington's Pharmaceutical Sciences, MACK PUBL. CO, (1990), page 1435 171
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.