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Extract from the Register of European Patents

EP About this file: EP2170898

EP2170898 - METHODS FOR N-DEMETHYLATION OF MORPHINE AND TROPANE ALKALOIDS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.03.2017
Database last updated on 26.06.2024
Most recent event   Tooltip17.08.2018Lapse of the patent in a contracting state
New state(s): BG		published on 19.09.2018  [2018/38]
Applicant(s)For all designated states
Brock University
500 Glenridge Avenue
St. Catharines, Ontario L2S 3A1 / CA
[2010/14]
Inventor(s)01 / CARROLL, Robert
35-1 Raymond Street
St. Catharines, Ontario L2R 3B1 / CA
02 / LEISCH, Hannes
3 Church Street No.2
St. Catharines, Ontario L2R 3B1 / CA
03 / HUDLICKY, Tomas
173 Lockhart Drive
St. Catharines, Ontario L2T 1W7 / CA
 [2010/14]
Representative(s)HGF
HGF Limited
Mill House
North Street
York YO1 6JD / GB
[N/P]
Former [2016/18]Sanderson, Nigel Paul, et al
HGF Limited
Saviour House
9 St Saviourgate
York YO1 8NQ / GB
Former [2013/32]Sanderson, Nigel Paul, et al
Harrison Goddard Foote LLP
Saviour House
9 St Saviourgate
York YO1 8NQ / GB
Former [2010/14]Harrison Goddard Foote
106 Micklegate
York, North Yorkshire YO1 6JX / GB
Application number, filing date08772839.030.06.2008
[2010/14]
WO2008CA01179
Priority number, dateUS2007077122729.06.2007         Original published format: US 771227
[2010/14]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009003272
Date:08.01.2009
Language:EN
[2009/02]
Type: A1 Application with search report 
No.:EP2170898
Date:07.04.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 08.01.2009 takes the place of the publication of the European patent application.
[2010/14]
Type: B1 Patent specification 
No.:EP2170898
Date:04.05.2016
Language:EN
[2016/18]
Search report(s)International search report - published on:CA08.01.2009
(Supplementary) European search report - dispatched on:EP01.08.2011
ClassificationIPC:C07D489/02, C07B43/04, B01J23/72, B01J23/44
[2010/14]
CPC:
C07D489/02 (EP,US); C07D451/06 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/18]
Former [2010/14]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERFAHREN ZUR N-DEMETHYLIERUNG VON MORPHIN- UND TROPANALKALOIDEN[2010/14]
English:METHODS FOR N-DEMETHYLATION OF MORPHINE AND TROPANE ALKALOIDS[2010/14]
French:PROCÉDÉS DE N-DÉMÉTHYLATION D'ALCALOÏDES MORPHINIQUES ET TROPANIQUES[2010/14]
Entry into regional phase29.01.2010National basic fee paid 
29.01.2010Search fee paid 
29.01.2010Designation fee(s) paid 
29.01.2010Examination fee paid 
Examination procedure29.01.2010Examination requested  [2010/14]
01.02.2012Amendment by applicant (claims and/or description)
08.01.2013Despatch of a communication from the examining division (Time limit: M04)
15.05.2013Reply to a communication from the examining division
06.05.2014Despatch of a communication from the examining division (Time limit: M04)
11.09.2014Reply to a communication from the examining division
22.09.2015Communication of intention to grant the patent
29.01.2016Communication of intention to grant the patent
14.03.2016Fee for grant paid
14.03.2016Fee for publishing/printing paid
14.03.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.01.2013
Opposition(s)07.02.2017No opposition filed within time limit [2017/15]
Fees paidRenewal fee
18.06.2010Renewal fee patent year 03
29.06.2011Renewal fee patent year 04
28.06.2012Renewal fee patent year 05
28.06.2013Renewal fee patent year 06
30.06.2014Renewal fee patent year 07
30.06.2015Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.06.2008
AT04.05.2016
BE04.05.2016
BG04.05.2016
CY04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
IS04.05.2016
LT04.05.2016
LV04.05.2016
MC04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SI04.05.2016
SK04.05.2016
TR04.05.2016
IE30.06.2016
LU30.06.2016
MT30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
[2018/38]
Former [2018/32]HU30.06.2008
AT04.05.2016
BE04.05.2016
CY04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
IS04.05.2016
LT04.05.2016
LV04.05.2016
MC04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SI04.05.2016
SK04.05.2016
TR04.05.2016
IE30.06.2016
LU30.06.2016
MT30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2018/29]HU30.06.2008
AT04.05.2016
BE04.05.2016
CY04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
MC04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SI04.05.2016
SK04.05.2016
TR04.05.2016
IE30.06.2016
LU30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2018/28]HU30.06.2008
AT04.05.2016
BE04.05.2016
CY04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
MC04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SI04.05.2016
SK04.05.2016
IE30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/37]AT04.05.2016
BE04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
MC04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SI04.05.2016
SK04.05.2016
IE30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/17]AT04.05.2016
BE04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
MC04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SK04.05.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/11]AT04.05.2016
BE04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SK04.05.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/10]BE04.05.2016
CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
PL04.05.2016
RO04.05.2016
SE04.05.2016
SK04.05.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/09]CZ04.05.2016
DK04.05.2016
EE04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
RO04.05.2016
SE04.05.2016
BE30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/07]DK04.05.2016
FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
SE04.05.2016
BE30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2017/03]FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
SE04.05.2016
BE30.06.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2016/52]FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
SE04.05.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2016/51]FI04.05.2016
HR04.05.2016
LT04.05.2016
LV04.05.2016
NL04.05.2016
NO04.08.2016
GR05.08.2016
PT05.09.2016
Former [2016/49]FI04.05.2016
LT04.05.2016
NL04.05.2016
NO04.08.2016
Former [2016/46]LT04.05.2016
NO04.08.2016
Documents cited:Search[X]WO0216367  (GLAXO WELLCOME AUSTRALIA LTD [AU], et al) [X] 1,3,11 * claims 1-4,9 *;
 [X]  - STEPHEN HANESSIAN ET AL, "The Power of Visual Imagery in Drug Design. Isopavines as a New Class of Morphinomimetics and Their Human Opioid Receptor Binding Activity +", JOURNAL OF MEDICINAL CHEMISTRY, (20030101), vol. 46, no. 1, doi:10.1021/jm020164l, ISSN 0022-2623, pages 34 - 48, XP055003207 [X] 1,3-5,11,12 * Scheme 2, reaction (i). *

DOI:   http://dx.doi.org/10.1021/jm020164l
 [X]  - K. C. MAJUMDAR ET AL, "Synthesis of 1-alkoxy-1,2,3,4-tetra-hydrocarbazoles by mercury(II) mediated heterocyclization of 2-cyclohex-2'-enyl- N -alkylanilines", CANADIAN JOURNAL OF CHEMISTRY, (19960801), vol. 74, no. 8, doi:10.1139/v96-175, ISSN 0008-4042, pages 1592 - 1596, XP055003232 [X] 1,4 * Scheme 3, reaction (iii). *

DOI:   http://dx.doi.org/10.1139/v96-175
 [X]  - ILEY J ET AL, "CHEMICAL AND MICROSOMAL OXIDATION OF TERTIARY AMIDES: REGIO- AND STEREOSELECTIVE ASPECTS", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 2, CHEMICAL SOCIETY. LETCHWORTH, GB, (20010101), vol. 2, no. 8, doi:10.1039/B102731J, ISSN 1472-779X, pages 1299 - 1305, XP001026985 [X] 1 * Scheme 3; page 1301.;; table 2 *

DOI:   http://dx.doi.org/10.1039/b102731j
 [A]  - THOMAS ROSENAU ET AL, "A General, Selective, High-Yield N-Demethylation Procedure for Tertiary Amines by Solid Reagents in a Convenient Column Chromatography-like Setup", ORGANIC LETTERS, (20040201), vol. 6, no. 4, doi:10.1021/ol036319g, ISSN 1523-7060, pages 541 - 544, XP055003263 [A] 1 * the whole document *

DOI:   http://dx.doi.org/10.1021/ol036319g
International search[A]  - RIPPER J.A. ET AL., "Photochemical N-Demethylation of Alkaloids", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2001), vol. 11, no. 4, pages 443 - 445, XP004230031

DOI:   http://dx.doi.org/10.1016/S0960-894X(00)00690-9
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.