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Extract from the Register of European Patents

EP About this file: EP2324841

EP2324841 - TRADITIONAL CHINESE MEDICINAL COMPOSITION FOR THE TREATMENT OF CARDIOVASCULAR DISEASE [Right-click to bookmark this link]
Former [2011/21]USE OF A TRADITIONAL CHINESE MEDICINAL COMPOSITION FOR PREPARING MEDICINE FOR PROMOTING BONE MARROW-DERIVED MESENCHYMAL STEM CELL SURVIVAL IN VIVO AND CARDIAC MUSCLE DIFFERENTIATION
[2018/08]
StatusNo opposition filed within time limit
Status updated on  17.05.2019
Database last updated on 26.06.2024
FormerThe patent has been granted
Status updated on  08.06.2018
FormerGrant of patent is intended
Status updated on  07.02.2018
FormerExamination is in progress
Status updated on  09.10.2017
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Hebei Yiling Medicine Research Institute Co., Ltd.
No.238 Tianshan Avenue New High-Tec Development Area Shijiazhuang
Hebei 050035 / CN
[2011/21]
Inventor(s)01 / YANG, Yuejin
No.238 Tianshan Street
Hi-Tech District
Shijiazhuang
Hebei 050035 / CN
02 / QIAN, Haiyan
No.238 Tianshan Street
Hi-Tech District
Shijiazhuang
Hebei 050035 / CN
 [2018/28]
Former [2011/21]01 / YANG, Yuejin
No.238 Tianshan Street Hi-Tech District Shijiazhuang
Hebei 050035 / CN
02 / QIAN, Haiyan
No.238 Tianshan Street Hi-Tech District Shijiazhuang
Hebei 050035 / CN
Representative(s)Kolster Oy Ab
(Salmisaarenaukio 1)
P.O. Box 204
00181 Helsinki / FI
[2018/28]
Former [2013/43]Kolster Oy Ab
Iso Roobertinkatu 23
PO Box 148
00121 Helsinki / FI
Former [2012/24]Friman, Tea Marika
Kolster OY AB
Iso Roobertinkatu 23
P.O. Box 148
00121 Helsinki / FI
Former [2011/21]Halmepuro, Liisa
Kolster Oy AB P.O. Box 148 Iso Roobertinkatu 23
FI-00121 Helsinki / FI
Application number, filing date08783591.429.07.2008
[2011/21]
WO2008CN01401
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010012127
Date:04.02.2010
Language:ZH
[2010/05]
Type: A1 Application with search report 
No.:EP2324841
Date:25.05.2011
Language:EN
[2011/21]
Type: B1 Patent specification 
No.:EP2324841
Date:11.07.2018
Language:EN
[2018/28]
Search report(s)International search report - published on:CN04.02.2010
(Supplementary) European search report - dispatched on:EP24.11.2011
ClassificationIPC:A61K36/25, A61K36/324, A61K36/65, A61K36/54, A61K36/185, A61K35/64, A61K35/62, A61K31/045, A61P9/10
[2011/50]
CPC:
A61K36/25 (EP,KR,US); A61K31/045 (EP,KR,US); A61K35/62 (EP,KR,US);
A61K35/63 (EP,KR,US); A61K35/646 (EP,KR,US); A61K35/648 (EP,KR,US);
A61K36/185 (EP,KR,US); A61K36/324 (EP,KR,US); A61K36/54 (EP,KR,US);
A61K36/65 (EP,KR,US); A61K47/46 (EP,KR,US); A61P9/00 (EP);
A61P9/10 (EP) (-)
C-Set:
A61K35/62, A61K2300/00 (US,EP);
A61K35/63, A61K2300/00 (EP,US);
A61K35/646, A61K2300/00 (EP,US);
A61K35/648, A61K2300/00 (EP,US);
A61K36/185, A61K2300/00 (US,EP);
A61K36/25, A61K2300/00 (US,EP);
A61K36/324, A61K2300/00 (US,EP);
A61K36/54, A61K2300/00 (EP,US);
A61K36/65, A61K2300/00 (EP,US)
(-)
Former IPC [2011/21]A61K36/725, A61K36/71, A61K36/48, A61K36/328, A61K36/324, A61K36/258, A61K36/185, A61K35/64, A61K35/62, A61K31/045, A61K9/08, A61K9/10, A61K9/20, A61K9/48, A61P9/10, A61K125/00, A61K131/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/28]
Former [2011/21]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:TRADITIONELLE CHINESISCHE MEDIZINISCHE ZUSAMMENSETZUNG ZUR BEHANDLUNG VON KARDIOVASKULÄREN ERKRANKUNGEN[2018/08]
English:TRADITIONAL CHINESE MEDICINAL COMPOSITION FOR THE TREATMENT OF CARDIOVASCULAR DISEASE[2018/08]
French:COMPOSITION DE MÉDECINE CHINOISE TRADITIONNELLE POUR LE TRAITEMENT DES MALADIES CARDIOVASCULAIRES[2018/08]
Former [2011/21]VERWENDUNG EINER TRADITIONELLEN CHINESISCHEN MEDIZINISCHEN ZUSAMMENSETZUNG ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR FÖRDERUNG DES ÜBERLEBENS VON MESENCHYMALEN STAMMZELLEN AUS KNOCHENMARK IN VIVO UND HERZMUSKEL-DIFFERENZIERUNG
Former [2011/21]USE OF A TRADITIONAL CHINESE MEDICINAL COMPOSITION FOR PREPARING MEDICINE FOR PROMOTING BONE MARROW-DERIVED MESENCHYMAL STEM CELL SURVIVAL IN VIVO AND CARDIAC MUSCLE DIFFERENTIATION
Former [2011/21]UTILISATION D'UNE COMPOSITION DE MÉDECINE CHINOISE TRADITIONNELLE POUR LA PRÉPARATION D'UN MÉDICAMENT DESTINÉ À FAVORISER LA SURVIE IN VIVO DES CELLULES SOUCHES MÉSENCHYMATEUSES ISSUES DE LA MOELLE OSSEUSE ET UNE DIFFÉRENCIATION DU MUSCLE CARDIAQUE& xA;
Entry into regional phase25.02.2011Translation filed 
25.02.2011National basic fee paid 
25.02.2011Search fee paid 
25.02.2011Designation fee(s) paid 
25.02.2011Examination fee paid 
Examination procedure29.12.2009Request for preliminary examination filed
International Preliminary Examining Authority: CN
25.02.2011Amendment by applicant (claims and/or description)
25.02.2011Examination requested  [2011/21]
17.10.2013Observations by third parties
23.07.2015Despatch of a communication from the examining division (Time limit: M04)
23.11.2015Reply to a communication from the examining division
16.12.2015Despatch of a communication from the examining division (Time limit: M04)
08.04.2016Reply to a communication from the examining division
25.09.2017Cancellation of oral proceeding that was planned for 24.10.2017
28.09.2017Despatch of a communication from the examining division (Time limit: M02)
24.10.2017Date of oral proceedings (cancelled)
28.11.2017Reply to a communication from the examining division
08.02.2018Communication of intention to grant the patent
31.05.2018Fee for grant paid
31.05.2018Fee for publishing/printing paid
31.05.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.07.2015
Opposition(s)12.04.2019No opposition filed within time limit [2019/25]
Fees paidRenewal fee
25.02.2011Renewal fee patent year 03
12.07.2011Renewal fee patent year 04
13.07.2012Renewal fee patent year 05
10.07.2013Renewal fee patent year 06
14.07.2014Renewal fee patent year 07
10.07.2015Renewal fee patent year 08
11.07.2016Renewal fee patent year 09
12.07.2017Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT11.07.2018
CY11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
PT11.07.2018
RO11.07.2018
SE11.07.2018
SI11.07.2018
SK11.07.2018
TR11.07.2018
IE29.07.2018
LU29.07.2018
MT29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
[2020/32]
Former [2020/27]AT11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
PT11.07.2018
RO11.07.2018
SE11.07.2018
SI11.07.2018
SK11.07.2018
TR11.07.2018
IE29.07.2018
LU29.07.2018
MT29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2020/16]AT11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
SI11.07.2018
SK11.07.2018
TR11.07.2018
IE29.07.2018
LU29.07.2018
MT29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2020/08]AT11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
SI11.07.2018
SK11.07.2018
IE29.07.2018
LU29.07.2018
MT29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/37]AT11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
SI11.07.2018
SK11.07.2018
IE29.07.2018
LU29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/33]AT11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
SK11.07.2018
IE29.07.2018
LU29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/26]AT11.07.2018
CZ11.07.2018
DK11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
SK11.07.2018
LU29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/24]AT11.07.2018
CZ11.07.2018
EE11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
MC11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
SK11.07.2018
LU29.07.2018
BE31.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/22]AT11.07.2018
CZ11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
PL11.07.2018
RO11.07.2018
SE11.07.2018
LU29.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/21]AT11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
IT11.07.2018
LT11.07.2018
LV11.07.2018
PL11.07.2018
SE11.07.2018
LU29.07.2018
CH31.07.2018
LI31.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/17]AT11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
PL11.07.2018
SE11.07.2018
LU29.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/12]AT11.07.2018
ES11.07.2018
FI11.07.2018
HR11.07.2018
LT11.07.2018
LV11.07.2018
PL11.07.2018
SE11.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/11]AT11.07.2018
FI11.07.2018
HR11.07.2018
LT11.07.2018
PL11.07.2018
SE11.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/10]AT11.07.2018
FI11.07.2018
LT11.07.2018
PL11.07.2018
SE11.07.2018
BG11.10.2018
NO11.10.2018
GR12.10.2018
IS11.11.2018
Former [2019/08]FI11.07.2018
LT11.07.2018
NO11.10.2018
IS11.11.2018
Former [2019/07]LT11.07.2018
Documents cited:Search[X]  - QIAN HAI-YAN ET AL, "Effects of Tongxinluo-facilitated cellular cardiomyoplasty with autologous bone marrow-mesenchymal stem cells on postinfarct swine hearts.", CHINESE MEDICAL JOURNAL 20 AUG 2007 LNKD- PUBMED:17825171, (20070820), vol. 120, no. 16, ISSN 0366-6999, pages 1416 - 1425, XP002662899 [X] 1-10 * the whole document *
 [A]  - WU TAIXIANG ET AL, "Tongxinluo (Tong xin luo or Tong-xin-luo) capsule for unstable angina pectoris.", COCHRANE DATABASE OF SYSTEMATIC REVIEWS (ONLINE) 2006 LNKD- PUBMED:17054205, (2006), no. 4, ISSN 1469-493X, page CD004474, XP002662362 [A] 1-10 * table 1 *

DOI:   http://dx.doi.org/10.1002/14651858.CD004474.pub2
International search[X]CN1334121  (YILING PHARMACEUTICAL CO LTD S [CN]);
 [X]CN1709291  (HEBEI YILING MEDICINE INST CO [CN]);
 [X]CN1939438  (YILING MEDICAL ACADEMY CO LTD [CN]);
 [X]CN1954825  (HEBEI YILING MEDICAL INST CO L [CN])
by applicant   - SCHUSTER MD; KOCHER AA; SEKI T; MARTENS TP; XIANG G; HOMMA S ET AL., "Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration", AM J PHYSIOL HEART CIRC PHYSIOL, (2004), vol. 287, pages H525 - 532
    - MULLER-EHMSEN J; WHITTAKER P; KLONER RA; DOW JS; SAKODA T; LONG TI ET AL., "Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium", J MOL CELL CARDIOL, (2002), vol. 34, pages 107 - 116
    - SUZUKI K; SMOLENSKI RT; JAYA- KUMAR J; MURTUZA B; BRAND NJ; YACOUB MH, "Heat shock treatment enhances graft cell survival in skeletal myoblast transplantation to the heart", CIRCULATION, (2000), vol. 102, pages 111216 - 221
    - MANGI AA; NOISEUX N; KONG D; HE H; REZVANI M; INGWALL JS ET AL., "Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts", NAT MED, (2003), vol. 9, pages 1195 - 1201
    - TANG YL; TANG Y; ZHANG C; QIAN KP; SHEN LP; PHILLIPS ., "Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated Ferroheme Oxygenase-1 vector", J AM COLL CARDIOL, (2005), vol. 46, pages 1339 - 1350
    - WEIDNER N; SEMPLE JP; WELCH WR; FOLKMAN J, "Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma", N ENGL J MED, (1991), vol. 324, pages 1 - 8
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.