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Extract from the Register of European Patents

EP About this file: EP2176415

EP2176415 - PREPARING METHOD FOR (S)-3-HYDROXYBUTYRIC ACID AND (S)-3-HYDROXYBUTYRATE ESTER USING RECOMBINANT MICROORGANISM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.03.2015
Database last updated on 02.09.2024
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): LU, TR		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
LG Chem, Ltd.
20, Yoido-dong Youngdungpo-gu
Seoul 150-721 / KR
[2010/16]
Inventor(s)01 / PARK, Si Jae
202-615 Jugong Apt.
Wolpyeong 2-dong
Seo-gu
Daejeon 302-793 / KR
02 / LEE, Sang Hyun
410-207 Expo Apt.
Jeonmin-dong
Yuseong-gu
Daejeon 305-761 / KR
 [2014/19]
Former [2010/16]01 / PARK, Si Jae
202-615 Jugong Apt. Wolpyeong 2-dong Seo-gu
Daejeon 302-793 / KR
02 / LEE, Sang Hyun
410-207 Expo Apt. Jeonmin-dong Yuseong-gu
Daejeon 305-761 / KR
Representative(s)Goddar, Heinz J.
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[N/P]
Former [2014/19]Goddar, Heinz J.
Boehmert & Boehmert
Pettenkoferstrasse 20-22
80336 München / DE
Former [2010/16]Goddar, Heinz J.
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date08766179.910.06.2008
[2010/16]
WO2008KR03217
Priority number, dateKR2007008010909.08.2007         Original published format: KR 20070080109
[2010/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009020279
Date:12.02.2009
Language:EN
[2009/07]
Type: A1 Application with search report 
No.:EP2176415
Date:21.04.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 12.02.2009 takes the place of the publication of the European patent application.
[2010/16]
Type: B1 Patent specification 
No.:EP2176415
Date:07.05.2014
Language:EN
[2014/19]
Search report(s)International search report - published on:KR12.02.2009
(Supplementary) European search report - dispatched on:EP26.09.2011
ClassificationIPC:C12P7/42, C12P7/62
[2011/43]
CPC:
C12P7/62 (EP,US); C12N15/66 (KR); C12N15/09 (KR);
C12N15/52 (KR); C12P7/42 (EP,US)
Former IPC [2010/16]C12N15/66
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/16]
TitleGerman:HERSTELLUNGSVERFAHREN FÜR (S)-3-HYDROXYBUTTERSÄURE UND (S)-3-HYDROXYBUTTERSÄUREESTER UNTER VERWENDUNG REKOMBINANTER MIKROORGANISMEN[2010/16]
English:PREPARING METHOD FOR (S)-3-HYDROXYBUTYRIC ACID AND (S)-3-HYDROXYBUTYRATE ESTER USING RECOMBINANT MICROORGANISM[2010/16]
French:PROCÉDÉ DE PRÉPARATION D'ACIDE (S)-3-HYDROXYBUTYRIQUE ET D'ESTER DE (S)-3-HYDROXYBUTYRATE AU MOYEN D'UN MICROORGANISME RECOMBINÉ[2010/16]
Entry into regional phase25.01.2010National basic fee paid 
25.01.2010Search fee paid 
25.01.2010Designation fee(s) paid 
25.01.2010Examination fee paid 
Examination procedure25.01.2010Examination requested  [2010/16]
11.04.2012Amendment by applicant (claims and/or description)
18.09.2013Despatch of a communication from the examining division (Time limit: M04)
16.01.2014Reply to a communication from the examining division
19.02.2014Communication of intention to grant the patent
25.03.2014Fee for grant paid
25.03.2014Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.09.2013
Opposition(s)10.02.2015No opposition filed within time limit [2015/16]
Fees paidRenewal fee
11.06.2010Renewal fee patent year 03
13.06.2011Renewal fee patent year 04
14.06.2012Renewal fee patent year 05
10.06.2013Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.06.2008
AT07.05.2014
BE07.05.2014
BG07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
MC07.05.2014
MT07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SI07.05.2014
SK07.05.2014
TR07.05.2014
IE10.06.2014
LU10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
[2016/33]
Former [2016/32]HU10.06.2008
AT07.05.2014
BE07.05.2014
BG07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
MC07.05.2014
MT07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SI07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2016/25]AT07.05.2014
BE07.05.2014
BG07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
MC07.05.2014
MT07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SI07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2016/21]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
MC07.05.2014
MT07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SI07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2016/16]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
MT07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SI07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/36]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SI07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/22]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
IT07.05.2014
LT07.05.2014
LV07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/21]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SK07.05.2014
IE10.06.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/20]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SK07.05.2014
CH30.06.2014
LI30.06.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/12]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
NL07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SK07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/11]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
PL07.05.2014
RO07.05.2014
SE07.05.2014
SK07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/10]AT07.05.2014
BE07.05.2014
CY07.05.2014
CZ07.05.2014
DK07.05.2014
EE07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
PL07.05.2014
SE07.05.2014
SK07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/08]AT07.05.2014
BE07.05.2014
CY07.05.2014
DK07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
PL07.05.2014
SE07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2015/02]AT07.05.2014
CY07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
PL07.05.2014
SE07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
PT08.09.2014
Former [2014/51]AT07.05.2014
CY07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
PL07.05.2014
SE07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
Former [2014/50]CY07.05.2014
ES07.05.2014
FI07.05.2014
HR07.05.2014
LT07.05.2014
LV07.05.2014
PL07.05.2014
SE07.05.2014
NO07.08.2014
GR08.08.2014
IS07.09.2014
Former [2014/49]CY07.05.2014
FI07.05.2014
LT07.05.2014
NO07.08.2014
IS07.09.2014
Former [2014/48]CY07.05.2014
LT07.05.2014
Former [2014/47]CY07.05.2014
Documents cited:Search[XP]  - SANG-HYUN LEE ET AL, "Biosynthesis of enantiopure (S)-3-hydroxybutyric acid in metabolically engineered Escherichia coli", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, (20080507), vol. 79, no. 4, ISSN 1432-0614, pages 633 - 641, XP019623626 [XP] 1-10 * the whole document *
International search[XP]  - LEE, S. H. et al., "Biosynthesis of enantiopure (S)-3-hydroxybutyric acid in metabolically engineered Escherichia coli.", Applied Microbiology and Biotechnology., (20080507), vol. 79, no. 4, pages 633 - 641, XP002744605 [XP] 1-10

DOI:   http://dx.doi.org/10.1007/s00253-008-1473-7
 [A]  - LIU, Q. et al., "Microbial production of R-3-hydroxybutyric acid by recombinant E. coli harboring genes of phbA, phbB, and tesB.", Applied Microbiology and Biotechnology., (20070704), vol. 76, no. 4, pages 811 - 818, XP019538724 [A] 1-10

DOI:   http://dx.doi.org/10.1007/s00253-007-1063-0
 [A]  - LEE, S. Y. et al., "Metabolic engineering of Escherichia coli for production of enantiomerically pure (R)-(-)-hydroxycarboxylic acids.", Applied and Environmental Microbiology, (20030600), vol. 69, no. 6, pages 3421 - 3426, XP002372566 [A] 1-10

DOI:   http://dx.doi.org/10.1128/AEM.69.6.3421-3426.2003
 [A]  - GAO, H. J. et al., "Enhanced production of D-(-)-3-hydroxybutyric acid by recombinant Escherichia coli.", FEMS Microbiology Letter., (20020716), vol. 213, no. 1, pages 59 - 65, XP002583389 [A] 1-10
 [A]  - COLBY, G. D. et al., "Purification and properties of 3-hydroxybutyryl-coenzyme A dehydrogenase from Clostridium beijerinckii (''Clostridium butylicum'') NRRL B593.", Applied and Environmental Microbiology, (19921000), vol. 58, no. 10, pages 3297 - 3302, XP009135608 [A] 1-10
by applicant   - SPECIALITY CHEMICALS MAGAZINE, APRIL, (2004), page 39
    - T. FERREIRA ET AL., TETRAHEDRON, (1990), vol. 46, page 6311
    - K. MORI ET AL., TETRAHEDRON, (1981), vol. 37, page 1341
    - T. CHIBA ET AL., CHEMISTRY LETTERS, (1987), vol. 16, page 2187
    - B. N. ZHOU ET AL., JOURNAL OF AMERICAN CHEMICAL SOCIETY, (1983), vol. 105, page 5925
    - R. NOYORI ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (1987), vol. 109, page 5856
    - TETRAHEDRON LETTERS, (1993), vol. 34, page 3949
    - LEE ET AL., BIOTECHNOL BIOENG, (1999), vol. 65, page 363
    - LEE; LEE, APPL ENVRON MICROBIOL, (2003), vol. 69, page 1295
    - GAO ET AL., FEMS MICROBIOL LETT, (2002), vol. 213, page 59
    - LEE; LEE, APPL ENVIRON MICROBIAL, (2003), vol. 69, page 1295
    - PARK; LEE, J. BACTERIOL., (2003), vol. 185, pages 5391 - 5397
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.