EP2148867 - DEUTERATED MORPHOLINYL COMPOUNDS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 17.07.2015 Database last updated on 03.06.2024 | Most recent event Tooltip | 13.10.2017 | Lapse of the patent in a contracting state New state(s): BG, HU, TR | published on 15.11.2017 [2017/46] | Applicant(s) | For all designated states Concert Pharmaceuticals Inc. 99 Hayden Avenue, Suite 100 Lexington, MA 02421 / US | [2010/05] | Inventor(s) | 01 /
PERSICHETTI, Rose, A. 375 Harvard Road Stow, Massachusetts 01775 / US | 02 /
HARBESON, Scott, L. 203 Pemberton Street, 5 Cambridge, Massachusetts 02140 / US | [2010/05] | Representative(s) | Robertson, James Alexander Marks & Clerk LLP 90 Long Acre London WC2E 9RA / GB | [2014/37] |
Former [2013/33] | Robertson, James Alexander Marks & Clerk LLP 90 Long Acre London WC2E 9RA / GB | ||
Former [2010/05] | Waldren, Robin Michael Marks & Clerk LLP 90 Long Acre London WC2E 9RA / GB | Application number, filing date | 08746315.4 | 18.04.2008 | [2010/05] | WO2008US60877 | Priority number, date | US20070912807P | 19.04.2007 Original published format: US 912807 P | [2010/05] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2008131259 | Date: | 30.10.2008 | Language: | EN | [2008/44] | Type: | A1 Application with search report | No.: | EP2148867 | Date: | 03.02.2010 | Language: | EN | The application published by WIPO in one of the EPO official languages on 30.10.2008 takes the place of the publication of the European patent application. | [2010/05] | Type: | B1 Patent specification | No.: | EP2148867 | Date: | 10.09.2014 | Language: | EN | [2014/37] | Search report(s) | International search report - published on: | EP | 30.10.2008 | Classification | IPC: | C07D265/30, A61P3/10, A61P1/00, A61K31/5375 | [2010/05] | CPC: |
C07D265/30 (EP,KR,US);
A61K31/5375 (KR);
A61P1/00 (EP);
A61P1/04 (EP);
A61P1/08 (EP);
A61P1/10 (EP);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2010/05] | Title | German: | DEUTERIERTE MORPHOLINYLVERBINDUNGEN | [2010/05] | English: | DEUTERATED MORPHOLINYL COMPOUNDS | [2010/05] | French: | COMPOSÉS SUBSTITUÉS DE MORPHOLINYLE | [2010/05] | Entry into regional phase | 19.11.2009 | National basic fee paid | 19.11.2009 | Designation fee(s) paid | 19.11.2009 | Examination fee paid | Examination procedure | 19.11.2009 | Examination requested [2010/05] | 12.01.2010 | Amendment by applicant (claims and/or description) | 14.06.2011 | Despatch of a communication from the examining division (Time limit: M06) | 22.12.2011 | Reply to a communication from the examining division | 12.10.2012 | Despatch of a communication from the examining division (Time limit: M06) | 08.04.2013 | Reply to a communication from the examining division | 09.04.2014 | Communication of intention to grant the patent | 29.07.2014 | Fee for grant paid | 29.07.2014 | Fee for publishing/printing paid | 29.07.2014 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 14.06.2011 | Opposition(s) | 11.06.2015 | No opposition filed within time limit [2015/34] | Fees paid | Renewal fee | 26.04.2010 | Renewal fee patent year 03 | 25.04.2011 | Renewal fee patent year 04 | 25.04.2012 | Renewal fee patent year 05 | 29.04.2013 | Renewal fee patent year 06 | 26.03.2014 | Renewal fee patent year 07 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 18.04.2008 | AT | 10.09.2014 | BE | 10.09.2014 | BG | 10.09.2014 | CY | 10.09.2014 | CZ | 10.09.2014 | DK | 10.09.2014 | EE | 10.09.2014 | FI | 10.09.2014 | HR | 10.09.2014 | LT | 10.09.2014 | LV | 10.09.2014 | MC | 10.09.2014 | MT | 10.09.2014 | NL | 10.09.2014 | PL | 10.09.2014 | RO | 10.09.2014 | SE | 10.09.2014 | SI | 10.09.2014 | SK | 10.09.2014 | TR | 10.09.2014 | NO | 10.12.2014 | GR | 11.12.2014 | IS | 10.01.2015 | PT | 12.01.2015 | GB | 18.04.2015 | IE | 18.04.2015 | IT | 18.04.2015 | LU | 18.04.2015 | ES | 19.04.2015 | CH | 30.04.2015 | FR | 30.04.2015 | LI | 30.04.2015 | [2017/39] |
Former [2017/03] | AT | 10.09.2014 | |
BE | 10.09.2014 | ||
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
MT | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
IE | 18.04.2015 | ||
IT | 18.04.2015 | ||
LU | 18.04.2015 | ||
ES | 19.04.2015 | ||
CH | 30.04.2015 | ||
FR | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/35] | AT | 10.09.2014 | |
BE | 10.09.2014 | ||
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
IE | 18.04.2015 | ||
IT | 18.04.2015 | ||
LU | 18.04.2015 | ||
ES | 19.04.2015 | ||
CH | 30.04.2015 | ||
FR | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/33] | AT | 10.09.2014 | |
BE | 10.09.2014 | ||
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
IE | 18.04.2015 | ||
IT | 18.04.2015 | ||
LU | 18.04.2015 | ||
CH | 30.04.2015 | ||
FR | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/20] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
IE | 18.04.2015 | ||
IT | 18.04.2015 | ||
LU | 18.04.2015 | ||
CH | 30.04.2015 | ||
FR | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/12] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
IT | 18.04.2015 | ||
LU | 18.04.2015 | ||
CH | 30.04.2015 | ||
FR | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/08] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
IT | 18.04.2015 | ||
LU | 18.04.2015 | ||
CH | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/07] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
GB | 18.04.2015 | ||
LU | 18.04.2015 | ||
CH | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/06] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
LU | 18.04.2015 | ||
CH | 30.04.2015 | ||
LI | 30.04.2015 | ||
Former [2016/01] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
MC | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
LU | 18.04.2015 | ||
Former [2015/52] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
LU | 18.04.2015 | ||
Former [2015/50] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SI | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
Former [2015/35] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
DK | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
Former [2015/25] | AT | 10.09.2014 | |
CY | 10.09.2014 | ||
CZ | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
Former [2015/24] | CY | 10.09.2014 | |
CZ | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
PL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
Former [2015/23] | CY | 10.09.2014 | |
CZ | 10.09.2014 | ||
EE | 10.09.2014 | ||
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
SK | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
IS | 10.01.2015 | ||
PT | 12.01.2015 | ||
Former [2015/22] | CY | 10.09.2014 | |
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
RO | 10.09.2014 | ||
SE | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
PT | 12.01.2015 | ||
Former [2015/16] | CY | 10.09.2014 | |
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
NL | 10.09.2014 | ||
SE | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
Former [2015/12] | CY | 10.09.2014 | |
FI | 10.09.2014 | ||
HR | 10.09.2014 | ||
LT | 10.09.2014 | ||
LV | 10.09.2014 | ||
SE | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
Former [2015/11] | CY | 10.09.2014 | |
FI | 10.09.2014 | ||
LT | 10.09.2014 | ||
SE | 10.09.2014 | ||
NO | 10.12.2014 | ||
GR | 11.12.2014 | ||
Former [2015/10] | FI | 10.09.2014 | |
LT | 10.09.2014 | ||
SE | 10.09.2014 | ||
NO | 10.12.2014 | ||
Former [2015/09] | FI | 10.09.2014 | |
LT | 10.09.2014 | ||
SE | 10.09.2014 | ||
Former [2015/08] | LT | 10.09.2014 | Cited in | International search | [Y]EP0243959 (DAINIPPON PHARMACEUTICAL CO [JP]) [Y] 1,12,18 * example 14 * * page 2, paragraph 1 *; | [X] - KATO, SHIRO ET AL, "Synthesis of deuterated mosapride citrate", JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS , 36(10), 927-32 CODEN: JLCRD4; ISSN: 0362-4803, (1995), XP002495539 [X] 1,12,18 * the whole document * DOI: http://dx.doi.org/10.1002/jlcr.2580361004 | [Y] - ARMSTRONG ET AL, "Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, ELSEVIER, NEW YORK, NY, US, (20060501), vol. 53, no. 3, ISSN 1056-8719, pages 198 - 205, XP005427273 [Y] 1,12,18 * page 202, paragraph 2 * | [Y] - KUSHNER DJ ET AL, "Pharmacological uses and perspectives of heavy water and deuterated compounds", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, OTTAWA, ONT, CA, (19990201), vol. 77, no. 2, pages 79 - 88, XP009086918 [Y] 1,12,18 * the whole document * | [Y] - FOSTER A B, "Deuterium isotope effects in the metabolism of drugs and xenobiotics: implications for drug design", ADVANCES IN DRUG RESEARCH, ACADEMIC PRESS, LONDON, GB, (19850101), vol. 14, ISSN 0065-2490, pages 1 - 40, XP009086953 [Y] 1,12,18 * the whole document * | by applicant | EP0243959 | - KATO, S.; HIROKAWA, Y., "Synthesis of deuterated mosapride citrate", J LABEL COMPD RADIOPHARM, (1995), vol. 36, pages 927 - 932 | - ARMSTRONG SR ET AL., "Measurement of 5-HT4 receptor-mediated esophageal responses by digital sonomicrometry in the anesthetized rat", J PHARMACOL TOXICOL METHODS, (200606), vol. 53, no. 3, pages 198 - 205 | - "Scientific Tables", Geigy Pharmaceuticals, ARDSLEY, (1970), page 537 |